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Lycopene alleviates age-related cognitive deficit via activating liver-brain fibroblast growth factor-21 signalling. Redox Biol. (IF 10.7) Pub Date : 2024-09-19 Jia Wang,Lu Li,Li Li,Yuqi Shen,Fubin Qiu
Brain function is linked with many peripheral tissues, including the liver, where hepatic fibroblast growth factor 21 (FGF21) mediates communication between the liver and brain. Lycopene (LYC), a naturally occurring carotenoid, posses multiple health-promoting properties, including neuroprotective function. Here, we investigated the effects of LYC on age-related memory impairment and the relative contribution
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LncRNA-HMG incites colorectal cancer cells to chemoresistance via repressing p53-mediated ferroptosis. Redox Biol. (IF 10.7) Pub Date : 2024-09-18 Zechang Xin,Chenyu Hu,Chunfeng Zhang,Ming Liu,Juan Li,Xiaoyan Sun,Yang Hu,Xiaofeng Liu,Kun Wang
Upon chemotherapy, excessive reactive oxygen species (ROS) often lead to the production of massive lipid peroxides in cancer cells and induce cell death, namely ferroptosis. The elimination of ROS is pivotal for tumor cells to escape from ferroptosis and acquire drug resistance. Nevertheless, the precise functions of long non-coding RNAs (lncRNAs) in ROS metabolism and tumor drug-resistance remain
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Sensor systems of KEAP1 uniquely detecting oxidative and electrophilic stresses separately In vivo. Redox Biol. (IF 10.7) Pub Date : 2024-09-17 Miu Sato,Nahoko Yaguchi,Takuya Iijima,Aki Muramatsu,Liam Baird,Takafumi Suzuki,Masayuki Yamamoto
In the KEAP1-NRF2 stress response system, KEAP1 acts as a sensor for oxidative and electrophilic stresses through formation of S-S bond and C-S bond, respectively. Of the many questions left related to the sensor activity, following three appear important; whether these KEAP1 sensor systems are operating in vivo, whether oxidative and electrophilic stresses are sensed by the similar or distinct systems
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Glucoraphanin and sulforaphane mitigate TNFα-induced Caco-2 monolayers permeabilization and inflammation Redox Biol. (IF 10.7) Pub Date : 2024-09-17 Wei Zhu, Eleonora Cremonini, Angela Mastaloudis, Patricia I. Oteiza
Intestinal permeabilization is central to the pathophysiology of chronic gut inflammation. This study investigated the efficacy of glucoraphanin (GR), prevalent in cruciferous vegetables, particularly broccoli, and its derivative sulforaphane (SF), in inhibiting tumor necrosis factor alpha (TNFα)-induced Caco-2 cell monolayers inflammation and permeabilization through the regulation of redox-sensitive
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PPARγ drives mitochondrial stress signaling and the loss of atrial cardiomyocytes in newborn mice exposed to hyperoxia Redox Biol. (IF 10.7) Pub Date : 2024-09-12 E. David Cohen, Kyle Roethlin, Min Yee, Collynn F. Woeller, Paul S. Brookes, George A. Porter Jr., Michael A. O'Reilly
Diastolic dysfunction is increasingly common in preterm infants exposed to supplemental oxygen (hyperoxia). Previous studies in neonatal mice showed hyperoxia suppresses fatty acid synthesis genes required for proliferation and survival of atrial cardiomyocytes. The loss of atrial cardiomyocytes creates a hypoplastic left atrium that inappropriately fills the left ventricle during diastole. Here, we
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Phytic acid-loaded polyvinyl alcohol hydrogel promotes wound healing of injured corneal epithelium through inhibiting ferroptosis Redox Biol. (IF 10.7) Pub Date : 2024-09-11 Danni Gong, Nianxuan Wu, Huan Chen, Weijie Zhang, Chenxi Yan, Chunlei Zhang, Yao Fu, Hao Sun
As the important barrier of intraocular tissue, cornea is easy to suffer various kinds of injuries. Among them, acute alkali burn is a thorny ophthalmic emergency event, which can lead to corneal persistent epithelial defects, ulcers, and even perforation. Ferroptosis, a mode of regulatory cell death, has been found to play a key role in the process of corneal alkali burn, of which lipid peroxidation
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Targeting GPX4-mediated ferroptosis protection sensitizes BRCA1-deficient cancer cells to PARP inhibitors Redox Biol. (IF 10.7) Pub Date : 2024-09-11 Xuexia Xie, Congcong Chen, Cong Wang, Yongjian Guo, Binghe Sun, Jiaxin Tian, Jin Yan, Dake Li, Guo Chen
BRCA1 is one of the most frequently-mutated tumor suppressor genes in ovarian and breast cancers. Loss of BRCA1 triggers homologous recombination (HR) repair deficiency, consequently leading to genomic instability and PARP inhibitors (PARPi)-associated synthetic lethality. Although, the roles of BRCA1 in DNA repair and replication have been extensively investigated, its tumor suppressive functions
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UBR5 mediates colorectal cancer chemoresistance by attenuating ferroptosis via Lys 11 ubiquitin-dependent stabilization of Smad3-SLC7A11 signaling Redox Biol. (IF 10.7) Pub Date : 2024-09-10 Mei Song, Shuting Huang, Xiaoxue Wu, Ziyi Zhao, Xiaoting Liu, Chong Wu, Mengru Wang, Jialing Gao, Zunfu Ke, Xiaojing Ma, Weiling He
Chemoresistance remains a principal culprit for the treatment failure in colorectal cancer (CRC), especially for patients with recurrent or metastatic disease. Deciphering the molecular basis of chemoresistance may lead to novel therapeutic strategies for this fatal disease. Here, UBR5, an E3 ubiquitin ligase frequently overexpressed in human CRC, is demonstrated to mediate chemoresistance principally
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LOX-mediated ECM mechanical stress induces Piezo1 activation in hypoxic-ischemic brain damage and identification of novel inhibitor of LOX Redox Biol. (IF 10.7) Pub Date : 2024-09-07 Dongya Jiang, Jing Zhao, Jie Zheng, Yingmin Zhao, Meini Le, Dani Qin, Qiong Huang, Jinyu Huang, Qingshun Zhao, Long Wang, Xiaohua Dong
Hypoxic-ischemic encephalopathy (HIE) poses a significant challenge in neonatal medicine, often resulting in profound and lasting neurological deficits. Current therapeutic strategies for hypoxia-ischemia brain damage (HIBD) remain limited. Ferroptosis has been reported to play a crucial role in HIE and serves as a potential therapeutic target. However, the mechanisms underlying ferroptosis in HIBD
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High expression levels of haem oxygenase-1 promote ferroptosis in macrophage-derived foam cells and exacerbate plaque instability Redox Biol. (IF 10.7) Pub Date : 2024-09-07 Zhenyu Guo, Wan Zhang, Hongxia Gao, Yang Li, Xu Li, Xiaohu Yang, Longhua Fan
Plaque rupture with consequent thrombosis is the leading cause of acute cardiovascular events, during which macrophage death is a hallmark. Ferroptosis is a pivotal intermediate link between early and advanced atherosclerosis. Existing evidence indicates the involvement of macrophage ferroptosis in plaque vulnerability; however, the exact mechanism remains elusive. The aim of this study was to explore
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CARM1 phosphorylation at S595 by p38γ MAPK drives ROS-mediated cellular senescence Redox Biol. (IF 10.7) Pub Date : 2024-09-06 Yena Cho, Yong Kee Kim
CARM1 is predominantly localized in the nucleus and plays a pivotal role in maintaining mitochondrial homeostasis by regulating gene expression. It suppresses mitochondrial biogenesis by downregulating and expression, while promoting mitochondrial fission through increased expression. Under oxidative stress, CARM1 translocates to the cytoplasm, where it directly methylates DRP1 and accelerates mitochondrial
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Lipocalin-2 aggravates blood-brain barrier dysfunction after intravenous thrombolysis by promoting endothelial cell ferroptosis via regulating the HMGB1/Nrf2/HO-1 pathway Redox Biol. (IF 10.7) Pub Date : 2024-09-05 Jie Liu, Shu-Yan Pang, Sheng-Yu Zhou, Qian-Yan He, Ruo-Yu Zhao, Yang Qu, Yi Yang, Zhen-Ni Guo
Disruption of the blood-brain barrier (BBB) is a major contributor to hemorrhagic transformation (HT) in patients with acute ischemic stroke (AIS) following intravenous thrombolysis (IVT). However, the clinical therapies aimed at BBB protection after IVT remain limited. One hundred patients with AIS who underwent IVT were enrolled (42 with HT and 58 without HT 24 h after IVT). Based on the cytokine
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Comprehensive modulatory effects of whole grain consumption on immune-mediated inflammation in middle-aged and elderly community residents: A real-world randomized controlled trial Redox Biol. (IF 10.7) Pub Date : 2024-09-05 Cheng Li, Yaru Li, Nan Wang, Zhiwen Ge, Jia Wang, Bingjie Ding, Yanxia Bi, Yuxia Wang, Yisi Wang, Zebin Peng, Xinli Yang, Congcong Wang, Zhongxin Hong
Whole grain consumption is widely recognized as a vital component of a balanced diet. Dietary fiber has been well-documented to play a crucial role in these health benefits attributed to whole grain intake. However, population-based evidence directly linking whole grain consumption to anti-inflammatory effects, especially in the context of immune-mediated inflammation, remains limited. We hypothesized
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Oxidative stress promotes oral carcinogenesis via Thbs1-mediated M1-like tumor-associated macrophages polarization Redox Biol. (IF 10.7) Pub Date : 2024-09-05 Wei Li, Qingwen Zeng, Bing Wang, Chao Lv, Haoan He, Xi Yang, Bin Cheng, Xiaoan Tao
Although oxidative stress is closely associated with tumor invasion and metastasis, its’ exact role and mechanism in the initial stage of oral cancer remain ambiguous. Glutamine uptake mediated by alanine-serine-cysteine transporter 2 (ASCT2) participates in glutathione synthesis to resolve oxidative stress. Currently, we firstly found that ASCT2 deletion caused oxidative stress in oral mucosa and
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Role of mitochondria in reno-cardiac diseases: A study of bioenergetics, biogenesis, and GSH signaling in disease transition Redox Biol. (IF 10.7) Pub Date : 2024-09-05 Jairo Lumpuy-Castillo, Isabel Amador-Martínez, Miriam Díaz-Rojas, Oscar Lorenzo, José Pedraza-Chaverri, Laura Gabriela Sánchez-Lozada, Omar Emiliano Aparicio-Trejo
Acute kidney injury (AKI) and chronic kidney disease (CKD) are global health burdens with rising prevalence. Their bidirectional relationship with cardiovascular dysfunction, manifesting as cardio-renal syndromes (CRS) types 3 and 4, underscores the interconnectedness and interdependence of these vital organ systems. Both the kidney and the heart are critically reliant on mitochondrial function. This
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Impaired HDL antioxidant and anti-inflammatory functions are linked to increased mortality in acute heart failure patients Redox Biol. (IF 10.7) Pub Date : 2024-09-05 Anja Pammer, Iva Klobučar, Julia T. Stadler, Sabine Meissl, Hansjörg Habisch, Tobias Madl, Saša Frank, Vesna Degoricija, Gunther Marsche
Acute heart failure (AHF) is typified by inflammatory and oxidative stress responses, which are associated with unfavorable patient outcomes. Given the anti-inflammatory and antioxidant properties of high-density lipoprotein (HDL), this study sought to examine the relationship between impaired HDL function and mortality in AHF patients. The complex interplay between various HDL-related biomarkers and
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Corrigendum to "Dopamine-modified hyaluronic acid (DA-HA) as a novel dopamine-mimetics with minimal autoxidation and cytotoxicity" [Redox Biol. 76 (2024) 103320]. Redox Biol. (IF 10.7) Pub Date : 2024-09-05 Sunpil Kim,Ye-Ji Kim,Kyoung Hwan Park,Kang Moo Huh,Sun-Woong Kang,C Justin Lee,Dong Ho Woo
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Deciphering the ferroptosis pathways in dorsal root ganglia of Friedreich ataxia models. The role of LKB1/AMPK, KEAP1, and GSK3β in the impairment of the NRF2 response Redox Biol. (IF 10.7) Pub Date : 2024-09-04 Arabela Sanz-Alcázar, Marta Portillo-Carrasquer, Fabien Delaspre, Maria Pazos-Gil, Jordi Tamarit, Joaquim Ros, Elisa Cabiscol
Friedreich ataxia (FA) is a rare neurodegenerative disease caused by decreased levels of the mitochondrial protein frataxin. Frataxin has been related in iron homeostasis, energy metabolism, and oxidative stress. Ferroptosis has recently been shown to be involved in FA cellular degeneration; however, its role in dorsal root ganglion (DRG) sensory neurons, the cells that are affected the most and the
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Liver-secreted FGF21 induces sarcopenia by inhibiting satellite cell myogenesis via klotho beta in decompensated cirrhosis Redox Biol. (IF 10.7) Pub Date : 2024-08-30 Da Zhou, Yifan Shi, Donghua Zhang, Junbo Zuo, Chenghao Zeng, Gulsudum Mamtawla, LongChang Huang, Xuejin Gao, Li Zhang, Xinying Wang
Sarcopenia, a prevalent condition, significantly impacts the prognosis of patients with decompensated cirrhosis (DC). Serum fibroblast growth factor 21 (FGF21) levels are significantly higher in DC patients with sarcopenia. Satellite cells (SCs) play a role in aging- and cancer-induced sarcopenia. Here, we investigated the roles of FGF21 and SCs in DC-related sarcopenia as well as the underlying mechanisms
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Associations of dietary inflammation index and composite dietary antioxidant index with preserved ratio impaired spirometry in US adults and the mediating roles of triglyceride-glucose index: NHANES 2007–2012 Redox Biol. (IF 10.7) Pub Date : 2024-08-30 Yuyu Zheng, Wanlu Liu, Xinyu Zhu, Mengya Xu, Baihao Lin, Yansen Bai
Previous studies have shown that inflammatory and antioxidant dietary patterns can modify the risk of COPD, yet few studies have examined the association of these diets with its early signs (PRISm), and the potential role of metabolic disorders remains to be elucidated. Data from 9529 individuals who participated in the 2007–2012 National Health and Nutrition Examination Survey (NHANES) were analyzed
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Oxidative stress-mediated protein sulfenylation in human diseases: Past, present, and future Redox Biol. (IF 10.7) Pub Date : 2024-08-30 Baoquan Mu, Yan Zeng, Li Luo, Kui Wang
Reactive Oxygen Species (ROS) refer to a variety of derivatives of molecular oxygen that play crucial roles in regulating a wide range of physiological and pathological processes. Excessive ROS levels can cause oxidative stress, leading to cellular damage and even cell demise. However, moderately elevated levels of ROS can mediate the oxidative post-translational modifications (oxPTMs) of redox-sensitive
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A new paradigm in intracellular immunology: Mitochondria emerging as leading immune organelles Redox Biol. (IF 10.7) Pub Date : 2024-08-29 Keman Xu, Fatma Saaoud, Ying Shao, Yifan Lu, Qiaoxi Yang, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Mitochondria, traditionally recognized as cellular 'powerhouses' due to their pivotal role in energy production, have emerged as multifunctional organelles at the intersection of bioenergetics, metabolic signaling, and immunity. However, the understanding of their exact contributions to immunity and inflammation is still developing. This review first introduces the innovative concept of intracellular
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Intermittent ozone inhalation during house dust mite-induced sensitization primes for adverse asthma phenotype Redox Biol. (IF 10.7) Pub Date : 2024-08-28 Salik Hussain, Nairrita Majumder, Md Habibul Hasan Mazumder, Sara E. Lewis, Olanrewaju Olapeju, Murugesan Velayutham, Md Shahrier Amin, Kathleen Brundage, Eric E. Kelley, Jeroen Vanoirbeek
The ability of air pollution to induce acute exacerbation of asthma is well documented. However, the ability of ozone (O), the most reactive gaseous component of air pollution, to function as a modulator during sensitization is not well established. C57BL/6 J male mice were intranasally sensitized to house dust mite (HDM) (40 μg/kg) for 3 weeks on alternate days in parallel with once-a-week O exposure
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Role of Mitofusin 1 in mediating reactive oxygen species in alveolar macrophages during Streptococcuspneumoniae Redox Biol. (IF 10.7) Pub Date : 2024-08-27 David Thomas, Jianjun Yang, Soo Jung Cho, Heather Stout-Delgado
Alveolar macrophages (AM) are key effectors of the immune response and are essential for host responses to Mitochondria are highly dynamic organelles whose function aids in regulating the cell cycle, innate immunity, autophagy, redox signaling, calcium homeostasis, and mitochondrial quality control in AM. In response to cellular stress, mitochondria can engage in stress-induced mitochondrial hyperfusion
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Synergistic induction of ferroptosis by targeting HERC1-NCOA4 axis to enhance the photodynamic sensitivity of osteosarcoma Redox Biol. (IF 10.7) Pub Date : 2024-08-26 Ye Zhang, Yuxing Chen, Hai Mou, Qiu Huang, Changchun Jian, Yong Tao, Fuqiang Tan, Yunsheng Ou
Over the past 30 years, the survival rate for osteosarcoma (OS) has remained stagnant, indicating persistent challenges in diagnosis and treatment. Photodynamic therapy (PDT) has emerged as a novel and promising treatment modality for OS. Despite apoptosis being the primary mechanism attributed to PDT, it fails to overcome issues such as low efficacy and resistance. Ferroptosis, a Fe-dependent cell
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Association between the oxidative balance score and all-cause and cardiovascular mortality in patients with diabetes and prediabetes Redox Biol. (IF 10.7) Pub Date : 2024-08-23 Zichen Xu, Daoqin Liu, Ying Zhai, Yu Tang, Luqing Jiang, Lei Li, Qiwen Wu
Few studies have examined the link between systemic oxidative stress and mortality risk in diabetes and prediabetes patients. The Oxidative Balance Score (OBS) is a novel measure of systemic oxidative stress, with higher scores indicating greater antioxidant exposure. This study investigates the relationship between OBS and all-cause and cardiovascular mortality in these patients. This study analyzed
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High selenium diet attenuates pressure overload-induced cardiopulmonary oxidative stress, inflammation, and heart failure Redox Biol. (IF 10.7) Pub Date : 2024-08-22 Umesh Bhattarai, Rui Xu, Xiaochen He, Lihong Pan, Ziru Niu, Dongzhi Wang, Heng Zeng, Jian-Xiong Chen, John S. Clemmer, Yingjie Chen
Selenium (Se) deficiency is associated with the development of Keshan disease, a cardiomyopathy associated with massive cardiac immune cell infiltration that can lead to heart failure (HF). The purpose of this study was to determine whether high Se diet can attenuate systolic overload-induced cardiopulmonary inflammation and HF. Briefly, transverse aortic constriction (TAC)-induced cardiopulmonary
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The activity of therapeutic molecular cluster Ag5 is dependent on oxygen level and HIF-1 mediated signalling Redox Biol. (IF 10.7) Pub Date : 2024-08-22 Sophie A. Twigger, Blanca Dominguez, Vanesa Porto, Lina Hacker, Anthony J. Chalmers, Ross Breckenridge, Martin Treder, Adam C. Sedgwick, Fernando Dominguez, Ester M. Hammond
Regions of hypoxia occur in most solid tumours and are known to significantly impact therapy response and patient prognosis. Ag5 is a recently reported silver molecular cluster which inhibits both glutathione and thioredoxin signalling therefore limiting cellular antioxidant capacity. Ag5 treatment significantly reduces cell viability in a range of cancer cell lines with little to no impact on non-transformed
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AQP1 differentially orchestrates endothelial cell senescence Redox Biol. (IF 10.7) Pub Date : 2024-08-22 Khatereh Shabanian, Taraneh Shabanian, Gergely Karsai, Luca Pontiggia, Francesco Paneni, Frank Ruschitzka, Jürg H. Beer, Seyed Soheil Saeedi Saravi
Accumulation of senescent endothelial cells (ECs) with age is a pivotal driver of cardiovascular diseases in aging. However, little is known about the mechanisms and signaling pathways that regulate EC senescence. In this report, we delineate a previously unrecognized role of aquaporin 1 (AQP1) in orchestrating extracellular hydrogen peroxide (HO)-induced cellular senescence in aortic ECs. Our findings
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Unravelling the antioxidant behaviour of self-assembly β-Sheet in silk fibroin Redox Biol. (IF 10.7) Pub Date : 2024-08-20 Zhiyong Qian, Chang Sun, Qianqian Li, Yafan Xie, Lingpeng Zhan, Xiangli Liu, Guanbo Wang, Yen Wei, Juhui Qiu, Qin Peng
Local oxidative stress in diseases or injury severely hinders cell homeostasis and organ regeneration. Antioxidant therapy is an effective strategy for oxidative stress treatment. Biomaterials with good biocompatibility and reactive oxygen species (ROS) scavenging ability are good choices for antioxidant therapeutics. However, there are few natural biomaterials that are identified with both biocompatibility
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Z-ligustilide provides a neuroprotective effect by regulating the phenotypic polarization of microglia via activating Nrf2-TrxR axis in the Parkinson's disease mouse model Redox Biol. (IF 10.7) Pub Date : 2024-08-20 Shoujiao Peng, Yao Chen, Ran Wang, Jiange Zhang
The polarization phenotype of microglia is critical in the progression of Parkinson's disease (PD). Molecules that can polarize microglia toward the M2 phenotype represent a promising class of compounds for anti-PD medications. Z-ligustilide (ZLG) is a naturally occurring enol ester with diverse pharmacological properties, especially in neuroprotection. For the first time, we investigated the effect
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Tryptanthrin targets GSTP1 to induce senescence and increases the susceptibility to apoptosis by senolytics in liver cancer cells Redox Biol. (IF 10.7) Pub Date : 2024-08-20 Yuxuan Zhang, Biying Xiao, Shuying Yuan, Lele Ding, Yongfu Pan, Yanyu Jiang, Shenghao Sun, Xisong Ke, Lili Cai, Lijun Jia
Targeting senescence has emerged as a promising strategy for liver cancer treatment. However, the lack of a safe agent capable of inducing complete senescence and being combined with senolytics poses a limitation. Here, we screened a natural product library and identified tryptanthrin (TRYP) as a potent inducer of cellular senescence in liver cancer cells both and . Mechanistically, Glutathione S-transferase
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GHSR deficiency exacerbates Parkinson's disease pathology by impairing autophagy Redox Biol. (IF 10.7) Pub Date : 2024-08-20 Xue Xiao, Tingting Tang, Mingxia Bi, Jing Liu, Mengru Liu, Qian Jiao, Xi Chen, Chunling Yan, Xixun Du, Hong Jiang
In Parkinson's disease (PD), exogenous ghrelin protects dopaminergic neurons through its receptor, growth hormone secretagogue receptor (GHSR). However, in contrast to the strikingly low levels of ghrelin, GHSR is highly expressed in the substantia nigra (SN). What role does GHSR play in dopaminergic neurons is unknown. In this study, using GHSR knockout mice ( mice) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Dopamine-modified hyaluronic acid (DA-HA) as a novel dopamine-mimetics with minimal autoxidation and cytotoxicity Redox Biol. (IF 10.7) Pub Date : 2024-08-20 Sunpil Kim, Ye-Ji Kim, Kyoung Hwan Park, Kang Moo Huh, Sun-Woong Kang, C. Justin Lee, Dong Ho Woo
Dopamine-modified hyaluronic acid (DA-HA) has been initially developed as an efficient coating and adhesion material for industrial uses. However, the biological activity and safety of DA-HA in the brain have not been explored yet. Here, we report a series of evidence that DA-HA exhibits similar functionality as dopamine (DA), but with much lower toxicity arising from autoxidation. DA-HA shows very
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Mitohormesis during advanced stages of Duchenne muscular dystrophy reveals a redox-sensitive creatine pathway that can be enhanced by the mitochondrial-targeting peptide SBT-20 Redox Biol. (IF 10.7) Pub Date : 2024-08-20 Meghan C. Hughes, Sofhia V. Ramos, Aditya N. Brahmbhatt, Patrick C. Turnbull, Nazari N. Polidovitch, Madison C. Garibotti, Uwe Schlattner, Thomas J. Hawke, Jeremy A. Simpson, Peter H. Backx, Christopher GR. Perry
Mitochondrial creatine kinase (mtCK) regulates the “fast” export of phosphocreatine to support cytoplasmic phosphorylation of ADP to ATP which is more rapid than direct ATP export. Such “creatine-dependent” phosphate shuttling is attenuated in several muscles, including the heart, of the D2. mouse model of Duchenne muscular dystrophy at only 4 weeks of age. However, the degree to which creatine-dependent
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Epigenetic regulation of diverse regulated cell death modalities in cardiovascular disease: Insights into necroptosis, pyroptosis, ferroptosis, and cuproptosis Redox Biol. (IF 10.7) Pub Date : 2024-08-19 Cong Chen, Jie Wang, Shan Zhang, Xueying Zhu, Jun Hu, Chao Liu, Lanchun Liu
Cell death constitutes a critical component of the pathophysiology of cardiovascular diseases. A growing array of non-apoptotic forms of regulated cell death (RCD)—such as necroptosis, ferroptosis, pyroptosis, and cuproptosis—has been identified and is intimately linked to various cardiovascular conditions. These forms of RCD are governed by genetically programmed mechanisms within the cell, with epigenetic
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Systemic oxidative stress associates with the development of post-COVID-19 syndrome in non-hospitalized individuals Redox Biol. (IF 10.7) Pub Date : 2024-08-19 Larissa E. Vlaming-van Eijk, Marian L.C. Bulthuis, Bernardina T.F. van der Gun, Karin I. Wold, Alida C.M. Veloo, María F. Vincenti González, Martin H. de Borst, Wilfred F.A. den Dunnen, Jan-Luuk Hillebrands, Harry van Goor, Adriana Tami, Arno R. Bourgonje
Post-COVID-19 syndrome (PCS) remains a major health issue worldwide, while its pathophysiology is still poorly understood. Systemic oxidative stress (OS) may be involved in PCS, which is reflected by lower circulating free thiols (R–SH, sulfhydryl groups), as they are receptive to rapid oxidation by reactive species. This study aimed to investigate the longitudinal dynamics of serum R–SH after SARS-CoV-2
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ALDH2 deficiency augments atherosclerosis through the USP14-cGAS-dependent polarization of proinflammatory macrophages Redox Biol. (IF 10.7) Pub Date : 2024-08-17 Haiying Rui, Huaxiang Yu, Kai Chi, Ziqi Han, Wenyong Zhu, Jian Zhang, Haipeng Guo, Wenyi Zou, Fengxin Wang, Ping Xu, Dan Zou, Xiaoshuai Song, Lulu Liu, Xuting Wu, Wenxiao Wu, Dandan Qin, Yihai Cao, Feng Xu, Li Xue, Yuguo Chen
The aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism commonly exists in the East Asian populations and is associated with high risks of cardiovascular disease (CVD). However, the cellular and molecular mechanisms that underlie the ALDH2 rs671 mutant-linked high CVD remain elusive. Here, we show that macrophages derived from human ALDH2 rs671 carriers and ALDH2 knockout mice exhibited an enhanced
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Carbon monoxide-loaded red blood cells ameliorate metabolic dysfunction-associated steatohepatitis progression via enhancing AMP-activated protein kinase activity and inhibiting Kupffer cell activation Redox Biol. (IF 10.7) Pub Date : 2024-08-17 Hiroki Yanagisawa, Hitoshi Maeda, Isamu Noguchi, Motohiko Tanaka, Naoki Wada, Taisei Nagasaki, Kazuki Kobayashi, Gai Kanazawa, Kazuaki Taguchi, Victor Tuan Giam Chuang, Hiromi Sakai, Hiroyuki Nakashima, Manabu Kinoshita, Hiroaki Kitagishi, Yasuko Iwakiri, Yutaka Sasaki, Yasuhito Tanaka, Masaki Otagiri, Hiroshi Watanabe, Toru Maruyama
Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive form of nonalcoholic fatty liver disease characterised by fat accumulation, inflammation, oxidative stress, fibrosis, and impaired liver regeneration. In this study, we found that heme oxygenase-1 (HO-1) is induced in both MASH patients and in a MASH mouse model. Further, hepatic carbon monoxide (CO) levels in MASH model mice
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Plin4 exacerbates cadmium-decreased testosterone level via inducing ferroptosis in testicular Leydig cells Redox Biol. (IF 10.7) Pub Date : 2024-08-17 Xu-Dong Zhang, Jian Sun, Xin-Mei Zheng, Jin Zhang, Lu-Lu Tan, Long-Long Fan, Ye-Xin Luo, Yi-Fan Hu, Shen-Dong Xu, Huan Zhou, Yu-Feng Zhang, Hao Li, Zhi Yuan, Tian Wei, Hua-Long Zhu, De-Xiang Xu, Yong-Wei Xiong, Hua Wang
Strong evidence indicates that environmental stressors are the risk factors for male testosterone deficiency (TD). However, the mechanisms of environmental stress-induced TD remain unclear. Based on our all-cause male reproductive cohort, we found that serum ferrous iron (Fe⁺) levels were elevated in TD donors. Then, we explored the role and mechanism of ferroptosis in environmental stress-reduced
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Heme: A link between hemorrhage and retinopathy of prematurity progression Redox Biol. (IF 10.7) Pub Date : 2024-08-16 Tamás Gáll, Dávid Pethő, Katalin Erdélyi, Virág Egri, Jázon György Balla, Annamária Nagy, Annamária Nagy, Szilárd Póliska, Magnus Gram, Róbert Gábriel, Péter Nagy, József Balla, György Balla
Neovascularization is implicated in the pathology of retinopathy of prematurity (ROP), diabetic retinopathy (DR), and age-related macular degeneration (AMD), which are the leading causes of blindness worldwide. In our work, we analyzed how heme released during hemorrhage affects hypoxic response and neovascularization. Our retrospective clinical analysis demonstrated, that hemorrhage was associated
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Inhibition of MMP2 activity mitigates N-omega-nitro-l-arginine-methyl ester (l-NAME)-induced right heart failure Redox Biol. (IF 10.7) Pub Date : 2024-08-15 Rolf Schreckenberg, Rainer Schulz, Nadja Itani, Peter Ferdinandy, Peter Bencsik, Tamara Szabados, Susanne Rohrbach, Bernd Niemann, Klaus-Dieter Schlüter
In rats decreased bioavailability of nitric oxide induces oxidative stress and right heart failure. Oxidative stress can activate matrix metalloproteinase-2 (MMP2). We addressed the question whether increasing oxidative defense by administration of the SOD mimetic Tempol or direct inhibition of MMP2 activity by SB-3CT mitigates right heart failure. Rats received -NAME for four weeks and during week
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Copper overload exacerbates testicular aging mediated by lncRNA:CR43306 deficiency through ferroptosis in Drosophila Redox Biol. (IF 10.7) Pub Date : 2024-08-15 Qiuru Huang, Jiaxin Li, Yujuan Qi, Xuxin He, Cong Shen, Chenyu Wang, Xinda Wang, Qiushi Xia, Yi Zhang, Ziyue Pan, Qingqing Hu, Ziyu Cao, Yiheng Liu, Jingqi Huang, Guoqing Han, Ying Zheng, Bo Zheng, Xuhui Zeng, Xiaolin Bi, Jun Yu
Testicular aging manifests as impaired spermatogenesis and morphological alterations in . Nonetheless, the comprehensive molecular regulatory framework remains largely undisclosed. This investigation illustrates the impact of copper overload on testicular aging and underscores the interplay between copper overload and lncRNA. Copper overload triggers Cuproptosis through the mitochondrial TCA cycle
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Cardioprotective potential of oleuropein, hydroxytyrosol, oleocanthal and their combination: Unravelling complementary effects on acute myocardial infarction and metabolic syndrome Redox Biol. (IF 10.7) Pub Date : 2024-08-14 Andriana Christodoulou, Panagiota-Efstathia Nikolaou, Lydia Symeonidi, Konstantinos Katogiannis, Louisa Pechlivani, Theodora Nikou, Aimilia Varela, Christina Chania, Stelios Zerikiotis, Panagiotis Efentakis, Dimitris Vlachodimitropoulos, Nikolaos Katsoulas, Anna Agapaki, Costantinos Dimitriou, Maria Tsoumani, Nikolaos Kostomitsopoulos, Constantinos H. Davos, Alexios Leandros Skaltsounis, Alexandros
Clinical studies have previously established the role of olive products in cardiovascular disease (CVD) prevention, whilst the identification of the responsible constituents for the beneficial effects is still pending. We sought to assess and compare the cardioprotective potential of oleuropein (OL), hydroxytyrosol (HT), oleocanthal (OC) and oleanolic Acid (OA), regarding Ischemia/Reperfusion Injury
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Free radical fragmentation and oxidation in the polar part of lysophospholipids: Results of the study of blood serum of healthy donors and patients with acute surgical pathology Redox Biol. (IF 10.7) Pub Date : 2024-08-11 Alexey Fedoruk, Oleg Shadyro, Irina Edimecheva, Dmitry Fedoruk, Valery Khrutskin, Leanid Kirkovsky, Viktor Sorokin, Halina Talkachova
The interaction of reactive oxygen species with cell membrane lipids is usually considered in the context of lipid peroxidation in the nonpolar component of the membrane. In this work, for the first time, data were obtained indicating that damage to human cell membranes can occur in the polar part of lysophospholipids at the interface with the aqueous environment due to free radical fragmentation (FRF)
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SLC7A11 protects luminal A breast cancer cells against ferroptosis induced by CDK4/6 inhibitors Redox Biol. (IF 10.7) Pub Date : 2024-08-10 Yingshu Cui, Yi Li, Yuanyuan Xu, Xinxin Liu, Xiaofeng Kang, Junwen Zhu, Shan Long, Yuchen Han, Chunyuan Xue, Zhijia Sun, Yimeng Du, Jia Hu, Lu Pan, Feifan Zhou, Xiaojie Xu, Xiaosong Li
Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6 inhibitors) can significantly extend tumor response in patients with metastatic luminal A breast cancer, yet intrinsic and acquired resistance remains a prevalent issue. Understanding the molecular features of CDK4/6 inhibitor sensitivity and the potential efficacy of their combination with novel targeted cell death inducers may lead to improved patient
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Loss of NAMPT and SIRT2 but not SIRT1 attenuate GLO1 expression and activity in human skeletal muscle Redox Biol. (IF 10.7) Pub Date : 2024-08-10 Edwin R. Miranda, Pallavi Varshney, Corey E. Mazo, James Shadiow, Andrew T. Ludlow, Jacob M. Haus
Glyoxalase I (GLO1) is the primary enzyme for detoxification of the reactive dicarbonyl methylglyoxal (MG). Loss of GLO1 promotes accumulation of MG resulting in a recapitulation of diabetic phenotypes. We previously demonstrated attenuated GLO1 protein in skeletal muscle from individuals with type 2 diabetes (T2D). However, whether GLO1 attenuation occurs prior to T2D and the mechanisms regulating
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A reciprocal relationship between mitochondria and lipid peroxidation determines the chondrocyte intracellular redox environment Redox Biol. (IF 10.7) Pub Date : 2024-08-08 Madeline R. Hines, Piedad C. Gomez-Contreras, Suryamin Liman, Alexandria M. Wilson, Kevin J. Lu, Jaycie A. O'Neill, Jacob S. Fisher, Douglas C. Fredericks, Brett A. Wagner, Garry R. Buettner, Holly Van Remmen, Mitchell C. Coleman
In orthopedic research, many studies have applied vitamin E as a protective antioxidant or used -butyl hydroperoxide to induce oxidative injury to chondrocytes. These studies often support the hypothesis that joint pathology causes oxidative stress and increased lipid peroxidation that might be prevented with lipid antioxidants to improve cell survival or function and joint health; however, lipid antioxidant
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A potential therapeutic strategy based on acute oxidative stress induction for wild-type NRF2/KEAP1 lung squamous cell carcinoma Redox Biol. (IF 10.7) Pub Date : 2024-08-08 M. Sánchez-Ortega, A. Garrido, C. Cirauqui, L. Sanz-Gonzalez, M.C. Hernández, A. González-García, K. Obregon, I. Ferrer, L. Paz-Ares, A.C. Carrera
Extensive efforts have been conducted in the search for new targetable drivers of lung squamous cell carcinoma (LUSC); to date, however, candidates remain mostly unsuccessful. One of the oncogenic pathways frequently found to be active in LUSC is (NRF2 transcription factor), the levels of which are regulated by KEAP1. Mutations in or trigger NRF2 activation, an essential protector against reactive
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Vitamin E and GPX4 cooperatively protect treg cells from ferroptosis and alleviate intestinal inflammatory damage in necrotizing enterocolitis Redox Biol. (IF 10.7) Pub Date : 2024-08-08 Shunchang Luo, Yingying Zeng, Baozhu Chen, Junjie Yan, Fei Ma, Guiying Zhuang, Hu Hao, Guangchao Cao, Xin Xiao, Sitao Li
The notable decline in the number of Tregs within Necrotizing enterocolitis (NEC) intestinal tissues,contribute to excessive inflammation and necrosis, yet the precise underlying factors remain enigmatic. Ferroptosis, a novel cell death stemming from a disrupted lipid redox metabolism, is the focus of this investigation. Specifically, this study delves into the ferroptosis of Treg cells in the context
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FDX1 downregulation activates mitophagy and the PI3K/AKT signaling pathway to promote hepatocellular carcinoma progression by inducing ROS production Redox Biol. (IF 10.7) Pub Date : 2024-08-05 Bo Sun, Peng Ding, Yinghui Song, Jia Zhou, Xu Chen, Chuang Peng, Sulai Liu
Mitochondrial dysfunction and metabolic reprogramming can lead to the development and progression of hepatocellular carcinoma (HCC). Ferredoxin 1 (FDX1) is a small mitochondrial protein and recent studies have shown that FDX1 plays an important role in tumor cuproptosis, but its role in HCC is still elusive. In this study, we aim to investigate the expression and novel functions of FDX1 in HCC. FDX1
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TDP-43 dysfunction leads to bioenergetic failure and lipid metabolic rewiring in human cells Redox Biol. (IF 10.7) Pub Date : 2024-08-05 Miriam Ceron-Codorniu, Pascual Torres, Anna Fernàndez-Bernal, Santiago Rico-Rios, José CE. Serrano, Maria P. Miralles, Maria Beltran, Ana Garcera, Rosa M. Soler, Reinald Pamplona, Manuel Portero-Otín
The dysfunction of TAR DNA-binding protein 43 (TDP-43) is implicated in various neurodegenerative diseases, though the specific contributions of its toxic gain-of-function versus loss-of-function effects remain unclear. This study investigates the impact of loss on cellular metabolism and viability using human-induced pluripotent stem cell-derived motor neurons and HeLa cells. silencing led to reduced
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Cold atmospheric plasma enhances SLC7A11-mediated ferroptosis in non-small cell lung cancer by regulating PCAF mediated HOXB9 acetylation Redox Biol. (IF 10.7) Pub Date : 2024-08-03 Chenxing Zhang, Hongyang Liu, Xiaohu Li, Nan Xiao, Huanxiang Chen, Haoran Feng, Yang Li, Ying Yang, Ruike Zhang, Xiangzhuan Zhao, Yanmin Du, Lu Bai, Ruonan Ma, Junhu Wan
Lung cancer is a leading cause of cancer death worldwide, with high incidence and poor survival rates. Cold atmospheric plasma (CAP) technology has emerged as a promising therapeutic approach for cancer treatment, inducing oxidative stress in malignant tissues without causing thermal damage. However, the role of CAP in regulating lung cancer cell ferroptosis remains unclear. Here, we observed that
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Disulfide stress and its role in cardiovascular diseases Redox Biol. (IF 10.7) Pub Date : 2024-08-03 Shaoju Qian, Guanyu Chen, Ruixue Li, Yinghua Ma, Lin Pan, Xiaoping Wang, Xianwei Wang
Cardiovascular disease (CVD) is one of the leading causes of mortality in humans, and oxidative stress plays a pivotal role in disease progression. This phenomenon typically arises from weakening of the cellular antioxidant system or excessive accumulation of peroxides. This review focuses on a specialized form of oxidative stress—disulfide stress—which is triggered by an imbalance in the glutaredoxin
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Androgen receptor deficiency-induced TUG1 in suppressing ferroptosis to promote benign prostatic hyperplasia through the miR-188-3p/GPX4 signal pathway Redox Biol. (IF 10.7) Pub Date : 2024-08-02 Ming Zhan, Huan Xu, Guopeng Yu, Qi Chen, Ruifeng Yang, Yanbo Chen, Jianchao Ge, Zhong Wang, Ruimeng Yang, Bin Xu
Benign prostatic hyperplasia (BPH), characterized by the non-malignant enlargement of the prostate, exhibits a pronounced association with inflammation resulting from androgen receptor (AR) deficiency. Ferroptosis, a cell death mechanism triggered by iron-dependent lipid peroxidation and closely linked to inflammation, has yet to be fully understood in the context of BPH. Using RNA sequencing, we observed
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Role of sex as a biological variable in neonatal alveolar macrophages Redox Biol. (IF 10.7) Pub Date : 2024-08-02 Connor Leek, Abiud Cantu, Shilpa Sonti, Manuel Cantu Gutierrez, Laurie Eldredge, Eniko Sajti, He N. Xu, Krithika Lingappan
The lung macrophages play a crucial role in health and disease. Sexual dimorphism significantly impacts the phenotype and function of tissue-resident macrophages. The primary mechanisms responsible for sexually dimorphic outcomes in bronchopulmonary dysplasia (BPD) remain unidentified. We tested the hypothesis that biological sex plays a crucial role in the transcriptional state of alveolar macrophages
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Withdrawn: Combinatorial lipidomics and proteomics underscore erythrocyte lipid membrane aberrations in the development of adverse cardio-cerebrovascular complications in maintenance hemodialysis patients Redox Biol. (IF 10.7) Pub Date : 2024-07-31 Ke Zheng, Yujun Qian, Haiyun Wang, Dan Song, Hui You, Bo Hou, Fei Han, Yicheng Zhu, Feng Feng, Sin Man Lam, Guanghou Shui, Xuemei Li
This article has been withdrawn: please see Elsevier Policy on Article Withdrawal ().
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Intracellular peroxynitrite perturbs redox balance, bioenergetics, and Fe–S cluster homeostasis in Mycobacterium tuberculosis Redox Biol. (IF 10.7) Pub Date : 2024-07-31 Arshiya Dewan, Charu Jain, Mayashree Das, Ashutosh Tripathi, Ajay Kumar Sharma, Harshit Singh, Nitish Malhotra, Aswin Sai Narain Seshasayee, Harinath Chakrapani, Amit Singh
The ability of () to tolerate nitric oxide (NO) and superoxide (O) produced by phagocytes contributes to its success as a human pathogen. Recombination of NO and O generates peroxynitrite (ONOO), a potent oxidant produced inside activated macrophages causing lethality in diverse organisms. While the response of toward NO and O is well established, how responds to ONOO remains unclear. Filling this
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EGCG drives gut microbial remodeling-induced epithelial GPR43 activation to lessen Th1 polarization in colitis Redox Biol. (IF 10.7) Pub Date : 2024-07-30 Siyan Che, Beibei Qin, Kunfu Wu, Mingzhi Zhu, Han Hu, Can Peng, Zi Wang, Yulong Yin, Yaoyao Xia, Miaomiao Wu
Modulation of immune microenvironment is critical for inflammatory bowel disease (IBD) intervention. Epigallocatechin gallate (EGCG), as a natural low toxicity product, has shown promise in treating IBD. However, whether and how EGCG regulates the intestinal microenvironment is not fully understood. Here we report that EGCG lessens colitis by orchestrating Th1 polarization and self-amplification in
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A nitroreductase responsive probe for early diagnosis of pulmonary fibrosis disease Redox Biol. (IF 10.7) Pub Date : 2024-07-29 Shilan Peng, Yuanyuan Liang, Haotian Zhu, Yike Wang, Yun Li, Zuoquan Zhao, Yesen Li, Rongqiang Zhuang, Lumei Huang, Xianzhong Zhang, Zhide Guo
Idiopathic pulmonary fibrosis (IPF) is a serious interstitial lung disease. However, the definitive diagnosis of IPF is impeded by the limited capabilities of current diagnostic methods, which may fail to capture the optimal timing for treatment. The main goal of this study is to determine the feasibility of a nitroreductase (NTR) responsive probe, F-NCRP, for early detection and deterioration monitoring