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Single-cell live volume measurements using the fluorescence exclusion method Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-03-25 Larisa Venkova, Henri Popard
In this Tools of the Trade article, Venkova and Popard (Piel lab) discuss recent updates to the fluorescence exclusion method that now enable simultaneous measurement of cellular and nuclear size as well as investigation of small prokaryotic cells.
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Cellular and molecular mechanisms of skin wound healing Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-03-25 Oscar A. Peña, Paul Martin
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Protein N-terminal acetylation is entering the degradation end game Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-03-22 Thomas Arnesen, Ine Kjosås, Nina McTiernan
Despite being one of the most common protein modifications in eukaryotes, the cellular effect of N-terminal acetylation remains cryptic. Four decades ago, the nature of the N terminus was linked to protein stability. In this Comment, we discuss an emerging major role of N-terminal acetylation in shielding the proteome from degradation. Thomas Arnesen and colleagues discuss an emerging major role of
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Localized translation in the embryo Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-03-21 Ahna Skop, Karen Schindler
Ahna Skop and Karen Schindler describe a paper that found localized translation in mammalian embryos, demonstrating the importance of RNA transport for development.
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A code within the genetic code Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-03-21 Susanne Bornelöv
The story of a paper that established the concept of codon optimality and its connection with translation efficiency and mRNA decay.
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Co-transcriptional gene regulation in eukaryotes and prokaryotes Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-03-20 Morgan Shine, Jackson Gordon, Leonard Schärfen, Dagmar Zigackova, Lydia Herzel, Karla M. Neugebauer
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Spatiotemporal control over cell–matrix interactions using dynamic micropatterns Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-03-13 Aleksi Isomursu
In this Tools of the Trade article, Isomursu (Ivaska lab) describes a new method for dynamic micropatterning, which enables investigation of cell adhesion and migration on substrates that mimic different extracellular matrix environments.
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A SOX9 switch from regeneration to fibrosis Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-03-08 Kim Baumann
In mouse models of acute kidney injury, the outcome — scarless tissue repair versus fibrosis — depends on the activity of the transcription factor SOX9.
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Keeping a low cGAS profile in the nucleus Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-03-01 Eytan Zlotorynski
Harmful activity of the DNA sensor cGAS in the nucleus is suppressed by a dedicated ubiquitylation complex.
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Cellular and molecular control of vertebrate somitogenesis Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-02-28 Yuchuan Miao, Olivier Pourquié
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Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-02-27 Jin H. Yang, Anders S. Hansen
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Intrinsic calibration and deformation mapping for expansion microscopy using GelMap Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-02-21 Josiah B. Passmore, Hugo G. J. Damstra
In this Tools of the Trade article, Hugo Damstra and Josiah Passmore (Kapitein Lab) describe GelMap, which introduces a fluorescent reference grid into the workflow of expansion microscopy experiments, thus enabling a visual readout of sample deformation.
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Live-cell imaging powered by computation Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-02-20 Hari Shroff, Ilaria Testa, Florian Jug, Suliana Manley
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The cell biology of ferroptosis Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-02-16 Scott J. Dixon, James A. Olzmann
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Emerging mechanistic understanding of cilia function in cellular signalling Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-02-16 Keren I. Hilgendorf, Benjamin R. Myers, Jeremy F. Reiter
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A catalytic function for mammalian Argonautes Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-02-14 Joana A. Vidigal
Joana Vidigal reminds us of the first paper to report an endogenous role of the nucleolytic activity of the mammalian RNAi protein argonaute-2.
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Mechanisms and functions of protein S-acylation Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-02-14 Francisco S. Mesquita, Laurence Abrami, Maurine E. Linder, Shernaz X. Bamji, Bryan C. Dickinson, F. Gisou van der Goot
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AI-driven detection and analysis of label-free protein aggregates Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-02-08 Khalid A. Ibrahim
In this Tools of the Trade article, Khalid Ibrahim (Radenovic and Lashuel labs) describes a tool for the artificial intelligence (AI)-driven detection of cellular aggregates that bypasses the need for fluorescent labelling.
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Condensates burst the bridge for transcription Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-02-08 Eytan Zlotorynski
A recent study visualizes how enhancer–transcriptional condensate–gene interactions augment gene expression.
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A dynamic culture system that models the intricacy of the mammary gland Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-02-05 Lei Yuan
In this Tools of the Trade article, Lei Yuan (from the Cai lab) highlights a new culture system that allows in vitro reconstitution of a dynamic miniature mammary gland.
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CRISPR technologies for genome, epigenome and transcriptome editing Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-02-02 Lukas Villiger, Julia Joung, Luke Koblan, Jonathan Weissman, Omar O. Abudayyeh, Jonathan S. Gootenberg
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Bookmarking pluripotency genes Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-02-02 Lisa Heinke
Rapid reactivation of gene expression following mitosis-induced silencing is facilitated by a network of redundantly acting nuclear receptors that function as mitotic bookmarks.
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Transcription regulation by long non-coding RNAs: mechanisms and disease relevance Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-01-19 Jorge Ferrer, Nadya Dimitrova
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Translating the midbody for cytokinesis Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-01-09 Lisa Heinke
Farmer et al. show that mRNAs encoding abscission proteins are targeted to the midbody during cell division and are locally translated to enable cytokinesis.
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Phase separation of biomolecules on free-standing planar membranes Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-01-08 Yohan Lee
In this Tools of the Trade article, Yohan Lee (Stachowiak lab) describes a method to generate free-standing planar lipid membranes for the study of membrane-associated protein phase separation.
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Roles and regulation of tRNA-derived small RNAs in animals Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-01-05 Sowndarya Muthukumar, Cai-Tao Li, Ru-Juan Liu, Cristian Bellodi
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Patterning of the cell cortex by Rho GTPases Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-01-03 William M. Bement, Andrew B. Goryachev, Ann L. Miller, George von Dassow
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Cell quiescence sends argonaute-2 to transposons Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-12-19 Eytan Zlotorynski
Cell quiescence dampens mTOR signalling and enables AGO2 localization to the nucleus, where it suppresses retrotransposons by directly cleaving their RNA.
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A guide to cell death pathways Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-12-18 Junying Yuan, Dimitry Ofengeim
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Present and future of synthetic cell development Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-12-15 Katarzyna P. Adamala, Marileen Dogterom, Yuval Elani, Petra Schwille, Masahiro Takinoue, T-Y Dora Tang
Scientists are captivated by the prospect of creating a fully synthetic cell, offering the potential to revolutionize biology, medicine and biotechnology. In this Viewpoint, a panel of experts discusses the definitions of a synthetic cell and highlights current achievements, challenges and future opportunities of building such systems. Scientists are captivated by the prospect of creating a fully synthetic
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Structure and growth of plant cell walls Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-12-15 Daniel J. Cosgrove
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Adherens junctions as molecular regulators of emergent tissue mechanics Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-12-13 Otger Campàs, Ivar Noordstra, Alpha S. Yap
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White adipocyte dysfunction and obesity-associated pathologies in humans Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-12-12 Carolina E. Hagberg, Kirsty L. Spalding
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The bioethics of synthetic cells Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-12-11 Hub Zwart
The Building a Synthetic Cell (BaSyC) consortium — launched in 2017 — proposes to create “an autonomous self-reproducing cell that can sustain itself, replicate and divide”. I joined this consortium to explore the bioethics of creating synthetic cells, by embedding philosophical reflection into research practices. In this Comment, Hub Zwart discusses the importance of embedding philosophical reflection
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Energy-driven genome regulation by ATP-dependent chromatin remodellers Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-12-11 Sebastian Eustermann, Avinash B. Patel, Karl-Peter Hopfner, Yuan He, Philipp Korber
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The molecular basis of translation initiation and its regulation in eukaryotes Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-12-05 Jailson Brito Querido, Irene Díaz-López, V. Ramakrishnan
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Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-11-24 Carmine Settembre, Rushika M. Perera
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Does species-specific alternative splicing make us human? Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-11-22 Florian Heyd
Florian Heyd describes a paper that pointed towards alternative splicing as a driver of human cognitive abilities.
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Probing cytoskeletal remodelling by cutting and marking filaments Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-11-13 Manuela Richter
In this Tools of the Trade article, Manuela Richter (Dumont lab) describes a method to probe mechanisms of cytoskeletal network re-organization that uses a targeted laser to both trigger network remodelling and track network dynamics.
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The molecular basis for cellular function of intrinsically disordered protein regions Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-11-13 Alex S. Holehouse, Birthe B. Kragelund
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The nuance in DNA and transcription factor interactions Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-11-07 Emily Wong
Emily Wong describes a study that provided a quantitative methodology for analyzing ChIP experiments and shifted our understanding of the functionality of transcription factors.
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Extended heterochronic parabiosis as an approach to study rejuvenation Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-11-01 Bohan Zhang
In this Tools of the Trade article, Bohan Zhang (Gladyshev lab) discusses how the use of extended heterochronic parabiosis in mice (surgical connection between circulatory systems for an extended period), followed by detachment, can shed light on potential mechanisms that reverse mammalian ageing.
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Senescent cells support limb regeneration Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-11-01 Paulina Strzyz
Yu et al. identify senescent cells as important players in the regeneration of complex structures.
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Local and systemic mechanisms that control the hair follicle stem cell niche Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-10-30 Bing Zhang, Ting Chen
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Activation of human endogenous retroviruses and its physiological consequences Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-10-23 Nicholas Dopkins, Douglas F. Nixon
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ERMES — from myths to molecules Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-10-19 Mike F. Renne, Robert Ernst
Ernst and Renne highlight two papers, one that discovered and another that structurally defined the ER–mitochondria encounter structure (ERMES) that facilitates the exchange of lipids between the ER and mitochondria.
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Mechanism of sperm mtDNA elimination Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-10-19 Eytan Zlotorynski
Phosphorylation of the mitochondrial DNA (mtDNA) maintenance factor TFAM during spermatogenesis prevents its import into mitochondria, resulting in elimination of paternal mtDNA and leading to maternal inheritance.
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Challenges and opportunities in macromolecular structure determination Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-10-17 Xiao-chen Bai, Tamir Gonen, Angela M. Gronenborn, Anastassis Perrakis, Andrea Thorn, Jianyi Yang
Embedded within the complexity of biological systems lies a formidable task: deciphering the intricate architecture of macromolecules. In this Viewpoint, a panel of experts discuss the key challenges and opportunities of macromolecular structure determination, highlighting the crucial synergy between empirical experimentation and artificial intelligence-based techniques in unravelling these complexities
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Mechanisms of SNARE proteins in membrane fusion Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-10-17 Reinhard Jahn, David C. Cafiso, Lukas K. Tamm
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Identification of phase separating proteins associated with human disease Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-10-13 Christine M. Lim, Alicia González Díaz
In this Tools of the Trade article, Christine Lim and Alicia González Díaz (Vendruscolo lab) describe a pipeline for the identification and characterization of proteins whose phase separation is altered in disease.
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Gene silencing during oocyte specification requires heterochromatin and nucleoporins Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-10-06 Lisa Heinke
Sarkar et al. identify a feedback loop between the methyltransferase SETDB1 and nuclear pore complexes that ensures silencing of early-oogenesis genes as oocyte specification progresses.
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mTOR inhibits starvation-induced nuclear export of the proteasome Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-10-06 Kim Baumann
mTOR inhibition by deprivation of the amino acids Tyr, Trp and Phe promotes the translocation of the 26S proteasome from the nucleus to the cytosol, which is required for stress tolerance and cell survival.
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Base editing of organellar DNA with programmable deaminases Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-10-04 Jin-Soo Kim, Jia Chen
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Mechanisms and regulation of human mitochondrial transcription Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-10-02 Benedict G. Tan, Claes M. Gustafsson, Maria Falkenberg
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Mechanisms controlling cellular and systemic iron homeostasis Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-10-02 Bruno Galy, Marcus Conrad, Martina Muckenthaler
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Mitochondrial proteome research: the road ahead Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-09-29 Zakery N. Baker, Patrick Forny, David J. Pagliarini
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Lasker Award for AlphaFold Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-09-26 Paulina Strzyz
Congratulations to John Jumper and Demis Hassabis for winning the 2023 Albert Lasker Basic Medical Research Award.
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Author Correction: The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-09-26 Claire Goul, Roberta Peruzzo, Roberto Zoncu
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A quick guide to (transmembrane) planar cell polarity mouse strains Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-09-25 Sarah V. Paramore
In this Tools of the Trade article, Sarah Paramore (from the Devenport and Nelson labs) discusses the use of mouse strains carrying genomic alterations in PCP genes and how they can increase our understanding of mammalian planar cell polarity.
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Understanding mechanisms of antioxidant action in health and disease Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2023-09-15 Barry Halliwell