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Challenges and strategies for addressing antibacterial drug resistance in LMICs Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-09-13 Ursula Theuretzbacher
Antibacterial drug resistance is a critical global health issue that affects countries across all economic levels, though it disproportionately affects populations in low- and middle-income countries. Infection and resistance rates vary considerably, necessitating tailored interventions to meet the specific demands of each area. This underscores the need for global solidarity and national accountability
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Achieving sustainable access to antibiotics is more than just a last mile challenge Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-09-13 Manica Balasegaram, Viviana Muñoz Tellez
Improving access to antibiotics will save lives and reduce the rise and spread of drug-resistant infections. Instead of traditional ‘last mile’ global health solutions, global leaders need to support efforts to develop suitable antibiotics and their rational use, ensuring that countries have the capacity to make them available.
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Stronger commitment and faster action against antimicrobial resistance Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-09-13
As the United Nations convenes its second High-Level Meeting on antimicrobial resistance, urgent global action is needed. This Focus issue draws attention to pressing challenges of bacterial antimicrobial resistance and underscores the need for fast and coordinated international efforts.
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No viral rebound Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-09-10 Andrea Du Toit
A new study reports sustained HIV remission in an individual who underwent allogeneic haematopoietic stem cell transplantation with cells from a donor with wild-type CCR5.
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Bacterial siderophores: diversity, uptake pathways and applications Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-09-05 Isabelle J. Schalk
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Rediscovering plasmid-dependent phages Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-09-09 Daniel Cazares, Wendy Figueroa, Adrian Cazares
This Genome Watch highlights how the revived interest in phages that target plasmid-carrying bacteria is expanding our knowledge of viral diversity, ecology and evolution, which is fundamental for developing safe biotherapeutics.
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Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-09-09 Morgan R. Timm, Seongmi K. Russell, Scott J. Hultgren
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Things go sour in C. rodentium infection Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-09-02 Andrea Du Toit
This study shows that Citrobacter rodentium alters its growth and virulence in response to varying intestinal pH, and, in turn, the host actively induces stomach acidification.
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Unveiling plasmid diversity in nature Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-08-28 Antonio Pedro Camargo
This Genome Watch highlights recent metagenomic surveys that have revealed the extensive prevalence and diversity of plasmids in the human gut microbiome and discusses the challenges in accurately reporting plasmid genomes identified from metagenomic data.
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Terrabacteria: redefining bacterial envelope diversity, biogenesis and evolution Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-08-28 Basile Beaud Benyahia, Najwa Taib, Christophe Beloin, Simonetta Gribaldo
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Author Correction: Respiratory syncytial virus infection and novel interventions. Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-09-01 Annefleur C Langedijk,Louis J Bont
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Testing fast with uRAST Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-08-20 Agustina Taglialegna
In this study, Kim, Kang, Jang et al. report a phenotype-based, ultra-rapid and blood culture-free antimicrobial susceptibility testing approach.
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From soil to battling antimicrobial resistance Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-08-20 Agustina Taglialegna
In this study, Li, Feng et al. identify an antimicrobial compound produced by plant root-associated Pseudomonas fluorescens with potent activity against drug-resistant, Gram-positive bacteria.
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Tagging for degradation — bacteria do it too Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-08-19 Francesca Ester Morreale
In this Journal Club, Francesca Ester Morreale revisits a paper reporting that arginine phosphorylation marks proteins for degradation in bacteria.
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Harnessing the plant microbiome for sustainable crop production Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-08-15 Stéphane Compant, Fabricio Cassan, Tanja Kostić, Linda Johnson, Günter Brader, Friederike Trognitz, Angela Sessitsch
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Targeting the spread of antimicrobial resistance plasmids Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-08-13 Ashley York
A recent study demonstrates targeting plasmid-encoded bacterial proteins containing immunoglobulin-like domains to prevent the conjugation and spread of antimicrobial resistance plasmids.
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Towards improved biofilm models Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-08-07 Kendra P. Rumbaugh, Marvin Whiteley
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Designer antibiotics Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-29 Andrea Du Toit
This study used structure-based drug design and modular synthesis to identify small molecules with antimicrobial activity.
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Highly pathogenic H5N1 avian influenza virus outbreak in cattle: the knowns and unknowns Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-25 Gabriele Neumann, Yoshihiro Kawaoka
Highly pathogenic avian influenza (HPAI) viruses have occasionally infected humans, often with severe outcomes. Reports of HPAI in dairy cattle and the detection of high titres of the virus in cattle milk in the United States are therefore a cause for concern. Documented human infections linked to cattle infections, though mild, highlight the urgent need for enhanced biosecurity and vigilant monitoring
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Leave no transcripts behind Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-24 Madelyn Moy, Cecilia Kyany’a, Mailis Maes
This Genome Watch highlights the advances made in bacterial single-cell RNA sequencing, specifically in the context of host–microorganism interaction studies.
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Healthcare as a driver, reservoir and amplifier of antimicrobial resistance: opportunities for interventions Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-24 Derek Cocker, Gabriel Birgand, Nina Zhu, Jesus Rodriguez-Manzano, Raheelah Ahmad, Kondwani Jambo, Anna S. Levin, Alison Holmes
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The oral–gut microbiome axis in health and disease Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-22 Benoit J. Kunath, Charlotte De Rudder, Cedric C. Laczny, Elisabeth Letellier, Paul Wilmes
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The indoors microbiome and human health Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-19 Jack A. Gilbert, Erica M. Hartmann
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Malaria vaccines: a new era of prevention and control Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-18 Patrick E. Duffy, J. Patrick Gorres, Sara A. Healy, Michal Fried
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Tearing CRISPR apart Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-17 Andrea Du Toit
This study shows that the anti-CRISPR protein AcrIF25 inhibits the type I-F CRISPR–Cas system by pulling apart the fully assembled Csy complex.
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Indirect intervention Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-16 Andrea Du Toit
This study shows that accounting for spillover effects increased the cost-effectiveness of combined malaria-elimination interventions.
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Cross-kingdom nutrient exchange in the plant–arbuscular mycorrhizal fungus–bacterium continuum Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-16 Shilong Duan, Gu Feng, Erik Limpens, Paola Bonfante, Xianan Xie, Lin Zhang
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The interplay between diet and the gut microbiome: implications for health and disease Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-15 Fiona C. Ross, Dhrati Patangia, Ghjuvan Grimaud, Aonghus Lavelle, Eugene M. Dempsey, R. Paul Ross, Catherine Stanton
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Busting Cryptococcus with brilacidin Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-08 Agustina Taglialegna
In this study, Diehl et al. report that brilacidin could be a promising antifungal drug against Cryptococcus neoformans.
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Getting wound closure with Alcaligenes Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-08 Agustina Taglialegna
In this study, White et al. report that Alcaligenes faecalis mediates wound repair in diabetic foot ulcers.
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New WHO proposed terminology for respiratory pathogen transmission Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-03 Nancy H. L. Leung, Donald K. Milton
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Author Correction: Conservation and similarity of bacterial and eukaryotic innate immunity. Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-07-01 Hannah E Ledvina,Aaron T Whiteley
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Bacterial barcoding facilitates plant microbiome studies Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-26 Hualan Liu
This month’s Genome Watch highlights the use of genetic barcoding towards a better understanding of plant–microorganism interactions and colonization dynamics.
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The pathobiology of human fungal infections Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-25 Gordon D. Brown, Elizabeth R. Ballou, Steven Bates, Elaine M. Bignell, Andrew M. Borman, Alexandra C. Brand, Alistair J. P. Brown, Carolina Coelho, Peter C. Cook, Rhys A. Farrer, Nelesh P. Govender, Neil A. R. Gow, William Hope, J. Claire Hoving, Rachael Dangarembizi, Thomas S. Harrison, Elizabeth M. Johnson, Liliane Mukaremera, Mark Ramsdale, Christopher R. Thornton, Jane Usher, Adilia Warris, Duncan
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Pertussis vaccines, epidemiology and evolution Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-21 Matthieu Domenech de Cellès, Pejman Rohani
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Bacteria curb emissions in farmland Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-20 Agustina Taglialegna
In this study, Hiis et al. demonstrate that the N2O-respiring bacterial strain Cloacibacterium sp. CB-01 can reduce nitrous oxide emissions from soil.
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Gassy archaea Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-18 Andrea Du Toit
This study shows that archaea produce catalytically active ultraminimal as well as hybrid [FeFe] hydrogenases.
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Enterococcus faecium: evolution, adaptation, pathogenesis and emerging therapeutics Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-18 Yahan Wei, Dennise Palacios Araya, Kelli L. Palmer
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A virus hastens ageing in flies Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-14 Agustina Taglialegna
In this study, Niggs et al. show that Drosophila A virus infection modulates epithelial turnover in the intestine of Drosophila melanogaster, promoting premature intestinal dysplasia and reducing fly lifespan.
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Supra-structures to target lipid II Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-11 Andrea Du Toit
This study reports that plectasin uses a supramolecular antimicrobial mode of action, whereby the oligomerized peptide sequesters lipid II.
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ESKAPE pathogens: antimicrobial resistance, epidemiology, clinical impact and therapeutics Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-06-03 William R. Miller, Cesar A. Arias
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Co‐evolution of early Earth environments and microbial life Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-29 Timothy W. Lyons, Christopher J. Tino, Gregory P. Fournier, Rika E. Anderson, William D. Leavitt, Kurt O. Konhauser, Eva E. Stüeken
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Foodborne bacterial pathogens: genome-based approaches for enduring and emerging threats in a complex and changing world Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-24 Alison E. Mather, Matthew W. Gilmour, Stuart W. J. Reid, Nigel P. French
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The gut–airway microbiome axis in health and respiratory diseases Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-22 Mustafa Özçam, Susan V. Lynch
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Defending against plasmids Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-21 Andrea Du Toit
This study reports the mechanism of plasmid clearance by the DNA defence module DdmDE of the Vibrio cholerae seventh pandemic strain.
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Fat, Desulfovibrio and cancer Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-20 Agustina Taglialegna
This study by Chen et al. reveals that a high-fat diet leads to a predominance of Desulfovibrio species in the gut, correlating with a poor prognosis of breast cancer.
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Discovering molecular paradigms of microbial carcinogenesis Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-20 Carrie L. Shaffer
In this Journal Club, Carrie Shaffer discusses a study revealing that infection with CagA-positive Helicobacter pylori strains is associated with an increased risk of developing stomach adenocarcinoma.
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Breaking through the concept barrier to develop broad-spectrum antiviral counter-measures Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-20 Yi Shi
In this Journal Club, Yi Shi discusses a paper reporting that influenza virus infection in humans induces broadly cross-reactive and protective antibodies against the viral neuraminidase.
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Tracking pathogen evolution through climate change Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-16 Lia Bote, Mailis Maes
This Genome Watch article discusses the application of sequencing methods for monitoring the rise of infectious diseases associated with climate change.
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Viruses on the move Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-15 Andrea Du Toit
This study shows how two umbravirus-like viruses induce systemic infection in the plant host in the absence of virus-encoded movement proteins.
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A mosquito symbiont controls flaviviruses Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-10 Agustina Taglialegna
In this study, Zhang et al. report that a bacterial symbiont residing in the gut of Aedes albopictus mosquitoes protects them from flavivirus infection.
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Bacteriocin diversity, function, discovery and application as antimicrobials Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-05-10 Ivan Sugrue, R. Paul Ross, Colin Hill
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Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-30 Matthew J. Shepherd, Taoran Fu, Niamh E. Harrington, Anastasia Kottara, Kendall Cagney, James D. Chalmers, Steve Paterson, Joanne L. Fothergill, Michael A. Brockhurst
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Mycetocola to the rescue Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-24 Agustina Taglialegna
In this study, Carrasco Flores et al. report that the bacterium Mycetocola lacteus protects the microalga Chlamydomonas reinhardtii from the antagonistic activity of Pseudomonas protegens.
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Nitroplast organelle unveiled Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-24 Ashley York
A recent study reports the existence of a nitrogen-fixing organelle called the ‘nitroplast’.
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The complex life of the HIV-1 full-length RNA Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-24 Ricardo Soto-Rifo
In this Journal Club, Ricardo Soto-Rifo discusses a study on intron-containing HIV-1 RNA, revealing its role as a pathogen-associated molecular pattern in myeloid cells, which has implications for immune activation, inflammation and clinical outcomes.
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Phages get snappy Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-22 Andrea Du Toit
This study shows that a single-stranded RNA phage binds to the Pseudomonas aeruginosa type IV pilus, leading to phage entry into the cell and the detachment of the pilus, which impairs bacterial motility.
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Shaking up that sick feeling with biofilm sugars Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-18 Agustina Taglialegna
In this study, Granton et al. show that biofilm-associated exopolysaccharides produced by Pseudomonas aeruginosa control sickness during lung infection.
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COVID-19 drug discovery and treatment options Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-15 Jasper Fuk-Woo Chan, Shuofeng Yuan, Hin Chu, Siddharth Sridhar, Kwok-Yung Yuen
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Microbial adaptability in changing environments Nat. Rev. Microbiol. (IF 69.2) Pub Date : 2024-04-12 Sharon Greenblum
This Genome Watch article highlights the recent use of large-scale monitoring of natural microbiomes to examine feedback between environmental change and microbial adaptation.