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AI models collapse when trained on recursively generated data Nature (IF 50.5) Pub Date : 2024-07-24 Ilia Shumailov, Zakhar Shumaylov, Yiren Zhao, Nicolas Papernot, Ross Anderson, Yarin Gal
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Blood culture-free ultra-rapid antimicrobial susceptibility testing Nature (IF 50.5) Pub Date : 2024-07-24 Tae Hyun Kim, Junwon Kang, Haewook Jang, Hyelyn Joo, Gi Yoon Lee, Hamin Kim, Untack Cho, Hyeeun Bang, Jisung Jang, Sangkwon Han, Dong Young Kim, Chan Mi Lee, Chang Kyung Kang, Pyoeng Gyun Choe, Nam Joong Kim, Myoung-don Oh, Taek Soo Kim, Inho Kim, Wan Beom Park, Sunghoon Kwon
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Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain Nature (IF 50.5) Pub Date : 2024-07-24 Jennifer M. Kefauver, Markku Hakala, Luoming Zou, Josephine Alba, Javier Espadas, Maria G. Tettamanti, Jelena Gajić, Caroline Gabus, Pablo Campomanes, Leandro F. Estrozi, Nesli E. Sen, Stefano Vanni, Aurélien Roux, Ambroise Desfosses, Robbie Loewith
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A human autoimmune organoid model reveals IL-7 function in coeliac disease Nature (IF 50.5) Pub Date : 2024-07-24 António J. M. Santos, Vincent van Unen, Zhongqi Lin, Steven M. Chirieleison, Nhi Ha, Arpit Batish, Joshua E. Chan, Jose Cedano, Elisa T. Zhang, Qinghui Mu, Alexander Guh-Siesel, Madeline Tomaske, Deana Colburg, Sushama Varma, Shannon S. Choi, Asbjørn Christophersen, Ani Baghdasaryan, Kathryn E. Yost, Kasper Karlsson, Andrew Ha, Jing Li, Hongjie Dai, Zachary M. Sellers, Howard Y. Chang, James C. Y.
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Isolation of a methyl-reducing methanogen outside the Euryarchaeota Nature (IF 50.5) Pub Date : 2024-07-24 Kejia Wu, Lei Zhou, Guillaume Tahon, Laiyan Liu, Jiang Li, Jianchao Zhang, Fengfeng Zheng, Chengpeng Deng, Wenhao Han, Liping Bai, Lin Fu, Xiuzhu Dong, Chuanlun Zhang, Thijs J. G. Ettema, Diana Z. Sousa, Lei Cheng
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Cultivation and visualization of a methanogen of the phylum Thermoproteota Nature (IF 50.5) Pub Date : 2024-07-24 Anthony J. Kohtz, Nikolai Petrosian, Viola Krukenberg, Zackary J. Jay, Martin Pilhofer, Roland Hatzenpichler
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Deep, hot, ancient melting recorded by ultralow oxygen fugacity in peridotites Nature (IF 50.5) Pub Date : 2024-07-24 Suzanne K. Birner, Elizabeth Cottrell, Fred A. Davis, Jessica M. Warren
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Global net climate effects of anthropogenic reactive nitrogen Nature (IF 50.5) Pub Date : 2024-07-24 Cheng Gong, Hanqin Tian, Hong Liao, Naiqing Pan, Shufen Pan, Akihiko Ito, Atul K. Jain, Sian Kou-Giesbrecht, Fortunat Joos, Qing Sun, Hao Shi, Nicolas Vuichard, Qing Zhu, Changhui Peng, Federico Maggi, Fiona H. M. Tang, Sönke Zaehle
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Jurassic fossil juvenile reveals prolonged life history in early mammals Nature (IF 50.5) Pub Date : 2024-07-24 Elsa Panciroli, Roger B. J. Benson, Vincent Fernandez, Nicholas C. Fraser, Matt Humpage, Zhe-Xi Luo, Elis Newham, Stig Walsh
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Molecular basis of human noradrenaline transporter reuptake and inhibition Nature (IF 50.5) Pub Date : 2024-07-24 Jiaxin Tan, Yuan Xiao, Fang Kong, Xiaochun Zhang, Hanwen Xu, Angqi Zhu, Yiming Liu, Jianlin Lei, Boxue Tian, Yafei Yuan, Chuangye Yan
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Shifts in receptors during submergence of an encephalitic arbovirus Nature (IF 50.5) Pub Date : 2024-07-24 Wanyu Li, Jessica A. Plante, ChieYu Lin, Himanish Basu, Jesse S. Plung, Xiaoyi Fan, Joshua M. Boeckers, Jessica Oros, Tierra K. Buck, Praju V. Anekal, Wesley A. Hanson, Haley Varnum, Adrienne Wells, Colin J. Mann, Laurentia V. Tjang, Pan Yang, Rachel A. Reyna, Brooke M. Mitchell, Divya P. Shinde, Jordyn L. Walker, So Yoen Choi, Vesna Brusic, Paula Montero Llopis, Scott C. Weaver, Hisashi Umemori, Isaac
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Human TMEFF1 is a restriction factor for herpes simplex virus in the brain Nature (IF 50.5) Pub Date : 2024-07-24 Yi-Hao Chan, Zhiyong Liu, Paul Bastard, Noopur Khobrekar, Kennen M. Hutchison, Yasuhiro Yamazaki, Qing Fan, Daniela Matuozzo, Oliver Harschnitz, Nacim Kerrouche, Koji Nakajima, Param Amin, Ahmad Yatim, Darawan Rinchai, Jie Chen, Peng Zhang, Gabriele Ciceri, Jia Chen, Kerry Dobbs, Serkan Belkaya, Danyel Lee, Adrian Gervais, Kürşad Aydın, Ayse Kartal, Mary L. Hasek, Shuxiang Zhao, Eduardo Garcia Reino
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Single-cell multiregion dissection of Alzheimer’s disease Nature (IF 50.5) Pub Date : 2024-07-24 Hansruedi Mathys, Carles A. Boix, Leyla Anne Akay, Ziting Xia, Jose Davila-Velderrain, Ayesha P. Ng, Xueqiao Jiang, Ghada Abdelhady, Kyriaki Galani, Julio Mantero, Neil Band, Benjamin T. James, Sudhagar Babu, Fabiola Galiana-Melendez, Kate Louderback, Dmitry Prokopenko, Rudolph E. Tanzi, David A. Bennett, Li-Huei Tsai, Manolis Kellis
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Multi-heterojunctioned plastics with high thermoelectric figure of merit Nature (IF 50.5) Pub Date : 2024-07-24 Dongyang Wang, Jiamin Ding, Yingqiao Ma, Chunlin Xu, Zhiyi Li, Xiao Zhang, Yao Zhao, Yue Zhao, Yuqiu Di, Liyao Liu, Xiaojuan Dai, Ye Zou, BongSoo Kim, Fengjiao Zhang, Zitong Liu, Iain McCulloch, Myeongjae Lee, Cheng Chang, Xiao Yang, Dong Wang, Deqing Zhang, Li-Dong Zhao, Chong-an Di, Daoben Zhu
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Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy Nature (IF 50.5) Pub Date : 2024-07-24 Hussein Sultan, Yoshiko Takeuchi, Jeffrey P. Ward, Naveen Sharma, Tian-Tian Liu, Vladimir Sukhov, Maria Firulyova, Yuang Song, Samuel Ameh, Simone Brioschi, Darya Khantakova, Cora D. Arthur, J. Michael White, Heather Kohlmiller, Andres M. Salazar, Robert Burns, Helio A. Costa, Kelly D. Moynihan, Yik Andy Yeung, Ivana Djuretic, Ton N. Schumacher, Kathleen C. F. Sheehan, Marco Colonna, James P. Allison
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Global atmospheric methane uptake by upland tree woody surfaces Nature (IF 50.5) Pub Date : 2024-07-24 Vincent Gauci, Sunitha Rao Pangala, Alexander Shenkin, Josep Barba, David Bastviken, Viviane Figueiredo, Carla Gomez, Alex Enrich-Prast, Emma Sayer, Tainá Stauffer, Bertie Welch, Dafydd Elias, Niall McNamara, Myles Allen, Yadvinder Malhi
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peri-Fused polyaromatic molecular contacts for perovskite solar cells Nature (IF 50.5) Pub Date : 2024-07-24 Ke Zhao, Qingqing Liu, Libing Yao, Caner Değer, Jiahui Shen, Xu Zhang, Pengju Shi, Yuan Tian, Yixin Luo, Jiazhe Xu, Jingjing Zhou, Donger Jin, Sisi Wang, Wei Fan, Shaochen Zhang, Shenglong Chu, Xiaonan Wang, Liuwen Tian, Ruzhang Liu, Li Zhang, Ilhan Yavuz, Hong-fei Wang, Deren Yang, Rui Wang, Jingjing Xue
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In vivo interaction screening reveals liver-derived constraints to metastasis Nature (IF 50.5) Pub Date : 2024-07-24 Costanza Borrelli, Morgan Roberts, Davide Eletto, Marie-Didiée Hussherr, Hassan Fazilaty, Tomas Valenta, Atefeh Lafzi, Jonas A. Kretz, Elena Guido Vinzoni, Andromachi Karakatsani, Srivathsan Adivarahan, Ardian Mannhart, Shoichiro Kimura, Ab Meijs, Farah Baccouche Mhamedi, Ilhan E. Acar, Kristina Handler, Xenia Ficht, Randall J. Platt, Salvatore Piscuoglio, Andreas E. Moor
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TMEFF1 is a neuron-specific restriction factor for herpes simplex virus Nature (IF 50.5) Pub Date : 2024-07-24 Yao Dai, Manja Idorn, Manutea C. Serrero, Xiaoyong Pan, Emil A. Thomsen, Ryo Narita, Muyesier Maimaitili, Xiaoqing Qian, Marie B. Iversen, Line S. Reinert, Rasmus K. Flygaard, Muwan Chen, Xiangning Ding, Bao-cun Zhang, Madalina E. Carter-Timofte, Qing Lu, Zhuofan Jiang, Yiye Zhong, Shuhui Zhang, Lintai Da, Jinwei Zhu, Mark Denham, Poul Nissen, Trine H. Mogensen, Jacob Giehm Mikkelsen, Shen-Ying Zhang
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SMYD5 methylation of rpL40 links ribosomal output to gastric cancer Nature (IF 50.5) Pub Date : 2024-07-24 Juhyung Park, Jibo Wu, Krzysztof J. Szkop, Jinho Jeong, Predrag Jovanovic, Dylan Husmann, Natasha M. Flores, Joel W. Francis, Ying-Jiun C. Chen, Ana Morales Benitez, Emily Zahn, Shumei Song, Jaffer A. Ajani, Linghua Wang, Kamini Singh, Ola Larsson, Benjamin A. Garcia, Ivan Topisirovic, Or Gozani, Pawel K. Mazur
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Spillover of highly pathogenic avian influenza H5N1 virus to dairy cattle Nature (IF 50.5) Pub Date : 2024-07-25 Leonardo C. Caserta, Elisha A. Frye, Salman L. Butt, Melissa Laverack, Mohammed Nooruzzaman, Lina M. Covaleda, Alexis C. Thompson, Melanie Prarat Koscielny, Brittany Cronk, Ashley Johnson, Katie Kleinhenz, Erin E. Edwards, Gabriel Gomez, Gavin Hitchener, Mathias Martins, Darrell R. Kapczynski, David L. Suarez, Ellen Ruth Alexander Morris, Terry Hensley, John S. Beeby, Manigandan Lejeune, Amy K. Swinford
Highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b virus has caused the death of millions of domestic birds and thousands of wild birds in the U.S. since January, 20221–4 Throughout this outbreak, spillovers to mammals have been frequently documented5–12. We report spillover of HPAI H5N1 virus in dairy cattle herds across several states in the U.S. The affected cows displayed clinical signs
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Methyl-reducing methanogenesis by a thermophilic culture of Korarchaeia Nature (IF 50.5) Pub Date : 2024-07-24 Viola Krukenberg, Anthony J. Kohtz, Zackary J. Jay, Roland Hatzenpichler
Methanogenesis mediated by archaea is the major source of methane, a strong greenhouse gas, and thus is critical for understanding Earth’s climate dynamics. Recently, genes encoding diverse methanogenesis pathways were discovered in metagenome-assembled genomes affiliated with multiple archaeal phyla1–7. However, all experimental studies on methanogens are currently restricted to cultured representatives
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A temperate super-Jupiter imaged with JWST in the mid-infrared Nature (IF 50.5) Pub Date : 2024-07-24 E. C. Matthews, A. L. Carter, P. Pathak, C. V. Morley, M. W. Phillips, S. Krishanth P. M, F. Feng, M. J. Bonse, L. A. Boogaard, J. A. Burt, I. J. M. Crossfield, E. S. Douglas, Th. Henning, J. Hom, C.-L. Ko, M. Kasper, A.-M. Lagrange, D. Petit dit de la Roche, F. Philipot
Of the ~25 directly imaged planets to date, all are younger than 500Myr and all but 6 are younger than 100Myr1. Eps Ind A (HD209100, HIP108870) is a K5V star of roughly solar age (recently derived as 3.7-5.7Gyr2 and \({{\boldsymbol{3.5}}}_{-{\bf{1.3}}}^{+{\bf{0.8}}}\)Gyr3). A long-term radial velocity trend 4,5 as well as an astrometric acceleration6,7 led to claims of a giant planet2,8,9 orbiting
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Neural circuit basis of placebo pain relief Nature (IF 50.5) Pub Date : 2024-07-24 Chong Chen, Jesse K. Niehaus, Fatih Dinc, Karen L. Huang, Alexander L. Barnette, Adrien Tassou, S. Andrew Shuster, Lihua Wang, Andrew Lemire, Vilas Menon, Kimberly Ritola, Adam Hantman, Hongkui Zeng, Mark J. Schnitzer, Grégory Scherrer
Placebo effects are striking demonstrations of mind-body interactions 1,2. During pain perception, in the absence of any treatment, an expectation of pain relief can reduce the experience of pain, a phenomenon known as placebo analgesia 3–6. However, despite the strength of placebo effects and their impact on everyday human experience and failure of clinical trials for new therapeutics 7, the neural
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Neural general circulation models for weather and climate Nature (IF 50.5) Pub Date : 2024-07-22 Dmitrii Kochkov, Janni Yuval, Ian Langmore, Peter Norgaard, Jamie Smith, Griffin Mooers, Milan Klöwer, James Lottes, Stephan Rasp, Peter Düben, Sam Hatfield, Peter Battaglia, Alvaro Sanchez-Gonzalez, Matthew Willson, Michael P. Brenner, Stephan Hoyer
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Dopamine-mediated interactions between short- and long-term memory dynamics Nature (IF 50.5) Pub Date : 2024-07-22 Cheng Huang, Junjie Luo, Seung Je Woo, Lucas A. Roitman, Jizhou Li, Vincent A. Pieribone, Madhuvanthi Kannan, Ganesh Vasan, Mark J. Schnitzer
In dynamic environments, animals make behavioral decisions based on the innate valences of sensory cues and information learnt about these cues across multiple timescales1–3. However, it remains unclear how the innate valence of a sensory stimulus affects acquisition of learnt valence information and subsequent memory dynamics. Here we show that in the Drosophila brain, interconnected short- and long-term
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The enduring world forest carbon sink Nature (IF 50.5) Pub Date : 2024-07-17 Yude Pan, Richard A. Birdsey, Oliver L. Phillips, Richard A. Houghton, Jingyun Fang, Pekka E. Kauppi, Heather Keith, Werner A. Kurz, Akihiko Ito, Simon L. Lewis, Gert-Jan Nabuurs, Anatoly Shvidenko, Shoji Hashimoto, Bas Lerink, Dmitry Schepaschenko, Andrea Castanho, Daniel Murdiyarso
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Symbolic recording of signalling and cis-regulatory element activity to DNA Nature (IF 50.5) Pub Date : 2024-07-17 Wei Chen, Junhong Choi, Xiaoyi Li, Jenny F. Nathans, Beth Martin, Wei Yang, Nobuhiko Hamazaki, Chengxiang Qiu, Jean-Benoît Lalanne, Samuel Regalado, Haedong Kim, Vikram Agarwal, Eva Nichols, Anh Leith, Choli Lee, Jay Shendure
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Giant chiral magnetoelectric oscillations in a van der Waals multiferroic Nature (IF 50.5) Pub Date : 2024-07-17 Frank Y. Gao, Xinyue Peng, Xinle Cheng, Emil Viñas Boström, Dong Seob Kim, Ravish K. Jain, Deepak Vishnu, Kalaivanan Raju, Raman Sankar, Shang-Fan Lee, Michael A. Sentef, Takashi Kurumaji, Xiaoqin Li, Peizhe Tang, Angel Rubio, Edoardo Baldini
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Superconductivity in pressurized trilayer La4Ni3O10−δ single crystals Nature (IF 50.5) Pub Date : 2024-07-17 Yinghao Zhu, Di Peng, Enkang Zhang, Bingying Pan, Xu Chen, Lixing Chen, Huifen Ren, Feiyang Liu, Yiqing Hao, Nana Li, Zhenfang Xing, Fujun Lan, Jiyuan Han, Junjie Wang, Donghan Jia, Hongliang Wo, Yiqing Gu, Yimeng Gu, Li Ji, Wenbin Wang, Huiyang Gou, Yao Shen, Tianping Ying, Xiaolong Chen, Wenge Yang, Huibo Cao, Changlin Zheng, Qiaoshi Zeng, Jian-gang Guo, Jun Zhao
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Inhibition of IL-11 signalling extends mammalian healthspan and lifespan Nature (IF 50.5) Pub Date : 2024-07-17 Anissa A. Widjaja, Wei-Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Cibi Mary Dasan, Joyce Wei Ting Goh, Radiance Lim, Brijesh K. Singh, Jessie Tan, Chee Jian Pua, Sze Yun Lim, Eleonora Adami, Sebastian Schafer, Benjamin L. George, Mark Sweeney, Chen Xie, Madhulika Tripathi, Natalie A. Sims, Norbert Hübner, Enrico Petretto, Dominic J. Withers, Lena Ho, Jesus Gil, David Carling, Stuart
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An engineered enzyme embedded into PLA to make self-biodegradable plastic Nature (IF 50.5) Pub Date : 2024-07-17 M. Guicherd, M. Ben Khaled, M. Guéroult, J. Nomme, M. Dalibey, F. Grimaud, P. Alvarez, E. Kamionka, S. Gavalda, M. Noël, M. Vuillemin, E. Amillastre, D. Labourdette, G. Cioci, V. Tournier, V. Kitpreechavanich, P. Dubois, I. André, S. Duquesne, A. Marty
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Thresholds for adding degraded tropical forest to the conservation estate Nature (IF 50.5) Pub Date : 2024-07-17 Robert M. Ewers, C. David L. Orme, William D. Pearse, Nursyamin Zulkifli, Genevieve Yvon-Durocher, Kalsum M. Yusah, Natalie Yoh, Darren C. J. Yeo, Anna Wong, Joseph Williamson, Clare L. Wilkinson, Fabienne Wiederkehr, Bruce L. Webber, Oliver R. Wearn, Leona Wai, Maisie Vollans, Joshua P. Twining, Edgar C. Turner, Joseph A. Tobias, Jack Thorley, Elizabeth M. Telford, Yit Arn Teh, Heok Hui Tan, Tom Swinfield
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Adaptation to photoperiod via dynamic neurotransmitter segregation Nature (IF 50.5) Pub Date : 2024-07-17 G. Maddaloni, Y. J. Chang, R. A. Senft, S. M. Dymecki
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A hot-Jupiter progenitor on a super-eccentric retrograde orbit Nature (IF 50.5) Pub Date : 2024-07-17 Arvind F. Gupta, Sarah C. Millholland, Haedam Im, Jiayin Dong, Jonathan M. Jackson, Ilaria Carleo, Jessica Libby-Roberts, Megan Delamer, Mark R. Giovinazzi, Andrea S. J. Lin, Shubham Kanodia, Xian-Yu Wang, Keivan Stassun, Thomas Masseron, Diana Dragomir, Suvrath Mahadevan, Jason Wright, Jaime A. Alvarado-Montes, Chad Bender, Cullen H. Blake, Douglas Caldwell, Caleb I. Cañas, William D. Cochran, Paul
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Psilocybin desynchronizes the human brain Nature (IF 50.5) Pub Date : 2024-07-17 Joshua S. Siegel, Subha Subramanian, Demetrius Perry, Benjamin P. Kay, Evan M. Gordon, Timothy O. Laumann, T. Rick Reneau, Nicholas V. Metcalf, Ravi V. Chacko, Caterina Gratton, Christine Horan, Samuel R. Krimmel, Joshua S. Shimony, Julie A. Schweiger, Dean F. Wong, David A. Bender, Kristen M. Scheidter, Forrest I. Whiting, Jonah A. Padawer-Curry, Russell T. Shinohara, Yong Chen, Julia Moser, Essa
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A eukaryotic-like ubiquitination system in bacterial antiviral defence Nature (IF 50.5) Pub Date : 2024-07-17 Lydia R. Chambers, Qiaozhen Ye, Jiaxi Cai, Minheng Gong, Hannah E. Ledvina, Huilin Zhou, Aaron T. Whiteley, Raymond T. Suhandynata, Kevin D. Corbett
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A holistic platform for accelerating sorbent-based carbon capture Nature (IF 50.5) Pub Date : 2024-07-17 Charithea Charalambous, Elias Moubarak, Johannes Schilling, Eva Sanchez Fernandez, Jin-Yu Wang, Laura Herraiz, Fergus Mcilwaine, Shing Bo Peh, Matthew Garvin, Kevin Maik Jablonka, Seyed Mohamad Moosavi, Joren Van Herck, Aysu Yurdusen Ozturk, Alireza Pourghaderi, Ah-Young Song, Georges Mouchaham, Christian Serre, Jeffrey A. Reimer, André Bardow, Berend Smit, Susana Garcia
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Identification of plant transcriptional activation domains Nature (IF 50.5) Pub Date : 2024-07-17 Nicholas Morffy, Lisa Van den Broeck, Caelan Miller, Ryan J. Emenecker, John A. Bryant, Tyler M. Lee, Katelyn Sageman-Furnas, Edward G. Wilkinson, Sunita Pathak, Sanjana R. Kotha, Angelica Lam, Saloni Mahatma, Vikram Pande, Aman Waoo, R. Clay Wright, Alex S. Holehouse, Max V. Staller, Rosangela Sozzani, Lucia C. Strader
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Position-dependent function of human sequence-specific transcription factors Nature (IF 50.5) Pub Date : 2024-07-17 Sascha H. Duttke, Carlos Guzman, Max Chang, Nathaniel P. Delos Santos, Bayley R. McDonald, Jialei Xie, Aaron F. Carlin, Sven Heinz, Christopher Benner
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Groundwater-dependent ecosystem map exposes global dryland protection needs Nature (IF 50.5) Pub Date : 2024-07-17 Melissa M. Rohde, Christine M. Albano, Xander Huggins, Kirk R. Klausmeyer, Charles Morton, Ali Sharman, Esha Zaveri, Laurel Saito, Zach Freed, Jeanette K. Howard, Nancy Job, Holly Richter, Kristina Toderich, Aude-Sophie Rodella, Tom Gleeson, Justin Huntington, Hrishikesh A. Chandanpurkar, Adam J. Purdy, James S. Famiglietti, Michael Bliss Singer, Dar A. Roberts, Kelly Caylor, John C. Stella
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Singular dielectric nanolaser with atomic-scale field localization Nature (IF 50.5) Pub Date : 2024-07-17 Yun-Hao Ouyang, Hong-Yi Luan, Zi-Wei Zhao, Wen-Zhi Mao, Ren-Min Ma
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Mechanical release of homogenous proteins from supramolecular gels Nature (IF 50.5) Pub Date : 2024-07-17 Simona Bianco, Muhammad Hasan, Ashfaq Ahmad, Sarah-Jane Richards, Bart Dietrich, Matthew Wallace, Qiao Tang, Andrew J. Smith, Matthew I. Gibson, Dave J. Adams
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Clonal inactivation of TERT impairs stem cell competition Nature (IF 50.5) Pub Date : 2024-07-17 Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M. Ryan Corces, Patrick Neuhöfer, Victoria M. Gillespie, Peggie Cheung, Julia A. Belk, Yung-Hsin Huang, Yuning Wei, Lu Chen, Howard Y. Chang, Steven E. Artandi
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Sources of gene expression variation in a globally diverse human cohort Nature (IF 50.5) Pub Date : 2024-07-17 Dylan J. Taylor, Surya B. Chhetri, Michael G. Tassia, Arjun Biddanda, Stephanie M. Yan, Genevieve L. Wojcik, Alexis Battle, Rajiv C. McCoy
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Sunlight-powered sustained flight of an ultralight micro aerial vehicle Nature (IF 50.5) Pub Date : 2024-07-17 Wei Shen, Jinzhe Peng, Rui Ma, Jiaqing Wu, Jingyi Li, Zhiwei Liu, Jiaming Leng, Xiaojun Yan, Mingjing Qi
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Tubulin code eraser CCP5 binds branch glutamates by substrate deformation Nature (IF 50.5) Pub Date : 2024-07-17 Jiayi Chen, Elena A. Zehr, James M. Gruschus, Agnieszka Szyk, Yanjie Liu, Martin E. Tanner, Nico Tjandra, Antonina Roll-Mecak
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Bacteria conjugate ubiquitin-like proteins to interfere with phage assembly Nature (IF 50.5) Pub Date : 2024-07-17 Jens Hör, Sharon G. Wolf, Rotem Sorek
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In vivo single-cell CRISPR uncovers distinct TNF programmes in tumour evolution Nature (IF 50.5) Pub Date : 2024-07-17 Peter F. Renz, Umesh Ghoshdastider, Simona Baghai Sain, Fabiola Valdivia-Francia, Ameya Khandekar, Mark Ormiston, Martino Bernasconi, Clara Duré, Jonas A. Kretz, Minkyoung Lee, Katie Hyams, Merima Forny, Marcel Pohly, Xenia Ficht, Stephanie J. Ellis, Andreas E. Moor, Ataman Sendoel
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Split intein-mediated protein trans-splicing to express large dystrophins Nature (IF 50.5) Pub Date : 2024-07-17 Hichem Tasfaout, Christine L. Halbert, Timothy S. McMillen, James M. Allen, Theodore R. Reyes, Galina V. Flint, Dirk Grimm, Stephen D. Hauschka, Michael Regnier, Jeffrey S. Chamberlain
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Catalysis of an SN2 pathway by geometric preorganization Nature (IF 50.5) Pub Date : 2024-07-18 Gabriel J. Lovinger, Marcus H. Sak, Eric N. Jacobsen
Bimolecular nucleophilic substitution (SN2) mechanisms occupy a central place in the historical development and teaching of the field of organic chemistry1. Despite the importance of SN2 pathways in synthesis, catalytic control of ionic SN2 pathways is rare and notably uncommon even in biocatalysis2,3, reflecting the fact that any electrostatic interaction between a catalyst and the reacting ion pair
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A roadmap for affordable genetic medicines Nature (IF 50.5) Pub Date : 2024-07-17 Melinda Kliegman, Manar Zaghlula, Susan Abrahamson, Jonathan H. Esensten, Ross Wilson, Fyodor D. Urnov, Jennifer A. Doudna
Nineteen genetic therapies have been approved by the U.S. Food and Drug Administration (FDA) to date, a number that now includes the first CRISPR genome editing therapy for sickle cell disease, CASGEVY (exagamglogene autotemcel). This extraordinary milestone is widely celebrated because of the promise for future genome editing treatments of previously intractable genetic disorders and cancers. At the
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Inhomogeneous terminators on the exoplanet WASP-39 b Nature (IF 50.5) Pub Date : 2024-07-15 Néstor Espinoza, Maria E. Steinrueck, James Kirk, Ryan J. MacDonald, Arjun B. Savel, Kenneth Arnold, Eliza M.-R. Kempton, Matthew M. Murphy, Ludmila Carone, Maria Zamyatina, David A. Lewis, Dominic Samra, Sven Kiefer, Emily Rauscher, Duncan Christie, Nathan Mayne, Christiane Helling, Zafar Rustamkulov, Vivien Parmentier, Erin M. May, Aarynn L. Carter, Xi Zhang, Mercedes López-Morales, Natalie Allen
Transmission spectroscopy has been a workhorse technique over the past two decades to constrain the physical and chemical properties of exoplanet atmospheres 1–5. One of its classical key assumptions is that the portion of the atmosphere it probes — the terminator region — is homogeneous. Several works in the past decade, however, have put this into question for highly irradiated, hot (Teq ≳ 1000 K)
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De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome Nature (IF 50.5) Pub Date : 2024-07-11 Yuyang Chen, Ruebena Dawes, Hyung Chul Kim, Alicia Ljungdahl, Sarah L. Stenton, Susan Walker, Jenny Lord, Gabrielle Lemire, Alexandra C. Martin-Geary, Vijay S. Ganesh, Jialan Ma, Jamie M. Ellingford, Erwan Delage, Elston N. D’Souza, Shan Dong, David R. Adams, Kirsten Allan, Madhura Bakshi, Erin E. Baldwin, Seth I. Berger, Jonathan A. Bernstein, Ishita Bhatnagar, Ed Blair, Natasha J. Brown, Lindsay
Around 60% of individuals with neurodevelopmental disorders (NDD) remain undiagnosed after comprehensive genetic testing, primarily of protein-coding genes1. Large genome-sequenced cohorts are improving our ability to discover new diagnoses in the non-coding genome. Here, we identify the non-coding RNA RNU4-2 as a syndromic NDD gene. RNU4-2 encodes the U4 small nuclear RNA (snRNA), which is a critical
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Antiferromagnetic phase transition in a 3D fermionic Hubbard model Nature (IF 50.5) Pub Date : 2024-07-10 Hou-Ji Shao, Yu-Xuan Wang, De-Zhi Zhu, Yan-Song Zhu, Hao-Nan Sun, Si-Yuan Chen, Chi Zhang, Zhi-Jie Fan, Youjin Deng, Xing-Can Yao, Yu-Ao Chen, Jian-Wei Pan
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Phage anti-CRISPR control by an RNA- and DNA-binding helix–turn–helix protein Nature (IF 50.5) Pub Date : 2024-07-10 Nils Birkholz, Kotaro Kamata, Maximilian Feussner, Max E. Wilkinson, Christian Cuba Samaniego, Angela Migur, Dari Kimanius, Marijn Ceelen, Sam C. Went, Ben Usher, Tim R. Blower, Chris M. Brown, Chase L. Beisel, Zasha Weinberg, Robert D. Fagerlund, Simon A. Jackson, Peter C. Fineran
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Airborne DNA reveals predictable spatial and seasonal dynamics of fungi Nature (IF 50.5) Pub Date : 2024-07-10 Nerea Abrego, Brendan Furneaux, Bess Hardwick, Panu Somervuo, Isabella Palorinne, Carlos A. Aguilar-Trigueros, Nigel R. Andrew, Ulyana V. Babiy, Tan Bao, Gisela Bazzano, Svetlana N. Bondarchuk, Timothy C. Bonebrake, Georgina L. Brennan, Syndonia Bret-Harte, Claus Bässler, Luciano Cagnolo, Erin K. Cameron, Elodie Chapurlat, Simon Creer, Luigi P. D’Acqui, Natasha de Vere, Marie-Laure Desprez-Loustau
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Single-cell atlas of the human brain vasculature across development, adulthood and disease Nature (IF 50.5) Pub Date : 2024-07-10 Thomas Wälchli, Moheb Ghobrial, Marc Schwab, Shigeki Takada, Hang Zhong, Samuel Suntharalingham, Sandra Vetiska, Daymé Rodrigues Gonzalez, Ruilin Wu, Hubert Rehrauer, Anuroopa Dinesh, Kai Yu, Edward L. Y. Chen, Jeroen Bisschop, Fiona Farnhammer, Ann Mansur, Joanna Kalucka, Itay Tirosh, Luca Regli, Karl Schaller, Karl Frei, Troy Ketela, Mark Bernstein, Paul Kongkham, Peter Carmeliet, Taufik Valiante
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Repeated plague infections across six generations of Neolithic Farmers Nature (IF 50.5) Pub Date : 2024-07-10 Frederik Valeur Seersholm, Karl-Göran Sjögren, Julia Koelman, Malou Blank, Emma M. Svensson, Jacqueline Staring, Magdalena Fraser, Thomaz Pinotti, Hugh McColl, Charleen Gaunitz, Tatiana Ruiz-Bedoya, Lena Granehäll, Berenice Villegas-Ramirez, Anders Fischer, T. Douglas Price, Morten E. Allentoft, Astrid K. N. Iversen, Tony Axelsson, Torbjörn Ahlström, Anders Götherström, Jan Storå, Kristian Kristiansen
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Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury Nature (IF 50.5) Pub Date : 2024-07-10 Ke Lai, Iva Pritišanac, Zhen-Qi Liu, Han-Wei Liu, Li-Na Gong, Ming-Xian Li, Jian-Fei Lu, Xin Qi, Tian-Le Xu, Julie Forman-Kay, Hai-Bo Shi, Lu-Yang Wang, Shan-Kai Yin