-
-
A role for leucine-rich, glioma inactivated 1 in regulating pain sensitivity Brain (IF 10.6) Pub Date : 2024-09-20 Adham Farah, Ryan Patel, Piotr Poplawski, Benjamin J Wastie, Mandy Tseng, Allison M Barry, Omar Daifallah, Akash Dubb, Ivan Paul, Hoi lao Cheng, Faisal Feroz, Yuhe Su, Marva Chan, Hanns Ulrich Zeilhofer, Theodore Price, David L Bennett, Kirsty Bannister, John M Dawes
Neuronal hyperexcitability is a key driver of persistent pain states including neuropathic pain. Leucine-rich, glioma inactivated 1 (LGI1), is a secreted protein known to regulate excitability within the nervous system and is the target of autoantibodies from neuropathic pain patients. Therapies that block or reduce antibody levels are effective at relieving pain in these patients, suggesting that
-
Clinical-grade intranasal NGF fuels neurological and metabolic functions of Mecp2-deficient mice Brain (IF 10.6) Pub Date : 2024-09-20 Diego Pozzer, Marzia Indrigo, Martina Breccia, Elena Florio, Camilla Aurora Franchino, Giuseppina De Rocco, Francesca Maltecca, Antonio Fadda, Marzia Rossato, Andrea Aramini, Marcello Allegretti, Angelisa Frasca, Lidia De Filippis, Nicoletta Landsberger
MECP2 deficiency causes a broad spectrum of neuropsychiatric disorders that can affect both genders. Rett syndrome is the most common and is characterized by an apparently normal growth period followed by a regression phase in which patients lose most of their previously acquired skills. After this dramatic period, various symptoms progressively appear, including severe intellectual disability, epilepsy
-
Neural Activity Differentiates Novel and Learned Event Boundaries J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Youssef Ezzyat, Abby Clements
People parse continuous experiences at natural breakpoints called event boundaries, which is important for understanding an environment's causal structure and for responding to uncertainty within it. However, it remains unclear how different forms of uncertainty affect the parsing of continuous experiences and how such uncertainty influences the brain's processing of ongoing events. We exposed human
-
Experience Dependence of Alpha Rhythms and Neural Dynamics in the Mouse Visual Cortex J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Pouria Riyahi, Marnie A. Phillips, Nathaniel Boley, Matthew T. Colonnese
The role of experience in the development and maintenance of emergent network properties such as cortical oscillations and states is poorly understood. To define how early-life experience affects cortical dynamics in the visual cortex of adult, head-fixed mice, we examined the effects of two forms of blindness initiated before eye opening and continuing through recording: (1) bilateral loss of retinal
-
DMXL2 Is Required for Endocytosis and Recycling of Synaptic Vesicles in Auditory Hair Cells J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Hu Peng, Longhao Wang, Yunge Gao, Huihui Liu, Guotong Lin, Yu Kong, Pengcheng Xu, Hongchao Liu, Qingyue Yuan, Huanhai Liu, Lei Song, Tao Yang, Hao Wu
Ribbon synapses of inner hair cells (IHCs) are uniquely designed for ultrafast and indefatigable neurotransmission of the sound. The molecular machinery ensuring the efficient, compensatory recycling of the synaptic vesicles (SVs), however, remains elusive. This study showed that hair cell knock-out of murine Dmxl2, whose human homolog is responsible for nonsyndromic sensorineural hearing loss DFNA71
-
State- and Circuit-Dependent Opponent Processing of Fear J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Joanna Oi-Yue Yau, Amy Li, Lauren Abdallah, Leszek Lisowksi, Gavan P. McNally
The presence of valence coding neurons in the basolateral amygdala (BLA) that form distinct projections to other brain regions implies functional opposition between aversion and reward during learning. However, evidence for opponent interactions in fear learning is sparse and may only be apparent under certain conditions. Here we test this possibility by studying the roles of the BLA->central amygdala
-
Circadian Rhythms Tied to Changes in Brain Morphology in a Densely Sampled Male J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Elle M. Murata, Laura Pritschet, Hannah Grotzinger, Caitlin M. Taylor, Emily G. Jacobs
Circadian, infradian, and seasonal changes in steroid hormone secretion have been tied to changes in brain volume in several mammalian species. However, the relationship between circadian changes in steroid hormone production and rhythmic changes in brain morphology in humans is largely unknown. Here, we examined the relationship between diurnal fluctuations in steroid hormones and multiscale brain
-
Neurons of Macaque Frontal Eye Field Signal Reward-Related Surprise J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Michael R. Shteyn, Carl R. Olson
The frontal eye field (FEF) plays a well-established role in the control of visual attention. The strength of an FEF neuron's response to a visual stimulus presented in its receptive field is enhanced if the stimulus captures spatial attention by virtue of its salience. A stimulus can be rendered salient by cognitive factors as well as by physical attributes. These include surprise. The aim of the
-
A Perspective on Neuroscience Data Standardization with Neurodata Without Borders J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Andrea Pierré, Tuan Pham, Jonah Pearl, Sandeep Robert Datta, Jason T. Ritt, Alexander Fleischmann
Neuroscience research has evolved to generate increasingly large and complex experimental data sets, and advanced data science tools are taking on central roles in neuroscience research. Neurodata Without Borders (NWB), a standard language for neurophysiology data, has recently emerged as a powerful solution for data management, analysis, and sharing. We here discuss our labs’ efforts to implement
-
Generalized Encoding of the Relative Subjective Value of Cognitive Effort in the Dorsal ACC J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Jennifer L. Crawford, Rachel E. Brough, Sarah A. Eisenstein, Jonathan E. Peelle, Todd S. Braver
Making choices about whether and when to engage cognitive effort are a common feature of everyday experience, with important consequences for academic, career, and health outcomes. Yet, despite their hypothesized importance, very little is understood about the underlying mechanisms that support this form of human cost–benefit decision-making. To investigate these mechanisms, we used the Cognitive Effort
-
Selective Attention and Decision-Making Have Separable Neural Bases in Space and Time J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Denise Moerel, Anina N. Rich, Alexandra Woolgar
Attention and decision-making processes are fundamental to cognition. However, they are usually experimentally confounded, making it difficult to link neural observations to specific processes. Here we separated the effects of selective attention from the effects of decision-making on brain activity obtained from human participants (both sexes), using a two-stage task where the attended stimulus and
-
Investigating Egocentric Tuning in Hippocampal CA1 Neurons J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Jordan Carpenter, Jan Sigurd Blackstad, David Tingley, Valentin A. Normand, Edvard I. Moser, May-Britt Moser, Benjamin A. Dunn
Navigation requires integrating sensory information with a stable schema to create a dynamic map of an animal’s position using egocentric and allocentric coordinate systems. In the hippocampus, place cells encode allocentric space, but their firing rates may also exhibit directional tuning within egocentric or allocentric reference frames. We compared experimental and simulated data to assess the prevalence
-
Disentangling Temporal and Rate Codes in the Primate Somatosensory Cortex J. Neurosci. (IF 4.4) Pub Date : 2024-09-18 Thierri Callier, Thomas Gitchell, Michael A. Harvey, Sliman J. Bensmaia
Millisecond-scale temporal spiking patterns encode sensory information in the periphery, but their role in the neocortex remains controversial. The sense of touch provides a window into temporal coding because tactile neurons often exhibit precise, repeatable, and informative temporal spiking patterns. In the somatosensory cortex (S1), responses to skin vibrations exhibit phase locking that faithfully
-
Primate superior colliculus is causally engaged in abstract higher-order cognition. Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-19 Barbara Peysakhovich,Ou Zhu,Stephanie M Tetrick,Vinay Shirhatti,Alessandra A Silva,Sihai Li,Guilhem Ibos,Matthew C Rosen,W Jeffrey Johnston,David J Freedman
The superior colliculus is an evolutionarily conserved midbrain region that is thought to mediate spatial orienting, including saccadic eye movements and covert spatial attention. Here, we reveal a role for the superior colliculus in higher-order cognition, independent of its role in spatial orienting. We trained rhesus macaques to perform an abstract visual categorization task that involved neither
-
Anatomical and behavioural correlates of auditory perception in developmental dyslexia Brain (IF 10.6) Pub Date : 2024-09-19 Ting Qi, Maria Luisa Mandelli, Christa L Watson Pereira, Emma Wellman, Rian Bogley, Abigail E Licata, Zachary Miller, Boon Lead Tee, Jessica de Leon, Edward F Chang, Yulia Oganian, Maria Luisa Gorno-Tempini
Developmental dyslexia is typically associated with difficulties in basic auditory processing and in manipulating speech sounds. However, the neuroanatomical correlates of auditory difficulties in developmental dyslexia (DD) and their contribution to individual clinical phenotypes are still unknown. Recent intracranial electrocorticography findings associated processing of sound amplitude rises and
-
Interaction of motor behaviour, cortical oscillations and deep brain stimulation in Parkinson disease Brain (IF 10.6) Pub Date : 2024-09-19 Koorosh Mirpour, Nader Pouratian
Recent progress in the study of Parkinson's disease (PD) has highlighted the pivotal role of beta oscillations within the basal ganglia-thalamo-cortical network in modulating motor symptoms. Predominantly manifesting as transient bursts, these beta oscillations are central to the pathophysiology of PD motor symptoms, especially bradykinesia. Our central hypothesis is that increased bursting duration
-
Estrous cycle-dependent modulation of sexual receptivity in female mice by estrogen receptor beta-expressing cells in the dorsal raphe nucleus. J. Neurosci. (IF 4.4) Pub Date : 2024-09-19 Tomoaki Murakawa,Lisa Kogure,Kakuma Hata,Kansuke Hasunuma,Satoshi Takenawa,Kazuhiro Sano,Sonoko Ogawa
The sexual receptivity of female mice, shown as lordosis response, is mainly regulated by estradiol action on estrogen receptor alpha (ERα) and beta (ERβ), depending on the day of the estrous cycle. Previous studies revealed that ERα in the ventromedial nucleus of the hypothalamus (VMH) plays an essential role in the induction of lordosis on the day of estrus (Day 1). However, the mechanisms of the
-
Differential encoding of two-tone harmonics in the male and female mouse auditory cortex. J. Neurosci. (IF 4.4) Pub Date : 2024-09-19 Amiyangshu De,Swapna Agarwalla,Raghavendra Kaushik,Debdut Mandal,Sharba Bandyopadhyay
Harmonics are an integral part of music, speech and vocalizations of animals. Since the rest of the auditory environment is primarily made up of nonharmonic sounds, the auditory system needs to perceptually separate the above two kinds of sounds. In mice, harmonics, generally with two-tone components (two-tone harmonic complexes, TTHCs), form an important component of vocal communication. Communication
-
The effect of congruent vs. incongruent distractor positioning on electrophysiological signals during perceptual decision-making. J. Neurosci. (IF 4.4) Pub Date : 2024-09-19 Jaeger Wongtrakun,Shou-Han Zhou,Mark A Bellgrove,Trevor T-J Chong,James P Coxon
Key event-related potentials (ERPs) of perceptual decision-making such as the centroparietal positivity (CPP) elucidate how evidence is accumulated towards a given choice. Furthermore, this accumulation can be impacted by visual target selection signals such as the N2 contralateral (N2c). How these underlying neural mechanisms of perceptual decision-making are influenced by the spatial congruence of
-
Glucocorticoids rapidly modulate CaV1.2-mediated calcium signals through Kv2.1 channel clusters in hippocampal neurons. J. Neurosci. (IF 4.4) Pub Date : 2024-09-19 Di Wan,Tongchuang Lu,Chenyang Li,Changlong Hu
The precise regulation of Ca2+ signals plays a crucial role in the physiological functions of neurons. Here, we investigated the rapid effect of glucocorticoids on Ca2+ signals in cultured hippocampal neurons from both female and male rats. In cultured hippocampal neurons, glucocorticoids inhibited the spontaneous somatic Ca2+ spikes generated by Kv2.1-organized Ca2+ microdomains. Furthermore, glucocorticoids
-
A Novel Directed Seed-Based Connectivity Analysis Toolbox Applied to Human and Marmoset Resting-State fMRI. J. Neurosci. (IF 4.4) Pub Date : 2024-09-19 Takuto Okuno,Junichi Hata,Chino Kawai,Hideyuki Okano,Alexander Woodward
Estimating the direction of functional connectivity (FC) can help to further elucidate complex brain function. However, the estimation of directed FC at the voxel level in fMRI data, and evaluating its performance, has yet to be done. We therefore developed a novel directed seed-based connectivity analysis (SCA) method based on normalized pairwise Granger causality that provides greater detail and
-
Synergistic association of Aβ and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-18 Jonathan Gallego-Rudolf, Alex I. Wiesman, Alexa Pichet Binette, Sylvia Villeneuve, Sylvain Baillet
-
A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-18 Antoine Anfray, Samantha Schaeffer, Yorito Hattori, Monica M. Santisteban, Nicole Casey, Gang Wang, Michael Strickland, Ping Zhou, David M. Holtzman, Josef Anrather, Laibaik Park, Costantino Iadecola
-
Inhibiting Ca2+ channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-18 Nils Korte, Anna Barkaway, Jack Wells, Felipe Freitas, Huma Sethi, Stephen P. Andrews, John Skidmore, Beth Stevens, David Attwell
-
Biallelic EPB41L3 variants underlie a developmental disorder with seizures and myelination defects Brain (IF 10.6) Pub Date : 2024-09-18 Elizabeth A Werren, Guillermo Rodriguez Bey, Purvi Majethia, Parneet Kaur, Siddaramappa J Patil, Minal Kekatpure, Alexandra Afenjar, Leila Qebibo, Lydie Burglen, Hoda Tomoum, Florence Demurger, Christele Duborg, Shahyan Siddiqui, Yao-Chang Tsan, Uzma Abdullah, Zafar Ali, Saadia Maryam Saadi, Shahid Mahmood Baig, Henry Houlden, Reza Maroofian, Quasar Saleem Padiath, Stephanie L Bielas, Anju Shukla
Erythrocyte Membrane Protein Band 4.1 Like 3 (EPB41L3: NM_012307.5), also known as DAL-1, encodes the ubiquitously expressed, neuronally enriched 4.1B protein, part of the 4.1 superfamily of membrane-cytoskeleton adaptors. 4.1B plays key roles in cell spreading, migration, and cytoskeletal scaffolding that support oligodendrocyte axon adhesions essential for proper myelination. We herein describe six
-
Semi-orthogonal subspaces for value mediate a binding and generalization trade-off Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-17 W. Jeffrey Johnston, Justin M. Fine, Seng Bum Michael Yoo, R. Becket Ebitz, Benjamin Y. Hayden
-
Neuroanatomical changes observed over the course of a human pregnancy Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-16 Laura Pritschet, Caitlin M. Taylor, Daniela Cossio, Joshua Faskowitz, Tyler Santander, Daniel A. Handwerker, Hannah Grotzinger, Evan Layher, Elizabeth R. Chrastil, Emily G. Jacobs
-
Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-16 Kathleen A. Martin, Eleni S. Papadoyannis, Jennifer K. Schiavo, Saba Shokat Fadaei, Habon A. Issa, Soomin C. Song, Sofia Orrey Valencia, Nesibe Z. Temiz, Matthew J. McGinley, David A. McCormick, Robert C. Froemke
-
Tonic and burst-like locus coeruleus stimulation distinctly shift network activity across the cortical hierarchy Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-16 Christina Grimm, Sian N. Duss, Mattia Privitera, Brandon R. Munn, Nikolaos Karalis, Stefan Frässle, Maria Wilhelm, Tommaso Patriarchi, Daniel Razansky, Nicole Wenderoth, James M. Shine, Johannes Bohacek, Valerio Zerbi
-
Myelin lipid metabolism can provide energy for starved axons Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-12
-
Correction to: Expanded clinical phenotype spectrum correlates with variant function in SCN2A-related disorders. Brain (IF 10.6) Pub Date : 2024-09-13
-
Inside out: the neural basis of spontaneous and creative thinking Brain (IF 10.6) Pub Date : 2024-09-13 Alizée Lopez-Persem, Emmanuel Mandonnet, Emmanuelle Volle
This scientific commentary refers to ‘Default mode network electrophysiological dynamics and causal role in creative thinking’ by Bartoli et al. (https://doi.org/10.1093/brain/awae199).
-
Decision cost hypersensitivity underlies Huntington’s disease apathy Brain (IF 10.6) Pub Date : 2024-09-13 Lee-Anne Morris, Kyla-Louise Horne, Sanjay Manohar, Laura Paermentier, Christina Buchanan, Michael MacAskill, Daniel Myall, Matthew Apps, Richard Roxburgh, Tim Anderson, Masud Husain, Campbell Le Heron
The neuropsychiatric syndrome of apathy is now recognized to be a common and disabling condition in Huntington’s disease (HD). However, the mechanisms underlying it are poorly understood. One way to investigate apathy is to utilise a theoretical framework of normal motivated behaviour, to determine where breakdown has occurred in people with this behavioural disruption. A fundamental computation underlying
-
Musicianship and Prominence of Interhemispheric Connectivity Determine Two Different Pathways to Atypical Language Dominance J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Esteban Villar-Rodríguez, Lidón Marin-Marin, María Baena-Pérez, Cristina Cano-Melle, Maria Antònia Parcet, César Ávila
During infancy and adolescence, language develops from a predominantly interhemispheric control—through the corpus callosum (CC)—to a predominantly intrahemispheric control, mainly subserved by the left arcuate fasciculus (AF). Using multimodal neuroimaging, we demonstrate that human left-handers (both male and female) with an atypical language lateralization show a rightward participation of language
-
ELP1, the Gene Mutated in Familial Dysautonomia, Is Required for Normal Enteric Nervous System Development and Maintenance and for Gut Epithelium Homeostasis J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Marta Chaverra, Alexandra M. Cheney, Alpha Scheel, Alessa Miller, Lynn George, Anastasia Schultz, Katelyn Henningsen, Douglas Kominsky, Heather Walk, William R. Kennedy, Horacio Kaufmann, Seth Walk, Valérie Copié, Frances Lefcort
Familial dysautonomia (FD) is a rare sensory and autonomic neuropathy that results from a mutation in the ELP1 gene. Virtually all patients report gastrointestinal (GI) dysfunction and we have recently shown that FD patients have a dysbiotic gut microbiome and altered metabolome. These findings were recapitulated in an FD mouse model and moreover, the FD mice had reduced intestinal motility, as did
-
Decision-Making with Predictions of Others Likely and Unlikely Choices in the Human Brain J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Ning Ma, Norihiro Harasawa, Kenichi Ueno, Kang Cheng, Hiroyuki Nakahara
For better decisions in social interactions, humans often must understand the thinking of others and predict their actions. Since such predictions are uncertain, multiple predictions may be necessary for better decision-making. However, the neural processes and computations underlying such social decision-making remain unclear. We investigated this issue by developing a behavioral paradigm and performing
-
Effects of Phasic Activation of Locus Ceruleus on Cortical Neural Activity and Auditory Discrimination Behavior J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Xuejiao Wang, Zijie Li, Xueru Wang, Jingyu Chen, Ziyu Guo, Bingqing Qiao, Ling Qin
Although the locus ceruleus (LC) is recognized as a crucial modulator for attention and perception by releasing norepinephrine into various cortical regions, the impact of LC–noradrenergic (LC–NE) modulation on auditory discrimination behavior remains elusive. In this study, we firstly recorded local field potential and single-unit activity in multiple cortical regions associated with auditory–motor
-
Amyloid-{beta} Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Olga Prikhodko, Ronald K. Freund, Emily Sullivan, Matthew J. Kennedy, Mark L. Dell’Acqua
Neuronal excitatory synapses are primarily located on small dendritic protrusions called spines. During synaptic plasticity underlying learning and memory, Ca2+ influx through postsynaptic NMDA-type glutamate receptors (NMDARs) initiates signaling pathways that coordinate changes in dendritic spine structure and synaptic function. During long-term potentiation (LTP), high levels of NMDAR Ca2+ influx
-
The Hippocampus Represents Information about Movements in Their Temporal Position in a Learned Motor Sequence J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Nina Dolfen, Serena Reverberi, Hans Op de Beeck, Bradley R. King, Genevieve Albouy
Our repertoire of motor skills is filled with sequential movements that need to be performed in a specific order. Here, we used functional magnetic resonance imaging to investigate whether the human hippocampus, a region known to support temporal order in non-motor memory, represents information about the order of sequential motor actions in human participants (both sexes). We also examined such representations
-
Chinese Verbal Fluency Deficiency in Temporal Lobe Epilepsy with and without Hippocampal Sclerosis: A Multiscale Study J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Kangrun Wang, Fangfang Xie, Chaorong Liu, Ge Wang, Min Zhang, Jialinzi He, Langzi Tan, Haiyun Tang, Bo Xiao, Lily Wan, Lili Long
To test a Chinese character version of the phonemic verbal fluency task in patients with temporal lobe epilepsy (TLE) and assess the verbal fluency deficiency pattern in TLE with and without hippocampal sclerosis, a cross-sectional study was conducted including 30 patients with TLE and hippocampal sclerosis (TLE-HS), 28 patients with TLE and without hippocampal sclerosis (TLE-NHS), and 29 demographically
-
Heterogeneity in Slow Synaptic Transmission Diversifies Purkinje Cell Timing J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Riya Elizabeth Thomas, Franziska Mudlaff, Kyra Schweers, William Todd Farmer, Aparna Suvrathan
The cerebellum plays an important role in diverse brain functions, ranging from motor learning to cognition. Recent studies have suggested that molecular and cellular heterogeneity within cerebellar lobules contributes to functional differences across the cerebellum. However, the specific relationship between molecular and cellular heterogeneity and diverse functional outputs of different regions of
-
Medial Prefrontal Cortex Stimulation Reduces Retrieval-Induced Forgetting via Fronto-parietal Beta Desynchronization J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Ahsan Khan, Chun Hang Eden Ti, Kai Yuan, Maite Crespo Garcia, Michael C. Anderson, Raymond Kai-Yu Tong
The act of recalling memories can paradoxically lead to the forgetting of other associated memories, a phenomenon known as retrieval-induced forgetting (RIF). Inhibitory control mechanisms, primarily mediated by the prefrontal cortex, are thought to contribute to RIF. In this study, we examined whether stimulating the medial prefrontal cortex (mPFC) with transcranial direct current stimulation modulates
-
Encoding of 2D Self-Centered Plans and World-Centered Positions in the Rat Frontal Orienting Field J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Liujunli Li, Timo Flesch, Ce Ma, Jingjie Li, Yizhou Chen, Hung-Tu Chen, Jeffrey C. Erlich
The neural mechanisms of motor planning have been extensively studied in rodents. Preparatory activity in the frontal cortex predicts upcoming choice, but limitations of typical tasks have made it challenging to determine whether the spatial information is in a self-centered direction reference frame or a world-centered position reference frame. Here, we trained male rats to make delayed visually guided
-
DOR activation in mature oligodendrocytes regulates α-ketoglutarate metabolism leading to enhanced remyelination in aged mice Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-12 Guojiao Huang, Zhidan Li, Xuezhao Liu, Menglong Guan, Songlin Zhou, Xiaowen Zhong, Tao Zheng, Dazhuan Xin, Xiaosong Gu, Dezhi Mu, Yingkun Guo, Lin Zhang, Liguo Zhang, Q. Richard Lu, Xuelian He
-
-
-
-
Investigation of metaplasticity associated with transcranial focused ultrasound neuromodulation in humans. J. Neurosci. (IF 4.4) Pub Date : 2024-09-12 Mandy Yi Rong Ding,Tarun Arora,Can Sarica,Andrew Z Yang,Negar Nasrkhani,Talyta Grippe,Jean-François Nankoo,Stephanie Tran,Nardin Samuel,Xue Xia,Andres M Lozano,Robert Chen
Low intensity transcranial focused ultrasound stimulation (TUS) is a novel technique for non-invasive brain stimulation (NIBS). TUS delivered in a theta (5Hz) burst pattern (tbTUS) induces plasticity in the human primary motor cortex (M1) for 30-60 minutes, showing promise for therapeutic development. Metaplasticity refers to activity-dependent changes in neural functions governing synaptic plasticity;
-
Synaptotagmin 4 supports spontaneous axon sprouting after spinal cord injury. J. Neurosci. (IF 4.4) Pub Date : 2024-09-12 Kyoka Higuchi,Akiko Uyeda,Lili Quan,Shogo Tanabe,Yuki Kato,Yukio Kawahara,Rieko Muramatsu
Injuries to the central nervous system (CNS) can cause severe neurological deficits. Axonal regrowth is a fundamental process for the reconstruction of compensatory neuronal networks after injury; however, it is extremely limited in the adult mammalian CNS. In this study, we conducted a loss-of-function genetic screen in cortical neurons, combined with a web-resource-based phenotypic screen, and identified
-
Anterior olfactory cortices differentially transform bottom-up odor signals to produce inverse top-down outputs. J. Neurosci. (IF 4.4) Pub Date : 2024-09-12 David Wolf,Lars-Lennart Oettl,Laurens Winkelmeier,Christiane Linster,Wolfgang Kelsch
Odor information arrives first in the main olfactory bulb and is then broadcasted to the olfactory cortices and striatum. Downstream regions have unique cellular and connectivity architectures that may generate different coding patterns to the same odors. To reveal region-specific response features, tuning and decoding of single-unit populations, we recorded responses to the same odors under the same
-
A miR-383-5p signalling hub coordinates the axon regeneration response to inflammation. J. Neurosci. (IF 4.4) Pub Date : 2024-09-12 Matthew A Hintermayer,Camille A Juźwik,Barbara Morquette,Elizabeth Hua,Julia Zhang,Sienna Drake,Shan Shan Shi,Isabel Rambaldi,Vamshi Vangoor,Jeroen Pasterkamp,Craig Moore,Alyson E Fournier
Neuroinflammation can positively influence axon regeneration following injury in the central nervous system (CNS). Inflammation promotes the release of neurotrophic molecules and stimulates intrinsic pro-regenerative molecular machinery in neurons, but the detailed mechanisms driving this effect are not fully understood. We evaluated how microRNAs are regulated in retinal neurons in response to intraocular
-
Increases in amyloid-β42 slow cognitive and clinical decline in Alzheimer’s disease trials Brain (IF 10.6) Pub Date : 2024-09-11 Jesus Abanto, Alok K Dwivedi, Bruno P Imbimbo, Alberto J Espay
Positive effects of new anti-amyloid-β (Aβ) monoclonal antibodies in Alzheimer’s disease (AD) have been attributed to brain amyloid reduction. However, most anti-Aβ antibodies also increase the CSF levels of the 42-amino acid isoform (Aβ42). We evaluated the associations of changes in CSF Aβ42 and brain Aβ-PET with cognitive and clinical end points in randomized trials of anti-Aβ drugs that lowered
-
Piezo2 channels and tactile pain: an intriguing voltage connection Brain (IF 10.6) Pub Date : 2024-09-11 Jorge Fernández-Trillo, Ana Gomis, Félix Viana
This scientific commentary refers to ‘Piezo2 voltage-block regulates mechanical pain sensitivity’ by Sánchez-Carranza et al. (https://doi.org/10.1093/brain/awae227).
-
The Role of Intrinsic Plasticity in Engram Physiology and Temporal Memory Linking. J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Walter Peregrim,Tim O'Leary
-
The Future of Nonhuman Primate Neuroscience: Peril or Possibilities? J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Michele A Basso,Aaron P Batista,Steve W C Chang,Katalin M Gothard,Cory T Miller,Karen J Parker,Jan Zimmermann
-
Atp13a5 Marker Reveals Pericyte Specification in The Mouse Central Nervous System. J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Xinying Guo,Shangzhou Xia,Tenghuan Ge,Yangtao Lin,Shirley Hu,Haijian Wu,Xiaochun Xie,Bangyan Zhang,Sonia Zhang,Jianxiong Zeng,Jian-Fu Chen,Axel Montagne,Fan Gao,Qingyi Ma,Zhen Zhao
Perivascular mural cells including vascular smooth cells (VSMCs) and pericytes are integral components of the vascular system. In the central nervous system (CNS), pericytes are also indispensable for the blood-brain barrier (BBB), blood-spinal cord barrier and blood-retinal barrier, and play key roles in maintaining cerebrovascular and neuronal functions. However, the functional specifications of
-
Distinct neuron types contribute to hybrid auditory spatial coding. J. Neurosci. (IF 4.4) Pub Date : 2024-09-11 Chenggang Chen,Sen Song
Neural decoding is a tool for understanding how activities from a population of neurons inside the brain relate to the outside world and for engineering applications such as brain-machine interfaces. However, neural decoding studies mainly focused on different decoding algorithms rather than different neuron types which could use different coding strategies. In this study, we used two-photon calcium
-
The origins of freezing Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-09-10 Philip Tovote
Philip Tovote describes the 1980 paper in which Michael Fanselow systematically investigated freezing as a defensive response in rodents
-
VEGF-A-mediated venous endothelial cell proliferation results in neoangiogenesis during neuroinflammation Nat. Neurosci. (IF 21.2) Pub Date : 2024-09-10 Sanjid Shahriar, Saptarshi Biswas, Kaitao Zhao, Uğur Akcan, Mary Claire Tuohy, Michael D. Glendinning, Ali Kurt, Charlotte R. Wayne, Grace Prochilo, Maxwell Z. Price, Heidi Stuhlmann, Rolf A. Brekken, Vilas Menon, Dritan Agalliu