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Neural Activity Differentiates Novel and Learned Event Boundaries J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Youssef Ezzyat, Abby Clements
People parse continuous experiences at natural breakpoints called event boundaries, which is important for understanding an environment's causal structure and for responding to uncertainty within it. However, it remains unclear how different forms of uncertainty affect the parsing of continuous experiences and how such uncertainty influences the brain's processing of ongoing events. We exposed human
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Experience Dependence of Alpha Rhythms and Neural Dynamics in the Mouse Visual Cortex J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Pouria Riyahi, Marnie A. Phillips, Nathaniel Boley, Matthew T. Colonnese
The role of experience in the development and maintenance of emergent network properties such as cortical oscillations and states is poorly understood. To define how early-life experience affects cortical dynamics in the visual cortex of adult, head-fixed mice, we examined the effects of two forms of blindness initiated before eye opening and continuing through recording: (1) bilateral loss of retinal
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DMXL2 Is Required for Endocytosis and Recycling of Synaptic Vesicles in Auditory Hair Cells J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Hu Peng, Longhao Wang, Yunge Gao, Huihui Liu, Guotong Lin, Yu Kong, Pengcheng Xu, Hongchao Liu, Qingyue Yuan, Huanhai Liu, Lei Song, Tao Yang, Hao Wu
Ribbon synapses of inner hair cells (IHCs) are uniquely designed for ultrafast and indefatigable neurotransmission of the sound. The molecular machinery ensuring the efficient, compensatory recycling of the synaptic vesicles (SVs), however, remains elusive. This study showed that hair cell knock-out of murine Dmxl2, whose human homolog is responsible for nonsyndromic sensorineural hearing loss DFNA71
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State- and Circuit-Dependent Opponent Processing of Fear J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Joanna Oi-Yue Yau, Amy Li, Lauren Abdallah, Leszek Lisowksi, Gavan P. McNally
The presence of valence coding neurons in the basolateral amygdala (BLA) that form distinct projections to other brain regions implies functional opposition between aversion and reward during learning. However, evidence for opponent interactions in fear learning is sparse and may only be apparent under certain conditions. Here we test this possibility by studying the roles of the BLA->central amygdala
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Circadian Rhythms Tied to Changes in Brain Morphology in a Densely Sampled Male J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Elle M. Murata, Laura Pritschet, Hannah Grotzinger, Caitlin M. Taylor, Emily G. Jacobs
Circadian, infradian, and seasonal changes in steroid hormone secretion have been tied to changes in brain volume in several mammalian species. However, the relationship between circadian changes in steroid hormone production and rhythmic changes in brain morphology in humans is largely unknown. Here, we examined the relationship between diurnal fluctuations in steroid hormones and multiscale brain
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Neurons of Macaque Frontal Eye Field Signal Reward-Related Surprise J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Michael R. Shteyn, Carl R. Olson
The frontal eye field (FEF) plays a well-established role in the control of visual attention. The strength of an FEF neuron's response to a visual stimulus presented in its receptive field is enhanced if the stimulus captures spatial attention by virtue of its salience. A stimulus can be rendered salient by cognitive factors as well as by physical attributes. These include surprise. The aim of the
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A Perspective on Neuroscience Data Standardization with Neurodata Without Borders J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Andrea Pierré, Tuan Pham, Jonah Pearl, Sandeep Robert Datta, Jason T. Ritt, Alexander Fleischmann
Neuroscience research has evolved to generate increasingly large and complex experimental data sets, and advanced data science tools are taking on central roles in neuroscience research. Neurodata Without Borders (NWB), a standard language for neurophysiology data, has recently emerged as a powerful solution for data management, analysis, and sharing. We here discuss our labs’ efforts to implement
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Generalized Encoding of the Relative Subjective Value of Cognitive Effort in the Dorsal ACC J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Jennifer L. Crawford, Rachel E. Brough, Sarah A. Eisenstein, Jonathan E. Peelle, Todd S. Braver
Making choices about whether and when to engage cognitive effort are a common feature of everyday experience, with important consequences for academic, career, and health outcomes. Yet, despite their hypothesized importance, very little is understood about the underlying mechanisms that support this form of human cost–benefit decision-making. To investigate these mechanisms, we used the Cognitive Effort
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Selective Attention and Decision-Making Have Separable Neural Bases in Space and Time J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Denise Moerel, Anina N. Rich, Alexandra Woolgar
Attention and decision-making processes are fundamental to cognition. However, they are usually experimentally confounded, making it difficult to link neural observations to specific processes. Here we separated the effects of selective attention from the effects of decision-making on brain activity obtained from human participants (both sexes), using a two-stage task where the attended stimulus and
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Investigating Egocentric Tuning in Hippocampal CA1 Neurons J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Jordan Carpenter, Jan Sigurd Blackstad, David Tingley, Valentin A. Normand, Edvard I. Moser, May-Britt Moser, Benjamin A. Dunn
Navigation requires integrating sensory information with a stable schema to create a dynamic map of an animal’s position using egocentric and allocentric coordinate systems. In the hippocampus, place cells encode allocentric space, but their firing rates may also exhibit directional tuning within egocentric or allocentric reference frames. We compared experimental and simulated data to assess the prevalence
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Disentangling Temporal and Rate Codes in the Primate Somatosensory Cortex J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Thierri Callier, Thomas Gitchell, Michael A. Harvey, Sliman J. Bensmaia
Millisecond-scale temporal spiking patterns encode sensory information in the periphery, but their role in the neocortex remains controversial. The sense of touch provides a window into temporal coding because tactile neurons often exhibit precise, repeatable, and informative temporal spiking patterns. In the somatosensory cortex (S1), responses to skin vibrations exhibit phase locking that faithfully
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Synergistic association of Aβ and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-18 Jonathan Gallego-Rudolf, Alex I. Wiesman, Alexa Pichet Binette, Sylvia Villeneuve, Sylvain Baillet
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A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-18 Antoine Anfray, Samantha Schaeffer, Yorito Hattori, Monica M. Santisteban, Nicole Casey, Gang Wang, Michael Strickland, Ping Zhou, David M. Holtzman, Josef Anrather, Laibaik Park, Costantino Iadecola
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Inhibiting Ca2+ channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-18 Nils Korte, Anna Barkaway, Jack Wells, Felipe Freitas, Huma Sethi, Stephen P. Andrews, John Skidmore, Beth Stevens, David Attwell
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Biallelic EPB41L3 variants underlie a developmental disorder with seizures and myelination defects Brain (IF 10.6) Pub Date : 2024-09-18 Elizabeth A Werren, Guillermo Rodriguez Bey, Purvi Majethia, Parneet Kaur, Siddaramappa J Patil, Minal Kekatpure, Alexandra Afenjar, Leila Qebibo, Lydie Burglen, Hoda Tomoum, Florence Demurger, Christele Duborg, Shahyan Siddiqui, Yao-Chang Tsan, Uzma Abdullah, Zafar Ali, Saadia Maryam Saadi, Shahid Mahmood Baig, Henry Houlden, Reza Maroofian, Quasar Saleem Padiath, Stephanie L Bielas, Anju Shukla
Erythrocyte Membrane Protein Band 4.1 Like 3 (EPB41L3: NM_012307.5), also known as DAL-1, encodes the ubiquitously expressed, neuronally enriched 4.1B protein, part of the 4.1 superfamily of membrane-cytoskeleton adaptors. 4.1B plays key roles in cell spreading, migration, and cytoskeletal scaffolding that support oligodendrocyte axon adhesions essential for proper myelination. We herein describe six
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Semi-orthogonal subspaces for value mediate a binding and generalization trade-off Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-17 W. Jeffrey Johnston, Justin M. Fine, Seng Bum Michael Yoo, R. Becket Ebitz, Benjamin Y. Hayden
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Neuroanatomical changes observed over the course of a human pregnancy Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-16 Laura Pritschet, Caitlin M. Taylor, Daniela Cossio, Joshua Faskowitz, Tyler Santander, Daniel A. Handwerker, Hannah Grotzinger, Evan Layher, Elizabeth R. Chrastil, Emily G. Jacobs
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Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-16 Kathleen A. Martin, Eleni S. Papadoyannis, Jennifer K. Schiavo, Saba Shokat Fadaei, Habon A. Issa, Soomin C. Song, Sofia Orrey Valencia, Nesibe Z. Temiz, Matthew J. McGinley, David A. McCormick, Robert C. Froemke
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Tonic and burst-like locus coeruleus stimulation distinctly shift network activity across the cortical hierarchy Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-16 Christina Grimm, Sian N. Duss, Mattia Privitera, Brandon R. Munn, Nikolaos Karalis, Stefan Frässle, Maria Wilhelm, Tommaso Patriarchi, Daniel Razansky, Nicole Wenderoth, James M. Shine, Johannes Bohacek, Valerio Zerbi
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Myelin lipid metabolism can provide energy for starved axons Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-12
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Correction to: Expanded clinical phenotype spectrum correlates with variant function in SCN2A-related disorders. Brain (IF 10.6) Pub Date : 2024-09-13
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Inside out: the neural basis of spontaneous and creative thinking Brain (IF 10.6) Pub Date : 2024-09-13 Alizée Lopez-Persem, Emmanuel Mandonnet, Emmanuelle Volle
This scientific commentary refers to ‘Default mode network electrophysiological dynamics and causal role in creative thinking’ by Bartoli et al. (https://doi.org/10.1093/brain/awae199).
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Decision cost hypersensitivity underlies Huntington’s disease apathy Brain (IF 10.6) Pub Date : 2024-09-13 Lee-Anne Morris, Kyla-Louise Horne, Sanjay Manohar, Laura Paermentier, Christina Buchanan, Michael MacAskill, Daniel Myall, Matthew Apps, Richard Roxburgh, Tim Anderson, Masud Husain, Campbell Le Heron
The neuropsychiatric syndrome of apathy is now recognized to be a common and disabling condition in Huntington’s disease (HD). However, the mechanisms underlying it are poorly understood. One way to investigate apathy is to utilise a theoretical framework of normal motivated behaviour, to determine where breakdown has occurred in people with this behavioural disruption. A fundamental computation underlying
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Musicianship and Prominence of Interhemispheric Connectivity Determine Two Different Pathways to Atypical Language Dominance J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Esteban Villar-Rodríguez, Lidón Marin-Marin, María Baena-Pérez, Cristina Cano-Melle, Maria Antònia Parcet, César Ávila
During infancy and adolescence, language develops from a predominantly interhemispheric control—through the corpus callosum (CC)—to a predominantly intrahemispheric control, mainly subserved by the left arcuate fasciculus (AF). Using multimodal neuroimaging, we demonstrate that human left-handers (both male and female) with an atypical language lateralization show a rightward participation of language
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ELP1, the Gene Mutated in Familial Dysautonomia, Is Required for Normal Enteric Nervous System Development and Maintenance and for Gut Epithelium Homeostasis J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Marta Chaverra, Alexandra M. Cheney, Alpha Scheel, Alessa Miller, Lynn George, Anastasia Schultz, Katelyn Henningsen, Douglas Kominsky, Heather Walk, William R. Kennedy, Horacio Kaufmann, Seth Walk, Valérie Copié, Frances Lefcort
Familial dysautonomia (FD) is a rare sensory and autonomic neuropathy that results from a mutation in the ELP1 gene. Virtually all patients report gastrointestinal (GI) dysfunction and we have recently shown that FD patients have a dysbiotic gut microbiome and altered metabolome. These findings were recapitulated in an FD mouse model and moreover, the FD mice had reduced intestinal motility, as did
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Decision-Making with Predictions of Others Likely and Unlikely Choices in the Human Brain J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Ning Ma, Norihiro Harasawa, Kenichi Ueno, Kang Cheng, Hiroyuki Nakahara
For better decisions in social interactions, humans often must understand the thinking of others and predict their actions. Since such predictions are uncertain, multiple predictions may be necessary for better decision-making. However, the neural processes and computations underlying such social decision-making remain unclear. We investigated this issue by developing a behavioral paradigm and performing
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Effects of Phasic Activation of Locus Ceruleus on Cortical Neural Activity and Auditory Discrimination Behavior J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Xuejiao Wang, Zijie Li, Xueru Wang, Jingyu Chen, Ziyu Guo, Bingqing Qiao, Ling Qin
Although the locus ceruleus (LC) is recognized as a crucial modulator for attention and perception by releasing norepinephrine into various cortical regions, the impact of LC–noradrenergic (LC–NE) modulation on auditory discrimination behavior remains elusive. In this study, we firstly recorded local field potential and single-unit activity in multiple cortical regions associated with auditory–motor
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Amyloid-{beta} Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Olga Prikhodko, Ronald K. Freund, Emily Sullivan, Matthew J. Kennedy, Mark L. Dell’Acqua
Neuronal excitatory synapses are primarily located on small dendritic protrusions called spines. During synaptic plasticity underlying learning and memory, Ca2+ influx through postsynaptic NMDA-type glutamate receptors (NMDARs) initiates signaling pathways that coordinate changes in dendritic spine structure and synaptic function. During long-term potentiation (LTP), high levels of NMDAR Ca2+ influx
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The Hippocampus Represents Information about Movements in Their Temporal Position in a Learned Motor Sequence J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Nina Dolfen, Serena Reverberi, Hans Op de Beeck, Bradley R. King, Genevieve Albouy
Our repertoire of motor skills is filled with sequential movements that need to be performed in a specific order. Here, we used functional magnetic resonance imaging to investigate whether the human hippocampus, a region known to support temporal order in non-motor memory, represents information about the order of sequential motor actions in human participants (both sexes). We also examined such representations
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Chinese Verbal Fluency Deficiency in Temporal Lobe Epilepsy with and without Hippocampal Sclerosis: A Multiscale Study J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Kangrun Wang, Fangfang Xie, Chaorong Liu, Ge Wang, Min Zhang, Jialinzi He, Langzi Tan, Haiyun Tang, Bo Xiao, Lily Wan, Lili Long
To test a Chinese character version of the phonemic verbal fluency task in patients with temporal lobe epilepsy (TLE) and assess the verbal fluency deficiency pattern in TLE with and without hippocampal sclerosis, a cross-sectional study was conducted including 30 patients with TLE and hippocampal sclerosis (TLE-HS), 28 patients with TLE and without hippocampal sclerosis (TLE-NHS), and 29 demographically
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Heterogeneity in Slow Synaptic Transmission Diversifies Purkinje Cell Timing J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Riya Elizabeth Thomas, Franziska Mudlaff, Kyra Schweers, William Todd Farmer, Aparna Suvrathan
The cerebellum plays an important role in diverse brain functions, ranging from motor learning to cognition. Recent studies have suggested that molecular and cellular heterogeneity within cerebellar lobules contributes to functional differences across the cerebellum. However, the specific relationship between molecular and cellular heterogeneity and diverse functional outputs of different regions of
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Medial Prefrontal Cortex Stimulation Reduces Retrieval-Induced Forgetting via Fronto-parietal Beta Desynchronization J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Ahsan Khan, Chun Hang Eden Ti, Kai Yuan, Maite Crespo Garcia, Michael C. Anderson, Raymond Kai-Yu Tong
The act of recalling memories can paradoxically lead to the forgetting of other associated memories, a phenomenon known as retrieval-induced forgetting (RIF). Inhibitory control mechanisms, primarily mediated by the prefrontal cortex, are thought to contribute to RIF. In this study, we examined whether stimulating the medial prefrontal cortex (mPFC) with transcranial direct current stimulation modulates
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Encoding of 2D Self-Centered Plans and World-Centered Positions in the Rat Frontal Orienting Field J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Liujunli Li, Timo Flesch, Ce Ma, Jingjie Li, Yizhou Chen, Hung-Tu Chen, Jeffrey C. Erlich
The neural mechanisms of motor planning have been extensively studied in rodents. Preparatory activity in the frontal cortex predicts upcoming choice, but limitations of typical tasks have made it challenging to determine whether the spatial information is in a self-centered direction reference frame or a world-centered position reference frame. Here, we trained male rats to make delayed visually guided
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DOR activation in mature oligodendrocytes regulates α-ketoglutarate metabolism leading to enhanced remyelination in aged mice Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-12 Guojiao Huang, Zhidan Li, Xuezhao Liu, Menglong Guan, Songlin Zhou, Xiaowen Zhong, Tao Zheng, Dazhuan Xin, Xiaosong Gu, Dezhi Mu, Yingkun Guo, Lin Zhang, Liguo Zhang, Q. Richard Lu, Xuelian He
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Investigation of metaplasticity associated with transcranial focused ultrasound neuromodulation in humans. J. Neurosci. (IF 4.4) Pub Date : 2024-09-12 Mandy Yi Rong Ding,Tarun Arora,Can Sarica,Andrew Z Yang,Negar Nasrkhani,Talyta Grippe,Jean-François Nankoo,Stephanie Tran,Nardin Samuel,Xue Xia,Andres M Lozano,Robert Chen
Low intensity transcranial focused ultrasound stimulation (TUS) is a novel technique for non-invasive brain stimulation (NIBS). TUS delivered in a theta (5Hz) burst pattern (tbTUS) induces plasticity in the human primary motor cortex (M1) for 30-60 minutes, showing promise for therapeutic development. Metaplasticity refers to activity-dependent changes in neural functions governing synaptic plasticity;
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Synaptotagmin 4 supports spontaneous axon sprouting after spinal cord injury. J. Neurosci. (IF 4.4) Pub Date : 2024-09-12 Kyoka Higuchi,Akiko Uyeda,Lili Quan,Shogo Tanabe,Yuki Kato,Yukio Kawahara,Rieko Muramatsu
Injuries to the central nervous system (CNS) can cause severe neurological deficits. Axonal regrowth is a fundamental process for the reconstruction of compensatory neuronal networks after injury; however, it is extremely limited in the adult mammalian CNS. In this study, we conducted a loss-of-function genetic screen in cortical neurons, combined with a web-resource-based phenotypic screen, and identified
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Anterior olfactory cortices differentially transform bottom-up odor signals to produce inverse top-down outputs. J. Neurosci. (IF 4.4) Pub Date : 2024-09-12 David Wolf,Lars-Lennart Oettl,Laurens Winkelmeier,Christiane Linster,Wolfgang Kelsch
Odor information arrives first in the main olfactory bulb and is then broadcasted to the olfactory cortices and striatum. Downstream regions have unique cellular and connectivity architectures that may generate different coding patterns to the same odors. To reveal region-specific response features, tuning and decoding of single-unit populations, we recorded responses to the same odors under the same
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A miR-383-5p signalling hub coordinates the axon regeneration response to inflammation. J. Neurosci. (IF 4.4) Pub Date : 2024-09-12 Matthew A Hintermayer,Camille A Juźwik,Barbara Morquette,Elizabeth Hua,Julia Zhang,Sienna Drake,Shan Shan Shi,Isabel Rambaldi,Vamshi Vangoor,Jeroen Pasterkamp,Craig Moore,Alyson E Fournier
Neuroinflammation can positively influence axon regeneration following injury in the central nervous system (CNS). Inflammation promotes the release of neurotrophic molecules and stimulates intrinsic pro-regenerative molecular machinery in neurons, but the detailed mechanisms driving this effect are not fully understood. We evaluated how microRNAs are regulated in retinal neurons in response to intraocular
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Increases in amyloid-β42 slow cognitive and clinical decline in Alzheimer’s disease trials Brain (IF 10.6) Pub Date : 2024-09-11 Jesus Abanto, Alok K Dwivedi, Bruno P Imbimbo, Alberto J Espay
Positive effects of new anti-amyloid-β (Aβ) monoclonal antibodies in Alzheimer’s disease (AD) have been attributed to brain amyloid reduction. However, most anti-Aβ antibodies also increase the CSF levels of the 42-amino acid isoform (Aβ42). We evaluated the associations of changes in CSF Aβ42 and brain Aβ-PET with cognitive and clinical end points in randomized trials of anti-Aβ drugs that lowered
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Piezo2 channels and tactile pain: an intriguing voltage connection Brain (IF 10.6) Pub Date : 2024-09-11 Jorge Fernández-Trillo, Ana Gomis, Félix Viana
This scientific commentary refers to ‘Piezo2 voltage-block regulates mechanical pain sensitivity’ by Sánchez-Carranza et al. (https://doi.org/10.1093/brain/awae227).
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The Role of Intrinsic Plasticity in Engram Physiology and Temporal Memory Linking. J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Walter Peregrim,Tim O'Leary
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The Future of Nonhuman Primate Neuroscience: Peril or Possibilities? J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Michele A Basso,Aaron P Batista,Steve W C Chang,Katalin M Gothard,Cory T Miller,Karen J Parker,Jan Zimmermann
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Atp13a5 Marker Reveals Pericyte Specification in The Mouse Central Nervous System. J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Xinying Guo,Shangzhou Xia,Tenghuan Ge,Yangtao Lin,Shirley Hu,Haijian Wu,Xiaochun Xie,Bangyan Zhang,Sonia Zhang,Jianxiong Zeng,Jian-Fu Chen,Axel Montagne,Fan Gao,Qingyi Ma,Zhen Zhao
Perivascular mural cells including vascular smooth cells (VSMCs) and pericytes are integral components of the vascular system. In the central nervous system (CNS), pericytes are also indispensable for the blood-brain barrier (BBB), blood-spinal cord barrier and blood-retinal barrier, and play key roles in maintaining cerebrovascular and neuronal functions. However, the functional specifications of
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Distinct neuron types contribute to hybrid auditory spatial coding. J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Chenggang Chen,Sen Song
Neural decoding is a tool for understanding how activities from a population of neurons inside the brain relate to the outside world and for engineering applications such as brain-machine interfaces. However, neural decoding studies mainly focused on different decoding algorithms rather than different neuron types which could use different coding strategies. In this study, we used two-photon calcium
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The origins of freezing Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-09-10 Philip Tovote
Philip Tovote describes the 1980 paper in which Michael Fanselow systematically investigated freezing as a defensive response in rodents
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VEGF-A-mediated venous endothelial cell proliferation results in neoangiogenesis during neuroinflammation Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-10 Sanjid Shahriar, Saptarshi Biswas, Kaitao Zhao, Uğur Akcan, Mary Claire Tuohy, Michael D. Glendinning, Ali Kurt, Charlotte R. Wayne, Grace Prochilo, Maxwell Z. Price, Heidi Stuhlmann, Rolf A. Brekken, Vilas Menon, Dritan Agalliu
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An algorithm for drug-resistant epilepsy in Danish national registers Brain (IF 10.6) Pub Date : 2024-09-10 Eva Bølling-Ladegaard, Julie W Dreier, Jakob Christensen
Patients with drug-resistant epilepsy (DRE) have increased risks of premature death, injuries, psychosocial dysfunction, and a reduced quality of life. Identification of persons with DRE in administrative data can allow for effective large-scale research, and we therefore aimed to construct an algorithm for identification of DRE in Danish nation-wide health registers. We used a previously generated
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GluN3A and excitatory glycine receptors in the adult hippocampus. J. Neurosci. (IF 4.4) Pub Date : 2024-09-10 Emily P Hurley,Bandhan Mukherjee,Lisa Z Fang,Jocelyn R Barnes,Jessica C Barron,Firoozeh Nafar,Michiru Hirasawa,Matthew P Parsons
The GluN3A subunit of N-methyl-D-aspartate receptors (NMDARs) plays an established role in synapse development, but its contribution to neural circuits in the adult brain is less clear. Recent work has demonstrated that in select cell populations, GluN3A assembles with GluN1 to form GluN1/GluN3A receptors that are insensitive to glutamate and instead serve as functional excitatory glycine receptors
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Sequential activation of lateral hypothalamic neuronal populations during feeding and their assembly by gamma oscillations. J. Neurosci. (IF 4.4) Pub Date : 2024-09-10 Mahsa Altafi,Changwan Chen,Tatiana Korotkova,Alexey Ponomarenko
Neural circuits supporting innate behaviors, such as feeding, exploration, and social interaction, intermingle in the lateral hypothalamus (LH). Although previous studies have shown that individual LH neurons change their firing relative to the baseline during one or more behaviors, the firing rate dynamics of LH populations within behavioral episodes as well as the coordination of behavior-related
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PDE4B Missense Variant Increases Susceptibility to Post-Traumatic Stress Disorder-Relevant Phenotypes in Mice. J. Neurosci. (IF 4.4) Pub Date : 2024-09-10 Tatiana V Lipina,Shupeng Li,Ekaterina S Petrova,Tamara G Amstislavskaya,Ryan T Cameron,Christina Elliott,Yoichi Gondo,Alexander McGirr,Jonathan G L Mullins,George S Baillie,James R Woodgett,Steven J Clapcote
Large-scale genome-wide association studies (GWAS) have associated intronic variants in PDE4B, encoding cAMP-specific phosphodiesterase-4B (PDE4B), with increased risk for post-traumatic stress disorder (PTSD), as well as schizophrenia and substance use disorders that are often comorbid with it. However, the pathophysiological mechanisms of genetic risk involving PDE4B are poorly understood. To examine
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Mu-Opioid Receptor (MOR) Dependence of Pain in Chemotherapy-Induced Peripheral Neuropathy. J. Neurosci. (IF 4.4) Pub Date : 2024-09-10 Dionéia Araldi,Larissa Staurengo-Ferrari,Oliver Bogen,Ivan J M Bonet,Paul G Green,Jon D Levine
We recently demonstrated that transient attenuation of Toll-like receptor 4 (TLR4) in dorsal root ganglion (DRG) neurons, can both prevent and reverse pain associated with chemotherapy-induced peripheral neuropathy (CIPN), a severe side effect of cancer chemotherapy, for which treatment options are limited. Given the reduced efficacy of opioid analgesics to treat neuropathic, compared to inflammatory
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Oligodendroglial fatty acid metabolism as a central nervous system energy reserve Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-09 Ebrahim Asadollahi, Andrea Trevisiol, Aiman S. Saab, Zoe J. Looser, Payam Dibaj, Reyhane Ebrahimi, Kathrin Kusch, Torben Ruhwedel, Wiebke Möbius, Olaf Jahn, Jun Yup Lee, Anthony S. Don, Michelle-Amirah Khalil, Karsten Hiller, Myriam Baes, Bruno Weber, E. Dale Abel, Andrea Balabio, Brian Popko, Celia M. Kassmann, Hannelore Ehrenreich, Johannes Hirrlinger, Klaus-Armin Nave
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Circadian rhythms in conditioned threat extinction reflect time-of-day differences in ventromedial prefrontal cortex neural processing. J. Neurosci. (IF 4.4) Pub Date : 2024-09-09 Matthew J Hartsock,Catherine T Levy,Maria J Navarro,Michael P Saddoris,Robert L Spencer
Circadian rhythms in conditioned threat extinction emerge from a tissue-level circadian timekeeper, or local clock, in the ventromedial prefrontal cortex (vmPFC). Yet it remains unclear how this local clock contributes to extinction-dependent adaptations. Here we used single-unit and local field potential analyses to interrogate neural activity in the male rat vmPFC during repeated extinction sessions
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Dynamic organization of neuronal extracellular matrix revealed by HaloTag-HAPLN1. J. Neurosci. (IF 4.4) Pub Date : 2024-09-09 Igal Sterin,Ava Niazi,Jennifer Kim,Joosang Park,Sungjin Park
The brain's extracellular matrix (ECM) regulates neuronal plasticity and animal behavior. ECM staining shows a net-like structure around a subset of neurons, a ring-like structure at the Nodes of Ranvier, and diffuse staining in the interstitial matrix. However, understanding the structural features of ECM deposition across various neuronal types and subcellular compartments remains limited. To visualize
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μ-opioid receptor modulation of the glutamatergic/GABAergic midbrain inputs to the mouse dorsal hippocampus. J. Neurosci. (IF 4.4) Pub Date : 2024-09-09 Haram R Kim,Soumil Dey,Gabriella Sekerkova,Marco Martina
We used virus-mediated anterograde and retrograde tracing, optogenetic modulation, immuno-staining, in-situ hybridization, and patch clamp recordings in acute brain slices to study the release mechanism and μ-opioid modulation of the dual glutamatergic/GABAergic inputs from the VTA and supramammillary nucleus to the granule cells of dorsal hippocampus of male and female mice. In keeping with previous
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Retinal Input to Macaque Superior Colliculus Derives from Branching Axons Projecting to the Lateral Geniculate Nucleus. J. Neurosci. (IF 4.4) Pub Date : 2024-09-09 Yicen J Zheng,Daniel L Adams,Thomas N Gentry,Mikayla D Dilbeck,John R Economides,Jonathan C Horton
The superior colliculus receives a direct projection from retinal ganglion cells. In primates, it remains unknown if the same ganglion cells also supply the lateral geniculate nucleus. To address this issue, a double-label experiment was performed in 2 male macaques. The animals fixated a target while injection sites were scouted in the superior colliculus by recording and stimulating with a tetrode
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TRIM46 is required for microtubule fasciculation in vivo but not axon specification or axon initial segment formation. J. Neurosci. (IF 4.4) Pub Date : 2024-09-09 Allison J Melton,Victoria L Palfini,Yuki Ogawa,Juan A Oses Prieto,Anna Vainshtein,Alma L Burlingame,Elior Peles,Matthew N Rasband
Vertebrate nervous systems use the axon initial segment (AIS) to initiate action potentials and maintain neuronal polarity. The microtubule-associated protein tripartite motif containing 46 (TRIM46) was reported to regulate axon specification, AIS assembly, and neuronal polarity through the bundling, or fasciculation, of microtubules in the proximal axon. However, these claims are based on TRIM46 knockdown