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Imaging bioluminescence by detecting localized haemodynamic contrast from photosensitized vasculature Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-05-10 Robert Ohlendorf, Nan Li, Valerie Doan Phi Van, Miriam Schwalm, Yuting Ke, Miranda Dawson, Ying Jiang, Sayani Das, Brenna Stallings, Wen Ting Zheng, Alan Jasanoff
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Decoding cell replicational age from single-cell ATAC-seq data Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-09
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Tracking single-cell evolution using clock-like chromatin accessibility loci Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-09 Yu Xiao, Wan Jin, Lingao Ju, Jie Fu, Gang Wang, Mengxue Yu, Fangjin Chen, Kaiyu Qian, Xinghuan Wang, Yi Zhang
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An effective MASH drug is good, but biotech can make it better Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-08
Understanding this complex disease requires better model systems and large-scale data.
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A perfusion host‐microbe bioreactor (HMB) system that captures dynamic interactions of secreted metabolites between epithelial cells cocultured with a human gut anaerobe Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-05-08 Jingyun Yang, Jason Cassaday, Thomas P. Wyche, Brian Squadroni, William Newhard, Huong Trinh, Damien Cabral, Erik Hett, Theodore R. Sana, Kyongbum Lee, Stephen Kasper
The human microbiota impacts a variety of diseases and responses to therapeutics. Due to a lack of robust in vitro models, detailed mechanistic explanations of host‐microbiota interactions cannot often be recapitulated. We describe the design and development of a novel, versatile and modular in vitro system that enables indirect coculture of human epithelial cells with anaerobic bacteria for the characterization
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Identification of clinically relevant T cell receptors for personalized T cell therapy using combinatorial algorithms Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-07 Rémy Pétremand, Johanna Chiffelle, Sara Bobisse, Marta A. S. Perez, Julien Schmidt, Marion Arnaud, David Barras, Maria Lozano-Rabella, Raphael Genolet, Christophe Sauvage, Damien Saugy, Alexandra Michel, Anne-Laure Huguenin-Bergenat, Charlotte Capt, Jonathan S. Moore, Claudio De Vito, S. Intidhar Labidi-Galy, Lana E. Kandalaft, Denarda Dangaj Laniti, Michal Bassani-Sternberg, Giacomo Oliveira, Catherine
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Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-07 Stephan Eckert, Nicola Berner, Karl Kramer, Annika Schneider, Julian Müller, Severin Lechner, Sarah Brajkovic, Amirhossein Sakhteman, Christian Graetz, Jonas Fackler, Michael Dudek, Michael W. Pfaffl, Percy Knolle, Stephanie Wilhelm, Bernhard Kuster
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Should neurotechnologies go into the sandbox? Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-06 Walter G. Johnson
Emerging neurotechnologies such as brain–computer interfaces bring together components of biotechnology and digital technology, creating a number of different policy issues. These challenges can range from the safety of medical products to privacy issues with collecting and processing data from the human brain. Such different issues may call for different policy responses. For example, in April 2024
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Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-05-07 Di Yin, Yiye Zhong, Sikai Ling, Sicong Lu, Xiaoyuan Wang, Zhuofan Jiang, Jie Wang, Yao Dai, Xiaolong Tian, Qijing Huang, Xingbo Wang, Junsong Chen, Ziying Li, Yang Li, Zhijue Xu, Hewei Jiang, Yuqing Wu, Yi Shi, Quanjun Wang, Jianjiang Xu, Wei Hong, Heng Xue, Hang Yang, Yan Zhang, Lintai Da, Ze-guang Han, Sheng-ce Tao, Ruijiao Dong, Tianlei Ying, Jiaxu Hong, Yujia Cai
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Transthoracic ultrasound localization microscopy of myocardial vasculature in patients Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-05-06 Jipeng Yan, Biao Huang, Johanna Tonko, Matthieu Toulemonde, Joseph Hansen-Shearer, Qingyuan Tan, Kai Riemer, Konstantinos Ntagiantas, Rasheda A. Chowdhury, Pier D. Lambiase, Roxy Senior, Meng-Xing Tang
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Durable lymph-node expansion is associated with the efficacy of therapeutic vaccination Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-05-06 Alexander J. Najibi, Ryan S. Lane, Miguel C. Sobral, Giovanni Bovone, Shawn Kang, Benjamin R. Freedman, Joel Gutierrez Estupinan, Alberto Elosegui-Artola, Christina M. Tringides, Maxence O. Dellacherie, Katherine Williams, Hamza Ijaz, Sören Müller, Shannon J. Turley, David J. Mooney
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Vaccine process technology—A decade of progress Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-05-07 Barry Buckland, Gautam Sanyal, Todd Ranheim, David Pollard, Jim A. Searles, Sue Behrens, Stefanie Pluschkell, Jessica Josefsberg, Christopher J. Roberts
In the past decade, new approaches to the discovery and development of vaccines have transformed the field. Advances during the COVID‐19 pandemic allowed the production of billions of vaccine doses per year using novel platforms such as messenger RNA and viral vectors. Improvements in the analytical toolbox, equipment, and bioprocess technology have made it possible to achieve both unprecedented speed
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Higher efficiency of vanadate iron in heterogeneous Fenton‐like systems to pretreat sugarcane bagasse and its enzymatic saccharification Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-05-07 Ju Liang, Huiying Zeng, Yuting Zhang, Wenbing Zhou, Naidong Xiao
Pretreatment is crucial for effective enzymatic saccharification of lignocellulose such as sugarcane bagasse (SCB). In the present study, SCB was pretreated with five kinds of heterogeneous Fenton‐like systems (HFSs), respectively, in which α‐FeOOH, α‐Fe2O3, Fe3O4, and FeS2 worked as four traditional heterogeneous Fenton‐like catalysts (HFCs), while FeVO4 worked as a novel HFC. The enzymatic reducing
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Computational fluid dynamics based digital twins of fixed bed bioreactors validate scaling principles for recombinant adeno‐associated virus gene therapy manufacturing Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-05-06 Michael Hill, Colten White, Shaoying Wang, John Thomas, Brian DeVincentis, Nripen Singh
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Evaluation of various membranes at different fluxes to enable large‐volume single‐use perfusion bioreactors Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-05-04 Hassan Raza, Tiffany Tang, Baizhen Gao, Chelsea Phuangthong, Chienhung Billy Chen, Nuno D. S. Pinto
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Surfactant-mediated bio-manufacture: A unique strategy for promoting microbial biochemicals production Biotechnol. Adv. (IF 16.0) Pub Date : 2024-05-03 Yunxin Yi, Xiaofan Jin, Moutong Chen, Teodora Emilia Coldea, Haifeng Zhao
Biochemicals are widely used in the medicine and food industries and are more efficient and safer than synthetic chemicals. The amphipathic surfactants can interact with the microorganisms and embed the extracellular metabolites, which induce microbial metabolites secretion and biosynthesis, performing an attractive prospect of promoting the biochemical production. However, the commonness and differences
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Unearthing naturally-occurring cyclic antibacterial peptides and their structural optimization strategies Biotechnol. Adv. (IF 16.0) Pub Date : 2024-05-03 Ping Zeng, Honglan Wang, Pengfei Zhang, Sharon Shui Yee Leung
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Reinventing shake flask fermentation: The breathable flask Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-05-03 Vikash Kumar, Michael Tolosa, Xudong Ge, Govind Rao
Cultivating cells in shake flasks is a routine operation that is largely unchanged since its inception. A glass or plastic Erlenmeyer vessel with the primary gas exchange taking place across various porous plugs is used with media volumes typically ranging from 100 mL to 2 L. Oxygen limitation and carbon dioxide accumulation in the vessel is a major concern for studies involving shake flask cultures
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Transient pacing in pigs with complete heart block via myocardial injection of mRNA coding for the T-box transcription factor 18 Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-05-02 David W. Wolfson, Nam Kyun Kim, Ki Hong Lee, Jared P. Beyersdorf, Jonathan J. Langberg, Natasha Fernandez, Dahim Choi, Nadine Zureick, Tae Yun Kim, Seongho Bae, Jin-Mo Gu, Jonathan L. Kirschman, Jinqi Fan, Christina Y. Sheng, Danielle Gottlieb Sen, Bret Mettler, Jung Hoon Sung, Young-sup Yoon, Sung-Jin Park, Philip J. Santangelo, Hee Cheol Cho
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Mechanistic modeling of in vitro transcription incorporating effects of magnesium pyrophosphate crystallization Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-05-02 Nathan Merica Stover, Krystian Ganko, Richard D. Braatz
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Response to “The perpetual motion machine of AI-generated data and the distraction of ChatGPT as a ‘scientist’” Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-01 William Stafford Noble
Many of Jennifer Listgarten’s arguments are compelling: in particular, that the protein folding problem is an outlier relative to other grand challenges in science, both in terms of the precise way the problem can be stated and performance measured and in terms of the amount of available, high quality data1. However, although existing biological databases tend to be small relative to the compendia
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Targeted desialylation and cytolysis of tumour cells by fusing a sialidase to a bispecific T-cell engager Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-05-01 Zhuo Yang, Yingqin Hou, Geramie Grande, Jong Hyun Cho, Chao Wang, Yujie Shi, Jaroslav Zak, Yue Wan, Ke Qin, Dongfang Liu, John R. Teijaro, Richard A. Lerner, Peng Wu
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Designing drugs with reversible activity Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-30 Dario Neri
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Development of supramolecular anticoagulants with on-demand reversibility Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-30 Millicent Dockerill, Daniel J. Ford, Simona Angerani, Imala Alwis, Luke J. Dowman, Jorge Ripoll-Rozada, Rhyll E. Smythe, Joanna S. T. Liu, Pedro José Barbosa Pereira, Shaun P. Jackson, Richard J. Payne, Nicolas Winssinger
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Aptamer-modified paper-based analytical devices for the detection of food hazards: Emerging applications and future perspective Biotechnol. Adv. (IF 16.0) Pub Date : 2024-04-30 Mingwei Qin, Imran Mahmood Khan, Ning Ding, Shuo Qi, Xiaoze Dong, Yin Zhang, Zhouping Wang
Food analysis plays a critical role in assessing human health risks and monitoring food quality and safety. Currently, there is a pressing need for a reliable, portable, and quick recognition element for point-of-care testing (POCT) to better serve the demands of on-site food analysis. Aptamer-modified paper-based analytical devices (Apt-PADs) have excellent characteristics of high portability, high
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Rapid spectrophotometric detection for optimized production of landomycins and characterization of their therapeutic potential Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-04-30 Todd C. Chappell, Kathleen G. Maiello, Allison J. Tierney, Karin Yanagi, Jessica A. Lee, Kyongbum Lee, Charles R. Mace, Clay S. Bennett, Nikhil U. Nair
Microbial‐derived natural products remain a major source of structurally diverse bioactive compounds and chemical scaffolds that have the potential as new therapeutics to target drug‐resistant pathogens and cancers. In particular, genome mining has revealed the vast number of cryptic or low‐yield biosynthetic gene clusters in the genus Streptomyces. However, low natural product yields—improvements
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Unravelling the essential elements for recombinant adeno-associated virus (rAAV) production in animal cell-based platforms Biotechnol. Adv. (IF 16.0) Pub Date : 2024-04-29 David Catalán-Tatjer, Konstantina Tzimou, Lars K. Nielsen, Jesús Lavado-García
Recombinant adeno-associated viruses (rAAVs) stand at the forefront of gene therapy applications, holding immense significance for their safe and efficient gene delivery capabilities. The constantly increasing and unmet demand for rAAVs underscores the need for a more comprehensive understanding of AAV biology and its impact on rAAV production. In this literature review, we delved into AAV biology
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Hotspot Wizard‐informed engineering of a hyperthermophilic β‐glucosidase for enhanced enzyme activity at low temperatures Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-04-29 Mehmet Emre Erkanli, Khalid El‐Halabi, Ted Keunsil Kang, Jin Ryoun Kim
Hyperthermophilic enzymes serve as an important source of industrial enzymes due to their high thermostability. Unfortunately, most hyperthermophilic enzymes suffer from reduced activity at low temperatures (e.g., ambient temperature), limiting their applicability. In addition, evolving hyperthermophilic enzymes to increase low temperature activity without compromising other desired properties is generally
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Listening to life: Sonification for enhancing discovery in biological research Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-04-28 Rhea Braun, Maxwell Tfirn, Roseanne M. Ford
Sonification, or the practice of generating sound from data, is a promising alternative or complement to data visualization for exploring research questions in the life sciences. Expressing or communicating data in the form of sound rather than graphs, tables, or renderings can provide a secondary information source for multitasking or remote monitoring purposes or make data accessible when visualizations
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Bioprocess in‐line monitoring and control using Raman spectroscopy and Indirect Hard Modeling (IHM) Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-04-28 David Heinrich Müller, Marieke Börger, Julia Thien, Hans‐Jürgen Koß
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Structural and molecular insights into a bifunctional glycoside hydrolase 30 xylanase specific to glucuronoxylan Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-04-28 Christina Pentari, Christos Kosinas, Efstratios Nikolaivits, Maria Dimarogona, Evangelos Topakas
Glycoside hydrolase (GH) 30 family xylanases are enzymes of biotechnological interest due to their capacity to degrade recalcitrant hemicelluloses, such as glucuronoxylan (GX). This study focuses on a subfamily 7 GH30, TtXyn30A from Thermothelomyces thermophilus, which acts on GX in an “endo” and “exo” mode, releasing methyl‐glucuronic acid branched xylooligosaccharides (XOs) and xylobiose, respectively
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Correction to “Metabolic engineering of betacyanin in vegetables for anti‐inflammatory therapy” Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-04-28
Saito, S., Nishihara, M., Kohakura, M., Kimura, K., Yashiro, T., Takasawa, S., & Arimura, G.-i. (2023). Metabolic engineering of betacyanin in vegetables for anti-inflammatory therapy. Biotechnology and Bioengineering, 120, 1357–1365. https://doi.org/10.1002/bit.28335 In the originally published article, in Section 2.8, second paragraph, “4,4-dimethyl-4-silapentane-1-sulfonic acid” should read “dextran
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Analysis and benchmarking of small and large genomic variants across tandem repeats Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-26 Adam C. English, Egor Dolzhenko, Helyaneh Ziaei Jam, Sean K. McKenzie, Nathan D. Olson, Wouter De Coster, Jonghun Park, Bida Gu, Justin Wagner, Michael A. Eberle, Melissa Gymrek, Mark J. P. Chaisson, Justin M. Zook, Fritz J. Sedlazeck
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Sustainable media feedstocks for cellular agriculture Biotechnol. Adv. (IF 16.0) Pub Date : 2024-04-26 Lutz Grossmann
The global food system is shifting towards cellular agriculture, a second domestication marked by cultivating microorganisms and tissues for sustainable food production. This involves tissue engineering, precision fermentation, and microbial biomass fermentation to establish food value chains independent of traditional agriculture. However, these techniques rely on growth media sourced from agricultural
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Carbohydrate binding modules: Compact yet potent accessories in the specific substrate binding and performance evolution of carbohydrate-active enzymes Biotechnol. Adv. (IF 16.0) Pub Date : 2024-04-26 Yuxian You, Haocun Kong, Caiming Li, Zhengbiao Gu, Xiaofeng Ban, Zhaofeng Li
Carbohydrate binding modules (CBMs) are independent non-catalytic domains widely found in carbohydrate-active enzymes (CAZymes), and they play an essential role in the substrate binding process of CAZymes by guiding the appended catalytic modules to the target substrates. Owing to their precise recognition and selective affinity for different substrates, CBMs have received increasing research attention
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Systems engineering Escherichia coli for efficient production p‐coumaric acid from glucose Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-04-26 Chong Qiu, Xiaoge Wang, Jiaojiao Zuo, Runyang Li, Cong Gao, Xiulai Chen, Jia Liu, Wanqing Wei, Jing Wu, Guipeng Hu, Wei Song, Nan Xu, Liming Liu
P‐coumaric acid (p‐CA), a pant metabolite with antioxidant and anti‐inflammatory activity, is extensively utilized in biomedicine, food, and cosmetics industry. In this study, a synthetic pathway (PAL) for p‐CA was designed, integrating three enzymes (AtPAL2, AtC4H, AtATR2) into a higher l‐phenylalanine‐producing strain Escherichia coli PHE05. However, the lower soluble expression and activity of AtC4H
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Synthesized arsenic nanoparticles and their high potential in biomedical applications: A review Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-04-26 Seyed Soheil Hosseininasab, Mahin Naderifar, Majid Reza Akbarizadeh, Nooshin Hashemi, Mehdi Ghaderi, Hamid Pajavand, Naghmeh Satarzadeh, Amin Sadeghi Dousari
Arsenic with the scientific name AS is an element that exists everywhere. It is the fourth among the abundant elements in water, the twelfth in the human body, and the twentieth in the earth's crust. This element exists in sulfide, carbonate, and elemental forms. Different names of arsenic are known as white arsenic (As2O3), yellow arsenic (As2S3), and red arsenic (As4S4). Nowadays, due to its unique
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Covalent organic frameworks (COFs) as carrier for improved drug delivery and biosensing applications Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-04-26 Rida Younas, Farhat Jubeen, Nargis Bano, Silvana Andreescu, Hongxia Zhang, Akhtar Hayat
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Super7 passaging method to improve Chinese hamster ovary cell fed‐batch performance Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-04-25 Matthew J. Moran, Jin Chen, James M. Piret, R. Robert Balcarcel
Chinese hamster ovary (CHO) cells are widely used to manufacture biopharmaceuticals, most of all monoclonal antibodies (mAbs). Some CHO cell lines exhibit production instability, where the productivity of the cells decreases as a function of time in culture. To counter this, we designed a passaging strategy that, rather than maximizing the time spent in log‐growth phase, mimics the first 7 days of
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Integration of just‐in‐time learning with variational autoencoder for cell culture process monitoring based on Raman spectroscopy Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-04-24 Mohammad Rashedi, Hamid Khodabandehlou, Tony Wang, Matthew Demers, Aditya Tulsyan, Christopher Garvin, Cenk Undey
Protein production in the biopharmaceutical industry necessitates the utilization of multiple analytical techniques and control methodologies to ensure both safety and consistency. To facilitate real‐time monitoring and control of cell culture processes, Raman spectroscopy has emerged as a versatile analytical technology. This technique, categorized as a Process Analytical Technology, employs chemometric
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Assessing the laboratory performance of AI-generated enzymes Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-23
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Discovery of tumor-reactive T cell receptors by massively parallel library synthesis and screening Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-23 Ziva Moravec, Yue Zhao, Rhianne Voogd, Danielle R. Cook, Seon Kinrot, Benjamin Capra, Haiyan Yang, Brenda Raud, Jiayu Ou, Jiekun Xuan, Teng Wei, Lili Ren, Dandan Hu, Jun Wang, John B.A.G. Haanen, Ton N. Schumacher, Xi Chen, Ely Porter, Wouter Scheper
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Therapeutic application of circular RNA aptamers in a mouse model of psoriasis Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-23 Si-Kun Guo, Chu-Xiao Liu, Yi-Feng Xu, Xiao Wang, Fang Nan, Youkui Huang, Siqi Li, Shan Nan, Ling Li, Edo Kon, Chen Li, Meng-Yuan Wei, Rina Su, Jia Wei, Shiguang Peng, Nitay Ad-El, Jiaquan Liu, Dan Peer, Ting Chen, Li Yang, Ling-Ling Chen
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Computational scoring and experimental evaluation of enzymes generated by neural networks Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-23 Sean R. Johnson, Xiaozhi Fu, Sandra Viknander, Clara Goldin, Sarah Monaco, Aleksej Zelezniak, Kevin K. Yang
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The myriad ways to engineer cells Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-04-23
The widening range of strategies to alter the phenotypes and functions of mammalian cells is a boon for their biomedical applications.
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Engineering the next-generation synthetic cell factory driven by protein engineering Biotechnol. Adv. (IF 16.0) Pub Date : 2024-04-23 Ailin Guan, Zixi He, Xin Wang, Zhi-Jun Jia, Jiufu Qin
Synthetic cell factory offers substantial advantages in economically efficient production of biofuels, chemicals, and pharmaceutical compounds. However, to create a high-performance synthetic cell factory, precise regulation of cellular material and energy flux is essential. In this context, protein components including enzymes, transcription factor-based biosensors and transporters play pivotal roles
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Stabilization of galactose oxidase by high hydrostatic pressure: Insights on the role of cavities size Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-04-23 Min J. Kang, José I. Reyes‐De‐Corcuera
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Why Japan lacks a vibrant biotech industry Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-22 Mark Kessel, Chris Vickrey
Recent analysis of the biopharmaceutical industry in Japan has emphasized that the lack of a thriving biotech ecosystem in that country is largely due to tight controls on drug pricing1. However, this is only one part of the explanation, and any strategy to promote Japanese biotech must acknowledge the full complexity of the problem. Japan has long punched above its weight in innovative research in
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Biobased short chain fatty acid production - Exploring microbial community dynamics and metabolic networks through kinetic and microbial modeling approaches Biotechnol. Adv. (IF 16.0) Pub Date : 2024-04-22 Merve Atasoy, William T. Scott Jr, Alberte Regueira, Miguel Mauricio-Iglesias, Peter J. Schaap, Hauke Smidt
In recent years, there has been growing interest in harnessing anaerobic digestion technology for resource recovery from waste streams. This approach has evolved beyond its traditional role in energy generation to encompass the production of valuable carboxylic acids, especially volatile fatty acids (VFAs) like acetic acid, propionic acid, and butyric acid. VFAs hold great potential for various industries
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Self-controlled in silico gene knockdown strategies to enhance the sustainable production of heterologous terpenoid by Saccharomyces cerevisiae Metab. Eng. (IF 8.4) Pub Date : 2024-04-20 Na Zhang, Xiaohan Li, Qiang Zhou, Ying Zhang, Bo Lv, Bing Hu, Chun Li
Microbial bioengineering is a growing field for producing plant natural products (PNPs) in recent decades, using heterologous metabolic pathways in host cells. Once heterologous metabolic pathways have been introduced into host cells, traditional metabolic engineering techniques are employed to enhance the productivity and yield of PNP biosynthetic routes, as well as to manage competing pathways. The
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Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-04-19 DaeYong Lee, Kristin Huntoon, Yifan Wang, Minjeong Kang, Yifei Lu, Seong Dong Jeong, Todd M. Link, Thomas D. Gallup, Yaqing Qie, Xuefeng Li, Shiyan Dong, Benjamin R. Schrank, Adam J. Grippin, Abin Antony, JongHoon Ha, Mengyu Chang, Yi An, Liang Wang, Dadi Jiang, Jing Li, Albert C. Koong, John A. Tainer, Wen Jiang, Betty Y. S. Kim
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Optimization strategies for CO2 biological fixation Biotechnol. Adv. (IF 16.0) Pub Date : 2024-04-19 Xiutao Liu, Linqing Li, Guang Zhao, Peng Xiong
Global sustainable development faces a significant challenge in effectively utilizing CO. Meanwhile, CO biological fixation offers a promising solution. CO has the highest oxidation state (+4 valence state), whereas typical multi‑carbon chemicals have lower valence states. The Gibbs free energy (Δ) changes of CO reductive reactions are generally positive and this renders it necessary to input different
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Development of generic metabolic Raman calibration models using solution titration in aqueous phase and data augmentation for in-line cell culture analysis Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-04-19 Zhijun Zhang, Zhe Lang, Gong Chen, Hang Zhou, Weichang Zhou
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Engineering of the Lrp/AsnC-type transcriptional regulator DecR as a genetically encoded biosensor for multilevel optimization of L-cysteine biosynthesis pathway in Escherichia coli Biotechnol. Bioeng. (IF 3.8) Pub Date : 2024-04-18 Zhiyou Zhou, Zonglin Li, Yahui Zhong, Shuai Xu, Zhimin Li
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Customized molecular glue complexes with desired properties Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17 Iris Marchal
Degron tags can trigger rapid and temporally controlled degradation of proteins using small molecules known as molecular glues. These molecular glues induce or stabilize protein interactions between a target protein and a ubiquitin ligase. As research tools, molecular glue complexes are limited by the large size of degron tags, which prevents integration in endogenous protein-coding genes. In a study
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World’s priciest drug treats MLD Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17
The US Food and Drug Administration has approved the first therapy for metachromatic leukodystrophy (MLD), a rare fatal genetic disorder. The lysosomal storage disease affects about 40 children each year in the USA. It is caused by a mutation in the gene encoding the arylsulfatase enzyme that leads to progressive demyelination and progressive loss of motor and cognitive functions. There were previously
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Saving Cavendish Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17
Farmers have a green light to grow the first genetically modified banana. The wilt-proof strain of the Cavendish banana developed by researchers from the Queensland University of Technology is resistant to Panama disease (Fusarium wilt), a devastating fungus. The Office of the Gene Technology Regulator in Australia gave the go-ahead on 12 February to allow the genetically modified banana to be grown
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Prime editing Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17
Recent patents relating to methods and compositions for prime editing.
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FDA approves first MASH drug Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17
The first drug to treat fatty liver disease due to metabolic dysfunction-associated steatohepatitis (MASH) has been given a green light by the US Food and Drug Administration. Madrigal Pharmaceuticals’ Rezdiffra (resmetirom) received an accelerated approval to treat the disease, previously known as non-alcoholic steatohepatitis (NASH). In this progressive liver condition fat buildup triggers inflammation
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Biotech news from around the world Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-17
The Ministry of Health and Welfare selects Johnson & Johnson’s JLABS to operate the country’s global accelerator platform. JLABS will engage with various local incubators and collaborators in the startup ecosystem to offer venture development programs, stimulate employment and encourage commercialization to enhance the global competitiveness of Korea’s life sciences sector. Costa Rica revises its biotech