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Celebrating 30 years of chemical biology: A toast to multidisciplinarity Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-19 Mishtu Dey, Samantha Nelson
No Abstract
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Functional profiling of serine, threonine and tyrosine sites Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-09-23 Yizhou Li, Tao Xu, Huazheng Ma, Di Yue, Qiezhong Lamao, Ying Liu, Zhuo Zhou, Wensheng Wei
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Building better mRNA for therapeutics Nat. Biotechnol. (IF 33.1) Pub Date : 2024-09-23 Bei Liu, Tao Pan
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Plastic-eating bacteria boost growing business of bioremediation Nat. Biotechnol. (IF 33.1) Pub Date : 2024-09-23
Bacteria, fungi and plants can be grown and engineered to remove plastics, chemicals and pollutants from contaminated soil and water.
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Coordinated, multicellular patterns of transcriptional variation that stratify patient cohorts are revealed by tensor decomposition Nat. Biotechnol. (IF 33.1) Pub Date : 2024-09-23 Jonathan Mitchel, M. Grace Gordon, Richard K. Perez, Evan Biederstedt, Raymund Bueno, Chun Jimmie Ye, Peter V. Kharchenko
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Scalable and unsupervised discovery from raw sequencing reads using SPLASH2 Nat. Biotechnol. (IF 33.1) Pub Date : 2024-09-23 Marek Kokot, Roozbeh Dehghannasiri, Tavor Baharav, Julia Salzman, Sebastian Deorowicz
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Chemical and topological design of multicapped mRNA and capped circular RNA to augment translation Nat. Biotechnol. (IF 33.1) Pub Date : 2024-09-23 Hongyu Chen, Dangliang Liu, Abhishek Aditham, Jianting Guo, Jiahao Huang, Franklin Kostas, Kamal Maher, Mirco J. Friedrich, Ramnik J. Xavier, Feng Zhang, Xiao Wang
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Advances in the cell biology of the trafficking and processing of amyloid precursor protein: impact of familial Alzheimer's disease mutations. Biochem. J. (IF 4.4) Pub Date : 2024-10-02 Jingqi Wang,Lou Fourriere,Paul A Gleeson
The production of neurotoxic amyloid-β peptides (Aβ) is central to the initiation and progression of Alzheimer's disease (AD) and involves sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. APP and the secretases are transmembrane proteins and their co-localisation in the same membrane-bound sub-compartment is necessary for APP cleavage. The intracellular trafficking
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Retraction: Mechanism of short-term ERK activation by electromagnetic fields at mobile phone frequencies. Biochem. J. (IF 4.4) Pub Date : 2024-10-02
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RNA and condensates: Disease implications and therapeutic opportunities Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-19 Tina W. Han, Bede Portz, Richard A. Young, Ann Boija, Isaac A. Klein
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Where chemical biology meets physiology Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-09-20 Kimberly E. Beatty, Carsten Schultz
Research in the early days of chemical biology was mostly limited to the application of chemical tools to model cell lines grown in incubators. Now, discoveries are being made in more physiologically relevant systems, from tissues to organisms, using precisely targeted molecules. The 2023 Chemical Biology & Physiology meeting (in Portland, Oregon) discussed the latest advances in the field, with research
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CORD: The chordata olfactory receptor database. Protein Cell (IF 13.6) Pub Date : 2024-09-20 Wei Han,Siyu Bao,Jintao Liu,Yiran Wu,Liting Zeng,Tao Zhang,Ningmeng Chen,Kai Yao,Shunguo Fan,Aiping Huang,Yuanyuan Feng,Guiquan Zhang,Ruiyi Zhang,Hongjin Zhu,Tian Hua,Zhijie Liu,Lina Cao,Xingxu Huang,Suwen Zhao
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TBK1-Zyxin signaling controls tumor-associated macrophage recruitment to mitigate antitumor immunity. EMBO J. (IF 9.4) Pub Date : 2024-09-20 Ruyuan Zhou,Mengqiu Wang,Xiao Li,Yutong Liu,Yihan Yao,Ailian Wang,Chen Chen,Qian Zhang,Qirou Wu,Qi Zhang,Dante Neculai,Bing Xia,Jian-Zhong Shao,Xin-Hua Feng,Tingbo Liang,Jian Zou,Xiaojian Wang,Pinglong Xu
Mechanical control is fundamental for cellular localization within a tissue, including for tumor-associated macrophages (TAMs). While the innate immune sensing pathways cGAS-STING and RLR-MAVS impact the pathogenesis and therapeutics of malignant diseases, their effects on cell residency and motility remain incompletely understood. Here, we uncovered that TBK1 kinase, activated by cGAS-STING or RLR-MAVS
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Reflections from advisory board members and associate editors Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-19 Michelle Arkin, Sara Buhrlage, Ling-Ling Chen, Peng Chen, Jason Gestwicki, Chuan He, Gerald F. Joyce, Angela Koehler, Milka Kostic, Jun Liu, Jim Wells
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What is chemical biology? Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-19 Albert A. Antolin, Yimon Aye, Liron Bar-Peled, Elena De Vita, Natavan Dudkina, Michael C. Jewett, Hannah Kiely-Collins, Ralph Mazitschek, Zhenrun Jerry Zhang
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The next Nobel Prize in chemistry or in physiology or medicine Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-19 Cigall Kadoch, Jason M. Sheltzer, Hang Yin
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Meet the authors: Lydia P. Tsamouri and Daniel A. Bachovchin Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-19 Lydia P. Tsamouri, Daniel A. Bachovchin
In an interview with Dr. Mishtu Dey, editor-in-chief of Cell Chemical Biology, the authors of the article entitled “The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation” share their perspectives on the ways chemical biology enriches immunology research, the challenges and opportunities in the field, and their scientific career paths.
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Membrane remodeling via ubiquitin-mediated pathways Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-19 Anne-Claire Jacomin, Ivan Dikic
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Ligand discovery by activity-based protein profiling Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-19 Micah J. Niphakis, Benjamin F. Cravatt
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Advances in spatial proteomics: Mapping proteome architecture from protein complexes to subcellular localizations Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-19 Lisa M. Breckels, Charlotte Hutchings, Kishor D. Ingole, Suyeon Kim, Kathryn S. Lilley, Mehul V. Makwana, Kieran J.A. McCaskie, Eneko Villanueva
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New therapies on the horizon: Targeted protein degradation in neuroscience Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-19 James A. Gregory, Christopher M. Hickey, Juan Chavez, Angela M. Cacace
This minireview explores the burgeoning field of targeted protein degradation (TPD) and its promising applications in neuroscience and clinical development. TPD offers innovative strategies for modulating protein levels, presenting a paradigm shift in small-molecule drug discovery and therapeutic interventions. Importantly, small-molecule protein degraders specifically target and remove pathogenic
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Beware of extreme calculated lipophilicity when designing cyclic peptides Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-09-19 Vasanthanathan Poongavanam, Duc Duy Vo, Jan Kihlberg
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A tRNA modification with aminovaleramide facilitates AUA decoding in protein synthesis Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-09-19 Kenjyo Miyauchi, Satoshi Kimura, Naho Akiyama, Kazuki Inoue, Kensuke Ishiguro, Thien-Son Vu, Veerasak Srisuknimit, Kenta Koyama, Gosuke Hayashi, Akiko Soma, Asuteka Nagao, Mikako Shirouzu, Akimitsu Okamoto, Matthew K. Waldor, Tsutomu Suzuki
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Compact RNA editors with natural miniature Cas13j nucleases Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-09-19 Guo Li, Yaxian Cheng, Jingwen Yu, Yunfei Zhu, Hongru Ma, Yuqiao Zhou, Zhongji Pu, Guanglin Zhu, Yichen Yuan, Ziyue Zhang, Xinzhi Zhou, Kairen Tian, Jianjun Qiao, Xiaoxiang Hu, Xue-xin Chen, Quanjiang Ji, Xingxu Huang, Bin Ma, Yuan Yao
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Astrocyte allocation during brain development is controlled by Tcf4-mediated fate restriction. EMBO J. (IF 9.4) Pub Date : 2024-09-19 Yandong Zhang,Dan Li,Yuqun Cai,Rui Zou,Yilan Zhang,Xin Deng,Yafei Wang,Tianxiang Tang,Yuanyuan Ma,Feizhen Wu,Yunli Xie
Astrocytes in the brain exhibit regional heterogeneity contributing to regional circuits involved in higher-order brain functions, yet the mechanisms controlling their distribution remain unclear. Here, we show that the precise allocation of astrocytes to specific brain regions during development is achieved through transcription factor 4 (Tcf4)-mediated fate restriction based on their embryonic origin
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A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses. EMBO J. (IF 9.4) Pub Date : 2024-09-19 Masahiro Nagata,Yasmin Carvalho Schäfer,Laurens Wachsmuth,Manolis Pasparakis
Z-DNA-binding protein 1 (ZBP1) is an interferon-inducible sensor of Z-DNA and Z-RNA, which has emerged as a critical regulator of cell death and inflammation. ZBP1 binds Z-DNA and Z-RNA via its Zα domains, and signals by engaging RIPK3 and RIPK1 via its RIP homotypic interaction motifs (RHIMs). Here, we show that mice express an alternatively-spliced shorter ZBP1 isoform (ZBP1-S), which harbours the
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Nucleolin Malonylation as a Nuclear-Cytosol Signal Exchange Mechanism to Drive Cell Proliferation in Hepatocarcinoma by Enhancing AKT Translation. J. Biol. Chem. (IF 4.0) Pub Date : 2024-09-19 Liang Sun,Hanjing Meng,Tao Liu,Qiong Zhao,Mingyi Xia,Zhongjun Zhao,Yuting Qian,Hao Cui,Xuefei Zhong,Keli Chai,Yang Tian,Yang Sun,Bao Zhu,Jiehui Di,Guanghou Shui,Lianjun Zhang,Junnian Zheng,Shutao Guo,Yong Liu
Cancer cells undergo metabolic reprogramming that is intricately linked to malignancy. Protein acylations are especially responsive to metabolic changes, influencing signal transduction pathways and fostering cell proliferation. However, as a novel type of acylations, the involvement of malonylation in cancer remains poorly understood. In this study, we observed a significant reduction in malonyl-CoA
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The ubiquitin-specific protease 21 is critical for cancer cell mitochondrial function and regulates proliferation and migration. J. Biol. Chem. (IF 4.0) Pub Date : 2024-09-19 Magdalena Kulma,Bartłomiej Hofman,Małgorzata Szostakowska-Rodzoś,Dorota Dymkowska,Remigiusz Serwa,Katarzyna Piwowar,Agnieszka Belczyk-Ciesielska,Joanna Grochowska,Irina Tuszyńska,Angelika Muchowicz,Katarzyna Drzewicka,Krzysztof Zabłocki,Zbigniew Zasłona
Ubiquitin-Specific Peptidases (USPs) are the main members of deubiquitinases (DUBs) that catalyze removing ubiquitin chains from target proteins, thereby modulating their half-life and function. Enzymatic activity of USP21 regulates protein degradation which is critical for maintaining cell homeostasis. USP21 determines the stability of oncogenic proteins and therefore is implicated in carcinogenesis
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Structure of the endogenous insect acetyl-coA carboxylase carboxyltransferase domain. J. Biol. Chem. (IF 4.0) Pub Date : 2024-09-19 Dong Wang,Fan Bu,Ge Yang,Hannah Brenke,Bin Liu
Acetyl-coenzyme A carboxylases (ACCs) are pivotal in fatty acid metabolism, converting acetyl-CoA to malonyl-CoA. While ACCs in humans, plants, and microbes have been extensively studied, insect ACCs, crucial for lipid biosynthesis and physiological processes, remain relatively unexplored. Unlike mammals, which have ACC1 and ACC2 in different tissues, insects possess a single ACC gene, underscoring
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Light-driven Anion-Pumping Rhodopsin with Unique Cytoplasmic Anion-release Mechanism. J. Biol. Chem. (IF 4.0) Pub Date : 2024-09-19 Tomohiro Ishizuka,Kano Suzuki,Masae Konno,Keisei Shibata,Yuma Kawasaki,Hidefumi Akiyama,Takeshi Murata,Keiichi Inoue
Microbial rhodopsins are photoreceptive membrane proteins found in microorganisms with an all-trans-retinal chromophore. The function of many microbial rhodopsins is determined by three residues in the third transmembrane helix called motif residues. Here, we report a group of microbial rhodopsins with a novel Thr-Thr-Gly (TTG) motif. The ion-transport assay revealed that they function as light-driven
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Development of a high throughput cytochrome P450-ligand binding assay. J. Biol. Chem. (IF 4.0) Pub Date : 2024-09-19 Elyse Frydendall,Emily E Scott
Human cytochrome P450 enzymes are membrane-embedded monooxygenases responsible for xenobiotic metabolism, steroidogenesis, fatty acid metabolism, and vitamin metabolism. Their active sites can accommodate diverse small molecules and understanding these interactions is key to decoding enzymatic functionality and designing drugs. The most common method for characterizing small molecule binding is quantifying
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Microtubule-associated protein, MAP1B, encodes functionally distinct polypeptides. J. Biol. Chem. (IF 4.0) Pub Date : 2024-09-19 Tracy C Tan,Yusheng Shen,Lily B Stine,Barbara Mitchell,Kyoko Okada,Richard J McKenney,Kassandra M Ori-McKenney
Microtubule-associated protein, MAP1B, is crucial for neuronal morphogenesis and disruptions in MAP1B function are correlated with neurodevelopmental disorders. MAP1B encodes a single polypeptide that is processed into discrete proteins, a heavy chain (HC) and a light chain (LC); however, it is unclear if these two chains operate individually or as a complex within the cell. In vivo studies have characterized
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Cooperative Folding as a Molecular Switch in an Evolved Antibody Binder. J. Biol. Chem. (IF 4.0) Pub Date : 2024-09-19 Malin Jönsson,Ameeq Ul Mushtaq,Tamás Milán Nagy,Emma von Witting,John Löfblom,Kwangho Nam,Magnus Wolf-Watz,Sophia Hober
Designing proteins with tunable activities from easily accessible external cues remains a biotechnological challenge. Here, we set out to create a small antibody-binding domain equipped with a molecular switch inspired by the allosteric response to calcium seen in naturally derived proteins like calmodulin. We have focused on one of the three domains of Protein G that show inherent affinity to antibodies
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Breaking down taurine Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-09-18 Grant Miura
N-acetyltaurine is a metabolite whose levels fluctuate with diet and exercise and that undergoes hydrolysis to form taurine and acetate. However, the enzymes that facilitate this reaction were not known. In an effort to address this, Wei et al. used liquid chromatography–mass spectrometry-based activity guided analysis of mouse tissues, detecting high N-acetyltaurine hydrolysis activity in kidney and
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Anti-aggregate activity Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-09-18 Russell Johnson
The formation of pathological protein aggregates occurs in many neurodegenerative diseases, such as the aggregation of the protein tau in patients with Alzheimer’s disease. Removing these aggregates offers a possible route to treat these protein misfolding diseases; however, targeting the aggregated form of a protein while sparing the monomeric form, which is required for normal cellular function,
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Sweet RNA Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-09-18 Yiyun Song
By coupling rPAL to enzymatic glycan cleavage and sequential window acquisition of all theoretical mass spectra (SWATH-MS), the team found that acp3U was the most enriched linker (although other putative linker substrates were identified). Importantly, knocking out DTWD2, an enzyme responsible for installing acp3U in tRNAs, reduced glycoRNA levels. This study provides not only a useful tool for glycoRNA
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An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-09-18 Yuanjin Zhang, Zhonglin Liu, Marscha Hirschi, Oleg Brodsky, Eric Johnson, Sang Joon Won, Asako Nagata, Divya Bezwada, Matthew D. Petroski, Jaimeen D. Majmudar, Sherry Niessen, Todd VanArsdale, Adam M. Gilbert, Matthew M. Hayward, Al E. Stewart, Andrew R. Nager, Bruno Melillo, Benjamin F. Cravatt
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Targeting double-stranded nucleic acids using the λExo–pDNA system Nat. Biotechnol. (IF 33.1) Pub Date : 2024-09-18
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A developmental route to hematopoietic stem cells Nat. Biotechnol. (IF 33.1) Pub Date : 2024-09-18 Adam C. Wilkinson, Marella F. T. R. de Bruijn
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Bacteriophage λ exonuclease and a 5′-phosphorylated DNA guide allow PAM-independent targeting of double-stranded nucleic acids Nat. Biotechnol. (IF 33.1) Pub Date : 2024-09-18 Shengnan Fu, Junjie Li, Jing Chen, Linghao Zhang, Jiajia Liu, Huiyu Liu, Xin Su
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Acetylation of TIR domains in the TLR4-Mal-MyD88 complex regulates immune responses in sepsis. EMBO J. (IF 9.4) Pub Date : 2024-09-18 Xue Li,Xiangrong Li,Pengpeng Huang,Facai Zhang,Juanjuan K Du,Ying Kong,Ziqiang Shao,Xinxing Wu,Weijiao Fan,Houquan Tao,Chuanzan Zhou,Yan Shao,Yanling Jin,Meihua Ye,Yan Chen,Jong Deng,Jimin Shao,Jicheng Yue,Xiaju Cheng,Y Eugene Chinn
Activation of the Toll-like receptor 4 (TLR4) by bacterial endotoxins in macrophages plays a crucial role in the pathogenesis of sepsis. However, the mechanism underlying TLR4 activation in macrophages is still not fully understood. Here, we reveal that upon lipopolysaccharide (LPS) stimulation, lysine acetyltransferase CBP is recruited to the TLR4 signalosome complex leading to increased acetylation
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Histone methyltransferase KMT2A: Developmental regulation to oncogenic transformation. J. Biol. Chem. (IF 4.0) Pub Date : 2024-09-18 Jayme Ogino,Yali Dou
Our current understanding of epigenetic regulation is deeply rooted in the founding contributions of Dr. C. David Allis. In 2002, Allis and colleagues first characterized the lysine methyltransferase activity of the mammalian KMT2A (MLL1), a paradigm shifting discovery that brings epigenetic dysregulation into focus for many human diseases that carry KMT2A mutations. This review will discuss the current
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A novel EZH1/2 dual inhibitor inhibits GCB DLBCL through Cell Cycle Regulation and M2 Tumor-Associated Macrophage Polarization. J. Biol. Chem. (IF 4.0) Pub Date : 2024-09-18 Ran An,Zhimeng Zhang,Dongli Zhang,Yuqing Li,Yueling Lin,Hongtao Sun,Fang Xu,Manmei Li,Zhong Liu
The incidence of germinal center B-cell-like type diffuse large B-cell lymphoma (GCB DLBCL) is steadily increasing, with a known hereditary component. Although some molecular mechanisms in GCB DLBCL have been elucidated, understanding remains incomplete, limiting the effectiveness of targeted therapies. In GCB DLBCL patients, abnormally high expression of zeste homologs 2 (EZH2) is noted, and the compensatory
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Differential functional role of Orai1 variants in constitutive Ca2+ entry and calcification in luminal breast cancer cells. J. Biol. Chem. (IF 4.0) Pub Date : 2024-09-18 Alejandro Berna-Erro,Jose Javier Lopez,Isaac Jardin,Jose Sanchez-Collado,Gines M Salido,Juan A Rosado
Resting cytosolic Ca2+ concentration is tightly regulated to fine-tune Ca2+-dependent cellular functions. Luminal breast cancer cells exhibit constitutive Ca2+ entry mediated by Orai1 and the secretory pathway Ca2+-ATPase, SPCA2, which result in mammary microcalcifications that constitute a prognostic marker of mammary lesions. Two Orai1 isoforms have been identified, the full-length Orai1α, consisting
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Protein phosphatase PP2Cα S-glutathionylation regulates cell migration. J. Biol. Chem. (IF 4.0) Pub Date : 2024-09-18 Dhanushika S K Kukulage,Kusal T G Samarasinghe,Nadee N J Matarage Don,Madhu C Shivamadhu,Kyosuke Shishikura,William Schiff,Faezeh Mashhadi Ramezani,Rayavarapu Padmavathi,Megan L Matthews,Young-Hoon Ahn
Redox signaling is a fundamental mechanism that controls all major biological processes partly via protein cysteine oxidations, including S-glutathionylation. Despite over 2,000 cysteines identified to form S-glutathionylation in databases, the identification of redox cysteines functionally linked to a biological process of interest remains challenging. Here, we demonstrate a strategy combining glutathionylation
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The prodomain of bone morphogenetic protein 2 promotes dimerization and cleavage of BMP6 homodimers and BMP2/6 heterodimers. J. Biol. Chem. (IF 4.0) Pub Date : 2024-09-18 Pooja Chauhan,Yongqiang Xue,Hyung-Seok Kim,Allison L Fisher,Jodie L Babitt,Jan L Christian
Bone morphogenetic protein 2 (BMP2) and BMP6 are key regulators of systemic iron homeostasis. All BMPs are generated as inactive precursor proteins that dimerize and are cleaved to generate the bioactive ligand and inactive prodomain fragments, but nothing is known about how BMP2 or BMP6 homodimeric or heterodimeric precursor proteins are proteolytically activated. Here, we conducted in vitro cleavage
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ADAR promotes USP38 auto-deubiquitylation and stabilization in an RNA editing-independent manner in Esophageal Squamous Cell Carcinoma. J. Biol. Chem. (IF 4.0) Pub Date : 2024-09-18 Qingyong Hu,Yahui Chen,Qianru Zhou,Shanshan Deng,Wei Hou,Yong Yi,Chenghua Li,Jiancai Tang
Esophageal cancer is mainly divided into esophageal adenocarcinoma (EADC) and esophageal squamous cell carcinoma (ESCC). China is one of the high-incidence areas of esophageal cancer, of which about 90% are ESCC. The deubiquitinase USP38 has been reported to play significant roles in several biological processes, including inflammatory responses, antiviral infection, cell proliferation, migration,
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Downregulation of the m6A reader YTHDC2 upregulates exosome content in lung adenocarcinoma via inhibiting IFIT and OAS family members. J. Biol. Chem. (IF 4.0) Pub Date : 2024-09-18 Zhixin Yin,Lifang Ma,Xiaoting Tian,Qi Sun,Congcong Zhang,Yikun Wang,Yayou Miao,Xiangfei Xue,Yongjie Wang,Jiayi Wang,Xiao Zhang,Xumin Hou
N6-Methyladenosine (m6A) is the most prevalent mRNA modification. Its biological function primarily relies on its "Reader" protein, such as YTHDC2. Previous studies have shown that YTHDC2 downregulation is a pro-carcinogenic phenomenon in lung adenocarcinoma (LUAD). However, further investigation is needed to understand the molecular mechanisms of downstream genes and the associated biological phenomena
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The N-acetylglucosaminyltransferase Radical Fringe contributes to defects in JAG1-dependent turnover and signaling of NOTCH3 CADASIL mutants. J. Biol. Chem. (IF 4.0) Pub Date : 2024-09-18 Shodai Suzuki,Taiki Mashiko,Yohei Tsukamoto,Miyu Oya,Yuki Kotani,Saki Okawara,Takemi Matsumoto,Yuki Mizue,Hideyuki Takeuchi,Tetsuya Okajima,Motoyuki Itoh
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a genetic vascular dementia characterized by age-related degeneration of vascular mural cells and accumulation of a NOTCH3 mutant protein. NOTCH3 functions as a signaling receptor, activating downstream gene expression in response to ligands like JAG1 and DLL4, which regulate the development and
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An experimental census of retrons for DNA production and genome editing Nat. Biotechnol. (IF 33.1) Pub Date : 2024-09-17 Asim G. Khan, Matías Rojas-Montero, Alejandro González-Delgado, Santiago C. Lopez, Rebecca F. Fang, Kate D. Crawford, Seth L. Shipman
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Multicellular artificial neural network-type architectures demonstrate computational problem solving Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-09-16 Deepro Bonnerjee, Saswata Chakraborty, Biyas Mukherjee, Ritwika Basu, Abhishek Paul, Sangram Bagh
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Biosynthesis of peptide–nucleobase hybrids in ribosomal peptides Nat. Chem. Biol. (IF 12.9) Pub Date : 2024-09-16 Zeng-Fei Pei, Natalia M. Vior, Lingyang Zhu, Andrew W. Truman, Satish K. Nair
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ER-phagy restrains inflammatory responses through its receptor UBAC2. EMBO J. (IF 9.4) Pub Date : 2024-09-16 Xing He,Haowei He,Zitong Hou,Zheyu Wang,Qinglin Shi,Tao Zhou,Yaoxing Wu,Yunfei Qin,Jun Wang,Zhe Cai,Jun Cui,Shouheng Jin
ER-phagy, a selective form of autophagic degradation of endoplasmic reticulum (ER) fragments, plays an essential role in governing ER homeostasis. Dysregulation of ER-phagy is associated with the unfolded protein response (UPR), which is a major clue for evoking inflammatory diseases. However, the molecular mechanism underpinning the connection between ER-phagy and disease remains poorly defined. Here
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Non-autophagic Golgi-LC3 lipidation facilitates TFE3 stress response against Golgi dysfunction. EMBO J. (IF 9.4) Pub Date : 2024-09-16 Jaemin Kang,Cathena Meiling Li,Namhoon Kim,Jongyeon Baek,Yong-Keun Jung
Lipidated ATG8/LC3 proteins are recruited to single membrane compartments as well as autophagosomes, supporting their functions. Although recent studies have shown that Golgi-LC3 lipidation follows Golgi damage, its molecular mechanism and function under Golgi stress remain unknown. Here, by combining DLK1 overexpression as a new strategy for induction of Golgi-specific LC3 lipidation, and the application
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Acidity suppresses CD8 + T-cell function by perturbing IL-2, mTORC1, and c-Myc signaling. EMBO J. (IF 9.4) Pub Date : 2024-09-16 Romain Vuillefroy de Silly,Laetitia Pericou,Bili Seijo,Isaac Crespo,Melita Irving
CD8 + T cells have critical roles in tumor control, but a range of factors in their microenvironment such as low pH can suppress their function. Here, we demonstrate that acidity restricts T-cell expansion mainly through impairing IL-2 responsiveness, lowers cytokine secretion upon re-activation, and reduces the cytolytic capacity of CD8 + T cells expressing low-affinity TCR. We further find decreased
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Biotech news from around the world Nat. Biotechnol. (IF 33.1) Pub Date : 2024-09-13
Researchers from Kenya’s Egerton University and Makerere University in Uganda begin a pilot program to mass breed desert locusts as a sustainable, protein-rich food source for animals and humans. The locusts are grown in giant domed-shaped, temperature- and humidity-controlled greenhouses equipped with wire gauze cages to stop them escaping. The Locust4Industry project aims to enable industrial exploitation
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FDA approves first IDH-targeted glioma drug Nat. Biotechnol. (IF 33.1) Pub Date : 2024-09-13
Voranigo (vorasidenib), made by French drugmaker Servier Pharmaceuticals, was approved in August by the US Food and Drug Administration. The small-molecule isocitrate dehydrogenase-1 (IDH1) and isocitrate dehydrogenase-2 (IDH2) inhibitor has the go-ahead to treat patients with grade 2 astrocytoma or oligodendroglioma with IDH1 or IDH2 mutations. The approval follows a successful phase 3 trial showing
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Engineered parasite delivers therapeutic proteins to the mouse brain Nat. Biotechnol. (IF 33.1) Pub Date : 2024-09-13 Iris Marchal
Macromolecular drugs have limited applications in the brain because they cannot cross the blood–brain barrier. A parasite that does have the natural capacity to travel to the brain is Toxoplasma gondii. In a study in Nature Microbiology, Bracha et al. make use of this feature, engineering T. gondii to deliver large proteins to the brains of mice. The authors targeted several proteins with different
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Genentech, Sangamo ink Alzheimer’s deal Nat. Biotechnol. (IF 33.1) Pub Date : 2024-09-13
Genentech, part of Roche, has signed an exclusive license with Sangamo Therapeutics to develop genomic treatments for two neurodegenerative diseases. Sangamo will receive $50 million up front and could earn up to $1.9 billion in development and commercial milestone payments plus tiered royalties for its proprietary zinc finger repressors directed to the gene encoding the tau protein, which is involved
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Biogenetic Blooms: it’s microbial, and it’s art Nat. Biotechnol. (IF 33.1) Pub Date : 2024-09-13
Nearly a century later, in a bungalow three blocks from the sun-baked crowds of Rockaway Beach, New York, Karen Ingram meticulously paints portraits of flower blossoms in a Petri dish using a medium of yeast. She calls her series “Biogenetic Blooms”: blue roses, yellow and orange daffodils, red tulips, pink orchids, columbines, snapdragons, irises, black-eyed Susans. The process is surprisingly tricky