The hydrological process in the dry–warm valley of the mountainous area of southwestern China has unique characteristics and has attracted scientific attention worldwide. Given that this is an area with fragile ecosystems and intensive water resource conflicts in the upper reaches of the Yangtze River, a systematic identification of its hydrological responses to climate and land use variations needs

The topology optimization design of complex products can significantly improve material and power savings, and reduce inertial forces and mechanical vibrations effectively. In this study, a large-tonnage hydraulic press was chosen as a typically complex product to present the optimization method. We propose a new reliability topology optimization method based on the reliability-and-optimization decoupled

Hepatocellular carcinoma (HCC) remains one of the most lethal malignancies. We previously demonstrated that the chromosome 19 microRNA cluster (C19MC) was associated with tumor burden and prognosis in patients with HCC. In the current study, we aim to explore the role of miR-516a-3p—an identical mature microRNA (miRNA) co-spliced by four oncogenic pre-miRNAs of C19MC (i.e., mir-516a-1, mir-516a-2,

In this study, through experimental research and an investigation on large datasets of the durability parameters in ocean engineering, the values, ranges, and types of distribution of the durability parameters employed for the durability design in ocean engineering in northern China were confirmed. Based on a modified theoretical model of chloride diffusion and the reliability theory, the service lives

A growing body of research evidence has verified the old concept of entropy increase to be the common mechanism for various human diseases and aging and the preservation of low-entropy state to be the key for human health and longevity. However, how the human body maintains at a low-entropy state remains unclear. I propose herein four integrated systems as the main intrinsic machineries for minimizing

Organ transplant rejection (OTR) is a complex immune reaction involving multiple cells, and it determines graft survival and patient prognosis. At present, most transplant recipients are administered a combination of immunosuppressive and biological agents to protect them from OTR. However, immunosuppressive agents negatively impact the immune system of the patients, causing them to suffer from serious

Lung cancer is a leading cause of cancer-related death worldwide, with a very poor overall five-year survival rate. The intrinsic limitations associated with the conventional diagnosis and therapeutic strategies used for lung cancer have motivated the development of nanotechnology and nanomedicine approaches, in order to improve early diagnosis rate and develop more effective and safer therapeutic

Pollution involving pharmaceutical components in bodies of water is an increasingly serious environmental issue. Plasma discharge for the degradation of antibiotics is an emerging technology that may be relevant toward addressing this issue. In this work, a plasma-assisted rotating disk reactor (plasma-RDR) and a photocatalyst—namely, titanium dioxide (TiO2)—were coupled for the treatment of metronidazole

The wealth of user data acts as a fuel for network intelligence toward the sixth generation wireless networks (6G). Due to data heterogeneity and dynamics, decentralized data management (DM) is desirable for achieving transparent data operations across network domains, and blockchain can be a promising solution. However, the increasing data volume and stringent data privacy-preservation requirements

The molecular network features of spinal cord development that are integral to tissue engineering remain poorly understood in placental mammals, especially in terms of their relationships with vital biological processes such as regeneration. Here, using a large-scale temporal transcriptomic analysis of rat spinal cord from the embryonic stage to adulthood, we show that fluctuating RNA expression levels

Earned duration management (EDM) is a methodology for project schedule management (PSM) that can be considered an alternative to earned value management (EVM). EDM provides an estimation of deviations in schedule and a final project duration estimation. There is a key difference between EDM and EVM: In EDM, the value of activities is expressed as work periods; whereas in EVM, value is expressed in

Recently, “Object to Human” transmission route of SARS-CoV-2 with cold chain food as the medium has been confirmed by the frequent occurrence of Covid-19 infected patients who are practitioners of global cold chain logistics. The effective disinfection for cold chain food is the key to cut off this transmission route. However, there are great challenges to achieve the goal, due to the extremely massive

Spinal cord injury (SCI) is a tremendous disaster in a person’s life. It interrupts the brain–body neuronal circuits, resulting in functional deficits. Pathogenesis of SCI is a progressive and comprehensive event. In clinical trials, attempts to promote nerve regeneration and functional recovery after SCI have met with failures. Recently, with the development of transcriptome sequencing and biomaterials

Fully human antibodies have minimal immunogenicity and safety profiles. At present, most potential antibody drugs in clinical trials are humanized or fully human. Human antibodies are mostly generated using the phage display method (in vitro) or by transgenic mice (in vivo); other methods include B lymphocyte immortalization, human–human hybridoma, and single-cell polymerase chain reaction. Here, we

With the large-scale commercial launch of fifth generation (5G) mobile network, the development of new services and applications catering to the year 2030, along with the deep convergence of information, communication, and data technologies (ICDT), and the lessons and experiences from 5G practice will drive the evolution of the next generation of mobile networks. This article surveys the history and

Colorectal cancer (CRC) is the third leading cancer globally. Metagenomics has been widely used to analyze the association between the gut microbiota and CRC based on bacterial genus- or species-level comparisons, providing evidence of dysbiosis in CRC development. However, this kind of analysis is unable to provide strain-level information for understanding the individual role of a species in CRC

In analyses of protein families that may serve as drug targets, membrane-associated G-protein-coupled receptors (GPCRs) dominate, followed by ion channels, transporters, and—to a lesser extent—membrane-bound enzymes. However, various challenges put such membrane proteins among key groups of underutilized opportunities for the application of therapeutic antibodies. Antibodies hold the promise of exquisite

The Lancang–Mekong River (LMR) is an important transboundary river that originates from the Tibetan plateau, China and flows through six nations in Southeast Asia. Knowledge about the past and future changes in climate and water for this basin is critical in order to support regional sustainable development. This paper presents a comprehensive review of the scientific progress that has been made in

The hydropower sector is currently experiencing several technological developments. New technologies and sustainable practices are emerging to make hydropower more flexible and eco-friendly. Novel materials have also been recently developed to increase performance, durability, and reliability; however, no systematic discussions can be found in the literature. Therefore, in this paper, novel materials

Implantable biosensors are not yet at the developmental phase where they can be vital for personalized medicine, deconstructing healthcare as we see it today. However, the obstacles have been identified and multidisciplinary teams of researchers worldwide have been working to overcome the main technical problems that hamper their clinical application. TE strategies for implantable biosensors seem to

In current wireless communication and electronic systems, digital signals and electromagnetic (EM) radiation are processed by different modules. Here, we propose a mechanism to fuse the modulation of digital signals and the manipulation of EM radiation on a single programmable metasurface. The programmable metasurface consists of massive subwavelength-scale digital coding elements. A set of digital

The occurrence of coronavirus disease 2019 (COVID-19) was followed by a small burst of cases around the world; afterward, due to a series of emergency non-pharmaceutical interventions (NPIs), the increasing number of confirmed cases slowed down in many countries. However, the subsequent gradual easing of governance led to a sudden increase in cases in late July 2020, arousing deep concern across the

Recognizing the risk of fluvial bank erosion is an important challenge to ensure the early warning and prevention or control of bank collapse in river catchments, including in the Yangtze River. This study introduces a geomorphons-based algorithm to extract river bank erosion information by adjusting the flatness from multibeam echo-sounding data. The algorithm maps 10 subaqueous morphological elements

It is necessary to develop a new strategy for treatment of lung cancer since it is the main cause of cancer death. Tanshinone IIA (Tan IIA), an active ingredient of a commonly used traditional Chinese herb Salvia miltiorrhiza, provides a new direction to develop a new strategy for the treatment. It has been found that Tan IIA could inhibit lung cancer in vitro and in vivo by inducing autophagic apoptosis

Hydrated cement is one of the complex composite systems due to the presence of multi-scale phases with varying morphologies. Calcium silicate hydrate (C–S–H), which is the principal binder phase in the hydrated cement, is responsible for the stiffness, strength, and durability of Portland cement concrete. To understand the mechanical and durability behavior of concrete, it is important to investigate

The brain is the most heterogeneous and complex tissue in the body. Previous studies have shown that immune cells are essential functional components in both healthy and pathological brains. Cytometry by the time of flight (CyTOF) is a high-dimensional single-cell detection technology that allows measurements of up to 100 cell markers with a small number of samples. This technique enables the identification

Modeling and simulation have emerged as an indispensable approach to create numerical experiment platforms and study engineering systems. However, the increasingly complicated systems that engineers face today dramatically challenge state-of-the-art modeling and simulation approaches. Such complicated systems, which are composed of not only continuous states but also discrete events, and which contain

The low ionic conductivity of solid-state electrolytes (SSEs) and the inferior interfacial reliability between SSEs and solid-state electrodes are two urgent challenges hindering the application of solid-state sodium batteries (SSSBs). Herein, sodium (Na) super ionic conductor (NASICON)-type SSEs with a nominal composition of Na3+2xZr2–xMgxSi2PO12 were synthesized using a facile two-step solid-state

The rapid development of artificial intelligence (AI) facilitates various applications from all areas but also poses great challenges in its hardware implementation in terms of speed and energy because of the explosive growth of data. Optical computing provides a distinctive perspective to address this bottleneck by harnessing the unique properties of photons including broad bandwidth, low latency

Modern therapy of acute myeloid leukemia (AML) began in 1973 with the first report of the successful combination of daunorubicin and cytarabine, which led to complete remission in approximately 45% of patients. Accurate AML diagnosis was dependent on morphology, aided initially only by cytochemistry. Unlike acute lymphoblastic leukemia (ALL), immunophenotyping offered little in the diagnosis of AML

Multifunctional fillers are greatly required for dental resin composites (DRCs). In this work, a spray dryer with a three-fluid nozzle was applied for the first time to construct high-performance complex nanoparticle clusters (CNCs) consisting of different functional nanofillers for dental restoration. The application of a three-fluid nozzle can effectively avoid the aggregation of different nanoparticles

In this study, we used a network meta-analysis (NMA) to compare the effectiveness of medicines and supplements for idiopathic male infertility and to identify the best treatment. Medline, Excerpta Medica Database (EMBASE), Ovid, and China National Knowledge Infrastructure (CNKI), were searched for the period from January 1990 to June 2021 using the keywords “male infertility,” “medical therapy,” “supplement/nutrient

Patient-derived tumor xenografts (PDXs) are a powerful tool for drug discovery and screening in cancer. However, current studies have led to little understanding of genotype mismatches in PDXs, leading to massive economic losses. Here, we established PDX models from 53 lung cancer patients with a genotype matching rate of 79.2% (42/53). Furthermore, 17 clinicopathological features were examined and

Tunnel seismic detection methods are effective for obtaining the geological structure around the tunnel face, which is critical for safe construction and disaster mitigation in tunnel engineering. However, there is often a lack of accuracy in the acquired geological information and physical properties ahead of the tunnel face in the current tunnel seismic detection methods. Thus, we apply a frequency-domain

The immune response after implantation is a primary determinant of the tissue-repair effects of three-dimensional (3D)-printed scaffolds. Thus, scaffolds that can subtly regulate immune responses may display extraordinary functions. Inspired by the angiogenesis promotion effect of humoral immune response, we covalently combined mesoporous silica microrod (MSR)/polyethyleneimine (PEI)/ovalbumin (OVA)

The object of this article is to present the innovative technology system for the deep mining of metal mines in China. Based on the current situation and major problems of deep mining of metal mineral resources in China, the key engineering technology development strategies to solve the problems, such as the green intelligent mining modes, are proposed, which is conducive to ensuring the safety of

This paper synchronizes control theory with computer vision by formalizing object tracking as a sequential decision-making process. A reinforcement learning (RL) agent successfully tracks an interface between two liquids, which is often a critical variable to track in many chemical, petrochemical, metallurgical, and oil industries. This method utilizes less than 100 images for creating an environment

Polypropylene (PP) and polyethylene (PE) play central roles in our daily life. However, their immiscibility presents a major hurdle in both industry and academia when recycling them into alloys with favorable mechanical properties. Moreover, typical compatibilizer-enabled approaches are limited due to increased environmental concerns. Herein, inspired by a traditional Chinese technique, we report a

Due to sexual dimorphism in the growth of certain cultured fish species, the production of monosex fishes is desirable for the aquaculture industry. Nowadays, the most widely practiced technique available for the mass production of monosex fish populations is sex steroid-induced sex reversal. Here, a novel strategy for the successful production of all-female (AF) common carp (Cyprinus carpio L.), to

Intrahepatic cholangiocarcinoma (ICC) is the second most common liver cancer. Chemotherapy remains the main therapeutic strategy for advanced ICC patients, but chemosensitivity varies individually. Here, we applied cytometry by time-of-flight (CyTOF) to establish the immune profile of peripheral blood mononuclear cells (PBMCs) on the single-cell level at indicated time points before, during, and after

A large-span steel–concrete composite beam with precast hollow core slabs (CBHCSs) is a relatively new floor structure that can be applied to various long-span structures. However, human-induced vibrations may present serviceability issues in such structures. To alleviate vibrations, both the walking forces excited by humans and the associated floor responses must be elucidated. In this study, 150

Uncertain security threats caused by vulnerabilities and backdoors are the most serious and difficult problem in cyberspace. This paper analyzes the philosophical and technical causes of the existence of so-called “dark functions” such as system vulnerabilities and backdoors, and points out that endogenous security problems cannot be completely eliminated at the theoretical and engineering levels;

Breast cancer is marked by large increases in the protein fibers around tumor cells. These fibers increase the mechanical stiffness of the tissue, which has long been used for tumor diagnosis by manual palpation. Recent research in bioengineering has led to the development of novel biomaterials that model the mechanical and architectural properties of the tumor microenvironment and can be used to understand

Data-driven process-monitoring methods have been the mainstream for complex industrial systems due to their universality and the reduced need for reaction mechanisms and first-principles knowledge. However, most data-driven process-monitoring methods assume that historical training data and online testing data follow the same distribution. In fact, due to the harsh environment of industrial systems

Based on the analysis of the characteristics and operation status of the process industry, as well as the development of the global intelligent manufacturing industry, a new mode of intelligent manufacturing for the process industry, namely, deep integration of industrial artificial intelligence and the Industrial Internet with the process industry, is proposed. This paper analyzes the development

Chemical engineers rely on models for design, research, and daily decision-making, often with potentially large financial and safety implications. Previous efforts a few decades ago to combine artificial intelligence and chemical engineering for modeling were unable to fulfill the expectations. In the last five years, the increasing availability of data and computational resources has led to a resurgence

Cell voltage is a widely used signal that can be measured online from an industrial aluminum electrolysis cell. A variety of parameters for the analysis and control of industrial cells are calculated using the cell voltage. In this paper, the frequency segmentation of cell voltage is used as the basis for designing filters to obtain these parameters. Based on the qualitative analysis of the cell voltage

The prosperity of the biotherapeutics market reflects the feasibility and effectiveness of therapeutic antibodies for the treatment of cancers, inflammatory disorders, and refractory infections. As drawbacks emerge in clinical trials and practice, such as impeded binding, reduced effector functions, and frequent adverse reactions, modifications of therapeutic antibodies are unprecedently burgeoning

Early detection of hepatocellular carcinoma (HCC) while in its early stages is critical for reducing HCC mortality in high-risk patients. However, highly sensitive and specific surveillance biomarkers for early-stage HCC detection are still lacking. In recent years, great efforts have been made to research tumor-derived molecular features that are detectable in circulation, such as circulating tumor

With the concepts of Industry 4.0 and smart manufacturing gaining popularity, there is a growing notion that conventional manufacturing will witness a transition toward a new paradigm, targeting innovation, automation, better response to customer needs, and intelligent systems. Within this context, this review focuses on the concept of cyber-physical production system (CPPS) and presents a holistic

The shortage of computation methods and storage devices has largely limited the development of multi-objective optimization in industrial processes. To improve the operational levels of the process industries, we propose a multi-objective optimization framework based on cloud services and a cloud distribution system. Real-time data from manufacturing procedures are first temporarily stored in a local

The provision of water and sanitation services is a key challenge worldwide. The size, complexity, and critical nature of the water and wastewater infrastructure providing such services make the planning and management of these systems extremely difficult. Following the digital revolution in many areas of our lives, the water sector has begun to benefit from digital transformation. Effective utilization

Designing and preparing high-performance lignin-based dispersants are crucial steps in realizing the value-added utilization of lignin on an industrial scale. Such process depends heavily on an understanding of the dispersion mechanism of lignin-based dispersants. Here, atomic force microscopy (AFM) is employed to quantitatively investigate the dispersion mechanism of a lignosulfonate/silica (LS/SiO2)

Rapid, sensitive, point-of-care detection of pathogenic bacteria is important for food safety. In this study, we developed a novel quantum dot nanobeads-labelled lateral flow immunoassay strip (QBs-labelled LFIAS) combined with strand displacement loop-mediated isothermal amplification (SD-LAMP) for quantitative Salmonella Typhimurium (ST) detection. Quantum dot nanobeads (QBs) served as fluorescence