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A TBK1-independent primordial function of STING in lysosomal biogenesis Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Bo Lv, William A. Dion, Haoxiang Yang, Jinrui Xun, Do-Hyung Kim, Bokai Zhu, Jay Xiaojun Tan
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C2H2-zinc-finger transcription factors bind RNA and function in diverse post-transcriptional regulatory processes Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Syed Nabeel-Shah, Shuye Pu, James D. Burns, Ulrich Braunschweig, Nujhat Ahmed, Giovanni L. Burke, Hyunmin Lee, Ernest Radovani, Guoqing Zhong, Hua Tang, Edyta Marcon, Zhaolei Zhang, Timothy R. Hughes, Benjamin J. Blencowe, Jack F. Greenblatt
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Activation of automethylated PRC2 by dimerization on chromatin Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Paul V. Sauer, Egor Pavlenko, Trinity Cookis, Linda C. Zirden, Juliane Renn, Ankush Singhal, Pascal Hunold, Michaela N. Hoehne-Wiechmann, Olivia van Ray, Farnusch Kaschani, Markus Kaiser, Robert Hänsel-Hertsch, Karissa Y. Sanbonmatsu, Eva Nogales, Simon Poepsel
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Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Maya L. Gosztyla, Lijun Zhan, Sara Olson, Xintao Wei, Jack Naritomi, Grady Nguyen, Lena Street, Grant A. Goda, Francisco F. Cavazos, Jonathan C. Schmok, Manya Jain, Easin Uddin Syed, Eunjeong Kwon, Wenhao Jin, Eric Kofman, Alexandra T. Tankka, Allison Li, Valerie Gonzalez, Eric Lécuyer, Daniel Dominguez, Gene W. Yeo
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Large-scale map of RNA-binding protein interactomes across the mRNA life cycle Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Lena A. Street, Katherine L. Rothamel, Kristopher W. Brannan, Wenhao Jin, Benjamin J. Bokor, Kevin Dong, Kevin Rhine, Assael Madrigal, Norah Al-Azzam, Jenny Kim Kim, Yanzhe Ma, Darvesh Gorhe, Ahmed Abdou, Erica Wolin, Orel Mizrahi, Joshua Ahdout, Mayuresh Mujumdar, Ella Doron-Mandel, Marko Jovanovic, Gene W. Yeo
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Finish the unfinished: Chd1 resolving hexasome-nucleosome complex with FACT Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Hongxin Yin, Yang Liu
In this issue of Molecular Cell, Engeholm et al.1 present cryo-EM structures of the chromatin remodeler Chd1 bound to a hexasome-nucleosome complex, an intermediate state during transcription either with or without FACT to restore the missing H2A-H2B dimer. These two binding modes reveal how Chd1 and FACT cooperate in nucleosome re-establishment during transcription.
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Coming in out of the cold: Rho-dependent termination contributes to adaptation to cold shock Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Teppei Morita, Susan Gottesman
During cold shock, bacteria shut down translation of all but a set of cold-shock proteins critical for recovery; in this issue of Molecular Cell, Delaleau et al.1 show that Rho-dependent transcription termination plays an important role in cold adaptation, via temperature-regulated termination of the cold-shock protein mRNAs.
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Transcription regulation through selective partitioning: Weak interactions with a strong foundation Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Megan Palacio, Dylan J. Taatjes
In this issue of Molecular Cell, De La Cruz, Pradhan, Veettil et al.1 examine how selective partitioning of proteins via low-affinity IDR-dependent interactions may help regulate RNA polymerase II (RNA Pol II) function and identify sequence features that drive partitioning in cells.
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Ubiquitylation: Sword and shield in the bacterial arsenal Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Jonathan N. Pruneda, Felix Randow
In two recent studies in Nature, Hör et al.1 and Chambers et al.2 report that ubiquitin-like conjugation in bacteria antagonizes phage replication.
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Coagulation factor X promotes resistance to androgen-deprivation therapy in prostate cancer Cancer Cell (IF 48.8) Pub Date : 2024-09-19 Bianca Calì, Martina Troiani, Silvia Bressan, Giuseppe Attanasio, Sara Merler, Viola Moscarda, Simone Mosole, Elena Ricci, Christina Guo, Wei Yuan, Lewis Gallagher, Arian Lundberg, Ilona Bernett, Ines Figueiredo, Rydell Alvarez Arzola, Ernesto Bermudez Abreut, Mariantonietta D’Ambrosio, Nicolò Bancaro, Daniela Brina, Sara Zumerle, Andrea Alimonti
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Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer Cancer Cell (IF 48.8) Pub Date : 2024-09-19 Xueliang Wang, Yi Fang, Wei Liang, Chi Chun Wong, Huanlong Qin, Yaohui Gao, Meinong Liang, Lei Song, Yongxin Zhang, Miao Fan, Chuanfa Liu, Harry Cheuk-Hay Lau, Lixia Xu, Xiaoxing Li, Wu Song, Junlin Wang, Na Wang, Tao Yang, Mengmiao Mo, Xiang Zhang, Jun Yu
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Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation Cancer Cell (IF 48.8) Pub Date : 2024-09-19 Yang Gao, Jianan Li, Wenfeng Cheng, Tian Diao, Huilan Liu, Yufei Bo, Chang Liu, Wei Zhou, Minmin Chen, Yuanyuan Zhang, Zhihua Liu, Weidong Han, Rufu Chen, Jirun Peng, Linnan Zhu, Wenhong Hou, Zemin Zhang
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Fasting shapes chromatin architecture through an mTOR/RNA Pol I axis Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-19 Nada Al-Refaie, Francesco Padovani, Johanna Hornung, Lorenz Pudelko, Francesca Binando, Andrea del Carmen Fabregat, Qiuxia Zhao, Benjamin D. Towbin, Elif Sarinay Cenik, Nicholas Stroustrup, Jan Padeken, Kurt M. Schmoller, Daphne S. Cabianca
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Clathrin-associated carriers enable recycling through a kiss-and-run mechanism Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-19 Jiachao Xu, Yu Liang, Nan Li, Song Dang, Amin Jiang, Yiqun Liu, Yuting Guo, Xiaoyu Yang, Yi Yuan, Xinyi Zhang, Yaran Yang, Yongtao Du, Anbing Shi, Xiaoyun Liu, Dong Li, Kangmin He
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The long non-coding RNA ROSALIND protects the mitochondrial translational machinery from oxidative damage Cell Death Differ. (IF 13.7) Pub Date : 2024-09-18 Vicky Katopodi, Alessandro Marino, Nikoleta Pateraki, Yvessa Verheyden, Sonia Cinque, Elena Lara Jimenez, Sara Adnane, Ewout Demesmaeker, Alice Scomparin, Rita Derua, Elisabetta Groaz, Eleonora Leucci
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Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3tm1Flv mice Cell Death Differ. (IF 13.7) Pub Date : 2024-09-17 Felix D. Weiss, Yubell Alvarez, Farhad Shakeri, Anshupa Sahu, Petro Leka, Alesja Dernst, Jessika Rollheiser, Matilde Vasconcelos, Adriana Geraci, Fraser Duthie, Rainer Stahl, Hye Eun Lee, Anne-Kathrin Gellner, Andreas Buness, Eicke Latz, Felix Meissner
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PDIA3 defines a novel subset of adipose macrophages to exacerbate the development of obesity and metabolic disorders Cell Metab. (IF 27.7) Pub Date : 2024-09-17 Jia-Hui Luo, Fa-Xi Wang, Jia-Wei Zhao, Chun-Liang Yang, Shan-Jie Rong, Wan-Ying Lu, Qi-Jie Chen, Qing Zhou, Jun Xiao, Ya-Nan Wang, Xi Luo, Yang Li, Dan-Ni Song, Cai Chen, Cheng-Liang Zhang, Su-Hua Chen, Ping Yang, Fei Xiong, Qi-Lin Yu, Shu Zhang, Cong-Yi Wang
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Plasma membrane curvature regulates the formation of contacts with the endoplasmic reticulum Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-17 Yang Yang, Luis A. Valencia, Chih-Hao Lu, Melissa L. Nakamoto, Ching-Ting Tsai, Chun Liu, Huaxiao Yang, Wei Zhang, Zeinab Jahed, Wan-Ru Lee, Francesca Santoro, Jen Liou, Joseph C. Wu, Bianxiao Cui
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Synaptotagmin-1 in phase: Condensate biology reveals new insights into the synaptic calcium sensor. J. Cell Biol. (IF 7.4) Pub Date : 2024-09-17 Johannes Vincent Tromm,Dragomir Milovanovic
Two recent papers by Mehta et al. and Zhu et al. in this issue (https://doi.org/10.1083/jcb.202311191) discover that synaptotagmin-1, the primary calcium sensor at the synapse, forms biomolecular condensates, identifying a new layer of regulation in calcium-triggered synaptic vesicle exocytosis.
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Mitophagy protects against ferroptosis Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-12 Petra Gross
Mitophagy, the selective autophagy of damaged mitochondria, is mediated by several receptors, including BNIP3 and NIX, and is important for mitochondrial homeostasis. Mitochondria are also the major source of reactive oxygen species (ROS); mitochondrial ROS (mtROS) can give rise to lipid peroxides, which, in turn, induce ferroptosis, a specific type of cell death. In this study, Kanki and co-workers
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Profiling cell death in COVID-19 pathology Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-12 Zhe Wang
SARS-CoV-2 infection can lead to various types of cell death including apoptosis, necroptosis and pyroptosis. Liang et al. report the dynamics and features of cell death in infected human airway epithelial cells, the primary target cell type that hosts SARS-CoV-2 replication. The authors first showed that SARS-CoV-2 infection in ACE2-expressing lung epithelial cells initially induced apoptosis and
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Ribotoxic stress drives cell death by UV Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-12 Petra Gross
UV radiation not only induces DNA damage, but also damages RNA, eliciting a ribotoxic stress response (RSR), but its contribution to subsequent cell death remains unclear. Green and colleagues establish a detailed timeline of signalling events activated in cells upon UV damage and report that UV-mediated apoptosis is driven by RSR, and not the DNA damage response. The authors show that the immediate-early
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Ferroptosis disseminates afar in development Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-12 Zhe Wang
Ferroptosis is a distinct form of iron-dependent cell death that can propagate over a distance through a population of cells in a wave-like process. Co et al. further characterize this phenomenon and report ferroptotic trigger waves as a large-scale cell death mechanism to control limb development. The authors developed a cellular system to pinpoint the time and location of ferroptosis induction through
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Navigating the biology of cell death Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-12
This issue presents a Focus of specially commissioned articles that discuss cell death in its multiple forms, implications for homeostatic physiology and disease and outstanding questions in this expanding field.
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Spatial omics advances for in situ RNA biology Mol. Cell (IF 14.5) Pub Date : 2024-09-12 Jingyi Ren, Shuchen Luo, Hailing Shi, Xiao Wang
Spatial regulation of RNA plays a critical role in gene expression regulation and cellular function. Understanding spatially resolved RNA dynamics and translation is vital for bringing new insights into biological processes such as embryonic development, neurobiology, and disease pathology. This review explores past studies in subcellular, cellular, and tissue-level spatial RNA biology driven by diverse
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Endothelial metabolic control of insulin sensitivity through resident macrophages Cell Metab. (IF 27.7) Pub Date : 2024-09-12 Jing Zhang, Kim Anker Sjøberg, Songlin Gong, Tongtong Wang, Fengqi Li, Andrew Kuo, Stephan Durot, Adam Majcher, Raphaela Ardicoglu, Thibaut Desgeorges, Charlotte Greta Mann, Ines Soro Arnáiz, Gillian Fitzgerald, Paola Gilardoni, E. Dale Abel, Shigeyuki Kon, Danyvid Olivares-Villagómez, Nicola Zamboni, Christian Wolfrum, Thorsten Hornemann, Katrien De Bock
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Human pluripotent stem cell-derived organoids repair damaged bowel in vivo Cell Stem Cell (IF 19.8) Pub Date : 2024-09-12 Holly M. Poling, Nambirajan Sundaram, Garrett W. Fisher, Akaljot Singh, Joseph R. Shiley, Kalpana Nattamai, Vinothini Govindarajah, Alexander R. Cortez, Maksym O. Krutko, Séverine Ménoret, Ignacio Anegon, Magdalena Kasendra, James M. Wells, Christopher N. Mayhew, Takanori Takebe, Maxime M. Mahe, Michael A. Helmrath
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Ovarian cancer metastasis: Looking beyond the surface Cancer Cell (IF 48.8) Pub Date : 2024-09-12 Emine Bayraktar, Sisy Chen, Sara Corvigno, Jinsong Liu, Anil K. Sood
Historically, ovarian cancer (OC) was thought to metastasize by surface-to-surface spread, but recent developments have yielded a new understanding of the paths of metastatic spread. Given the histologic and molecular heterogeneity of OC, we will focus on high-grade serous carcinoma (HGSC). Here, we provide a critical and more holistic view of the evidence supporting various routes of metastasis, including
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From backstage to the spotlight: γδT cells in cancer Cancer Cell (IF 48.8) Pub Date : 2024-09-12 Robert Wiesheu, Seth B. Coffelt
γδT cells represent a group of immune cells that are understudied but whose utility has been recognized for cancer immunotherapy purposes. Recent studies have highlighted a critical role for these cells in tumor initiation, growth, and metastasis and revealed an increasingly complex biology of γδT cell subsets that is context and tissue specific. We discuss here how γδT cell subsets are regulated,
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Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain Cancer Cell (IF 48.8) Pub Date : 2024-09-12 Siting Gan, Danilo G. Macalinao, Sayyed Hamed Shahoei, Lin Tian, Xin Jin, Harihar Basnet, Catherine Bibby, James T. Muller, Pranita Atri, Evan Seffar, Walid Chatila, Ali Karacay, Pharto Chanda, Anna-Katerina Hadjantonakis, Nikolaus Schultz, Edi Brogi, Tejus A. Bale, Nelson S. Moss, Rajmohan Murali, Dana Pe’er, Joan Massagué
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Solid tumour-induced systemic immunosuppression involves dichotomous myeloid–B cell interactions Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-12 Xiaoxin Hao, Yichao Shen, Jun Liu, Angela Alexander, Ling Wu, Zhan Xu, Liqun Yu, Yang Gao, Fengshuo Liu, Hilda L. Chan, Che-Hsing Li, Yunfeng Ding, Weijie Zhang, David G. Edwards, Nan Chen, Azadeh Nasrazadani, Naoto T. Ueno, Bora Lim, Xiang H.-F. Zhang
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The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-11 Aleksander T. Szczurek, Emilia Dimitrova, Jessica R. Kelley, Neil P. Blackledge, Robert J. Klose
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Ammonia-induced lysosomal and mitochondrial damage causes cell death of effector CD8+ T cells Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-11 Huafeng Zhang, Jincheng Liu, Wu Yuan, Qian Zhang, Xiao Luo, Yonggang Li, Yue’e Peng, Jingyu Feng, Xiaoyu Liu, Jie Chen, Yabo Zhou, Jiadi Lv, Nannan Zhou, Jingwei Ma, Ke Tang, Bo Huang
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Inverse blebs operate as hydraulic pumps during mouse blastocyst formation Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-11 Markus F. Schliffka, Julien G. Dumortier, Diane Pelzer, Arghyadip Mukherjee, Jean-Léon Maître
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Feeding cancer to death - a triad of aromatic acids reduces tumor growth Cell Death Differ. (IF 13.7) Pub Date : 2024-09-12 Audrey Xavier, Ivan Dikic
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The E3 ligase ASB3 downregulates antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation Cell Death Differ. (IF 13.7) Pub Date : 2024-09-12 Mingyang Cheng, Yiyuan Lu, Jiarui Wang, Haixu Wang, Yu Sun, Wenhui Zhao, Junhong Wang, Chunwei Shi, Jiawei Luo, Ming Gao, Tianxin Yu, Jianzhong Wang, Jiayao Guan, Nan Wang, Wentao Yang, Yanlong Jiang, Haibin Huang, Guilian Yang, Xin Cao, Dongqin Yang, Chunfeng Wang, Yan Zeng
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Inhibition of nucleo-cytoplasmic proteasome translocation by the aromatic amino acids or silencing Sestrin3—their sensing mediator—is tumor suppressive Cell Death Differ. (IF 13.7) Pub Date : 2024-09-12 Ido Livneh, Bertrand Fabre, Gilad Goldhirsh, Chen Lulu, Adar Zinger, Yael Shammai Vainer, Maya Kaduri, Aviva Dahan, Tamar Ziv, Avi Schroeder, Yinon Ben-Neriah, Yaniv Zohar, Victoria Cohen-Kaplan, Aaron Ciechanover
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Intracellular zinc protects tumours from T cell-mediated cytotoxicity Cell Death Differ. (IF 13.7) Pub Date : 2024-09-11 Emily J. Lelliott, Jonathan Naddaf, Katherine Ganio, Jessica Michie, Shelly Wang, Lin Liu, Natasha Silke, Antonio Ahn, Kelly M. Ramsbottom, Amelia J. Brennan, Andrew J. Freeman, Shom Goel, Stephin J. Vervoort, Conor J. Kearney, Paul A. Beavis, Christopher A. McDevitt, John Silke, Jane Oliaro
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Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT Mol. Cell (IF 14.5) Pub Date : 2024-09-12 Maik Engeholm, Johann J. Roske, Elisa Oberbeckmann, Christian Dienemann, Michael Lidschreiber, Patrick Cramer, Lucas Farnung
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A new player in the biogenesis of lysosome-related organelles. J. Cell Biol. (IF 7.4) Pub Date : 2024-09-11 Anbing Shi
How are Rab GTPases regulated during lysosome-related organelle (LRO) biogenesis? Li et al. (https://doi.org/10.1083/jcb.202402016) identify LYSMD proteins as crucial activators of Rab32-family GTPases in LRO development, shedding light on the previously ambiguous mechanisms governing Rab functionality in this process.
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Dietary-timing-induced gut microbiota diurnal oscillations modulate inflammatory rhythms in rheumatoid arthritis Cell Metab. (IF 27.7) Pub Date : 2024-09-10 Fopei Ma, Zhuang Li, Haihua Liu, Shixian Chen, Songyuan Zheng, Junqing Zhu, Hao Shi, Haixin Ye, Zhantu Qiu, Lei Gao, Bingqi Han, Qian Yang, Xing Wang, Yang Zhang, Lifang Cheng, Huijie Fan, Shuaijun Lv, Xiaoshan Zhao, Hongwei Zhou, Juan Li, Mukeng Hong
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Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids Cell Stem Cell (IF 19.8) Pub Date : 2024-09-10 Jiuru Li, Alexandra Wiesinger, Lianne Fokkert, Priscilla Bakker, Dylan K. de Vries, Anke J. Tijsen, Yigal M. Pinto, Arie O. Verkerk, Vincent M. Christoffels, Gerard J.J. Boink, Harsha D. Devalla
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The role of the haematopoietic stem cell niche in development and ageing Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-09-10 Terri L. Cain, Marta Derecka, Shannon McKinney-Freeman
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PHGDH/SYK: a hub integrating anti-fungal immunity and serine metabolism Cell Death Differ. (IF 13.7) Pub Date : 2024-09-10 Xinyong Zhang, Dongdong Hu, Xiaoyan Sun, Yichun Gu, Yong Zhou, Chuanxin Su, Shi Liu, Caiyan Zhang, Guoping Lu, Qiwen Wu, Aidong Chen
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RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages Mol. Cell (IF 14.5) Pub Date : 2024-09-10 Teodorus Theo Susanto, Victoria Hung, Andrew G. Levine, Yuxiang Chen, Craig H. Kerr, Yongjin Yoo, Juan A. Oses-Prieto, Lisa Fromm, Zijian Zhang, Travis C. Lantz, Kotaro Fujii, Marius Wernig, Alma L. Burlingame, Davide Ruggero, Maria Barna
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HOPping to the vacuole: Autophagosome and late endosomes combine to control plant autophagosome degradation Dev. Cell (IF 10.7) Pub Date : 2024-09-09 Jonathan Dragwidge, Amélie Bernard
In this issue of Developmental Cell, Jiang et al. report that the Arabidopsis HOPS tethering complex subunit VPS41 acts to catalyze the formation of a degradation pathway composed of a hybrid of autophagosomes and late endosomes.
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Epigenetic reprogramming enables NF1A/B oncogenic role in SHH medulloblastoma Dev. Cell (IF 10.7) Pub Date : 2024-09-09 Sara Badodi, Silvia Marino
In this issue of Developmental Cell, Shiraishi et al. investigate the epigenetic changes occurring during the formation of SHH medulloblastoma and show that an epigenomic shift renders Nuclear Factor I family of transcription factors oncogenic.
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m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1 Cell Metab. (IF 27.7) Pub Date : 2024-09-09 Ling Xiao, Dario F. De Jesus, Cheng-Wei Ju, Jiang Bo Wei, Jiang Hu, Ava DiStefano-Forti, Tadataka Tsuji, Cheryl Cero, Ville Männistö, Suvi M. Manninen, Siying Wei, Oluwaseun Ijaduola, Matthias Blüher, Aaron M. Cypess, Jussi Pihlajamäki, Yu-Hua Tseng, Chuan He, Rohit N. Kulkarni
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Mechanisms of mechanotransduction and physiological roles of PIEZO channels Nat. Rev. Mol. Cell Biol. (IF 81.3) Pub Date : 2024-09-09 Bailong Xiao
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Perturbing TET2 condensation promotes aberrant genome-wide DNA methylation and curtails leukaemia cell growth Nat. Cell Biol. (IF 17.3) Pub Date : 2024-09-09 Lei Guo, Tingting Hong, Yi-Tsang Lee, Xue Hu, Guokai Pan, Rongjie Zhao, Yuhan Yang, Jingwen Yang, Xiaoli Cai, Logan Rivera, Jie Liang, Rui Wang, Yaling Dou, Srikanth Kodali, Wenbo Li, Leng Han, Bruno Di Stefano, Yubin Zhou, Jia Li, Yun Huang
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Classifying cancer-associated fibroblasts—The good, the bad, and the target Cancer Cell (IF 48.8) Pub Date : 2024-09-09 Lena Cords, Natalie de Souza, Bernd Bodenmiller
Cancer-associated fibroblasts (CAFs) are heterogeneous and ubiquitous stromal cells within the tumor microenvironment (TME). Numerous CAF types have been described, typically using single-cell technologies such as single-cell RNA sequencing. There is no general classification system for CAFs, hampering their study and therapeutic targeting. We propose a simple CAF classification system based on single-cell
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Assessing clonal changes in T cells over time following immunotherapy is a breeze with Cyclone Cancer Cell (IF 48.8) Pub Date : 2024-09-09 Anthony R. Cillo, John M. Kirkwood
Combination immunotherapy improves outcomes in metastatic melanoma, but the underlying mechanisms remain unclear. In this issue of Cancer Cell, Wang et al.1 report dynamics and transcriptional states of CD8+ T cell clones over time in patients treated with anti-PD-1, anti-CTLA-4, or a combination of the two. These findings have important implications for understanding and monitoring combination immunotherapy
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Fibrotic response to anti-CSF-1R therapy potentiates glioblastoma recurrence Cancer Cell (IF 48.8) Pub Date : 2024-09-09 Spencer S. Watson, Anoek Zomer, Nadine Fournier, Joao Lourenco, Manfredo Quadroni, Agnieszka Chryplewicz, Sina Nassiri, Pauline Aubel, Simona Avanthay, Davide Croci, Erik Abels, Marike L.D. Broekman, Douglas Hanahan, Jason T. Huse, Roy T. Daniel, Monika E. Hegi, Krisztian Homicsko, Giulia Cossu, Andreas F. Hottinger, Johanna A. Joyce
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Glioblastoma induces the recruitment and differentiation of dendritic-like “hybrid” neutrophils from skull bone marrow Cancer Cell (IF 48.8) Pub Date : 2024-09-09 Meeki Lad, Angad S. Beniwal, Saket Jain, Poojan Shukla, Venina Kalistratova, Jangham Jung, Sumedh S. Shah, Garima Yagnik, Atul Saha, Ankita Sati, Husam Babikir, Alan T. Nguyen, Sabraj Gill, Jennifer Rios, Jacob S. Young, Austin Lui, Diana Salha, Aaron Diaz, Manish K. Aghi
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Circulating tumor DNA-based stratification strategy for chemotherapy plus PD-1 inhibitor in advanced non-small-cell lung cancer Cancer Cell (IF 48.8) Pub Date : 2024-09-09 Jiachen Xu, Rui Wan, Yiran Cai, Shangli Cai, Lin Wu, Baolan Li, Jianchun Duan, Ying Cheng, Xiaoling Li, Xicheng Wang, Liang Han, Xiaohong Wu, Yun Fan, Yan Yu, Dongqing Lv, Jianhua Shi, Jianjin Huang, Shaozhang Zhou, Baohui Han, Guogui Sun, Qisen Guo, Youxin Ji, Xiaoli Zhu, Sheng Hu, Wei Zhang, Qiming Wang, Yuming Jia, Ziping Wang, Yong Song, Jingxun Wu, Meiqi Shi, Xingya Li, Zhigang Han, Yunpeng Liu
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Targeting APT2 improves MAVS palmitoylation and antiviral innate immunity Mol. Cell (IF 14.5) Pub Date : 2024-09-09 Lang Bu, Huan Wang, Shuishen Zhang, Yi Zhang, Miaowen Liu, Zhengkun Zhang, Xueji Wu, Qiwei Jiang, Lei Wang, Wei Xie, Miao He, Zhengran Zhou, Chao Cheng, Jianping Guo
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SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation Cell Metab. (IF 27.7) Pub Date : 2024-09-06 Wenhui Liu, Danming You, Jiayang Lin, Huren Zou, Lei Zhang, Shenjian Luo, Youwen Yuan, Zhiyi Wang, Jingwen Qi, Weiwei Wang, Xueru Ye, Xiaoyu Yang, Yajuan Deng, Fei Teng, Xiaojun Zheng, Yuhao Lin, Zhiwei Huang, Yan Huang, Zhi Yang, Xuan Zhou, Huijie Zhang
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Integrated electrophysiological and genomic profiles of single cells reveal spiking tumor cells in human glioma Cancer Cell (IF 48.8) Pub Date : 2024-09-05 Rachel N. Curry, Qianqian Ma, Malcolm F. McDonald, Yeunjung Ko, Snigdha Srivastava, Pey-Shyuan Chin, Peihao He, Brittney Lozzi, Prazwal Athukuri, Junzhan Jing, Su Wang, Arif O. Harmanci, Benjamin Arenkiel, Xiaolong Jiang, Benjamin Deneen, Ganesh Rao, Akdes Serin Harmanci
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Heterochromatin: Hiding from the remodeling machines Mol. Cell (IF 14.5) Pub Date : 2024-09-05 Craig L. Peterson
In this issue of Molecular Cell, Sahu et al.1 find that shielding heterochromatin from SWI/SNF chromatin remodelers is essential to maintain and epigenetically propagate pre-existing heterochromatin domains, whereas SWI/SNF action protects facultative heterochromatic regions from premature silencing.
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Proteasomes safeguard the plant stress granule homeostasis Mol. Cell (IF 14.5) Pub Date : 2024-09-05 Qi Chen, Xiaoxin Chen, Peiguo Yang
In this issue of Molecular Cell, Xie et al.1 revealed that the proteasome is a constitutive component of plant stress granules (SGs), and that enhanced proteolytic activity is essential for efficient SG disassembly and plant survival during the stress response.