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Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages Cell Metab. (IF 27.7) Pub Date : 2024-09-20 Xiaoli Wei, Dongqing Wu, Jing Li, Miaomiao Wu, Qianhui Li, Zhaodi Che, Xu Cheng, Qianying Cheng, Fan Yin, Hao Zhang, Xuefu Wang, Shabnam Abtahi, Li Zuo, Lei Hang, Lili Ma, Wei-Ting Kuo, Xiaoying Liu, Jerrold R. Turner, Hua Wang, Jia Xiao, Fei Wang
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PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders Cell Metab. (IF 27.7) Pub Date : 2024-09-17 Jia-Hui Luo, Fa-Xi Wang, Jia-Wei Zhao, Chun-Liang Yang, Shan-Jie Rong, Wan-Ying Lu, Qi-Jie Chen, Qing Zhou, Jun Xiao, Ya-Nan Wang, Xi Luo, Yang Li, Dan-Ni Song, Cai Chen, Cheng-Liang Zhang, Su-Hua Chen, Ping Yang, Fei Xiong, Qi-Lin Yu, Shu Zhang, Cong-Yi Wang
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Endothelial metabolic control of insulin sensitivity through resident macrophages Cell Metab. (IF 27.7) Pub Date : 2024-09-12 Jing Zhang, Kim Anker Sjøberg, Songlin Gong, Tongtong Wang, Fengqi Li, Andrew Kuo, Stephan Durot, Adam Majcher, Raphaela Ardicoglu, Thibaut Desgeorges, Charlotte Greta Mann, Ines Soro Arnáiz, Gillian Fitzgerald, Paola Gilardoni, E. Dale Abel, Shigeyuki Kon, Danyvid Olivares-Villagómez, Nicola Zamboni, Christian Wolfrum, Thorsten Hornemann, Katrien De Bock
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Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis Cell Metab. (IF 27.7) Pub Date : 2024-09-10 Fopei Ma, Zhuang Li, Haihua Liu, Shixian Chen, Songyuan Zheng, Junqing Zhu, Hao Shi, Haixin Ye, Zhantu Qiu, Lei Gao, Bingqi Han, Qian Yang, Xing Wang, Yang Zhang, Lifang Cheng, Huijie Fan, Shuaijun Lv, Xiaoshan Zhao, Hongwei Zhou, Juan Li, Mukeng Hong
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m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1 Cell Metab. (IF 27.7) Pub Date : 2024-09-09 Ling Xiao, Dario F. De Jesus, Cheng-Wei Ju, Jiang Bo Wei, Jiang Hu, Ava DiStefano-Forti, Tadataka Tsuji, Cheryl Cero, Ville Männistö, Suvi M. Manninen, Siying Wei, Oluwaseun Ijaduola, Matthias Blüher, Aaron M. Cypess, Jussi Pihlajamäki, Yu-Hua Tseng, Chuan He, Rohit N. Kulkarni
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SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation Cell Metab. (IF 27.7) Pub Date : 2024-09-06 Wenhui Liu, Danming You, Jiayang Lin, Huren Zou, Lei Zhang, Shenjian Luo, Youwen Yuan, Zhiyi Wang, Jingwen Qi, Weiwei Wang, Xueru Ye, Xiaoyu Yang, Yajuan Deng, Fei Teng, Xiaojun Zheng, Yuhao Lin, Zhiwei Huang, Yan Huang, Zhi Yang, Xuan Zhou, Huijie Zhang
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Gene-metabolite linkage marks stored red blood cell quality Cell Metab. (IF 27.7) Pub Date : 2024-09-03 Changhan Chen, Wuping Liu, Yang Xia
Red blood cell (RBC) transfusion has long been the cornerstone of treatment for multiple diseases, but there is a knowledge gap between biological and genetic factors impacting RBC storage quality and transfusion efficacy. In this issue of Cell Metabolism, Nemkov et al. present a multiomics approach to identify gene-metabolite associations in fresh and stored RBCs. These findings provide potential
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Bacteroides acidifaciens: Linking dietary fiber to liver health Cell Metab. (IF 27.7) Pub Date : 2024-09-03 Viacheslav A. Petrov, Cédric C. Laczny, Paul Wilmes
While innumerous associative microbiome studies have been published, mechanistic links between the microbiome and host physiology remain much scarcer. In Cell Host & Microbe, Shen et al. report the effect of soluble dietary fibers in alcohol-related liver disease. Through microbiome remodeling, dietary fiber triggers upregulation of liver ornithine aminotransferase and a subsequent reduction in hepatic
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Defying “IL-11ness” by inhibiting inflammation: Strategy for health and longevity Cell Metab. (IF 27.7) Pub Date : 2024-09-03 Hee-Hoon Kim, Vishwa Deep Dixit
Organismal aging involves several hallmark pathways, including chronic inflammation and metabolic dysfunction. However, the origin of age-related inflammation is incompletely understood. In a recent study published in Nature,1 Widjaja et al. show that blocking the age-related increase in IL-11 restores immune-metabolic homeostasis and extends healthspan and lifespan in mice.
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The crosstalk between metabolism and translation Cell Metab. (IF 27.7) Pub Date : 2024-09-03 Stefano Biffo, Davide Ruggero, Massimo Mattia Santoro
Metabolism and mRNA translation represent critical steps involved in modulating gene expression and cellular physiology. Being the most energy-consuming process in the cell, mRNA translation is strictly linked to cellular metabolism and in synchrony with it. Indeed, several mRNAs for metabolic pathways are regulated at the translational level, resulting in translation being a coordinator of metabolism
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Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport Cell Metab. (IF 27.7) Pub Date : 2024-09-03 Laura van Rosmalen, Jiaoyue Zhu, Geraldine Maier, Erica G. Gacasan, Terry Lin, Elena Zhemchuzhnikova, Vince Rothenberg, Swithin Razu, Shaunak Deota, Ramesh K. Ramasamy, Robert L. Sah, Andrew D. McCulloch, Roelof A. Hut, Satchidananda Panda
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Glucagon promotes increased hepatic mitochondrial oxidation and pyruvate carboxylase flux in humans with fatty liver disease Cell Metab. (IF 27.7) Pub Date : 2024-08-27 Kitt Falk Petersen, Sylvie Dufour, Wajahat Z. Mehal, Gerald I. Shulman
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Serine and glycine physiology reversibly modulate retinal and peripheral nerve function Cell Metab. (IF 27.7) Pub Date : 2024-08-26 Esther W. Lim, Regis J. Fallon, Caleb Bates, Yoichiro Ideguchi, Takayuki Nagasaki, Michal K. Handzlik, Emeline Joulia, Roberto Bonelli, Courtney R. Green, Brendan R.E. Ansell, Maki Kitano, Ilham Polis, Amanda J. Roberts, Shigeki Furuya, Rando Allikmets, Martina Wallace, Martin Friedlander, Christian M. Metallo, Marin L. Gantner
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Misregulation of mitochondrial 6mA promotes the propagation of mutant mtDNA and causes aging in C. elegans Cell Metab. (IF 27.7) Pub Date : 2024-08-21 Anne Hahn, Grace Ching Ching Hung, Arnaud Ahier, Chuan-Yang Dai, Ina Kirmes, Brian M. Forde, Daniel Campbell, Rachel Shin Yie Lee, Josiah Sucic, Tessa Onraet, Steven Zuryn
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A nutrigeroscience approach: Dietary macronutrients and cellular senescence Cell Metab. (IF 27.7) Pub Date : 2024-08-22 Mariah F. Calubag, Paul D. Robbins, Dudley W. Lamming
Cellular senescence, a process in which a cell exits the cell cycle in response to stressors, is one of the hallmarks of aging. Senescence and the senescence-associated secretory phenotype (SASP)—a heterogeneous set of secreted factors that disrupt tissue homeostasis and promote the accumulation of senescent cells—reprogram metabolism and can lead to metabolic dysfunction. Dietary interventions have
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Mitochondrial membrane lipids in the regulation of bioenergetic flux Cell Metab. (IF 27.7) Pub Date : 2024-08-22 Stephen Thomas Decker, Katsuhiko Funai
Oxidative phosphorylation (OXPHOS) occurs through and across the inner mitochondrial membrane (IMM). Mitochondrial membranes contain a distinct lipid composition, aided by lipid biosynthetic machinery localized in the IMM and class-specific lipid transporters that limit lipid traffic in and out of mitochondria. This unique lipid composition appears to be essential for functions of mitochondria, particularly
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Obesity intensifies sex-specific interferon signaling to selectively worsen central nervous system autoimmunity in females Cell Metab. (IF 27.7) Pub Date : 2024-08-20 Brendan Cordeiro, Jeeyoon Jennifer Ahn, Saurabh Gawde, Carmen Ucciferri, Nuria Alvarez-Sanchez, Xavier S. Revelo, Natalie Stickle, Kaylea Massey, David G. Brooks, Joel M. Guthridge, Gabriel Pardo, Daniel A. Winer, Robert C. Axtell, Shannon E. Dunn
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Acetate enables metabolic fitness and cognitive performance during sleep disruption Cell Metab. (IF 27.7) Pub Date : 2024-08-19 Qinqin He, Liwei Ji, Yanyan Wang, Yarong Zhang, Haiyan Wang, Junyan Wang, Qing Zhu, Maodi Xie, Wei Ou, Jun Liu, Kuo Tang, Kening Lu, Qingmei Liu, Jian Zhou, Rui Zhao, Xintian Cai, Nanfang Li, Yang Cao, Tao Li
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Physical exercise mediates cortical synaptic protein lactylation to improve stress resilience Cell Metab. (IF 27.7) Pub Date : 2024-08-19 Lan Yan, Yajie Wang, Haidong Hu, Diran Yang, Wenjing Wang, Zhihua Luo, Yangze Wang, Fengzhen Yang, Kwok-Fai So, Li Zhang
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Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation Cell Metab. (IF 27.7) Pub Date : 2024-08-16 Traci E. LaMoia, Brandon T. Hubbard, Mateus T. Guerra, Ali Nasiri, Ikki Sakuma, Mario Kahn, Dongyan Zhang, Russell P. Goodman, Michael H. Nathanson, Yasemin Sancak, Mark Perelis, Vamsi K. Mootha, Gerald I. Shulman
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Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11 Cell Metab. (IF 27.7) Pub Date : 2024-08-14
Nonalcoholic fatty liver disease (NAFLD), including its more severe manifestation nonalcoholic steatohepatitis (NASH), is a global public health chall…
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Integrative clinical and preclinical studies identify FerroTerminator1 as a potent therapeutic drug for MASH Cell Metab. (IF 27.7) Pub Date : 2024-08-13
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Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism Cell Metab. (IF 27.7) Pub Date : 2024-08-07 Yiming Zhang, Cassandra B. Higgins, Stefani Tica, Joshua A. Adams, Jiameng Sun, Shannon C. Kelly, Xiaoyu Zong, Dennis J. Dietzen, Terri Pietka, Samuel J. Ballentine, Leah P. Shriver, Gary J. Patti, Yin Cao, Brian J. DeBosch
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Nourishing the mind: Fasting for brain health Cell Metab. (IF 27.7) Pub Date : 2024-08-06
Aging and obesity are intertwined in a vicious circle that leads to declining general and brain-specific functions. Kapogiannis and colleagues demonstrate that implementing just 8 weeks of two distinct low-calorie regimes can enhance cognition and biochemical markers of aging in older people with obesity.
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Lactylation: Linking the Warburg effect to DNA damage repair Cell Metab. (IF 27.7) Pub Date : 2024-08-06
In this issue of Cell Metabolism, Li et al. report that the highly expressed aldehyde dehydrogenase 1 family member A3 interacts with pyruvate kinase M2 (PKM2) in glioblastoma cells. Consequently, PKM2 tetramerization and activation promote lactate production, leading to the lactylation and nuclear translocation of XRCC1 for DNA damage repair and therapeutic resistance.
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A pattern emerges in chromatin aging: AP-1 steals the show Cell Metab. (IF 27.7) Pub Date : 2024-08-06
During aging, transcriptional programs of cell identity are partially eroded, reducing cellular fitness and resilience. Patrick et al.1 unveil a general mechanism for this process that consists of the progressive loss of transcription factor AP-1 from cell identity enhancers and its relocation by competition to stress-response elements.
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Understanding the metabolism of infants using whole-body metabolic models Cell Metab. (IF 27.7) Pub Date : 2024-08-06
A whole-body model is a computational representation of sex-specific and organ-resolved whole-body metabolism. In this issue of Cell Metabolism, Zaunseder et al. report whole-body models of infants that represent metabolic, physiological, energetic, and nutritional features, accurately simulating the growth of infants and providing foundations for personalized medicine for infants.
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Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis Cell Metab. (IF 27.7) Pub Date : 2024-08-06
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Zinc transporter 1 functions in copper uptake and cuproptosis Cell Metab. (IF 27.7) Pub Date : 2024-08-06 Yehua Li, Jiahao Ma, Rui Wang, Yuanhanyu Luo, Sanduo Zheng, Xiaodong Wang
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SLC25A48 controls mitochondrial choline import and metabolism Cell Metab. (IF 27.7) Pub Date : 2024-08-06 Anthony R.P. Verkerke, Xu Shi, Mark Li, Yusuke Higuchi, Tadashi Yamamuro, Daisuke Katoh, Hiroshi Nishida, Christopher Auger, Ichitaro Abe, Robert E. Gerszten, Shingo Kajimura
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Hepatic BMAL1 and HIF1α regulate a time-dependent hypoxic response and prevent hepatopulmonary-like syndrome Cell Metab. (IF 27.7) Pub Date : 2024-08-05 Vaishnavi Dandavate, Nityanand Bolshette, Rachel Van Drunen, Gal Manella, Hanna Bueno-Levy, Mirie Zerbib, Ippei Kawano, Marina Golik, Yaarit Adamovich, Gad Asher
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Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle Cell Metab. (IF 27.7) Pub Date : 2024-07-30 Ariana Vargas-Castillo, Yizhi Sun, Amanda L. Smythers, Louisa Grauvogel, Phillip A. Dumesic, Margo P. Emont, Linus T. Tsai, Evan D. Rosen, Nathan W. Zammit, Sydney M. Shaffer, Martha Ordonez, Edward T. Chouchani, Steven P. Gygi, Tongtong Wang, Anand K. Sharma, Miroslav Balaz, Christian Wolfrum, Bruce M. Spiegelman
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Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes Cell Metab. (IF 27.7) Pub Date : 2024-07-30 Tongtong Wang, Anand Kumar Sharma, Chunyan Wu, Claudia Irene Maushart, Adhideb Ghosh, Wu Yang, Patrik Stefanicka, Zuzana Kovanicova, Jozef Ukropec, Jing Zhang, Myrtha Arnold, Manuel Klug, Katrien De Bock, Ulrich Schneider, Cristina Popescu, Bo Zheng, Lianggong Ding, Fen Long, Revati Sumukh Dewal, Caroline Moser, Christian Wolfrum
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A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH Cell Metab. (IF 27.7) Pub Date : 2024-07-29 Yi Zhang, Xuemei Wang, Jun Lin, Jia Liu, Kai Wang, Qixing Nie, Chuan Ye, Lulu Sun, Yanpeng Ma, Ruize Qu, Yuejian Mao, Xuguang Zhang, Hua Lu, Pengyan Xia, Dongyu Zhao, Guang Wang, Zhipeng Zhang, Wei Fu, Changtao Jiang, Yanli Pang
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International consensus on fasting terminology Cell Metab. (IF 27.7) Pub Date : 2024-07-25 Daniela A. Koppold, Carolin Breinlinger, Etienne Hanslian, Christian Kessler, Holger Cramer, Anika Rajput Khokhar, Courtney M. Peterson, Grant Tinsley, Claudio Vernieri, Richard J. Bloomer, Michael Boschmann, Nicola L. Bragazzi, Sebastian Brandhorst, Kelsey Gabel, Alan C. Goldhamer, Martin M. Grajower, Michelle Harvie, Leonie Heilbronn, Benjamin D. Horne, Spyridon N. Karras, Jost Langhorst, Eva Lischka
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Cyclic fasting-mimicking diet in cancer treatment: Preclinical and clinical evidence Cell Metab. (IF 27.7) Pub Date : 2024-07-25 Claudio Vernieri, Francesca Ligorio, Debu Tripathy, Valter D. Longo
In preclinical tumor models, cyclic fasting and fasting-mimicking diets (FMDs) produce antitumor effects that become synergistic when combined with a wide range of standard anticancer treatments while protecting normal tissues from treatment-induced adverse events. More recently, results of phase 1/2 clinical trials showed that cyclic FMD is safe, feasible, and associated with positive metabolic and
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Brain responses to intermittent fasting and the healthy living diet in older adults Cell Metab. (IF 27.7) Pub Date : 2024-07-16 Dimitrios Kapogiannis, Apostolos Manolopoulos, Roger Mullins, Konstantinos Avgerinos, Francheska Delgado-Peraza, Maja Mustapic, Carlos Nogueras-Ortiz, Pamela J. Yao, Krishna A. Pucha, Janet Brooks, Qinghua Chen, Shalaila S. Haas, Ruiyang Ge, Lisa M. Hartnell, Mark R. Cookson, Josephine M. Egan, Sophia Frangou, Mark P. Mattson
No Abstract
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A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation Cell Metab. (IF 27.7) Pub Date : 2024-07-09 Lynn Bonetti, Veronika Horkova, Melanie Grusdat, Joseph Longworth, Luana Guerra, Henry Kurniawan, Davide G. Franchina, Leticia Soriano-Baguet, Carole Binsfeld, Charlène Verschueren, Sabine Spath, Anouk Ewen, Eric Koncina, Jean-Jacques Gérardy, Takumi Kobayashi, Catherine Dostert, Sophie Farinelle, Janika Härm, Yu-Tong Fan, Ying Chen, Isaac S. Harris, Philipp A. Lang, Vasilis Vasiliou, Ari Waisman,
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TNF compromises intestinal bile-acid tolerance dictating colitis progression and limited infliximab response Cell Metab. (IF 27.7) Pub Date : 2024-07-05 Mengqi Zheng, Yunjiao Zhai, Yanbo Yu, Jing Shen, Shuzheng Chu, Enrico Focaccia, Wenyu Tian, Sui Wang, Xuesong Liu, Xi Yuan, Yue Wang, Lixiang Li, Bingcheng Feng, Zhen Li, Xiaohuan Guo, Ju Qiu, Cuijuan Zhang, Jiajie Hou, Yiyuan Sun, Xiaoyun Yang, Shiyang Li
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Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease Cell Metab. (IF 27.7) Pub Date : 2024-07-02 Jelena Kolic, WenQing Grace Sun, Haoning Howard Cen, Jessica D. Ewald, Jason C. Rogalski, Shugo Sasaki, Han Sun, Varsha Rajesh, Yi Han Xia, Renata Moravcova, Søs Skovsø, Aliya F. Spigelman, Jocelyn E. Manning Fox, James Lyon, Leanne Beet, Jianguo Xia, Francis C. Lynn, Anna L. Gloyn, Leonard J. Foster, Patrick E. MacDonald, James D. Johnson
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Biological and genetic determinants of glycolysis: Phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes Cell Metab. (IF 27.7) Pub Date : 2024-07-03 Travis Nemkov, Daniel Stephenson, Eric J. Earley, Gregory R. Keele, Ariel Hay, Alicia Key, Zachary B. Haiman, Christopher Erickson, Monika Dzieciatkowska, Julie A. Reisz, Amy Moore, Mars Stone, Xutao Deng, Steven Kleinman, Steven L. Spitalnik, Eldad A. Hod, Krystalyn E. Hudson, Kirk C. Hansen, Bernhard O. Palsson, Gary A. Churchill, Angelo D’Alessandro
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From whence it came: Mitochondrial mRNA leaves, a protein returns Cell Metab. (IF 27.7) Pub Date : 2024-07-02 Kevin A. Janssen, Angela Song
Small peptides have previously been reported to be encoded in mitochondrial rRNA and translated by cytosolic ribosomes. In this issue of Cell Metabolism, Hu et al. use mass spectrometry to identify a cytosolically translated protein, encoded instead in mitochondrial mRNA, that is surprisingly targeted back into the mitochondrial matrix.
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Fit for purpose: Selecting the best mitochondrial DNA for the job Cell Metab. (IF 27.7) Pub Date : 2024-07-02 Sarah J. Pickett, Robert W. Taylor, Robert McFarland
The factors determining levels of pathogenic mitochondrial DNA in cells and tissues are critical to disease pathology but remain poorly understood and contentious. In Nature, Kotrys et al. published a single-cell-based analysis casting fresh light on this thorny problem and introduced a powerful new investigative tool.
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Human cardiac metabolism Cell Metab. (IF 27.7) Pub Date : 2024-07-02 Marc R. Bornstein, Rong Tian, Zoltan Arany
The heart is the most metabolically active organ in the human body, and cardiac metabolism has been studied for decades. However, the bulk of studies have focused on animal models. The objective of this review is to summarize specifically what is known about cardiac metabolism in humans. Techniques available to study human cardiac metabolism are first discussed, followed by a review of human cardiac
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Thermal facial image analyses reveal quantitative hallmarks of aging and metabolic diseases Cell Metab. (IF 27.7) Pub Date : 2024-07-02 Zhengqing Yu, Yong Zhou, Kehang Mao, Bo Pang, Kai Wang, Tang Jin, Haonan Zheng, Haotian Zhai, Yiyang Wang, Xiaohan Xu, Hongxiao Liu, Yi Wang, Jing-Dong J. Han
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Association of genetic risk, lifestyle, and their interaction with obesity and obesity-related morbidities Cell Metab. (IF 27.7) Pub Date : 2024-07-02 Min Seo Kim, Injeong Shim, Akl C. Fahed, Ron Do, Woong-Yang Park, Pradeep Natarajan, Amit V. Khera, Hong-Hee Won
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The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening Cell Metab. (IF 27.7) Pub Date : 2024-07-02 Ralph Patrick, Marina Naval-Sanchez, Nikita Deshpande, Yifei Huang, Jingyu Zhang, Xiaoli Chen, Ying Yang, Kanupriya Tiwari, Mohammadhossein Esmaeili, Minh Tran, Amin R. Mohamed, Binxu Wang, Di Xia, Jun Ma, Jacqueline Bayliss, Kahlia Wong, Michael L. Hun, Xuan Sun, Benjamin Cao, Denny L. Cottle, Tara Catterall, Hila Barzilai-Tutsch, Robin-Lee Troskie, Zhian Chen, Andrea F. Wise, Sheetal Saini, Ye Mon
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Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor Cell Metab. (IF 27.7) Pub Date : 2024-06-29 Ajit Regmi, Eitaro Aihara, Michael E. Christe, Gabor Varga, Thomas P. Beyer, Xiaoping Ruan, Emily Beebe, Libbey S. O’Farrell, Melissa A. Bellinger, Aaron K. Austin, Yanzhu Lin, Haitao Hu, Debra L. Konkol, Samantha Wojnicki, Adrienne K. Holland, Jessica L. Friedrich, Robert A. Brown, Amanda S. Estelle, Hannah S. Badger, Gabriel S. Gaidosh, William Roell
No Abstract
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Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation Cell Metab. (IF 27.7) Pub Date : 2024-06-20 Jian Zhou, Lifang Zhang, Jianhua Peng, Xianhui Zhang, Fan Zhang, Yuanyuan Wu, An Huang, Fengling Du, Yuyan Liao, Yijing He, Yuke Xie, Long Gu, Chenghao Kuang, Wei Ou, Maodi Xie, Tianqi Tu, Jinwei Pang, Dingkun Zhang, Kecheng Guo, Yue Feng, Yong Jiang
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PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer Cell Metab. (IF 27.7) Pub Date : 2024-06-19 Min Zhu, Yunguan Wang, Tianshi Lu, Jason Guo, Lin Li, Meng-Hsiung Hsieh, Purva Gopal, Yi Han, Naoto Fujiwara, Darren P. Wallace, Alan S.L. Yu, Xiangyi Fang, Crystal Ransom, Sara Verschleisser, David Hsiehchen, Yujin Hoshida, Amit G. Singal, Adam Yopp, Tao Wang, Hao Zhu
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Brain responses to intermittent fasting and the healthy living diet in older adults Cell Metab. (IF 27.7) Pub Date : 2024-06-19 Dimitrios Kapogiannis, Apostolos Manolopoulos, Roger Mullins, Konstantinos Avgerinos, Francheska Delgado-Peraza, Maja Mustapic, Carlos Nogueras-Ortiz, Pamela J. Yao, Krishna A. Pucha, Janet Brooks, Qinghua Chen, Shalaila S. Haas, Ruiyang Ge, Lisa M. Hartnell, Mark R. Cookson, Josephine M. Egan, Sophia Frangou, Mark P. Mattson
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Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer Cell Metab. (IF 27.7) Pub Date : 2024-06-18 Yu Jiang, Yawen Wang, Guofeng Chen, Fei Sun, Qijing Wu, Qiong Huang, Dongqiang Zeng, Wenjun Qiu, Jiao Wang, Zhiqi Yao, Bishan Liang, Shaowei Li, Jianhua Wu, Na Huang, Yuanyuan Wang, Jingsong Chen, Xiaohui Zhai, Li Huang, Beibei Xu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Wangjun Liao, Min Shi
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Short-term cold exposure induces persistent epigenomic memory in brown fat Cell Metab. (IF 27.7) Pub Date : 2024-06-17 Shin-ichi Inoue, Matthew J. Emmett, Hee-Woong Lim, Mohit Midha, Hannah J. Richter, Isaac J. Celwyn, Rashid Mehmood, Maria Chondronikola, Samuel Klein, Amy K. Hauck, Mitchell A. Lazar
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Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor Cell Metab. (IF 27.7) Pub Date : 2024-06-14 Ajit Regmi, Eitaro Aihara, Michael E. Christe, Gabor Varga, Thomas P. Beyer, Xiaoping Ruan, Emily Beebe, Libbey S. O’Farrell, Melissa A. Bellinger, Aaron K. Austin, Yanzhu Lin, Haitao Hu, Debra L. Konkol, Samantha Wojnicki, Adrienne K. Holland, Jessica L. Friedrich, Robert A. Brown, Amanda S. Estelle, Hannah S. Badger, Gabriel S. Gaidosh, William Roell
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Myocardial infarction accelerates the progression of MASH by triggering immunoinflammatory response and induction of periostin Cell Metab. (IF 27.7) Pub Date : 2024-06-14 Wei Xie, Jing Gan, Xiaodong Zhou, Huiying Tian, Xingchao Pan, Wenyue Liu, Xiaokun Li, Jie Du, Aimin Xu, Minghua Zheng, Fan Wu, Yulin Li, Zhuofeng Lin
No Abstract
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Electron transport chain inhibition increases cellular dependence on purine transport and salvage Cell Metab. (IF 27.7) Pub Date : 2024-06-13 Zheng Wu, Divya Bezwada, Feng Cai, Robert C. Harris, Bookyung Ko, Varun Sondhi, Chunxiao Pan, Hieu S. Vu, Phong T. Nguyen, Brandon Faubert, Ling Cai, Hongli Chen, Misty Martin-Sandoval, Duyen Do, Wen Gu, Yuanyuan Zhang, Yuannyu Zhang, Bailey Brooks, Sherwin Kelekar, Lauren G. Zacharias, Ralph J. DeBerardinis
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Reactive oxygen species regulation by NCF1 governs ferroptosis susceptibility of Kupffer cells to MASH Cell Metab. (IF 27.7) Pub Date : 2024-06-07 Jing Zhang, Yu Wang, Meiyang Fan, Yanglong Guan, Wentao Zhang, Fumeng Huang, Zhengqiang Zhang, Xiaomeng Li, Bingyu Yuan, Wenbin Liu, Manman Geng, Xiaowei Li, Jing Xu, Congshan Jiang, Wenjuan Zhao, Feng Ye, Wenhua Zhu, Liesu Meng, Shemin Lu, Rikard Holmdahl
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Nuclear SMAD5 dances to a different tune in regulating insulin secretion Cell Metab. (IF 27.7) Pub Date : 2024-06-04 John Orlowski
In this issue of Cell Metabolism, Fang et al.1 report a novel pH-sensitive cellular signaling mechanism involving the transcription factor SMAD5 that regulates the vesicular secretion of insulin from pancreatic β cells in response to dietary challenges. Dysregulation of this pathway may contribute to metabolic disorders such as type 2 diabetes mellitus.