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Tonic-ing emissions and compatibility to turbocharge CAR-T Nat. Metab. (IF 20.8) Pub Date : 2024-04-24 Haopeng Wang, Yuwei Huang, Ruoning Wang
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Extracellular domains of CARs reprogramme T cell metabolism without antigen stimulation Nat. Metab. (IF 20.8) Pub Date : 2024-04-24 Aliya Lakhani, Ximin Chen, Laurence C. Chen, Mihe Hong, Mobina Khericha, Yu Chen, Yvonne Y. Chen, Junyoung O. Park
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NCOR1/2 and glucocorticoid receptor orchestrate hepatic function Nat. Metab. (IF 20.8) Pub Date : 2024-04-15 Chloé Van Leene, Karolien De Bosscher
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Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis Nat. Metab. (IF 20.8) Pub Date : 2024-04-15 Amy K. Hauck, Rashid Mehmood, Bryce J. Carpenter, Maxwell T. Frankfurter, Michael C. Tackenberg, Shin-ichi Inoue, Maria K. Krieg, Fathima N. Cassim Bawa, Mohit K. Midha, Delaine M. Zundell, Kirill Batmanov, Mitchell A. Lazar
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Co-evolved genes improve the biosynthesis of secondary metabolites Nat. Metab. (IF 20.8) Pub Date : 2024-04-12
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Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis Nat. Metab. (IF 20.8) Pub Date : 2024-04-12 Xinran Wang, Ningxin Chen, Pablo Cruz-Morales, Biming Zhong, Yangming Zhang, Jian Wang, Yifan Xiao, Xinnan Fu, Yang Lin, Suneil Acharya, Zhibo Li, Huaxiang Deng, Yuhui Sun, Linquan Bai, Xiaoyu Tang, Jay D. Keasling, Xiaozhou Luo
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Macrophage vesicles in antidiabetic drug action Nat. Metab. (IF 20.8) Pub Date : 2024-04-11 Rinke Stienstra, Eric Kalkhoven
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A call for accessible tools to unlock single-cell immunometabolism research Nat. Metab. (IF 20.8) Pub Date : 2024-04-11 Jason Cosgrove, Antoine Marçais, Felix J. Hartmann, Andreas Bergthaler, Ivan Zanoni, Mauro Corrado, Leïla Perié, Nina Cabezas-Wallscheid, Philippe Bousso, Theodore Alexandrov, Tammy Kielian, Nuria Martínez-Martín, Christiane A. Opitz, Costas A. Lyssiotis, Rafael J. Argüello, Jan Van den Bossche
Recent technological advances permit the profiling of metabolic changes in single cells, which sheds light on how metabolism regulates immune responses. We advocate for accessible and standardized tools to reduce the barrier of entry to immunometabolism studies and facilitate the translation of fundamental findings towards clinical applications.
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Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization Nat. Metab. (IF 20.8) Pub Date : 2024-04-11 Theresa V. Rohm, Felipe Castellani Gomes Dos Reis, Roi Isaac, Cairo Murphy, Karina Cunha e Rocha, Gautam Bandyopadhyay, Hong Gao, Avraham M. Libster, Rizaldy C. Zapata, Yun Sok Lee, Wei Ying, Charlene Miciano, Allen Wang, Jerrold M. Olefsky
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Postprandial sodium sensing by enteric neurons in Drosophila Nat. Metab. (IF 20.8) Pub Date : 2024-04-03 Byoungsoo Kim, Gayoung Hwang, Sung-Eun Yoon, Meihua Christina Kuang, Jing W. Wang, Young-Joon Kim, Greg S. B. Suh
Sodium is essential for all living organisms1. Animals including insects and mammals detect sodium primarily through peripheral taste cells2,3,4,5,6,7. It is not known, however, whether animals can detect this essential micronutrient independently of the taste system. Here, we report that Drosophila Ir76b mutants that were unable to detect sodium2 became capable of responding to sodium following a
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A spatiotemporal proteomic map of human adipogenesis Nat. Metab. (IF 20.8) Pub Date : 2024-04-02 Felix Klingelhuber, Scott Frendo-Cumbo, Muhmmad Omar-Hmeadi, Lucas Massier, Pamela Kakimoto, Austin J. Taylor, Morgane Couchet, Sara Ribicic, Martin Wabitsch, Ana C. Messias, Arcangela Iuso, Timo D. Müller, Mikael Rydén, Niklas Mejhert, Natalie Krahmer
White adipocytes function as major energy reservoirs in humans by storing substantial amounts of triglycerides, and their dysfunction is associated with metabolic disorders; however, the mechanisms underlying cellular specialization during adipogenesis remain unknown. Here, we generate a spatiotemporal proteomic atlas of human adipogenesis, which elucidates cellular remodelling as well as the spatial
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Maternal rhythms suppress neonatal inflammation Nat. Metab. (IF 20.8) Pub Date : 2024-04-01 Xia Li, Markus Sperandio, Christoph Scheiermann
Maternal circadian rhythms influence the health of infants. Cui, Xu and colleagues find that disruption of maternal rhythms impairs neonatal immune cell function and aggravates neonatal inflammatory disorders, which can be rescued by the administration of docosahexaenoic acid (a metabolite found in breast milk).
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Maternal circadian rhythm disruption affects neonatal inflammation via metabolic reprograming of myeloid cells Nat. Metab. (IF 20.8) Pub Date : 2024-04-01 Zhaohai Cui, Haixu Xu, Fan Wu, Jiale Chen, Lin Zhu, Zhuxia Shen, Xianfu Yi, Jinhao Yang, Chunhong Jia, Lijuan Zhang, Pan Zhou, Mulin Jun Li, Lu Zhu, Shengzhong Duan, Zhi Yao, Ying Yu, Qiang Liu, Jie Zhou
Disruption of circadian rhythm during pregnancy produces adverse health outcomes in offspring; however, the role of maternal circadian rhythms in the immune system of infants and their susceptibility to inflammation remains poorly understood. Here we show that disruption of circadian rhythms in pregnant mice profoundly aggravates the severity of neonatal inflammatory disorders in both male and female
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Non-invasive measurements of blood glucose levels by time-gating mid-infrared optoacoustic signals Nat. Metab. (IF 20.8) Pub Date : 2024-03-27 Nasire Uluç, Sarah Glasl, Francesca Gasparin, Tao Yuan, Hailong He, Dominik Jüstel, Miguel A. Pleitez, Vasilis Ntziachristos
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Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities Nat. Metab. (IF 20.8) Pub Date : 2024-03-26 Chad Stroope, Felix Sebastian Nettersheim, Brian Coon, Alexandra C. Finney, Martin A. Schwartz, Klaus Ley, Oren Rom, Arif Yurdagul
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Blood glucose concentration measurement without finger pricking Nat. Metab. (IF 20.8) Pub Date : 2024-03-27
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Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia Nat. Metab. (IF 20.8) Pub Date : 2024-03-19 Mathieu Membrez, Eugenia Migliavacca, Stefan Christen, Keisuke Yaku, Jennifer Trieu, Alaina K. Lee, Francesco Morandini, Maria Pilar Giner, Jade Stiner, Mikhail V. Makarov, Emma S. Garratt, Maria F. Vasiloglou, Lucie Chanvillard, Emilie Dalbram, Amy M. Ehrlich, José Luis Sanchez-Garcia, Carles Canto, Leonidas G. Karagounis, Jonas T. Treebak, Marie E. Migaud, Ramin Heshmat, Farideh Razi, Neerja Karnani
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AMPK and insulin control the switch between mitochondrial hitchhiking of Pink1 mRNA and mitophagy in neurons Nat. Metab. (IF 20.8) Pub Date : 2024-03-19
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How to let your data shine Nat. Metab. (IF 20.8) Pub Date : 2024-03-19
When preparing your manuscript, clear presentation of the data and concise writing are key. In this Editorial, we offer tips on how to better communicate your results.
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Insulin signalling regulates Pink1 mRNA localization via modulation of AMPK activity to support PINK1 function in neurons Nat. Metab. (IF 20.8) Pub Date : 2024-03-19 J. Tabitha Hees, Simone Wanderoy, Jana Lindner, Marlena Helms, Hariharan Murali Mahadevan, Angelika B. Harbauer
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A waste product’s unexpected role in wasting Nat. Metab. (IF 20.8) Pub Date : 2024-03-18 Jack D. Sanford, Marcus D. Goncalves
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Activation of GPR81 by lactate drives tumour-induced cachexia Nat. Metab. (IF 20.8) Pub Date : 2024-03-18 Xidan Liu, Shijin Li, Qionghua Cui, Bujing Guo, Wanqiu Ding, Jie Liu, Li Quan, Xiaochuan Li, Peng Xie, Li Jin, Ye Sheng, Wenxin Chen, Kai Wang, Fanxin Zeng, Yifu Qiu, Changlu Liu, Yan Zhang, Fengxiang Lv, Xinli Hu, Rui-Ping Xiao
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Metformin induces a Lac-Phe gut–brain signalling axis Nat. Metab. (IF 20.8) Pub Date : 2024-03-18 Tara TeSlaa
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Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans Nat. Metab. (IF 20.8) Pub Date : 2024-03-18 Barry Scott, Emily A. Day, Katie L. O’Brien, John Scanlan, Grace Cromwell, Aine Ni Scannail, Marie E. McDonnell, David K. Finlay, Lydia Lynch
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Lac-Phe mediates the effects of metformin on food intake and body weight Nat. Metab. (IF 20.8) Pub Date : 2024-03-18 Shuke Xiao, Veronica L. Li, Xuchao Lyu, Xudong Chen, Wei Wei, Fahim Abbasi, Joshua W. Knowles, Alan Sheng-Hwa Tung, Shuliang Deng, Gaurav Tiwari, Xu Shi, Shuning Zheng, Laurie Farrell, Zsu-Zsu Chen, Kent D. Taylor, Xiuqing Guo, Mark O. Goodarzi, Alexis C. Wood, Yii-Der Ida Chen, Leslie A. Lange, Stephen S. Rich, Jerome I. Rotter, Clary B. Clish, Usman A. Tahir, Robert E. Gerszten, Mark D. Benson, Jonathan
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Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake Nat. Metab. (IF 20.8) Pub Date : 2024-03-11 Yawen Zhao, Yang Liu, Tian Tao, Jinshan Zhang, Wenying Guo, Handan Deng, Mengxue Han, Haocong Mo, Xiaohan Tong, Song Lin, Jie Yang, Hening Zhai, Qimeng Wang, Zhengfang Hu, Weizhen Zhang, Hui Chen, Geyang Xu
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The pressure not to eat Nat. Metab. (IF 20.8) Pub Date : 2024-03-11 Choi Sang Daniel Lam, M. Maya Kaelberer
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Futile lipid cycling: from biochemistry to physiology Nat. Metab. (IF 20.8) Pub Date : 2024-03-08 Anand Kumar Sharma, Radhika Khandelwal, Christian Wolfrum
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Regulation of urea cycle by reversible high-stoichiometry lysine succinylation Nat. Metab. (IF 20.8) Pub Date : 2024-03-06 Ran Zhang, Jingqi Fang, Xueshu Xie, Chris Carrico, Jesse G. Meyer, Lei Wei, Joanna Bons, Jacob Rose, Rebeccah Riley, Ryan Kwok, Prasanna Vadhana Ashok Kumaar, Yini Zhang, Wenjuan He, Yuya Nishida, Xiaojing Liu, Jason W. Locasale, Birgit Schilling, Eric Verdin
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Glycogen from spinal astrocytes dials up the pain Nat. Metab. (IF 20.8) Pub Date : 2024-03-05 Carlos Manlio Díaz-García
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Neuron–astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain Nat. Metab. (IF 20.8) Pub Date : 2024-03-05 Sebastián Marty-Lombardi, Shiying Lu, Wojciech Ambroziak, Katrin Schrenk-Siemens, Jialin Wang, Anna A. DePaoli-Roach, Anna M. Hagenston, Hagen Wende, Anke Tappe-Theodor, Manuela Simonetti, Hilmar Bading, Jürgen G. Okun, Rohini Kuner, Thomas Fleming, Jan Siemens
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Determinants of obesity in Latin America Nat. Metab. (IF 20.8) Pub Date : 2024-03-04 Sandra Roberta G. Ferreira, Yazmín Macotela, Licio A. Velloso, Marcelo A. Mori
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Enhanced branched-chain amino acid metabolism improves age-related reproduction in C. elegans Nat. Metab. (IF 20.8) Pub Date : 2024-02-28 Chen Lesnik, Rachel Kaletsky, Jasmine M. Ashraf, Salman Sohrabi, Vanessa Cota, Titas Sengupta, William Keyes, Shijing Luo, Coleen T. Murphy
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The weight-loss-independent benefits of fasting Nat. Metab. (IF 20.8) Pub Date : 2024-03-01 Benjamin D. Horne
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Systemic proteome adaptions to 7-day complete caloric restriction in humans Nat. Metab. (IF 20.8) Pub Date : 2024-03-01 Maik Pietzner, Burulça Uluvar, Kristoffer J. Kolnes, Per B. Jeppesen, S. Victoria Frivold, Øyvind Skattebo, Egil I. Johansen, Bjørn S. Skålhegg, Jørgen F. P. Wojtaszewski, Anders J. Kolnes, Giles S. H. Yeo, Stephen O’Rahilly, Jørgen Jensen, Claudia Langenberg
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Histone butyrylation in the mouse intestine is mediated by the microbiota and associated with regulation of gene expression Nat. Metab. (IF 20.8) Pub Date : 2024-02-27 Leah A. Gates, Bernardo Sgarbi Reis, Peder J. Lund, Matthew R. Paul, Marylene Leboeuf, Annaelle M. Djomo, Zara Nadeem, Mariana Lopes, Francisca N. Vitorino, Gokhan Unlu, Thomas S. Carroll, Kivanç Birsoy, Benjamin A. Garcia, Daniel Mucida, C. David Allis
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Slowing reproductive ageing by preserving BCAT-1 Nat. Metab. (IF 20.8) Pub Date : 2024-02-28 Leah E. Jamerson, Patrick C. Bradshaw
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Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity Nat. Metab. (IF 20.8) Pub Date : 2024-02-28 Gerald Grandl, Gustav Collden, Jin Feng, Sreya Bhattacharya, Felix Klingelhuber, Leopold Schomann, Sara Bilekova, Ansarullah, Weiwei Xu, Fataneh Fathi Far, Monica Tost, Tim Gruber, Aimée Bastidas-Ponce, Qian Zhang, Aaron Novikoff, Arkadiusz Liskiewicz, Daniela Liskiewicz, Cristina Garcia-Caceres, Annette Feuchtinger, Matthias H. Tschöp, Natalie Krahmer, Heiko Lickert, Timo D. Müller
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Histone butyrylation is a dietary link to epigenetics Nat. Metab. (IF 20.8) Pub Date : 2024-02-27 Yudong Sun, Jason W. Locasale
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PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics Nat. Metab. (IF 20.8) Pub Date : 2024-02-27 Tsz-Leung To, Jason G. McCoy, Naomi K. Ostriker, Lev S. Sandler, Carmen A. Mannella, Vamsi K. Mootha
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Resisting weight gain with prebiotic fibre Nat. Metab. (IF 20.8) Pub Date : 2024-02-26 Matthew M. Carter, Sean P. Spencer
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Sclerostin secreted from bone mediates cognitive decline in the brains of aged and Alzheimer’s disease mice Nat. Metab. (IF 20.8) Pub Date : 2024-02-26
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Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer’s disease progression Nat. Metab. (IF 20.8) Pub Date : 2024-02-26 Tianshu Shi, Siyu Shen, Yong Shi, Qianjin Wang, Guanqun Zhang, Jiaquan Lin, Jiang Chen, Feng Bai, Lei Zhang, Yangyufan Wang, Wang Gong, Xiaoyan Shao, Guiquan Chen, Wenjin Yan, Xiang Chen, Yuze Ma, Liming Zheng, Jianghui Qin, Ke Lu, Na Liu, Yun Xu, Yun Stone Shi, Qing Jiang, Baosheng Guo
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Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota Nat. Metab. (IF 20.8) Pub Date : 2024-02-26 Huating Li, Lei Zhang, Jun Li, Qian Wu, Lingling Qian, Junsheng He, Yueqiong Ni, Petia Kovatcheva-Datchary, Rui Yuan, Shuangbo Liu, Li Shen, Mingliang Zhang, Bin Sheng, Ping Li, Kang Kang, Liang Wu, Qichen Fang, Xiaoxue Long, Xiaolin Wang, Yanli Li, Yaorui Ye, Jianping Ye, Yuqian Bao, Yueliang Zhao, Guowang Xu, Xinyu Liu, Gianni Panagiotou, Aimin Xu, Weiping Jia
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From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research Nat. Metab. (IF 20.8) Pub Date : 2024-02-21 Cynthia L. Hsu, Rohit Loomba
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Enteric and systemic postprandial lactate shuttle phases and dietary carbohydrate carbon flow in humans Nat. Metab. (IF 20.8) Pub Date : 2024-02-22 Robert G. Leija, Casey C. Curl, Jose A. Arevalo, Adam D. Osmond, Justin J. Duong, Melvin J. Huie, Umesh Masharani, George A. Brooks
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Metabolic engineering for optimized CAR-T cell therapy Nat. Metab. (IF 20.8) Pub Date : 2024-02-22 Sarah J. McPhedran, Gillian A. Carleton, Julian J. Lum
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Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism Nat. Metab. (IF 20.8) Pub Date : 2024-02-20 Alain J. De Solis, Almudena Del Río-Martín, Jan Radermacher, Weiyi Chen, Lukas Steuernagel, Corinna A. Bauder, Fynn R. Eggersmann, Donald A. Morgan, Anna-Lena Cremer, Michael Sué, Maximilian Germer, Christian Kukat, Stefan Vollmar, Heiko Backes, Kamal Rahmouni, Peter Kloppenburg, Jens C. Brüning
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Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk Nat. Metab. (IF 20.8) Pub Date : 2024-02-19 Xiangyu Zhang, Divya Kapoor, Se-Jin Jeong, Alan Fappi, Jeremiah Stitham, Vasavi Shabrish, Ismail Sergin, Eman Yousif, Astrid Rodriguez-Velez, Yu-Sheng Yeh, Arick Park, Arif Yurdagul, Oren Rom, Slava Epelman, Joel D. Schilling, Marco Sardiello, Abhinav Diwan, Jaehyung Cho, Nathan O. Stitziel, Ali Javaheri, Irfan J. Lodhi, Bettina Mittendorfer, Babak Razani
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MCT1 helps brown fat suck up succinate Nat. Metab. (IF 20.8) Pub Date : 2024-02-20 Jens Lund, Marie Sophie Isidor, Zachary Gerhart-Hines
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Simultaneous targeting of POMC and AgRP neurons Nat. Metab. (IF 20.8) Pub Date : 2024-02-20 Liangyou Rui
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Monocarboxylate transporters facilitate succinate uptake into brown adipocytes Nat. Metab. (IF 20.8) Pub Date : 2024-02-20 Anita Reddy, Sally Winther, Nhien Tran, Haopeng Xiao, Josefine Jakob, Ryan Garrity, Arianne Smith, Martha Ordonez, Dina Laznik-Bogoslavski, Jeffrey D. Rothstein, Evanna L. Mills, Edward T. Chouchani
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Accumulation of G3P and pEtN drives cellular senescence via altered lipid metabolism Nat. Metab. (IF 20.8) Pub Date : 2024-02-19
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A leucine–macrophage mTORC1 connection drives increased risk of atherosclerosis with high-protein diets Nat. Metab. (IF 20.8) Pub Date : 2024-02-19 Adam J. Rose, Patricia M. Rusu
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A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism Nat. Metab. (IF 20.8) Pub Date : 2024-02-19 Khaled Tighanimine, José Américo Nabuco Leva Ferreira Freitas, Ivan Nemazanyy, Alexia Bankolé, Delphine Benarroch-Popivker, Susanne Brodesser, Gregory Doré, Lucas Robinson, Paule Benit, Sophia Ladraa, Yara Bou Saada, Bertrand Friguet, Philippe Bertolino, David Bernard, Guillaume Canaud, Pierre Rustin, Eric Gilson, Oliver Bischof, Stefano Fumagalli, Mario Pende
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Best practices in collecting and reporting continuous glucose monitoring data in research settings Nat. Metab. (IF 20.8) Pub Date : 2024-02-15 Margaretha M. Visser, Pieter Gillard
Continuous glucose monitoring (CGM) is increasingly being used to collect and evaluate data on glycaemic control for research purposes. However, the use of CGM in research settings requires proper understanding and handling of these devices for correct data collection and interpretation.
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Selenium abandons selenoproteins to inhibit ferroptosis rapidly Nat. Metab. (IF 20.8) Pub Date : 2024-02-13 Ian G. Chambers, Rajiv R. Ratan
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Selenium reduction of ubiquinone via SQOR suppresses ferroptosis Nat. Metab. (IF 20.8) Pub Date : 2024-02-13 Namgyu Lee, Sung Jin Park, Mike Lange, Tenzin Tseyang, Mihir B. Doshi, Tae Yong Kim, Yoseb Song, Dong In Kim, Paul L. Greer, James A. Olzmann, Jessica B. Spinelli, Dohoon Kim
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Hypermetabolism and energetic constraints in mitochondrial disorders Nat. Metab. (IF 20.8) Pub Date : 2024-02-09 Alexander J. Sercel, Gabriel Sturm, Dympna Gallagher, Marie-Pierre St-Onge, Christopher P. Kempes, Herman Pontzer, Michio Hirano, Martin Picard
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Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis Nat. Metab. (IF 20.8) Pub Date : 2024-02-09 Krithika Ramachandran, Christopher R. Futtner, Meredith A. Sommars, Mattia Quattrocelli, Yasuhiro Omura, Ellen Fruzyna, Janice C. Wang, Nathan J. Waldeck, Madhavi D. Senagolage, Carmen G. Telles, Alexis R. Demonbreun, Erin Prendergast, Nicola Lai, Daniel Arango, Ilya R. Bederman, Elizabeth M. McNally, Grant D. Barish