-
Regulation of mitochondrial fission by fatty acyl-coenzyme A Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-23
-
Zeb1-controlled metabolic plasticity enables remodeling of chromatin accessibility in the development of neuroendocrine prostate cancer Cell Death Differ. (IF 12.4) Pub Date : 2024-04-23 Deng Wang, Genyu Du, Xinyu Chen, Jinming Wang, Kaiyuan Liu, Huifang Zhao, Chaping Cheng, Yuman He, Na Jing, Penghui Xu, Wei Bao, Xialian Xi, Yingchao Zhang, Nan Wang, Yiyun Liu, Yujiao Sun, Kai Zhang, Pengcheng Zhang, Wei-Qiang Gao, Helen He Zhu
-
Principles of chromosome organization for meiotic recombination Mol. Cell (IF 16.0) Pub Date : 2024-04-23 Mathilde Biot, Attila Toth, Christine Brun, Leon Guichard, Bernard de Massy, Corinne Grey
-
DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice Dev. Cell (IF 11.8) Pub Date : 2024-04-23 Dingfeng Zou, Kai Li, Luying Su, Jun Liu, Yan Lu, Rong Huang, Mengzhen Li, Xinyu Mang, Qi Geng, Pengyu Li, Jielin Tang, Zhixin Yu, Zexuan Zhang, Dingyao Chen, Shiying Miao, Jia Yu, Wei Yan, Wei Song
-
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK Cell Metab. (IF 29.0) Pub Date : 2024-04-23 Yajuan Li, Daniel Munoz-Mayorga, Yuhang Nie, Ningxin Kang, Yuren Tao, Jessica Lagerwall, Carla Pernaci, Genevieve Curtin, Nicole G. Coufal, Jerome Mertens, Lingyan Shi, Xu Chen
-
The senescence-associated secretory phenotype and its physiological and pathological implications Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-04-23 Boshi Wang, Jin Han, Jennifer H. Elisseeff, Marco Demaria
-
Unlocking trophectoderm mysteries: In vivo and in vitro perspectives on human and mouse trophoblast fate induction Dev. Cell (IF 11.8) Pub Date : 2024-04-22 Meir Azagury, Yosef Buganim
In recent years, the pursuit of inducing the trophoblast stem cell (TSC) state has gained prominence as a compelling research objective, illuminating the establishment of the trophoblast lineage and unlocking insights into early embryogenesis. In this review, we examine how advancements in diverse technologies, including in vivo time course transcriptomics, cellular reprogramming to TSC state, chemical
-
Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation Cell Metab. (IF 29.0) Pub Date : 2024-04-22 Alasdair Leeson-Payne, Jean Iyinikkel, Cameron Malcolm, Brian Y.H. Lam, Nadine Sommer, Georgina K.C. Dowsett, Pablo B. Martinez de Morentin, Dawn Thompson, Alasdair Mackenzie, Raffaella Chianese, Katherine Kentistou, Eugene J. Gardner, John R.B. Perry, Felix Grassmann, John R. Speakman, Justin J. Rochford, Giles S.H. Yeo, Fiona Murray, Lora K. Heisler
-
Is endocytosis by caveolae dependent on dynamin? Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-04-22 Robert G. Parton, Justin W. Taraska, Richard Lundmark
-
Cell death as an architect of adult skin stem cell niches Cell Death Differ. (IF 12.4) Pub Date : 2024-04-22 Kim Lecomte, Annagiada Toniolo, Esther Hoste
-
-
Human DNA polymerase θ does not harbor intrinsic nuclease activity Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Denisse Carvajal-Maldonado, Karl Zahn, Ryan Jensen, Richard D. Wood, Sylvie Doublié
Abstract not available
-
Meet the authors: Guy Zoltsman and Rina Rosenzweig Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Guy Zoltsman, Rina Rosenzweig
We talk to first and last authors Guy Zoltsman and Rina Rosenzweig about their paper, “A unique chaperoning mechanism in Class A JDPs recognizes and stabilizes mutant p53,” how every result may be important in the right context, and the importance to Rina that her lab is an encouraging and collaborative place.
-
Entangling and disentangling mitotic chromosomes Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Jonathan Baxter
The DNA topological challenges generated by cellular manipulation of extremely long DNA fibers remain poorly understood. In this issue of Molecular Cell, Hildebrand et al.1 describe how mitotic chromosomes are self entangled and that disentanglement requires TOP2 activity in late mitosis.
-
Free ribosomal proteins as culprits for nucleolar stress Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Ina Huppertz
Nucleolar stress has been consistently linked to age-related diseases. In this issue, Sirozh et al.1 find that the common molecular signature of nucleolar stress is the accumulation of free ribosomal proteins, which leads to premature aging in mice; however, it can be reversed by mTOR inhibition.
-
Shining light on DHX9: UV-induced stress granules illuminate protective mechanisms for daughter cell resilience Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Dylan M. Parker, Gaia R. Bublitz, Roy Parker
In a recent article in Cell, Zhou et al. investigate the origins, composition, and biological consequences of UV-induced stress granules. They find that UV-induced stress granules are triggered by the formation of RNA-protein crosslinks, uniquely contain DHX9 as a marker, form during mitosis independently of translation repression, and are enriched in intron-containing RNAs and splicing factors. Moreover
-
Sequential requirements for distinct Polθ domains during theta-mediated end joining Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Carel Fijen, Lea Drogalis Beckham, Dante Terino, Yuzhen Li, Dale A. Ramsden, Richard D. Wood, Sylvie Doublié, Eli Rothenberg
-
No evidence for ac4C within human mRNA upon data reassessment Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Joseph Georgeson, Schraga Schwartz
Cytidine acetylation (ac4C) of RNA is a post-transcriptional modification catalyzed by Nat10. Recently, an approach termed RedaC:T was employed to map ac4C in human mRNA, relying on detection of C>T mutations in WT but not in Nat10-KO cells. RedaC:T suggested widespread ac4C presence. Here, we reanalyze RedaC:T data. We find that mismatch signatures are not reproducible, as C>T mismatches are nearly
-
Detection of ac4C in human mRNA is preserved upon data reassessment Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Hamid Beiki, David Sturgill, Daniel Arango, Sebastien Relier, Sarah Schiffers, Shalini Oberdoerffer
We recently reported the distribution of N4-acetylcytidine (ac4C) in HeLa mRNA at base resolution through chemical reduction and the induction of C:T mismatches in sequencing (RedaC:T-seq). Our results contradicted an earlier report from Schwartz and colleagues utilizing a similar method termed ac4C-seq. Here, we revisit both datasets and reaffirm our findings. Through RedaC:T-seq reanalysis, we establish
-
Retraction Notice to: Human DNA polymerase θ harbors DNA end-trimming activity critical for DNA repair Mol. Cell (IF 16.0) Pub Date : 2024-04-18 Karl E. Zahn, Ryan B. Jensen, Richard D. Wood, Sylvie Doublie
Abstract not available
-
Pten, PI3K, and PtdIns(3,4,5)P3 dynamics control pulsatile actin branching in Drosophila retina morphogenesis Dev. Cell (IF 11.8) Pub Date : 2024-04-18 Jacob Malin, Christian Rosa-Birriel, Victor Hatini
-
Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication Dev. Cell (IF 11.8) Pub Date : 2024-04-18 Adler Guerrero Zuniga, Timothy J. Aikin, Connor McKenney, Yovel Lendner, Alain Phung, Paul W. Hook, Amy Meltzer, Winston Timp, Sergi Regot
-
Antagonistic control of rice immunity against distinct pathogens by the two transcription modules via salicylic acid and jasmonic acid pathways Dev. Cell (IF 11.8) Pub Date : 2024-04-18 Xiaoying Zhu, Yudan Zhao, Cheng-Min Shi, Guojuan Xu, Nana Wang, Shimin Zuo, Yuese Ning, Houxiang Kang, Wende Liu, Ruyi Wang, Shuangyong Yan, Guo-Liang Wang, Xuli Wang
-
Mannose controls mesoderm specification and symmetry breaking in mouse gastruloids Dev. Cell (IF 11.8) Pub Date : 2024-04-17 Chaitanya Dingare, Dominica Cao, Jenny Jingni Yang, Berna Sozen, Benjamin Steventon
-
Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos Dev. Cell (IF 11.8) Pub Date : 2024-04-17 Bingyan Zhou, Chenzhao Feng, Song Sun, Xuyong Chen, Didi Zhuansun, Di Wang, Xiaosi Yu, Xinyao Meng, Jun Xiao, Luyao Wu, Jing Wang, Jing Wang, Ke Chen, Zejian Li, Jingyi You, Handan Mao, Shimin Yang, Jiaxin Zhang, Chunlei Jiao, Zhi Li, Jiexiong Feng
-
QDPR deficiency drives immune suppression in pancreatic cancer Cell Metab. (IF 29.0) Pub Date : 2024-04-19 Ji Liu, Xiaowei He, Shuang Deng, Sihan Zhao, Shaoping Zhang, Ziming Chen, Chunling Xue, Lingxing Zeng, Hongzhe Zhao, Yifan Zhou, Ruihong Bai, Zilan Xu, Shaoqiu Liu, Quanbo Zhou, Mei Li, Jialiang Zhang, Xudong Huang, Rufu Chen, Liqin Wang, Dongxin Lin, Jian Zheng
-
Generation of human alveolar epithelial type I cells from pluripotent stem cells Cell Stem Cell (IF 23.9) Pub Date : 2024-04-19 Claire L. Burgess, Jessie Huang, Pushpinder S. Bawa, Konstantinos-Dionysios Alysandratos, Kasey Minakin, Lauren J. Ayers, Michael P. Morley, Apoorva Babu, Carlos Villacorta-Martin, Maria Yampolskaya, Anne Hinds, Bibek R. Thapa, Feiya Wang, Adeline Matschulat, Pankaj Mehta, Edward E. Morrisey, Xaralabos Varelas, Darrell N. Kotton
-
Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence Cell Stem Cell (IF 23.9) Pub Date : 2024-04-16 Xue Han, Linqing Xing, Yantao Hong, Xuechun Zhang, Bo Hao, J. Yuyang Lu, Mengyuan Huang, Zuhui Wang, Shaoqian Ma, Ge Zhan, Tong Li, Xiaowen Hao, Yibing Tao, Guanwen Li, Shuqin Zhou, Zheng Zheng, Wen Shao, Yitian Zeng, Dacheng Ma, Wenhao Zhang, Xiaohua Shen
-
Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization Cancer Cell (IF 50.3) Pub Date : 2024-04-18 Wenying Wang, Tianran Li, Yue Cheng, Fei Li, Shuhong Qi, Min Mao, Jingjing Wu, Qing Liu, Xiaoning Zhang, Xuegang Li, Lu Zhang, Haoyue Qi, Lan Yang, Kaidi Yang, Zhicheng He, Shuaishuai Ding, Zhongyi Qin, Ying Yang, Xi Yang, Chunhua Luo, Yu Shi
-
Next questions in autophagy Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-19 Ana Maria Cuervo, Zvulun Elazar, Chantell Evans, Liang Ge, Malene Hansen, Marja Jäättelä, Jin Rui (Amos) Liang, Ben Loos, Noboru Mizushima, Anna Katharina Simon, Sharon Tooze, Tamotsu Yoshimori, Shuhei Nakamura
Our understanding of the basic mechanisms of autophagy is growing, but many questions remain about the types of autophagy cells use, when they use them, and how they function in different contexts. We asked emerging and established leaders in the field to discuss the questions and areas that they are most excited about to deepen our understanding of autophagy.
-
Pooled multicolour tagging for visualizing subcellular protein dynamics Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-19 Andreas Reicher, Jiří Reiniš, Maria Ciobanu, Pavel Růžička, Monika Malik, Marton Siklos, Victoria Kartysh, Tatjana Tomek, Anna Koren, André F. Rendeiro, Stefan Kubicek
-
Relaying gasdermin D to the membrane Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-04-17 Lisa Heinke
Reversible S-palmitoylation regulates gasdermin D cleavage, membrane translocation and pore formation to control pyroptosis following bacterial infection.
-
The PML1-WDR5 axis regulates H3K4me3 marks and promotes stemness of estrogen receptor-positive breast cancer Cell Death Differ. (IF 12.4) Pub Date : 2024-04-16 Chun-Peng Pai, Han Wang, Darcie D. Seachrist, Neel Agarwal, Joshua A. Adams, Zhenghao Liu, Ruth A. Keri, Kaixiang Cao, William P. Schiemann, Hung-Ying Kao
-
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons Cell Stem Cell (IF 23.9) Pub Date : 2024-04-15 Osama Al-Dalahmah, Matti Lam, Julie J. McInvale, Wenhui Qu, Trang Nguyen, Jeong-Yeon Mun, Sam Kwon, Nkechime Ifediora, Aayushi Mahajan, Nelson Humala, Tristan Winters, Ellen Angeles, Kelly A. Jakubiak, Rebekka Kühn, Yoon A. Kim, Maria Caterina De Rosa, Claudia A. Doege, Fahad Paryani, Xena Flowers, Athanassios Dovas, Gunnar Hargus
-
Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites Dev. Cell (IF 11.8) Pub Date : 2024-04-15 Marine Bretou, Ragna Sannerud, Abril Escamilla-Ayala, Tom Leroy, Céline Vrancx, Zoë P. Van Acker, Anika Perdok, Wendy Vermeire, Inge Vorsters, Sophie Van Keymolen, Michelle Maxson, Benjamin Pavie, Keimpe Wierda, Eeva-Liisa Eskelinen, Wim Annaert
-
In memoriam Judy Campisi: spreading cellular senescence Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-04-12 Fabrizio d’Adda di Fagagna
In the Journal Club, Fabrizio d’Adda di Fagagna remembers how the work of Judy Campisi changed our understanding of cellular senescence and its effect on physiology and ageing, shaping the future of this research field.
-
Early insights into co-translational assembly of protein complexes Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-04-12 Ayala Shiber
The first evidence that the formation of protein complexes is linked to protein synthesis was already provided in the early 1960s.
-
Accelerating data sharing and reuse in volume electron microscopy Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-12 Kirk James Czymmek, Ilya Belevich, Johanna Bischof, Aastha Mathur, Lucy Collinson, Eija Jokitalo
-
The intersection of frailty and metabolism Cell Metab. (IF 29.0) Pub Date : 2024-04-12 Manish Mishra, Judy Wu, Alice E. Kane, Susan E. Howlett
On average, aging is associated with unfavorable changes in cellular metabolism, which are the processes involved in the storage and expenditure of energy. However, metabolic dysregulation may not occur to the same extent in all older individuals as people age at different rates. Those who are aging rapidly are at increased risk of adverse health outcomes and are said to be “frail.” Here, we explore
-
Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling Mol. Cell (IF 16.0) Pub Date : 2024-04-12 Nathanael A. Caveney, Grayson E. Rodriguez, Christoph Pollmann, Thomas Meyer, Marta T. Borowska, Steven C. Wilson, Nan Wang, Xinyu Xiang, Karsten D. Householder, Pingdong Tao, Leon L. Su, Robert A. Saxton, Jacob Piehler, K. Christopher Garcia
-
A validation strategy to assess the role of phase separation as a determinant of macromolecular localization Mol. Cell (IF 16.0) Pub Date : 2024-04-12 Marius Hedtfeld, Alicia Dammers, Carolin Koerner, Andrea Musacchio
-
Mechanical state transitions in the regulation of tissue form and function Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-04-10 Yanlan Mao, Sara A. Wickström
-
A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-11 Christopher Chidley, Alicia M. Darnell, Benjamin L. Gaudio, Evan C. Lien, Anna M. Barbeau, Matthew G. Vander Heiden, Peter K. Sorger
-
OTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation Cell Death Differ. (IF 12.4) Pub Date : 2024-04-11 Yaxing Liu, Jiahua Yuan, Yuling Zhang, Fei Qin, Xuemei Bai, Wanwei Sun, Tian Chen, Feng Liu, Yi Zheng, Xiaopeng Qi, Wei Zhao, Bingyu Liu, Chengjiang Gao
-
The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia Cancer Cell (IF 50.3) Pub Date : 2024-04-11 Mingyang Liu, Yu Ren, Zhijun Zhou, Jingxuan Yang, Xiuhui Shi, Yang Cai, Alex X. Arreola, Wenyi Luo, Kar-Ming Fung, Chao Xu, Ryan D. Nipp, Michael S. Bronze, Lei Zheng, Yi-Ping Li, Courtney W. Houchen, Yuqing Zhang, Min Li
-
New and emerging treatments for metabolic dysfunction-associated steatohepatitis Cell Metab. (IF 29.0) Pub Date : 2024-04-11 Monica A. Tincopa, Quentin M. Anstee, Rohit Loomba
Metabolic dysfunction-associated steatohepatitis (MASH) is a leading etiology of chronic liver disease worldwide, with increasing incidence and prevalence in the setting of the obesity epidemic. MASH is also a leading indication for liver transplantation, given its associated risk of progression to end-stage liver disease. A key challenge in managing MASH is the lack of approved pharmacotherapy. In
-
ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes Cell Metab. (IF 29.0) Pub Date : 2024-04-11 Zhen Lu, Noreen McBrearty, Jinyun Chen, Vivek S. Tomar, Hongru Zhang, Gianluca De Rosa, Aiwen Tan, Aalim M. Weljie, Daniel P. Beiting, Zhen Miao, Subin S. George, Allison Berger, Gurpanna Saggu, J. Alan Diehl, Constantinos Koumenis, Serge Y. Fuchs
Abstract not available
-
Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development Cell Stem Cell (IF 23.9) Pub Date : 2024-04-11 Hsueh-Fu Wu, Kenyi Saito-Diaz, Chia-Wei Huang, Jessica L. McAlpine, Dong Eun Seo, D. Sumner Magruder, Mohamed Ishan, Harrison C. Bergeron, William H. Delaney, Fabio R. Santori, Smita Krishnaswamy, Gerald W. Hart, Ya-Wen Chen, Robert J. Hogan, Hong-Xiang Liu, Natalia B. Ivanova, Nadja Zeltner
-
Adding a transcription-coupled repair pathway Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-10 Marco Saponaro
-
Tissue pressure and YAP during organogenesis Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-10 Qian Xu, Thomas G. H. Diekwisch
-
Transcription-coupled DNA–protein crosslink repair by CSB and CRL4CSA-mediated degradation Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-10 Marjolein van Sluis, Qing Yu, Melanie van der Woude, Camila Gonzalo-Hansen, Shannon C. Dealy, Roel C. Janssens, Hedda B. Somsen, Anisha R. Ramadhin, Dick H. W. Dekkers, Hannah Lena Wienecke, Joris J. P. G. Demmers, Anja Raams, Carlota Davó-Martínez, Diana A. Llerena Schiffmacher, Marvin van Toorn, David Häckes, Karen L. Thijssen, Di Zhou, Judith G. Lammers, Alex Pines, Wim Vermeulen, Joris Pothof,
-
Endogenous aldehyde-induced DNA–protein crosslinks are resolved by transcription-coupled repair Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-10 Yasuyoshi Oka, Yuka Nakazawa, Mayuko Shimada, Tomoo Ogi
-
Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB Nat. Cell Biol. (IF 21.3) Pub Date : 2024-04-10 Christopher J. Carnie, Aleida C. Acampora, Aldo S. Bader, Chimeg Erdenebat, Shubo Zhao, Elnatan Bitensky, Diana van den Heuvel, Avital Parnas, Vipul Gupta, Giuseppina D’Alessandro, Matylda Sczaniecka-Clift, Pedro Weickert, Fatih Aygenli, Maximilian J. Götz, Jacqueline Cordes, Isabel Esain-Garcia, Larry Melidis, Annelotte P. Wondergem, Simon Lam, Maria S. Robles, Shankar Balasubramanian, Sheera Adar
-
The birth of death, 30 years ago Cell Death Differ. (IF 12.4) Pub Date : 2024-04-10 Gerry Melino, Richard A. Knight, Tak Wah Mak, Mauro Piacentini, Hans-Uwe Simon, Yufang Shi
-
Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators Cell Metab. (IF 29.0) Pub Date : 2024-04-10 Wanyu Tao, Zhengqing Yu, Jing-Dong J. Han
-
Learning from chromatin reconstitution: Pioneer factors enabling nucleosome remodelers Mol. Cell (IF 16.0) Pub Date : 2024-04-10 Ken Zaret
No Abstract
-
SAFB restricts contact domain boundaries associated with L1 chimeric transcription Mol. Cell (IF 16.0) Pub Date : 2024-04-10 Yaqiang Hong, Luyao Bie, Tao Zhang, Xiaohan Yan, Guangpu Jin, Zhuo Chen, Yang Wang, Xiufeng Li, Gaofeng Pei, Yongyan Zhang, Yantao Hong, Liang Gong, Pilong Li, Wei Xie, Yanfen Zhu, Xiaohua Shen, Nian Liu
-
Three-step mechanism of promoter escape by RNA polymerase II Mol. Cell (IF 16.0) Pub Date : 2024-04-10 Yumeng Zhan, Frauke Grabbe, Elisa Oberbeckmann, Christian Dienemann, Patrick Cramer
-
Response to “Learning from chromatin reconstitution: Pioneering factors enabling nucleosome remodelers” Mol. Cell (IF 16.0) Pub Date : 2024-04-10 Kami Ahmad, Sandipan Brahma, Steven Henikoff
Abstract not available
-
Modelling tauopathies Nat. Rev. Mol. Cell Biol. (IF 112.7) Pub Date : 2024-04-09 Kim Baumann
This study presents a new iPS cell-based model to study the mechanisms of tau propagation in 4R tauopathies.