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Enhancing the Efficiency of Enterprise Shutdowns for Environmental Protection: An Agent-Based Modeling Approach with High Spatial-Temporal Resolution Data Engineering (IF 12.8) Pub Date : 2024-03-08 Qi Zhou, Shen Qu, Miaomiao Liu, Jianxun Yang, Jia Zhou, Yunlei She, Zhouyi Liu, Jun Bi
Top-down environmental policies aim to mitigate environmental risks but inevitably lead to economic losses due to the market entry or exit of enterprises. This study developed a universal dynamic agent-based supply chain model to achieve tradeoffs between environmental risk reduction and economic sustainability. The model was used to conduct high-resolution daily simulations of the dynamic shifts in
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Carbon Footprint Drivers in China’s Municipal Wastewater Treatment Plants and Mitigation Opportunities through Electricity and Chemical Efficiency Engineering (IF 12.8) Pub Date : 2024-03-08 Shen Qu, Yuchen Hu, Renke Wei, Ke Yu, Zhouyi Liu, Qi Zhou, Chenchen Wang, Lujing Zhang
Reducing greenhouse gas (GHG) emissions to address climate change is a global consensus, and municipal wastewater treatment plants (MWWTPs) should lead the way in low-carbon sustainable development. However, achieving effluent discharge standards often requires considerable energy and chemical consumption during operation, resulting in significant carbon footprints. In this study, GHG emissions are
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Designing a Mordenite Catalyst with Enhanced Acidity for Dimethyl Ether Carbonylation by Engineering Open Sn Sites Engineering (IF 12.8) Pub Date : 2024-03-05 Ying Li, Man Yu, Guodong Qi, Yunduo Liu, Jing Lv, Shouying Huang, Xinbin Ma
Due to their tunable acidity, shape selectivity, and excellent stability, zeolites are of great importance as solid acid materials in industrial catalysis. Tuning the properties of the acid sites in zeolites allows for the rational design and fabrication of catalysts for target reactions. Dimethyl ether (DME) carbonylation, a critical chain-growth reaction for C1 resource utilization, is selectively
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Mechanism Design and Motion Planning of a Hexapod Curling Robot Exhibited during the Beijing 2022 Winter Olympics Engineering (IF 12.8) Pub Date : 2024-03-01 Ke Yin, Yue Gao, Feng Gao, Xianbao Chen, Yue Zhao, Yuguang Xiao, Qiao Sun, Jing Sun
When a curling rock slides on an ice sheet with an initial rotation, a lateral movement occurs, which is known as the curling phenomenon. The force of friction between the curling rock and the ice sheet changes continually with changes in the environment; thus, the sport of curling requires great skill and experience. The throwing of the curling rock is a great challenge in robot design and control
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The Future Landscape and Framework of Precision Nutrition Engineering (IF 12.8) Pub Date : 2024-02-29 Tianshu Han, Wei Wei, Wenbo Jiang, Yiding Geng, Zijie Liu, Ruiming Yang, Chenrun Jin, Yating Lei, Xinyi Sun, Jiaxu Xu, Chen Juan, Changhao Sun
The concept of precision nutrition was first proposed almost a decade ago. Current research in precision nutrition primarily focuses on comprehending individualized variations in response to dietary intake, with little attention being given to other crucial aspects of precision nutrition. Moreover, there is a dearth of comprehensive review studies that portray the landscape and framework of precision
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NASA Satellite Sets Blistering Optical Communication Speed Record Engineering (IF 12.8) Pub Date : 2024-02-28 Chris Palmer
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Customers Start Eating Lab-Grown Meat—With a Side of Uncertainty Engineering (IF 12.8) Pub Date : 2024-02-28 Sarah C.P. Williams
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Ecological-Based Mining: A Coal–Water–Thermal Collaborative Paradigm in Ecologically Fragile Areas in Western China Engineering (IF 12.8) Pub Date : 2024-02-28 Xiaoxiu Liu, Yifan Zeng, Qiang Wu, Shihao Meng, Jiyue Liang, Zhuping Hou
A substantial reduction in groundwater level, exacerbated by coal mining activities, is intensifying water scarcity in Western China’s ecologically fragile coal mining areas. China’s national strategic goal of achieving a carbon peak and carbon neutrality has made eco-friendly mining that prioritizes the protection and efficient use of water resources essential. Based on the resource characteristics
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Underestimated Methane Emissions from Solid Waste Disposal Sites Reveal Missed Greenhouse Gas Mitigation Opportunities Engineering (IF 12.8) Pub Date : 2024-02-23 Yao Wang, Chuanbin Zhou, Ziyang Lou, Houhu Zhang, Abid Hussain, Liangtong Zhan, Ke Yin, Mingliang Fang, Xunchang Fei
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Waste cotton-derived fiber-based thermoelectric aerogel for wearable and self-powered temperature-compression strain dual-parameter sensing Engineering (IF 12.8) Pub Date : 2024-02-23 Xinyang He, Mingyuan Liu, Jiaxin Cai, Zhen Li, Zhilin Teng, Yunna Hao, Yifan Cui, Jianyong Yu, Liming Wang, Xiaohong Qin
The rapid development of the global economy and population growth are accompanied by the production of numerous waste textiles. This leads to a waste of limited resources and serious environmental pollution problems caused by improper disposal. The rational recycling of wasted textiles and their transformation into high-value-added emerging products, such as smart wearable devices, is fascinating.
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Snapshot Survey of the Presence of Perfluoroalkyl Substances in Products, Articles, and the Environment in Ecuador Engineering (IF 12.8) Pub Date : 2024-02-22 Heidelore Fiedler, Luis Vega Bustillos, Jenny Arias Pastrano, Lander Vinicio Pérez Aldás, Jose Castro Díaz
The Stockholm Convention on Persistent Organic Pollutants (POPs) is a legally binding instrument for 186 Parties (status: April 2023). Accordingly, among other responsibilities, countries are obliged to report the production, import, or export of the POPs listed in Annexes A, B, or C; provide information to registers; maintain inventories; and monitor the presence of POPs in the environment. In the
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An Implantable and Self-Powered Sensing System for the In Vivo Monitoring of Dynamic H2O2 Level in Plants Engineering (IF 12.8) Pub Date : 2024-02-21 Chao Zhang, Xinyue Wu, Shiyun Yao, Yuzhou Shao, Chi Zhang, Shenghan Zhou, Jianfeng Ping, Yibin Ying
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A Retrodirective Array Enabled by CMOS Chips for Two-Way Wireless Communication with Automatic Beam Tracking Engineering (IF 12.8) Pub Date : 2024-02-13 Jiacheng Guo, Yizhu Shen, Guoqing Dong, Zhuang Han, Sanming Hu
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Further Empowering Humans in Specific Fields and Rethinking AGI Testing Engineering (IF 12.8) Pub Date : 2024-02-13 Yue-Guang Lyu, Fei Wu
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The Static Stability Region of an Integrated Electricity-Gas System Considering Voltage and Gas Pressure Engineering (IF 12.8) Pub Date : 2024-02-10 Yunfei Mu, Zhibin Liu, Xiangwei Guo, Hongjie Jia, Kai Hou, Xiaodan Yu, Bofeng Luo, Hairun Li
In an integrated electricity-gas system (IEGS), load fluctuations affect not only the voltage in the power system but also the gas pressure in the natural gas system. The static voltage stability region (SVSR) method is a tool for analyzing the overall static voltage stability in a power system. However, in an IEGS, the SVSR boundary may be overly optimistic because the gas pressure may collapse before
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Rational Engineering of Secondary Metabolic Pathways in a Heterologous Host to Enable the Biosynthesis of Hibarimicin Derivatives with Enhanced Anti-Melanomic Activity Engineering (IF 12.8) Pub Date : 2024-02-10 Xiangyang Liu, Fei-Peng Zhao, Tian Tian, Wei-Chen Wang, Zaizhou Liu, Qiang Zhou, Xian-Feng Hou, Jing Wang, Wenli Guo, Shuangjun Lin, Yasuhiro Igarashi, Gong-Li Tang
A 61-kb biosynthetic gene cluster (BGC), which is accountable for the biosynthesis of hibarimicin (HBM) B from subsp. TP-A0121, was heterologously expressed in M1154, which generated a trace of the target products but accumulated a large amount of shunt products. Based on rational analysis of the relevant secondary metabolism, directed engineering of the biosynthetic pathways resulted in the high production
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Chain Elongation Using Native Soil Inocula: Exceptional n-Caproate Biosynthesis Performance and Microbial Mechanisms Engineering (IF 12.8) Pub Date : 2024-02-10 Lin Deng, Yang Lv, Tian Lan, Qing-Lian Wu, Wei-Tong Ren, Hua-Zhe Wang, Bing-Jie Ni, Wan-Qian Guo
This study demonstrates the feasibility and effectiveness of utilizing native soils as a resource for inocula to produce -caproate through the chain elongation (CE) platform, offering new insights into anaerobic soil processes. The results reveal that all five of the tested soil types exhibit CE activity when supplied with high concentrations of ethanol and acetate, highlighting the suitability of
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Repurposing Loperamide as an Anti-Infection Drug for the Treatment of Intracellular Bacterial Pathogens Engineering (IF 12.8) Pub Date : 2024-02-09 Hongtao Liu, Siqi Li, Le Deng, Zhenxu Shi, Chenxiao Jiang, Jingyan Shu, Yuan Liu, Xuming Deng, Jianfeng Wang, Zhimin Guo, Jiazhang Qiu
Infections caused by intracellular bacterial pathogens are difficult to treat since most antibiotics have low cell permeability and undergo rapid degradation within cells. The rapid development and dissemination of antimicrobial–resistant strains have exacerbated this dilemma. With the increasing knowledge of host–pathogen interactions, especially bacterial strategies for survival and proliferation
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Advanced Compressed Air Energy Storage Systems: Fundamentals and Applications Engineering (IF 12.8) Pub Date : 2024-02-09 Xinjing Zhang, Ziyu Gao, Bingqian Zhou, Huan Guo, Yujie Xu, Yulong Ding, Haisheng Chen
Decarbonization of the electric power sector is essential for sustainable development. Low-carbon generation technologies, such as solar and wind energy, can replace the CO-emitting energy sources (coal and natural gas plants). As a sustainable engineering practice, long-duration energy storage technologies must be employed to manage imbalances in the variable renewable energy supply and electricity
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Multimodal Machine Learning Guides Low Carbon Aeration Strategies in Urban Wastewater Treatment Engineering (IF 12.8) Pub Date : 2024-02-09 Hong-Cheng Wang, Yu-Qi Wang, Xu Wang, Wan-Xin Yin, Ting-Chao Yu, Chen-Hao Xue, Ai-Jie Wang
The potential for reducing greenhouse gas (GHG) emissions and energy consumption in wastewater treatment can be realized through intelligent control, with machine learning (ML) and multimodality emerging as a promising solution. Here, we introduce an ML technique based on multimodal strategies, focusing specifically on intelligent aeration control in wastewater treatment plants (WWTPs). The generalization
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Procyanidin C1 Modulates the Microbiome to Increase FOXO1 Signaling and Valeric Acid Levels to Protect the Mucosal Barrier in Inflammatory Bowel Disease Engineering (IF 12.8) Pub Date : 2024-02-08 Xifan Wang, Pengjie Wang, Yixuan Li, Huiyuan Guo, Ran Wang, Siyuan Liu, Ju Qiu, Xiaoyu Wang, Yanling Hao, Yunyi Zhao, Haiping Liao, Zhongju Zou, Josephine Thinwa, Rong Liu
Inflammatory bowel disease (IBD) refers to a pair of prevalent conditions (Crohn’s disease and ulcerative colitis) distinguished by persistent inflammation of the large intestine. Procyanidin C1 (PCC1) is a naturally occurring substance derived from grape seeds that has demonstrated notable anti-inflammatory properties. This study examines the potential utility of PCC1 as a treatment for IBD and subsequently
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Properties and Characteristics of Regolith-Based Materials for Extraterrestrial Construction Engineering (IF 12.8) Pub Date : 2024-02-07 Cheng Zhou, Yuyue Gao, Yan Zhou, Wei She, Yusheng Shi, Lieyun Ding, Changwen Miao
The construction of extraterrestrial bases has become a new goal in the active exploration of deep space. Among the construction techniques, in situ resource-based construction is one of the most promising because of its good sustainability and acceptable economic cost, triggering the development of various types of extraterrestrial construction materials. A comprehensive survey and comparison of materials
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Carbon Storage Potential of Shale Reservoirs Based on CO2 Fracturing Technology Engineering (IF 12.8) Pub Date : 2024-02-07 Siwei Meng, Fengyuan Zhang, Jiaping Tao, Xu Jin, Jianchun Xu, He Liu
The development of shale reservoirs is important in ensuring China’s national energy security by achieving energy independence. Among the key technologies for shale oil production, CO fracturing is an effective method that can not only enhance oil recovery but also promote large amounts of CO storage, thereby supporting China’s goals of achieving a carbon peak and carbon neutrality. This research paper
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Bioactivities, Mechanisms, Production, and Potential Application of Bile Acids in Preventing and Treating Infectious Diseases Engineering (IF 12.8) Pub Date : 2024-02-07 Shuang Liu, Shuo Yang, Biljana Blazekovic, Lu Li, Jidan Zhang, Yi Wang
Infectious diseases are a global public health problem, with emerging and re-emerging infectious diseases on the rise worldwide. Therefore, their prevention and treatment are still major challenges. Bile acids are common metabolites in both hosts and microorganisms that play a significant role in controlling the metabolism of lipids, glucose, and energy. Bile acids have historically been utilized as
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Proximal Femur Bionic Nail (PFBN): A Panacea for Unstable Intertrochanteric Femur Fracture Engineering (IF 12.8) Pub Date : 2024-02-07 Kaixuan Zhang, Wei Chen, Yingze Zhang
With the aging population, intertrochanteric femur fracture in the elderly has become one of the most serious public health issues and a hot topic of research in trauma orthopedics. Due to the limitations of internal fixation techniques and the insufficient mechanical design of nails, the occurrence of complications delays patient recovery after surgical treatment. Design of a proximal femur bionic
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Spontaneous Recovery in Directed Dynamical Networks Engineering (IF 12.8) Pub Date : 2024-02-06 Xueming Liu, Xian Yan, H. Eugene Stanley
Complex networked systems, which range from biological systems in the natural world to infrastructure systems in the human-made world, can exhibit spontaneous recovery after a failure; for example, a brain may spontaneously return to normal after a seizure, and traffic flow can become smooth again after a jam. Previous studies on the spontaneous recovery of dynamical networks have been limited to undirected
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Digital Twins for Engineering Asset Management: Synthesis, Analytical Framework, and Future Directions Engineering (IF 12.8) Pub Date : 2024-02-06 Yongkui Li, Qinyue Wang, Xiyu Pan, Jian Zuo, Jinying Xu, Yilong Han
Effective engineering asset management (EAM) is critical to economic development and improving livability in society, but its complexity often impedes optimal asset functionalities. Digital twins (DTs) could revolutionize the EAM paradigm by bidirectionally linking the physical and digital worlds in real time. There is great industrial and academic interest in DTs for EAM. However, previous review
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Breakthrough of Carbon–Ash Recalcitrance in Hydrochar via Molten Carbonate: Engineering Mineral-Rich Biowaste towards Sustainable Platform Carbon Materials Engineering (IF 12.8) Pub Date : 2024-02-02 Zihan Wang, Leli Zhang, Yuanhui Zhang, Zhidan Liu
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Unmanned Aerial Vehicle Inspection Routing and Scheduling for Engineering Management Engineering (IF 12.8) Pub Date : 2024-02-02 Lu Zhen, Zhiyuan Yang, Gilbert Laporte, Wen Yi, Tianyi Fan
Technological advancements in unmanned aerial vehicles (UAVs) have revolutionized various industries, enabling the widespread adoption of UAV-based solutions. In engineering management, UAV-based inspection has emerged as a highly efficient method for identifying hidden risks in high-risk construction environments, surpassing traditional inspection techniques. Building on this foundation, this paper
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EEG Opto-Processor: Epileptic Seizure Detection Using Diffractive Photonic Computing Units Engineering (IF 12.8) Pub Date : 2024-02-01 Tao Yan, Maoqi Zhang, Hang Chen, Sen Wan, Kaifeng Shang, Haiou Zhang, Xun Cao, Xing Lin, Qionghai Dai
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Natural Products Improve Organ Microcirculation Dysfunction Following Ischemia/Reperfusion- and Lipopolysaccharide-Induced Disturbances: Mechanistic and Therapeutic Views Engineering (IF 12.8) Pub Date : 2024-02-01 Jingyan Han, Quan Li, Kai Sun, Chunshui Pan, Jian Liu, Ping Huang, Juan Feng, Yanchen Liu, Gerald A. Meininger
Microcirculatory disturbances are complex processes caused by many factors, including abnormal vasomotor responses, decreased blood flow velocity, vascular endothelial cell injury, altered leukocyte and endothelial cell interactions, plasma albumin leakage, microvascular hemorrhage, and thrombosis. These disturbances involve multiple mechanisms and interactions among mechanisms that can include energy
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Dynamics of Land Use/Land Cover (LULC) Considering Ecosystem Services for a Dense-Population Watershed Based on a Hybrid Dual-Subject Agent and Cellular Automaton Modeling Approach Engineering (IF 12.8) Pub Date : 2024-02-01 Yutong Li, Yanpeng Cai, Qiang Fu, Xiaodong Zhang, Hang Wan, Zhifeng Yang
Land use/land cover represents the interactive and comprehensive influences between human activities and natural conditions, leading to potential conflicts among natural and human-related issues as well as among stakeholders. This study introduced economic standards for farmers. A hybrid approach (CA-ABM) of cellular automaton (CA) and an agent-based model (ABM) was developed to effectively deal with
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Generation of Eco-Friendly and Disease-Resistant Channel Catfish (Ictalurus punctatus) Harboring the Alligator Cathelicidin Gene via CRISPR/Cas9 Engineering Engineering (IF 12.8) Pub Date : 2024-02-01 Jinhai Wang, Baofeng Su, De Xing, Timothy J. Bruce, Shangjia Li, Logan Bern, Mei Shang, Andrew Johnson, Rhoda Mae C. Simora, Michael Coogan, Darshika U. Hettiarachchi, Wenwen Wang, Tasnuba Hasin, Jacob Al-Armanazi, Cuiyu Lu, Rex A. Dunham
As a precise and versatile tool for genome manipulation, the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) platform holds promise for modifying fish traits of interest. With the aim of reducing transgene introgression and controlling reproduction, upscaled disease resistance and reproductive intervention in catfish species have been studied to
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Impacts of Comorbidity and Mental Shock on Organic Micropollutants in Surface Water during and after the COVID-19 Pandemic in Wuhan (2019–2021), China Engineering (IF 12.8) Pub Date : 2024-01-26 Jian Zhao, Jin Kang, Xiaofeng Cao, Rui Bian, Gang Liu, Shengchao Hu, Xinghua Wu, Chong Li, Dianchang Wang, Weixiao Qi, Cunrui Huang, Huijuan Liu, Jiuhui Qu
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A Single-Cell Landscape of Human Liver Transplantation Reveals a Pathogenic Immune Niche Associated with Early Allograft Dysfunction Engineering (IF 12.8) Pub Date : 2024-01-26 Xin Shao, Zheng Wang, Kai Wang, Xiaoyan Lu, Ping Zhang, Rongfang Guo, Jie Liao, Penghui Yang, Xiao Xu, Xiaohui Fan
Liver transplantation (LT) is the standard therapy for individuals afflicted with end-stage liver disease. Despite notable advancements in LT technology, the incidence of early allograft dysfunction (EAD) remains a critical concern, exacerbating the current organ shortage and detrimentally affecting the prognosis of recipients. Unfortunately, the perplexing hepatic heterogeneity has impeded characterization
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Large-Scale Preparation of Mechanically High-Performance and Biodegradable PLA/PHBV Melt-Blown Nonwovens with Nanofibers Engineering (IF 12.8) Pub Date : 2024-01-24 Gaohui Liu, Jie Guan, Xianfeng Wang, Jianyong Yu, Bin Ding
Biodegradable polylactic acid (PLA) melt-blown nonwovens are attractive candidates to replace non-degradable polypropylene melt-blown nonwovens. However, it is still an extremely challenging task to prepare PLA melt-blown nonwovens with sufficient mechanical properties for practical application. Herein, we report a simple strategy for the large-scale preparation of biodegradable PLA/poly(3-hydroxy
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STAT3-Dependent Effects of Polymeric Immunoglobulin Receptor in Regulating Interleukin-17 Signaling and Preventing Autoimmune Hepatitis Engineering (IF 12.8) Pub Date : 2024-01-20 Ting Li, Tongtong Pan, Nannan Zheng, Xiong Ma, Xiaodong Wang, Fang Yan, Huimian Jiang, Yuxin Wang, Hongwei Lin, Jing Lin, Huadong Zhang, Jia Huang, Lingming Kong, Anmin Huang, Qingxiu Liu, Yongping Chen, Dazhi Chen
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Safe Motion Planning and Control Framework for Automated Vehicles with Zonotopic TRMPC Engineering (IF 12.8) Pub Date : 2024-01-19 Hao Zheng, Yinong Li, Ling Zheng, Ehsan Hashemi
Model mismatches can cause multi-dimensional uncertainties for the receding horizon control strategies of automated vehicles (AVs). The uncertainties may lead to potentially hazardous behaviors when the AV tracks ideal trajectories that are individually optimized by the AV's planning layer. To address this issue, this study proposes a safe motion planning and control (SMPAC) framework for AVs. For
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New Technologies for Monitoring and Upscaling Marine Ecosystem Restoration in Deep-Sea Environments Engineering (IF 12.8) Pub Date : 2024-01-19 Jacopo Aguzzi, Thomsen Laurenz, Sascha Flögel, Nathan J. Robinson, Giacomo Picardi, Damianos Chatzievangelou, Nixon Bahamon, Sergio Stefanni, Jordi Grinyó, Emanuela Fanelli, Cinzia Corinaldesi, Joaquin Del Rio Fernandez, Marcello Calisti, Furu Mienis, Elias Chatzidouros, Corrado Costa, Simona Violino, Michael Tangherlini, Roberto Danovaro
The United Nations (UN)’s call for a decade of “ecosystem restoration” was prompted by the need to address the extensive impact of anthropogenic activities on natural ecosystems. Marine ecosystem restoration is increasingly necessary due to increasing habitat loss in deep waters (> 200 m depth). At these depths, which are far beyond those accessible by divers, only established and emerging robotic
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A Case Study Applying Mesoscience to Deep Learning Engineering (IF 12.8) Pub Date : 2024-01-19 Li Guo, Fanyong Meng, Pengfei Qin, Zhaojie Xia, Qi Chang, Jianhua Chen, Jinghai Li
In this paper, we propose mesoscience-guided deep learning (MGDL), a deep learning modeling approach guided by mesoscience, to study complex systems. When establishing sample dataset based on the same system evolution data, different from the operation of conventional deep learning method, MGDL introduces the treatment of the dominant mechanisms of complex system and interactions between them according
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Editorial for the Special Issue on Safety for Intelligent and Connected Vehicles Engineering (IF 12.8) Pub Date : 2024-01-18 Jun Li, Henry Liu, Hong Wang
Abstract not available
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Nanobubbles for the Mitigation of Composite Fouling in Wastewater Distribution Systems Engineering (IF 12.8) Pub Date : 2024-01-18 Yang Xiao, Bo Zhou, Siyuan Tan, Lei Li, Tahir Muhammad, Buchun Si, Changjian Ma, Sunny C. Jiang, Yunkai Li
The increasing demand for wastewater treatment has become a notable trend for addressing global water scarcity. However, composite fouling is a significant challenge for wastewater distribution engineering systems. This study provides an approach using nanobubbles (NBs) to control composite fouling. The antifouling capacities of three types of NBs (oxygen, nitrogen, and helium), six oxygen concentrations
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Life-Cycle Carbon Emissions (LCCE) of Buildings: Implications, Calculations, and Reductions Engineering (IF 12.8) Pub Date : 2024-01-17 Zujian Huang, Hao Zhou, Zhijian Miao, Hao Tang, Borong Lin, Weimin Zhuang
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Increasing Threat of Scarcity Prompts Rise in Water Recycling Engineering (IF 12.8) Pub Date : 2024-01-17 Chris Palmer
Abstract not available
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Is There a Bright Future for Solar Power from Space? Engineering (IF 12.8) Pub Date : 2024-01-17 Mitch Leslie
Abstract not available
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Enhanced Precision Therapy of Multiple Myeloma through Engineered Biomimetic Nanoparticles with Dual Targeting Engineering (IF 12.8) Pub Date : 2024-01-17 Ruogu Qi, Shanshan Wang, Jiayi Yu, Tianming Lu, Zhiqiang Bi, Weibo Liu, Yuanyuan Guo, Yong Bian, Jianliang Shen, Xuesong Zhang, Wenhao Hu
Multiple myeloma (MM) is the second most prevalent hematological malignancy. Current MM treatment strategies are hampered by systemic toxicity and suboptimal therapeutic efficacy. This study addressed these limitations through the development of a potent MM-targeting chemotherapy strategy, which capitalized on the high binding affinity of alendronate for hydroxyapatite in the bone matrix and the homologous
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Germline Gene-Editing Creates Enhanced Livestock—Technical and Especially Ethical Issues Challenge Its Use in Humans Engineering (IF 12.8) Pub Date : 2024-01-17 Jennifer Welsh
Abstract not available
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A Survey on an Emerging Safety Challenge for Autonomous Vehicles: Safety of the Intended Functionality Engineering (IF 12.8) Pub Date : 2024-01-10 Hong Wang, Wenbo Shao, Chen Sun, Kai Yang, Dongpu Cao, Jun Li
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A Deep-Learning and Transfer-Learning Hybrid Aerosol Retrieval Algorithm for FY4-AGRI: Development and Verification over Asia Engineering (IF 12.8) Pub Date : 2024-01-10 Disong Fu, Hongrong Shi, Christian A. Gueymard, Dazhi Yang, Yu Zheng, Huizheng Che, Xuehua Fan, Xinlei Han, Lin Gao, Jianchun Bian, Minzheng Duan, Xiangao Xia
The Advanced Geosynchronous Radiation Imager (AGRI) is a mission-critical instrument for the Fengyun series of satellites. AGRI acquires full-disk images every 15 min and views East Asia every 5 min through 14 spectral bands, enabling the detection of highly variable aerosol optical depth (AOD). Quantitative retrieval of AOD has hitherto been challenging, especially over land. In this study, an AOD
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3D Printing Strategies for Precise and Functional Assembly of Silk-based Biomaterials Engineering (IF 12.8) Pub Date : 2024-01-09 Xiaoliang Cui, Jun Zhang, Yan Qian, Siqi Chang, Benjamin J. Allardyce, Rangam Rajkhowa, Hui Wang, Ke-Qin Zhang
In recent years, significant progress has been made in both three-dimensional (3D) printing technologies and the exploration of silk as an ink to produce biocompatible constructs. Combined with the unlimited design potential of 3D printing, silk can be processed into a broad range of functional materials and devices for various biomedical applications. The ability of silk to be processed into various
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Toward Next-Generation Heterogeneous Catalysts: Empowering Surface Reactivity Prediction with Machine Learning Engineering (IF 12.8) Pub Date : 2024-01-05 Xinyan Liu, Hong-Jie Peng
Heterogeneous catalysis remains at the core of various bulk chemical manufacturing and energy conversion processes, and its revolution necessitates the hunt for new materials with ideal catalytic activities and economic feasibility. Computational high-throughput screening presents a viable solution to this challenge, as machine learning (ML) has demonstrated its great potential in accelerating such
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A Discussion on the Flexible Regulation Capacity Requirements of China’s Power System Engineering (IF 12.8) Pub Date : 2024-01-05 Qiang Zhao, Yuqiong Zhang, Xiaoxin Zhou, Ziwei Chen, Huaguang Yan, Honghua Yang
Abstract not available
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Unveiling the Mechanism Underlying the Effects of Ammonia on n-Caproate Production: Influenced Pathways, Key Enzymes, and Microbiota Functions Engineering (IF 12.8) Pub Date : 2024-01-03 Qing-Lian Wu, Ke-Xin Yuan, Wei-Tong Ren, Lin Deng, Hua-Zhe Wang, Xiao-Chi Feng, He-Shan Zheng, Nan-Qi Ren, Wan-Qian Guo
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A Dual-Functional System for the Classification and Diameter Measurement of Aortic Dissections Using CTA Volumes via Deep Learning Engineering (IF 12.8) Pub Date : 2024-01-04 Zhihui Huang, Rui Wang, Hui Yu, Yifan Xu, Cheng Cheng, Guangwei Wang, Haosen Cao, Xiang Wei, Hai-Tao Zhang
Acute aortic dissection is one of the most life-threatening cardiovascular diseases, with a high mortality rate. Its prevalence ranges from 0.2% to 0.8% in humans, resulting in a significant number of deaths due to being missed in manual examinations. More importantly, the aortic diameter—a critical indicator for surgical selection—significantly influences the outcomes of surgeries post-diagnosis.
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Toward Efficient Metal Recovery from Industrial Wastewater: An Electrochemical System in Potential Oscillation and Turbulence Mode Engineering (IF 12.8) Pub Date : 2024-01-03 Li Chen, Gong Zhang, Huijuan Liu, Shiyu Miao, Qingbai Chen, Huachun Lan, Jiuhui Qu
Efficient metal recovery from industrial wastewater facilitates addressing of the environmental hazards and resource requirements of heavy metals. The conventional electrodeposition recovery method is hampered by the limitations of interfacial ion transport in charge-transfer reactions, creating challenges for simultaneous rapid and high-quality metal recovery. Therefore, we proposed integrating a
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Reachability-Based Confidence-Aware Probabilistic Collision Detection in Highway Driving Engineering (IF 12.8) Pub Date : 2023-12-28 Xinwei Wang, Zirui Li, Javier Alonso-Mora, Meng Wang
Risk assessment is a crucial component of collision warning and avoidance systems for intelligent vehicles. Reachability-based formal approaches have been developed to ensure driving safety to accurately detect potential vehicle collisions. However, they suffer from over-conservatism, potentially resulting in false–positive risk events in complicated real-world applications. In this paper, we combine
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Facilitated Prediction of Micropollutant Degradation via UV-AOPs in Various Waters by Combining Model Simulation and Portable Measurement Engineering (IF 12.8) Pub Date : 2023-12-20 Yanyan Huang, Mengkai Li, Zhe Sun, Wentao Li, James R. Bolton, Zhimin Qiang
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Rockburst Hazard Control Using the Excavation Compensation Method (ECM): A Case Study in the Qinling Water Conveyance Tunnel Engineering (IF 12.8) Pub Date : 2023-12-20 Jie Hu, Manchao He, Hongru Li, Zhigang Tao, Dongqiao Liu, Tai Cheng, Di Peng
Rockburst disasters occur frequently during deep underground excavation, yet traditional concepts and methods can hardly meet the requirements for support under high geo-stress conditions. Consequently, rockburst control remains challenging in the engineering field. In this study, the mechanism of excavation-induced rockburst was briefly described, and it was proposed to apply the excavation compensation
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Not in Control, but Liable? Attributing Human Responsibility for Fully Automated Vehicle Accidents Engineering (IF 12.8) Pub Date : 2023-12-16 Siming Zhai, Lin Wang, Peng Liu
Human agency has become increasingly limited in complex systems with increasingly automated decision-making capabilities. For instance, human occupants are passengers and do not have direct vehicle control in fully automated cars (i.e., driverless cars). An interesting question is whether users are responsible for the accidents of these cars. Normative ethical and legal analyses frequently argue that