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Ring finger protein 138 inhibits transcription factor C/EBPα protein turnover leading to differentiation arrest in acute myeloid leukemia Biochem. J. (IF 4.1) Pub Date : 2024-05-22 Singh, Anil Kumar, Upadhyay, Vishal, Sethi, Arppita, Chowdhury, Sangita, Mishra, Shivkant, Verma, Shailendra Prasad, Bhatt, Madan Lal Brahma, Trivedi, Arun Kumar
E3 ubiquitin ligase, ring finger protein 138 (RNF138) is involved in several biological processes; however, its role in myeloid differentiation or tumorigenesis remains unclear. RNAseq data from TNMplot showed that RNF138 mRNA levels are highly elevated in acute myeloid leukemia (AML) bone marrow samples as compared with bone marrow of normal volunteers. Here, we show that RNF138 serves as an E3 ligase
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RNA-based programmable DNA cleavage Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-05-10 Madeleine B. King, Audrone Lapinaite
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Epigenetic mechanisms linking early-life adversities and mental health Biochem. J. (IF 4.1) Pub Date : 2024-05-22 Cánepa, Eduardo T., Berardino, Bruno G.
Early-life adversities, whether prenatal or postnatal exposure, have been linked to adverse mental health outcomes later in life increasing the risk of several psychiatric disorders. Research on its neurobiological consequences demonstrated an association between exposure to adversities and persistent alterations in the structure, function, and connectivity of the brain. Consistent evidence supports
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Validation of GCN5L1/BLOC1S1/BLOS1 antibodies using knockout cells and tissue Biochem. J. (IF 4.1) Pub Date : 2024-05-22 Bugga, Paramesha, Stoner, Michael W., Manning, Janet R., Mushala, Bellina A.S., Bhattarai, Nisha, Sharifi-Sanjani, Maryam, Webster, Bradley R., Thapa, Dharendra, Scott, Iain
GCN5L1, also known as BLOC1S1 and BLOS1, is a small intracellular protein involved in many key biological processes. Over the last decade, GCN5L1 has been implicated in the regulation of protein lysine acetylation, energy metabolism, endo-lysosomal function, and cellular immune pathways. An increasing number of published papers have used commercially-available reagents to interrogate GCN5L1 function
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Correction: The uncharacterized Pseudomonas aeruginosa PA4189 is a novel and efficient aminoacetaldehyde dehydrogenase Biochem. J. (IF 4.1) Pub Date : 2024-05-22 Muñoz-Clares, Arline Fernández-Silva, Ana L. Juárez-Vázquez, Lilian González-Segura, Javier Andrés Juárez-Díaz, Rosario A.
The authors of the original article titled ‘The uncharacterized Pseudomonas aeruginosa PA4189 is a novel and efficient aminoacetaldehyde dehydrogenase’ 10.1042/BCJ20220567 would like to correct Equation 4 on page 277. The equation contained an error in the numerator. The requested correction has been assessed and agreed upon by the Editorial Board. The authors declare that these corrections do not
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Behavioral control through the direct, focal silencing of neuronal activity Cell Chem. Bio. (IF 8.6) Pub Date : 2024-05-09 Anna V. Elleman, Nikola Milicic, Damian J. Williams, Jane Simko, Christine J. Liu, Allison L. Haynes, David E. Ehrlich, Christopher D. Makinson, J. Du Bois
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Decoding cell replicational age from single-cell ATAC-seq data Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-09
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Tracking single-cell evolution using clock-like chromatin accessibility loci Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-09 Yu Xiao, Wan Jin, Lingao Ju, Jie Fu, Gang Wang, Mengxue Yu, Fangjin Chen, Kaiyu Qian, Xinghuan Wang, Yi Zhang
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An effective MASH drug is good, but biotech can make it better Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-08
Understanding this complex disease requires better model systems and large-scale data.
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Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-05-08 Zhe Li, Zhi-min Xu, Wei-peng Chen, Xiao-jing Du, Chun-xian Ou, Zi-kang Luo, Rong Wang, Chu-qing Zhang, Chao-dong Ge, Meng Han, Fudi Wang, Rong-Rong He, Wan-yang Sun, Jun Ma, Xiao-yu Liang, Zhuo-wei Liu
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Stimulating STING for cancer therapy: Taking the extracellular route Cell Chem. Bio. (IF 8.6) Pub Date : 2024-05-08 Lingyin Li
Ten years ago, the second messenger cGAMP was discovered as the activator of the anti-cancer STING pathway. The characterization of cGAMP’s paracrine action and dominant extracellular hydrolase ENPP1 cemented cGAMP as an intercellular immunotransmitter that coordinates the innate and adaptive immune systems to fight cancer. In this Perspective, I look back at a decade of discovery of extracellular
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Time-resolved HT-SAXS discovers allosteric chemotypes for redox target AIF Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-05-06
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Identification of clinically relevant T cell receptors for personalized T cell therapy using combinatorial algorithms Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-07 Rémy Pétremand, Johanna Chiffelle, Sara Bobisse, Marta A. S. Perez, Julien Schmidt, Marion Arnaud, David Barras, Maria Lozano-Rabella, Raphael Genolet, Christophe Sauvage, Damien Saugy, Alexandra Michel, Anne-Laure Huguenin-Bergenat, Charlotte Capt, Jonathan S. Moore, Claudio De Vito, S. Intidhar Labidi-Galy, Lana E. Kandalaft, Denarda Dangaj Laniti, Michal Bassani-Sternberg, Giacomo Oliveira, Catherine
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Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-07 Stephan Eckert, Nicola Berner, Karl Kramer, Annika Schneider, Julian Müller, Severin Lechner, Sarah Brajkovic, Amirhossein Sakhteman, Christian Graetz, Jonas Fackler, Michael Dudek, Michael W. Pfaffl, Percy Knolle, Stephanie Wilhelm, Bernhard Kuster
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Should neurotechnologies go into the sandbox? Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-06 Walter G. Johnson
Emerging neurotechnologies such as brain–computer interfaces bring together components of biotechnology and digital technology, creating a number of different policy issues. These challenges can range from the safety of medical products to privacy issues with collecting and processing data from the human brain. Such different issues may call for different policy responses. For example, in April 2024
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Structures, mechanisms and applications of RNA-centric CRISPR–Cas13 Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-05-03 Hui Yang, Dinshaw J. Patel
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Molecular glues for protein-protein interactions: Progressing toward a new dream Cell Chem. Bio. (IF 8.6) Pub Date : 2024-05-02 Markella Konstantinidou, Michelle R. Arkin
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Response to “The perpetual motion machine of AI-generated data and the distraction of ChatGPT as a ‘scientist’” Nat. Biotechnol. (IF 46.9) Pub Date : 2024-05-01 William Stafford Noble
Many of Jennifer Listgarten’s arguments are compelling: in particular, that the protein folding problem is an outlier relative to other grand challenges in science, both in terms of the precise way the problem can be stated and performance measured and in terms of the amount of available, high quality data1. However, although existing biological databases tend to be small relative to the compendia
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Designing drugs with reversible activity Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-30 Dario Neri
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Development of supramolecular anticoagulants with on-demand reversibility Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-30 Millicent Dockerill, Daniel J. Ford, Simona Angerani, Imala Alwis, Luke J. Dowman, Jorge Ripoll-Rozada, Rhyll E. Smythe, Joanna S. T. Liu, Pedro José Barbosa Pereira, Shaun P. Jackson, Richard J. Payne, Nicolas Winssinger
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Molecular glues and induced proximity: An evolution of tools and discovery Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-29 Stephanie Anne Robinson, Jennifer Anne Co, Steven Mark Banik
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Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1 Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-27 Seth D. Ludwig, Bunyarit Meksiriporn, Jiacheng Tan, Rakeeb Kureshi, Akhilesh Mishra, Kyle J. Kaeo, Angela Zhu, Georgia Stavrakis, Stephen J. Lee, David J. Schodt, Michael J. Wester, Dhiraj Kumar, Keith A. Lidke, Andrea L. Cox, Helen M. Dooley, Sridhar Nimmagadda, Jamie B. Spangler
No Abstract
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Engineering from evolution Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-26 Francesco Zamberlan
Polyketides are a group of natural products with valuable pharmacological activities, biosynthesized by bacterial or fungal megaenzymes called polyketide synthases (PKSs). These are composed of multiple modules in an assembly line, each introducing a specific moiety of the final compound in a stepwise manner. Among them, trans-acyltransferase PKSs have evolved through the recombination of biosynthetic
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Bacteria lose a pep in their step Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-26 Gene Chong
Zhang et al. hypothesized that a structurally similar disaccharide, GlcNAc-1,6-anhydro-MurNAc, could be a minimal moiety that acts as a competitive inhibitor to lipid II and lacks a reducing end for glycan chain elongation. The authors developed a 15-step total synthesis of the disaccharide-pentapeptide unit, called compound 1, and the disaccharide-only compound, 1-deAA. They incubated compound 1 with
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Setting the pace for degrons Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-26 Yiyun Song
Immunomodulatory drugs (IMiDs), including thalidomide, pomalidomide and lenalidomide, act as molecular glues to induce the ubiquitination and degradation of their target proteins (referred to as neosubstrates) by facilitating their direct interaction with cereblon (CRBN), the substrate receptor of the CRL4CRBN E3 ubiquitin ligase. Some neosubstrates contain a C2H2 zinc finger motif that is responsible
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Chemical screening by time-resolved X-ray scattering to discover allosteric probes Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-26 Chris A. Brosey, Todd M. Link, Runze Shen, Davide Moiani, Kathryn Burnett, Greg L. Hura, Darin E. Jones, John A. Tainer
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Analysis and benchmarking of small and large genomic variants across tandem repeats Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-26 Adam C. English, Egor Dolzhenko, Helyaneh Ziaei Jam, Sean K. McKenzie, Nathan D. Olson, Wouter De Coster, Jonghun Park, Bida Gu, Justin Wagner, Michael A. Eberle, Melissa Gymrek, Mark J. P. Chaisson, Justin M. Zook, Fritz J. Sedlazeck
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Current advances in photocatalytic proximity labeling Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-24 Steve D. Knutson, Benito F. Buksh, Sean W. Huth, Danielle C. Morgan, David W.C. MacMillan
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Pyro(phospho)mania Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-25 Claire E. Eyers, Christopher J. Clarke
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Minimizing higher-order aggregation maximizes iron mobilization by small molecules Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-25 Andrew D. Blake, Jianhua Chao, Anna M. SantaMaria, Stella Ekaputri, Kelsie J. Green, Samantha T. Brown, Christopher K. Rakowski, Eun-Kyung Choi, Luisa Aring, Peng-Jui Chen, Nicholas M. Snead, Douglas M. Matje, Tao Geng, Angela Octaviani, Keith Bailey, Stanley J. Hollenbach, Timothy M. Fan, Young-Ah Seo, Martin D. Burke
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Extensive protein pyrophosphorylation revealed in human cell lines Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-25 Jeremy A. M. Morgan, Arpita Singh, Leonie Kurz, Michal Nadler-Holly, Max Ruwolt, Shubhra Ganguli, Sheenam Sharma, Martin Penkert, Eberhard Krause, Fan Liu, Rashna Bhandari, Dorothea Fiedler
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Expression of neuronal NO synthase α- and β-isoforms in skeletal muscle of mice Biochem. J. (IF 4.1) Pub Date : 2024-05-08 Baum, Oliver
Knowledge of the primary structure of neuronal NO synthase (nNOS) in skeletal muscle is still conflicting and needs further clarification. To elucidate the expression patterns of nNOS isoforms at both mRNA and protein level, systematic reverse transcription (RT)-PCR and epitope mapping by qualitative immunoblot analysis on skeletal muscle of C57/BL6 mice were performed. The ability of the nNOS isoforms
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Structural basis for α-tubulin-specific and modification state-dependent glutamylation Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-24 Kishore K. Mahalingan, Danielle A. Grotjahn, Yan Li, Gabriel C. Lander, Elena A. Zehr, Antonina Roll-Mecak
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Molecular recording of calcium signals via calcium-dependent proximity labeling Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-24 J. Wren Kim, Adeline J. H. Yong, Erin E. Aisenberg, Joseph H. Lobel, Wei Wang, Ted M. Dawson, Valina L. Dawson, Ruixuan Gao, Yuh Nung Jan, Helen S. Bateup, Nicholas T. Ingolia
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Repurposing AS1411 for constructing ANM-PROTACs Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-23 Xuekun Fu, Jin Li, Xinxin Chen, Hongzhen Chen, Zhuqian Wang, Fang Qiu, Duoli Xie, Jie Huang, Siran Yue, Chunhao Cao, Yiying Liang, Aiping Lu, Chao Liang
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Addendum: Designing microbial consortia with defined social interactions Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-22 Wentao Kong, James J. Collins, Ting Lu
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Assessing the laboratory performance of AI-generated enzymes Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-23
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Discovery of tumor-reactive T cell receptors by massively parallel library synthesis and screening Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-23 Ziva Moravec, Yue Zhao, Rhianne Voogd, Danielle R. Cook, Seon Kinrot, Benjamin Capra, Haiyan Yang, Brenda Raud, Jiayu Ou, Jiekun Xuan, Teng Wei, Lili Ren, Dandan Hu, Jun Wang, John B.A.G. Haanen, Ton N. Schumacher, Xi Chen, Ely Porter, Wouter Scheper
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Therapeutic application of circular RNA aptamers in a mouse model of psoriasis Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-23 Si-Kun Guo, Chu-Xiao Liu, Yi-Feng Xu, Xiao Wang, Fang Nan, Youkui Huang, Siqi Li, Shan Nan, Ling Li, Edo Kon, Chen Li, Meng-Yuan Wei, Rina Su, Jia Wei, Shiguang Peng, Nitay Ad-El, Jiaquan Liu, Dan Peer, Ting Chen, Li Yang, Ling-Ling Chen
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Computational scoring and experimental evaluation of enzymes generated by neural networks Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-23 Sean R. Johnson, Xiaozhi Fu, Sandra Viknander, Clara Goldin, Sarah Monaco, Aleksej Zelezniak, Kevin K. Yang
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SORL1 is a receptor for tau that promotes tau seeding J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-23 Joanna M. Cooper, Aurelien Lathuiliere, Enming J. Su, Yuyu Song, Daniel Torrente, Youhwa Jo, Nicholas Weinrich, Jennifer Diaz Sales, Mary Migliorini, Thomas H. Sisson, Daniel A. Lawrence, Bradley T. Hyman, Dudley K. Strickland
Sortilin-related receptor 1 (SORL1) is an intracellular sorting receptor genetically implicated in Alzheimer’s disease (AD) that impacts amyloid precursor protein trafficking. The objective of these studies was to test the hypothesis that SORL1 binds tau, modulates its cellular trafficking and impacts the aggregation of cytoplasmic tau induced by pathological forms of tau. Using surface plasmon resonance
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Vitamin A enhanced periosteal osteoclastogenesis is associated with increased number of tissue-derived macrophages/osteoclast progenitors J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-23 Petra Henning, Anna Westerlund, Karin Horkeby, Vikte Lionikaite, Karin H. Nilsson, Sofia Movérare-Skrtic, H. Herschel Conaway, Ulf H. Lerner
A deleterious effect of elevated levels of vitamin A on bone health has been reported in numerous clinical studies. Mechanistic studies in rodents have shown that numbers of periosteal osteoclasts are increased, while endocortical osteoclasts are simultaneously decreased by vitamin A treatment. These observations indicate that osteoclastogenesis on the endocortical and periosteal surfaces of bone is
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UFL1 triggers replication fork degradation by MRE11 in BRCA1/2-deficient cells Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-22 Tian Tian, Junliang Chen, Huacun Zhao, Yulin Li, Feiyu Xia, Jun Huang, Jinhua Han, Ting Liu
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Why Japan lacks a vibrant biotech industry Nat. Biotechnol. (IF 46.9) Pub Date : 2024-04-22 Mark Kessel, Chris Vickrey
Recent analysis of the biopharmaceutical industry in Japan has emphasized that the lack of a thriving biotech ecosystem in that country is largely due to tight controls on drug pricing1. However, this is only one part of the explanation, and any strategy to promote Japanese biotech must acknowledge the full complexity of the problem. Japan has long punched above its weight in innovative research in
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Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria Biochem. J. (IF 4.1) Pub Date : 2024-04-24 Al-Sadeq, Duaa W., Conter, Carolina, Thanassoulas, Angelos, Al-Dewik, Nader, Safieh-Garabedian, Bared, Martínez-Cruz, Luis Alfonso, Nasrallah, Gheyath K., Astegno, Alessandra, Nomikos, Michail
Homocystinuria is a rare disease caused by mutations in the CBS gene that results in a deficiency of cystathionine β-synthase (CBS). CBS is an essential pyridoxal 5′-phosphate (PLP)-dependent enzyme in the transsulfuration pathway, responsible for combining serine with homocysteine to produce cystathionine, whose activity is enhanced by the allosteric regulator S-adenosylmethionine (SAM). CBS also
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AMP-activated protein kinase can be allosterically activated by ADP but AMP remains the key activating ligand Biochem. J. (IF 4.1) Pub Date : 2024-04-24 Hawley, Simon A., Russell, Fiona M., Hardie, D. Grahame
The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status. When activated by increases in ADP:ATP and/or AMP:ATP ratios (signalling energy deficit), AMPK acts to restore energy balance. Binding of AMP to one or more of three CBS repeats (CBS1, CBS3, CBS4) on the AMPK-γ subunit activates the kinase complex by three complementary mechanisms: (i) promoting α-subunit Thr172 phosphorylation
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Facile generation of biepitopic antibodies with intrinsic agonism for activating tumor necrosis factor receptors Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-22 Harkamal S. Jhajj, John S. Schardt, Namir Khalasawi, Emily L. Yao, Timon S. Lwo, Na-Young Kwon, Ryen L. O’Meara, Alec A. Desai, Peter M. Tessier
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The role of histone H3 leucine 126 in fine-tuning the copper reductase activity of nucleosomes J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-22 Nataliya P. Tod, Maria Vogelauer, Chen Cheng, Ansar Karimian, Stefan Schmollinger, Dimitrios Camacho, Siavash K. Kurdistani
The copper reductase activity of histone H3 suggests undiscovered characteristics within the protein. Here, we investigated the function of leucine 126 (H3L126), which occupies an axial position relative to the copper binding. Typically found as methionine or leucine in copper-binding proteins, the axial ligand influences the reduction potential of the bound ion, modulating its tendency to accept or
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Liquid–liquid phase separation of the prion protein is regulated by the octarepeat domain independently of histidines and copper J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-22 Janine Kamps, Verian Bader, Konstanze F. Winklhofer, Jörg Tatzelt
Liquid-liquid phase separation (LLPS) of the mammalian prion protein is mainly driven by its intrinsically disordered N-terminal domain (N-PrP). However, the specific intermolecular interactions that promote LLPS remain largely unknown. Here, we used extensive mutagenesis and comparative analyses of evolutionarily distant PrP species to gain insight into the relationship between protein sequence and
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African swine fever virus infection regulates pyroptosis by cleaving gasdermin A via active caspase-3 and caspase-4 J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-22 Shuai Li, Jie Song, jia Liu, Shijun Zhou, Gaihong Zhao, Tingting Li, Li Huang, Jiangnan Li, Changjiang Weng
African swine fever, caused by the African swine fever virus (ASFV), is a viral hemorrhagic disease that affects domestic pigs and wild boars. ASFV infection causes extensive tissue damage, and the associated mechanism is poorly understood. Pyroptosis is characterized by the activation of inflammatory caspases and pore formation in the cellular plasma membrane, resulting in the release of inflammatory
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Meet the authors: Lori Emert-Sedlak and Tom Smithgall Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-18 Lori Emert-Sedlak, Tom Smithgall
In an interview with Samantha Nelson, a scientific editor of Cell Chemical Biology, the first and corresponding authors of the research article entitled “PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication” share insights on their paper and life as scientists.
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Meet the Authors: Christopher R. Mansfield and Emily R. Derbyshire Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-18 Christopher R. Mansfield, Emily R. Derbyshire
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Dual-action compounds unleash a one-two punch against tuberculosis Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-18 Wendy Le Mouëllic, Yannick Poquet, Olivier Neyrolles
In this issue of Cell Chemical Biology, Gries et al.1 employ an innovative screening approach to identify anti-tuberculosis compounds with dual modes of action: anti-virulence against the type VII secretion system ESX-1 and enhanced ethionamide efficacy. These compounds hold promise for developing multi-target tuberculosis drugs with potential clinical applications.
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METTL3: Melting the tumor microenvironment for improved immunotherapy Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-18 Longfei Gao, Lei Ding
The tumor microenvironment (TME) dictates the outcome of cancer immunotherapy. In this issue of Cell Chemical Biology, Yu et al.1 report that targeting Mettl3 leads to a more inflamed, “hot” TME and effective anti-PD-1 therapy. This study points to a new target in remodeling the TME for improved immunotherapy.
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SARS-CoV-2 resistance to monoclonal antibodies and small-molecule drugs Cell Chem. Bio. (IF 8.6) Pub Date : 2024-04-18 Sho Iketani, David D. Ho
Over four years have passed since the beginning of the COVID-19 pandemic. The scientific response has been rapid and effective, with many therapeutic monoclonal antibodies and small molecules developed for clinical use. However, given the ability for viruses to become resistant to antivirals, it is perhaps no surprise that the field has identified resistance to nearly all of these compounds. Here,
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Zinc utilization by microglia in Alzheimer’s disease J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-20 Daniel C. Shippy, Sophia F. Oliai, Tyler K. Ulland
Alzheimer’s disease (AD) is the most common form of dementia defined by two key pathological characteristics in the brain, amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau. Microglia, the primary innate immune cells of the central nervous system (CNS), provide neuroprotection through Aβ and tau clearance but may also be neurotoxic by promoting neuroinflammation
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A peptide dehydratase with core strength Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-19 Daniel Richter, Anna Lisa Vagstad
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Forced rewiring of RTK signaling Nat. Chem. Biol. (IF 14.8) Pub Date : 2024-04-18 Ahsan Ausaf Ali, Mahmoud Amouzadeh Tabrizi, Mingxu You
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Critical amino acid residues regulating TRPA1 Zn2+ response: A comparative study across species J. Biol. Chem. (IF 5.5) Pub Date : 2024-04-18 Masaki Matsubara, Yukiko Muraki, Hiroka Suzuki, Noriyuki Hatano, Katsuhiko Muraki
Cellular zinc ions (Zn) are crucial for signal transduction in various cell types. The transient receptor potential (TRP) ankyrin 1 (TRPA1) channel, known for its sensitivity to intracellular Zn ([Zn]), has been a subject of limited understanding regarding its molecular mechanism. Here, we used metal ion-affinity prediction, three-dimensional structural modeling, and mutagenesis, utilizing data from