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Harnessing our lived experience for science communication Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-04-24 Adrian Liston
Adrian Liston, professor of pathology at the University of Cambridge, UK, has published several illustrated children’s books on the topic of vaccination and has developed a computer game called ‘VirusFighter’. Here, he shares his thoughts on how to become an effective science communicator.
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Weaker skin immunity in males due to androgen effects on ILC2s Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-04-24 Lucy Bird
Sex hormones in male mice negatively regulate type 2 innate lymphoid cells in the skin, impairing the induction and activation of dendritic cells and thereby contributing to differences in immunity in males and females.
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Engineering immune-evasive allogeneic cellular immunotherapies Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-04-24 Karen E. Martin, Quirin Hammer, Karlo Perica, Michel Sadelain, Karl-Johan Malmberg
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JAK-STAT signaling maintains homeostasis in T cells and macrophages Nat. Immunol. (IF 30.5) Pub Date : 2024-04-24 Nikolaus Fortelny, Matthias Farlik, Victoria Fife, Anna-Dorothea Gorki, Caroline Lassnig, Barbara Maurer, Katrin Meissl, Marlies Dolezal, Laura Boccuni, Aarathy Ravi Sundar Jose Geetha, Mojoyinola Joanna Akagha, Anzhelika Karjalainen, Stephen Shoebridge, Asma Farhat, Ulrike Mann, Rohit Jain, Shweta Tikoo, Nina Zila, Wolfgang Esser-Skala, Thomas Krausgruber, Katarzyna Sitnik, Thomas Penz, Anastasiya
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Cancer cell metabolism and antitumour immunity Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-04-22 Mara De Martino, Jeffrey C. Rathmell, Lorenzo Galluzzi, Claire Vanpouille-Box
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25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages Immunity (IF 32.4) Pub Date : 2024-04-18 Jun Xiao, Shuang Wang, Longlong Chen, Xinyu Ding, Yuanhao Dang, Mingshun Han, Yuxiao Zheng, Huan Shen, Sifan Wu, Mingchang Wang, Dan Yang, Na Li, Chen Dong, Miao Hu, Chen Su, Weiyun Li, Lijian Hui, Youqiong Ye, Huiru Tang, Bin Wei, Hongyan Wang
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Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages Immunity (IF 32.4) Pub Date : 2024-04-17 Jay K. Mandula, Rosa A. Sierra-Mondragon, Rachel V. Jimenez, Darwin Chang, Eslam Mohamed, Shiun Chang, Julio A. Vazquez-Martinez, Yu Cao, Carmen M. Anadon, Sae Bom Lee, Satyajit Das, Léo Rocha-Munguba, Vincent M. Pham, Roger Li, Ahmad A. Tarhini, Muhammad Furqan, William Dalton, Michelle Churchman, Carlos M. Moran-Segura, Jonathan Nguyen, Paulo C. Rodriguez
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c-MAF and BLIMP-1 inhibit pathobiont-induced colitis by common and distinct immune pathways Nat. Immunol. (IF 30.5) Pub Date : 2024-04-19
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Aged nasal epithelium is more prone to severe COVID-19 Nat. Immunol. (IF 30.5) Pub Date : 2024-04-19 Ivan Zanoni
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Coordination of transcription factors and SWI–SNF complexes regulates chromatin priming in developing T cells Nat. Immunol. (IF 30.5) Pub Date : 2024-04-19 Jingwen Liao, Diana C. Hargreaves
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Hepatocytes coordinate immune evasion in cancer via release of serum amyloid A proteins Nat. Immunol. (IF 30.5) Pub Date : 2024-04-19 Meredith L. Stone, Jesse Lee, Jae W. Lee, Heather Coho, Mito Tariveranmoshabad, Max M. Wattenberg, Hana Choi, Veronica M. Herrera, Yuqing Xue, Shaanti Choi-Bose, Sofia K. Zingone, Dhruv Patel, Kelly Markowitz, Devora Delman, Vinod P. Balachandran, Gregory L. Beatty
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Serine enrichment in tumors promotes regulatory T cell accumulation through sphinganine-mediated regulation of c-Fos Sci. Immunol (IF 24.8) Pub Date : 2024-04-19 Sicong Ma, Roger Sandhoff, Xiu Luo, Fuwei Shang, Qiaozhen Shi, Zhaolong Li, Jingxia Wu, Yanan Ming, Frank Schwarz, Alaa Madi, Nina Weisshaar, Alessa Mieg, Marvin Hering, Ferdinand Zettl, Xin Yan, Kerstin Mohr, Nora ten Bosch, Zhe Li, Gernot Poschet, Hans-Reimer Rodewald, Nina Papavasiliou, Xi Wang, Pu Gao, Guoliang Cui
CD4 + regulatory T (T reg ) cells accumulate in the tumor microenvironment (TME) and suppress the immune system. Whether and how metabolite availability in the TME influences T reg cell differentiation is not understood. Here, we measured 630 metabolites in the TME and found that serine and palmitic acid, substrates required for the synthesis of sphingolipids, were enriched. A serine-free diet or a
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TIM-3 + CD8 T cells with a terminally exhausted phenotype retain functional capacity in hematological malignancies Sci. Immunol (IF 24.8) Pub Date : 2024-04-19 Simone A. Minnie, Olivia G. Waltner, Ping Zhang, Shuichiro Takahashi, Nicole S. Nemychenkov, Kathleen S. Ensbey, Christine R. Schmidt, Samuel R. W. Legg, Melissa Comstock, Julie R. Boiko, Ethan Nelson, Shruti S. Bhise, Alec B. Wilkens, Motoko Koyama, Madhav V. Dhodapkar, Marta Chesi, Stanley R. Riddell, Damian J. Green, Andrew Spencer, Scott N. Furlan, Geoffrey R. Hill
Chronic antigen stimulation is thought to generate dysfunctional CD8 T cells. Here, we identify a CD8 T cell subset in the bone marrow tumor microenvironment that, despite an apparent terminally exhausted phenotype (T PHEX ), expressed granzymes, perforin, and IFN-γ. Concurrent gene expression and DNA accessibility revealed that genes encoding these functional proteins correlated with BATF expression
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Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis Sci. Immunol (IF 24.8) Pub Date : 2024-04-19 Pablo Canales-Herrerias, Mathieu Uzzan, Akihiro Seki, Rafael S. Czepielewski, Bram Verstockt, Alexandra E. Livanos, Fiona Raso, Alexandra Dunn, Daniel Dai, Andrew Wang, Zainab Al-taie, Jerome Martin, Thomas Laurent, Huaibin M. Ko, Minami Tokuyama, Michael Tankelevich, Hadar Meringer, Francesca Cossarini, Divya Jha, Azra Krek, John D. Paulsen, Matthew D. Taylor, Mohammad Zuber Nakadar, Joshua Wong,
Vedolizumab (VDZ) is a first-line treatment in ulcerative colitis (UC) that targets the α4β7- mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) axis. To determine the mechanisms of action of VDZ, we examined five distinct cohorts of patients with UC. A decrease in naïve B and T cells in the intestines and gut-homing (β7 + ) plasmablasts in circulation of VDZ-treated patients suggested
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Fat matters for natural killer cell activity Nat. Immunol. (IF 30.5) Pub Date : 2024-04-18 Pamela Wong, Todd A. Fehniger
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Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation Sci. Immunol (IF 24.8) Pub Date : 2024-04-12 Ioanna Tiniakou, Pei-Feng Hsu, Lorena S. Lopez-Zepeda, Görkem Garipler, Eduardo Esteva, Nicholas M. Adams, Geunhyo Jang, Chetna Soni, Colleen M. Lau, Fan Liu, Alireza Khodadadi-Jamayran, Tori C. Rodrick, Drew Jones, Aristotelis Tsirigos, Uwe Ohler, Mark T. Bedford, Stephen D. Nimer, Vesa Kaartinen, Esteban O. Mazzoni, Boris Reizis
The development of dendritic cells (DCs), including antigen-presenting conventional DCs (cDCs) and cytokine-producing plasmacytoid DCs (pDCs), is controlled by the growth factor Flt3 ligand (Flt3L) and its receptor Flt3. We genetically dissected Flt3L-driven DC differentiation using CRISPR-Cas9–based screening. Genome-wide screening identified multiple regulators of DC differentiation including subunits
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Neuronal TLR9 signalling crucial for memory formation Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-04-17 Alexandra Flemming
Memories are encoded by microcircuits of hippocampal neurons. These cells undergo energy-intensive molecular adaptations during learning that can result in transient DNA damage. Jovasevic et al. show that contextual fear conditioning in mice induces the formation of double-stranded DNA (dsDNA) breaks and gene signatures of inflammation in hippocampal CA1 excitatory neurons. These cells also upregulate
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Tumour cell consumption of taurine exhausts CD8+ T cells Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-04-17 Alexandra Flemming
The amino acid taurine is marketed as a nutritional supplement. Cao et al. now show that taurine can enhance the malignant behaviour of cancer cells, but also increase the survival and effector functions of CD8+ T cells. In mouse models of gastric cancer and melanoma, intratumoural injection of taurine promoted tumour growth in immunocompromised mice, but inhibited tumour growth in immunocompetent
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Bacterial serotonin induces Treg cells in neonates Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-04-17 Alexandra Flemming
The gut microbiota has a crucial role in immune development in early life. Sanidad et al. show that the mouse neonatal small intestine has a distinct microbiota compared with the adult small intestine and is enriched in neurotransmitters, including serotonin (5-HT). Both human and mouse neonates were found to have an increased abundance of 5-HT-producing bacteria in the small intestine. Gut bacteria
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PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape Nat. Immunol. (IF 30.5) Pub Date : 2024-04-17 Noah Gamble, Alexandra Bradu, Jason A. Caldwell, Joshua McKeever, Olubusayo Bolonduro, Ebru Ermis, Caroline Kaiser, YeEun Kim, Benjamin Parks, Sandy Klemm, William J. Greenleaf, Gerald R. Crabtree, Andrew S. Koh
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Blimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis Nat. Immunol. (IF 30.5) Pub Date : 2024-04-12 Marisol Alvarez-Martinez, Luke S. Cox, Claire F. Pearson, William J. Branchett, Probir Chakravarty, Xuemei Wu, Hubert Slawinski, Alaa Al-Dibouni, Vasileios A. Samelis, Leona Gabryšová, Simon L. Priestnall, Alejandro Suárez-Bonnet, Anna Mikolajczak, James Briscoe, Fiona Powrie, Anne O’Garra
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Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency Nat. Immunol. (IF 30.5) Pub Date : 2024-04-12 Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles Rauch, Shuichiro Nakabo, Hye Sun Kuehn, Mariël Swart, Yanli Wang, Nisa Ilgim Çelik, Anne Molitor, Vahid Ziaee, Nasim Movahedi, Mohammad Shahrooei, Nima Parvaneh, Nasrin Alipour-olyei, Raphael Carapito, Qin Xu, Silvia Preite, David B. Beck, Jae Jin Chae, Michele Nehrebecky, Amanda K. Ombrello, Patrycja
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Intraepithelial mast cells drive gasdermin C-mediated type 2 immunity Immunity (IF 32.4) Pub Date : 2024-04-12 Liu Yang, Huabin He, Xue-Kun Guo, Jiali Wang, Wenwen Wang, Da Li, Shaonan Liang, Feng Shao, Wanli Liu, Xiaoyu Hu
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Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction Immunity (IF 32.4) Pub Date : 2024-04-12 Shuai Liu, Yaqiang Cao, Kairong Cui, Gang Ren, Tingting Zhao, Xuezheng Wang, Danping Wei, Zuojia Chen, Rama Krishna Gurram, Chengyu Liu, Chuan Wu, Jinfang Zhu, Keji Zhao
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Resident tissue macrophages: Key coordinators of tissue homeostasis beyond immunity Sci. Immunol (IF 24.8) Pub Date : 2024-04-12 Jia Zhao, Ilya Andreev, Hernandez Moura Silva
Resident tissue macrophages (RTMs) encompass a highly diverse set of cells abundantly present in every tissue and organ. RTMs are recognized as central players in innate immune responses, and more recently their importance beyond host defense has started to be highlighted. Despite sharing a universal name and several canonical markers, RTMs perform remarkably specialized activities tailored to sustain
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Regulation of BCR-mediated Ca2+ mobilization by MIZ1-TMBIM4 safeguards IgG1+ GC B cell–positive selection Sci. Immunol (IF 24.8) Pub Date : 2024-04-05 Lingling Zhang, Amparo Toboso-Navasa, Arief Gunawan, Abdouramane Camara, Rinako Nakagawa, Katja Finsterbusch, Probir Chakravarty, Rebecca Newman, Yang Zhang, Martin Eilers, Andreas Wack, Pavel Tolar, Kai-Michael Toellner, Dinis Pedro Calado
The transition from immunoglobulin M (IgM) to affinity-matured IgG antibodies is vital for effective humoral immunity. This is facilitated by germinal centers (GCs) through affinity maturation and preferential maintenance of IgG+ B cells over IgM+ B cells. However, it is not known whether the positive selection of the different Ig isotypes within GCs is dependent on specific transcriptional mechanisms
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Rejuvenating an old immune system Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-04-09 Yvonne Bordon
Depletion of myeloid-biased haematopoietic stem cells can mitigate age-associated immune dysfunction.
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The enduring neutrophil–stroma dance of multiple myeloma Nat. Immunol. (IF 30.5) Pub Date : 2024-04-10 Daniela Cerezo-Wallis, Iván Ballesteros
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An IL-1β-driven neutrophil–stromal cell axis fosters a BAFF-rich protumor microenvironment in individuals with multiple myeloma Nat. Immunol. (IF 30.5) Pub Date : 2024-04-10 Madelon M. E. de Jong, Cathelijne Fokkema, Natalie Papazian, Ágnes Czeti, Marjolein K. Appelman, Michael Vermeulen, Teddie van Heusden, Remco M. Hoogenboezem, Gregory van Beek, Sabrin Tahri, Mathijs A. Sanders, Pieter C. van de Woestijne, Francesca Gay, Philippe Moreau, Maike Büttner-Herold, Heiko Bruns, Mark van Duin, Annemiek Broijl, Pieter Sonneveld, Tom Cupedo
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Immune dysregulation in long COVID Nat. Immunol. (IF 30.5) Pub Date : 2024-04-08 Laura Ceglarek, Onur Boyman
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Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease Nat. Immunol. (IF 30.5) Pub Date : 2024-04-08 Felicity Liew, Claudia Efstathiou, Sara Fontanella, Matthew Richardson, Ruth Saunders, Dawid Swieboda, Jasmin K. Sidhu, Stephanie Ascough, Shona C. Moore, Noura Mohamed, Jose Nunag, Clara King, Olivia C. Leavy, Omer Elneima, Hamish J. C. McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Victoria C. Harris, Linzy Houchen-Wolloff, Neil J. Greening, Nazir I. Lone, Matthew Thorpe, A. A. Roger Thompson
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Vaccine adjuvants: Tailoring innate recognition to send the right message Immunity (IF 32.4) Pub Date : 2024-04-09 Ed C. Lavelle, Craig P. McEntee
Adjuvants play pivotal roles in vaccine development, enhancing immunization efficacy through prolonged retention and sustained release of antigen, lymph node targeting, and regulation of dendritic cell activation. Adjuvant-induced activation of innate immunity is achieved via diverse mechanisms: for example, adjuvants can serve as direct ligands for pathogen recognition receptors or as inducers of
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Control of adaptive immunity by pattern recognition receptors Immunity (IF 32.4) Pub Date : 2024-04-09 Shaina L. Carroll, Chandrashekhar Pasare, Gregory M. Barton
One of the most significant conceptual advances in immunology in recent history is the recognition that signals from the innate immune system are required for induction of adaptive immune responses. Two breakthroughs were critical in establishing this paradigm: the identification of dendritic cells (DCs) as the cellular link between innate and adaptive immunity and the discovery of pattern recognition
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Stressed out neutrophils drive metastasis Immunity (IF 32.4) Pub Date : 2024-04-09 Federico Lupo, Seth B. Coffelt
Stress hormones can contribute to cancer progression, but how immune cells play a role in this process is unclear. In a recent study in Cancer Cell, He et al. showed that glucocorticoids potentiate metastasis by skewing neutrophils toward pro-tumorigenic functions.
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The NLR family of innate immune and cell death sensors Immunity (IF 32.4) Pub Date : 2024-04-09 Balamurugan Sundaram, Rebecca E. Tweedell, Sivakumar Prasanth Kumar, Thirumala-Devi Kanneganti
Nucleotide-binding oligomerization domain (NOD)-like receptors, also known as nucleotide-binding leucine-rich repeat receptors (NLRs), are a family of cytosolic pattern recognition receptors that detect a wide variety of pathogenic and sterile triggers. Activation of specific NLRs initiates pro- or anti-inflammatory signaling cascades and the formation of inflammasomes—multi-protein complexes that
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Depression: Monocytes on my mind Immunity (IF 32.4) Pub Date : 2024-04-09 Gisela Paola Lazzarino, David Engblom
Activation of the peripheral immune system contributes to stress-related neuropsychiatric symptoms. Recently in Nature, Cathomas et al. demonstrate that stress-induced social avoidance is mediated by monocyte-derived MMP8 that remodels the extracellular space of the nucleus accumbens.
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Innate immune activation in neurodegenerative diseases Immunity (IF 32.4) Pub Date : 2024-04-09 Sergio Castro-Gomez, Michael T. Heneka
Activation of the innate immune system following pattern recognition receptor binding has emerged as one of the major pathogenic mechanisms in neurodegenerative disease. Experimental, epidemiological, pathological, and genetic evidence underscores the meaning of innate immune activation during the prodromal as well as clinical phases of several neurodegenerative disorders including Alzheimer’s disease
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Gums make IL-23, no professionals needed Immunity (IF 32.4) Pub Date : 2024-04-09 Mandy J. McGeachy
IL-23 activates pathogenic Th17 cells to drive inflammatory disease at barrier surfaces. Kim et al. now identify oral epithelial cells as the critical producers of IL-23 in human and mouse periodontitis, linking microbial dysbiosis to non-hematopoietic regulation of IL-17-associated inflammation.
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Sensory neurons: An integrated component of innate immunity Immunity (IF 32.4) Pub Date : 2024-04-09 Liwen Deng, Jacob E. Gillis, Isaac M. Chiu, Daniel H. Kaplan
The sensory nervous system possesses the ability to integrate exogenous threats and endogenous signals to mediate downstream effector functions. Sensory neurons have been shown to activate or suppress host defense and immunity against pathogens, depending on the tissue and disease state. Through this lens, pro- and anti-inflammatory neuroimmune effector functions can be interpreted as evolutionary
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The conceptual foundations of innate immunity: Taking stock 30 years later Immunity (IF 32.4) Pub Date : 2024-04-09 Thomas Pradeu, Bart P.H.J. Thomma, Stephen E. Girardin, Bruno Lemaitre
While largely neglected over decades during which adaptive immunity captured most of the attention, innate immune mechanisms have now become central to our understanding of immunology. Innate immunity provides the first barrier to infection in vertebrates, and it is the sole mechanism of host defense in invertebrates and plants. Innate immunity also plays a critical role in maintaining homeostasis
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Hostile bile limits anti-cancer immunity Immunity (IF 32.4) Pub Date : 2024-04-09 Pavitha Parathan, Lisa A. Mielke
Various microbial metabolites promote cell transformation. In this issue of Immunity, Cong et al. show that deoxycholic acid (DCA), a microbial metabolite of bile, promotes tumor growth by suppressing antitumor CD8+ T cell responses via dysregulation of calcium efflux.
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Myeloid C-type lectin receptors in innate immune recognition Immunity (IF 32.4) Pub Date : 2024-04-09 Caetano Reis e Sousa, Sho Yamasaki, Gordon D. Brown
C-type lectin receptors (CLRs) expressed by myeloid cells constitute a versatile family of receptors that play a key role in innate immune recognition. Myeloid CLRs exhibit a remarkable ability to recognize an extensive array of ligands, from carbohydrates and beyond, and encompass pattern-associated molecular patterns (PAMPs), damage-associated molecular patterns (DAMPs), and markers of altered self
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Decoding Toll-like receptors: Recent insights and perspectives in innate immunity Immunity (IF 32.4) Pub Date : 2024-04-09 Taro Kawai, Moe Ikegawa, Daisuke Ori, Shizuo Akira
Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune system and are the first line of host defense against microbial pathogens by recognizing pathogen-associated molecular patterns (PAMPs). TLRs, categorized into cell surface and endosomal subfamilies, recognize diverse PAMPs, and structural elucidation of TLRs and PAMP complexes has revealed their intricate mechanisms
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Physiological functions of RIG-I-like receptors Immunity (IF 32.4) Pub Date : 2024-04-09 Mitsutoshi Yoneyama, Hiroki Kato, Takashi Fujita
RIG-I-like receptors (RLRs) are crucial for pathogen detection and triggering immune responses and have immense physiological importance. In this review, we first summarize the interferon system and innate immunity, which constitute primary and secondary responses. Next, the molecular structure of RLRs and the mechanism of sensing non-self RNA are described. Usually, self RNA is refractory to the RLR;
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DAMPs and DAMP-sensing receptors in inflammation and diseases Immunity (IF 32.4) Pub Date : 2024-04-09 Ming Ma, Wei Jiang, Rongbin Zhou
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules produced in cellular damage or stress, and they can activate the innate immune system. DAMPs contain multiple types of molecules, including nucleic acids, proteins, ions, glycans, and metabolites. Although these endogenous molecules do not trigger immune response under steady-state condition, they may undergo changes in distribution
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New frontiers in the cGAS-STING intracellular DNA-sensing pathway Immunity (IF 32.4) Pub Date : 2024-04-09 Steve Dvorkin, Stephanie Cambier, Hannah E. Volkman, Daniel B. Stetson
The cGAS-STING intracellular DNA-sensing pathway has emerged as a key element of innate antiviral immunity and a promising therapeutic target. The existence of an innate immune sensor that can be activated by any double-stranded DNA (dsDNA) of any origin raises fundamental questions about how cGAS is regulated and how it responds to “foreign” DNA while maintaining tolerance to ubiquitous self-DNA.
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MEF2C regulates NK cell effector functions through control of lipid metabolism Nat. Immunol. (IF 30.5) Pub Date : 2024-04-08 Joey H. Li, Adalia Zhou, Cassidy D. Lee, Siya N. Shah, Jeong Hyun Ji, Vignesh Senthilkumar, Eddie T. Padilla, Andréa B. Ball, Qinyan Feng, Christian G. Bustillos, Luke Riggan, Alain Greige, Ajit S. Divakaruni, Fran Annese, Jessica Cooley-Coleman, Steven A. Skinner, Christopher W. Cowan, Timothy E. O’Sullivan
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TCF1–LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases Nat. Immunol. (IF 30.5) Pub Date : 2024-04-08 Radomir Kratchmarov, Sarah Djeddi, Garrett Dunlap, Wenqin He, Xiaojiong Jia, Caitlin M. Burk, Tessa Ryan, Alanna McGill, Jessica R. Allegretti, Raghu P. Kataru, Babak J. Mehrara, Erin M. Taylor, Shailesh Agarwal, Neil Bhattacharyya, Regan W. Bergmark, Alice Z. Maxfield, Stella Lee, Rachel Roditi, Daniel F. Dwyer, Joshua A. Boyce, Kathleen M. Buchheit, Tanya M. Laidlaw, Wayne G. Shreffler, Deepak A
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Type I interferons induce an epigenetically distinct memory B cell subset in chronic viral infection Immunity (IF 32.4) Pub Date : 2024-04-08 Lucy Cooper, Hui Xu, Jack Polmear, Liam Kealy, Christopher Szeto, Ee Shan Pang, Mansi Gupta, Alana Kirn, Justin J. Taylor, Katherine J.L. Jackson, Benjamin J. Broomfield, Angela Nguyen, Catarina Gago da Graça, Nicole La Gruta, Daniel T. Utzschneider, Joanna R. Groom, Luciano Martelotto, Ian A. Parish, Meredith O’Keeffe, Christopher D. Scharer, Kim L. Good-Jacobson
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AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans Sci. Immunol (IF 24.8) Pub Date : 2024-04-05 Lilit Grigoryan, Yupeng Feng, Lorenza Bellusci, Lilin Lai, Bushra Wali, Madison Ellis, Meng Yuan, Prabhu S. Arunachalam, Mengyun Hu, Sangeeta Kowli, Sheena Gupta, Sofia Maysel-Auslender, Holden T. Maecker, Hady Samaha, Nadine Rouphael, Ian A. Wilson, Alberto C. Moreno, Mehul S. Suthar, Surender Khurana, Stéphane Pillet, Nathalie Charland, Brian J. Ward, Bali Pulendran
Vaccine adjuvants increase the breadth of serum antibody responses, but whether this is due to the generation of antigen-specific B cell clones with distinct specificities or the maturation of memory B cell clones that produce broadly cross-reactive antibodies is unknown. Here, we longitudinally analyzed immune responses in healthy adults after two-dose vaccination with either a virus-like particle
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Destressing microglia Nat. Immunol. (IF 30.5) Pub Date : 2024-04-02 Stephanie Houston
Na+/K+-ATPase (NKA) is a transmembrane protein that maintains neuronal resting membrane potential and has recently been shown to have a role in migraine, stroke and Parkinson’s disease. In Immunity, Huang et al. find that NKAα1 forms a complex with the P2X7R receptor, which regulates inflammasome activation in the microglia, and NKAα1 deficiency exacerbates neuronal excitability and anxiety-like behavior
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Tissue-specific nonheritable influences drive endometrial immune system variation Sci. Immunol (IF 24.8) Pub Date : 2024-04-05 Jonna Bister, Iva Filipovic, Dan Sun, Ylva Crona-Guterstam, Martin Cornillet, Andrea Ponzetta, Jakob Michaëlsson, Sebastian Gidlöf, Martin A. Ivarsson, Benedikt Strunz, Niklas K. Björkström
Although human twin studies have revealed the combined contribution of heritable and environmental factors in shaping immune system variability in blood, the contribution of these factors to immune system variability in tissues remains unexplored. The human uterus undergoes constant regeneration and is exposed to distinct environmental factors. To assess uterine immune system variation, we performed
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AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans Sci. Immunol (IF 24.8) Pub Date : 2024-04-05 Lilit Grigoryan, Yupeng Feng, Lorenza Bellusci, Lilin Lai, Bushra Wali, Madison Ellis, Meng Yuan, Prabhu S. Arunachalam, Mengyun Hu, Sangeeta Kowli, Sheena Gupta, Sofia Maysel-Auslender, Holden T. Maecker, Hady Samaha, Nadine Rouphael, Ian A. Wilson, Alberto C. Moreno, Mehul S. Suthar, Surender Khurana, Stéphane Pillet, Nathalie Charland, Brian J. Ward, Bali Pulendran
Vaccine adjuvants increase the breadth of serum antibody responses, but whether this is due to the generation of antigen-specific B cell clones with distinct specificities or the maturation of memory B cell clones that produce broadly cross-reactive antibodies is unknown. Here, we longitudinally analyzed immune responses in healthy adults after two-dose vaccination with either a virus-like particle
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Neutrophil subsets Nat. Immunol. (IF 30.5) Pub Date : 2024-04-02 Ioana Staicu
Tumor-associated neutrophils are thought to be immunosuppressive. In Cell, based on single-cell RNA sequencing of 17 cancer types (12 newly generated) from 143 patients, Wu et al. find that neutrophils exhibit diverse transcriptional profiles. Among the 10 states identified (S100A12+, HLA-DR+CD74+, VEGFA+SPP1+, TXNIP+, CXCL8+IL1B+, CXCR2+, IFIT1+ISG15+, MMP9+, NFKBIZ+HIF1A+ and ARG1+ neutrophils),
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Generating prophylactic immunity against arboviruses in vertebrates and invertebrates Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-04-03 Daniel J. Rawle, Leon E. Hugo, Abigail L. Cox, Gregor J. Devine, Andreas Suhrbier
The World Health Organization recently declared a global initiative to control arboviral diseases. These are mainly caused by pathogenic flaviviruses (such as dengue, yellow fever and Zika viruses) and alphaviruses (such as chikungunya and Venezuelan equine encephalitis viruses). Vaccines represent key interventions for these viruses, with licensed human and/or veterinary vaccines being available for
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Short-chain fatty acids: linking diet, the microbiome and immunity Nat. Rev. Immunol. (IF 100.3) Pub Date : 2024-04-02 Elizabeth R. Mann, Ying Ka Lam, Holm H. Uhlig
The short-chain fatty acids (SCFAs) butyrate, propionate and acetate are microbial metabolites and their availability in the gut and other organs is determined by environmental factors, such as diet and use of antibiotics, that shape the diversity and metabolism of the microbiota. SCFAs regulate epithelial barrier function as well as mucosal and systemic immunity via evolutionary conserved processes
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Facilitating broad antibody responses Nat. Immunol. (IF 30.5) Pub Date : 2024-04-02 Laurie A. Dempsey
A goal of immunization against highly mutable viruses is to elicit broadly neutralizing antibody responses. In Science, Sharma et al. report that the glycosphingolipid globotriaosylceramide (Gb3, also known as CD77) increases antibody affinity and diversity after immunization in a mouse model of influenza. Gb3 is highly expressed on germinal center B cells, where its abundance is regulated by α1,4-galactose
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Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders Nat. Immunol. (IF 30.5) Pub Date : 2024-04-02 Eunha Kim, Jun R. Huh, Gloria B. Choi
The intricate relationship between immune dysregulation and neurodevelopmental disorders (NDDs) has been observed across the stages of both prenatal and postnatal development. In this Review, we provide a comprehensive overview of various maternal immune conditions, ranging from infections to chronic inflammatory conditions, that impact the neurodevelopment of the fetus during pregnancy. Furthermore
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Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity Nat. Immunol. (IF 30.5) Pub Date : 2024-04-01 Megat H. B. A. Hamid, Pablo F. Cespedes, Chen Jin, Ji-Li Chen, Uzi Gileadi, Elie Antoun, Zhu Liang, Fei Gao, Renuka Teague, Nikita Manoharan, David Maldonado-Perez, Nasullah Khalid-Alham, Lucia Cerundolo, Raul Ciaoca, Svenja S. Hester, Adán Pinto-Fernández, Simeon D. Draganov, Iolanda Vendrell, Guihai Liu, Xuan Yao, Audun Kvalvaag, Delaney C. C. Dominey-Foy, Charunya Nanayakkara, Nikolaos Kanellakis
Cancer remains one of the leading causes of mortality worldwide, leading to increased interest in utilizing immunotherapy strategies for better cancer treatments. In the past decade, CD103+ T cells have been associated with better clinical prognosis in patients with cancer. However, the specific immune mechanisms contributing toward CD103-mediated protective immunity remain unclear. Here, we show an