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Three patterns link brain organization to genes in health and disease Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-24
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Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-22 Richard Dear, Konrad Wagstyl, Jakob Seidlitz, Ross D. Markello, Aurina Arnatkevičiūtė, Kevin M. Anderson, Richard A. I. Bethlehem, Armin Raznahan, Edward T. Bullmore, Petra E. Vértes
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In conversation with Fernando de Castro Soubriet Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-18 Elisa Floriddia
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved and where it is heading. This month we are talking to Fernando de Castro Soubriet, principal investigator at the Instituto Cajal (Spain). He is a neurodevelopmental biologist who is actively involved in
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Identification of senescent, TREM2-expressing microglia in aging and Alzheimer’s disease model mouse brain Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-18 Noa Rachmian, Sedi Medina, Ulysse Cherqui, Hagay Akiva, Daniel Deitch, Dunya Edilbi, Tommaso Croese, Tomer Meir Salame, Javier Maria Peralta Ramos, Liora Cahalon, Valery Krizhanovsky, Michal Schwartz
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Advancing the neuroscience of human pregnancy Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-10 Magdalena Martínez-García, Emily G. Jacobs, Ann-Marie G. de Lange, Susana Carmona
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Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-10 Raffaella De Pace, Saikat Ghosh, Veronica H. Ryan, Mira Sohn, Michal Jarnik, Paniz Rezvan Sangsari, Nicole Y. Morgan, Ryan K. Dale, Michael E. Ward, Juan S. Bonifacino
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Widespread changes in alternative splicing in developing and adult mouse brain Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-09
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Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-09 Anoushka Joglekar, Wen Hu, Bei Zhang, Oleksandr Narykov, Mark Diekhans, Jordan Marrocco, Jennifer Balacco, Lishomwa C. Ndhlovu, Teresa A. Milner, Olivier Fedrigo, Erich D. Jarvis, Gloria Sheynkman, Dmitry Korkin, M. Elizabeth Ross, Hagen U. Tilgner
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Restoring sensation to prosthetics Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-08 Henrietta Howells
Amputees often experience paresthesia and difficulties using prosthetic limbs because of impaired sensorimotor processing. Artificial peripheral nerve stimulation has shown promise in restoring brain–body communication for sensory processing. In a recent Nature Communications publication, Valle et al. report a biomimetic neurostimulation technique that improved mobility in people with lower-limb amputation
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HDAC3 stokes microglia in stroke Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-08 George Andrew S. Inglis
Microglia play a complex role in the response to brain injury, with past work showing that these cells can both aid in the recovery from ischemic stroke and exacerbate its pathology. A recent study in Science Advances explores this topic through the chromatin remodeling protein HDAC3, which broadly activates the expression of target genes. The authors surgically induced transient focal cerebral ischemia
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Pushing the bounds on dimensionality Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-08 Luis A. Mejia
Low-dimensional representations can capture structure in neural dynamics data, but it is unclear whether additional structure is being missed, especially when larger populations are sampled. Manley et al. have imaged the activity of up to a million neurons in dorsal cortex of awake head-fixed mice to directly measure how neural dimensionality scales with population size. Using shared variance component
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Neuronal activity rapidly reprograms dendritic translation via eIF4G2:uORF binding Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-08 Ezgi Hacisuleyman, Caryn R. Hale, Natalie Noble, Ji-dung Luo, John J. Fak, Misa Saito, Jin Chen, Jonathan S. Weissman, Robert B. Darnell
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Centripetal integration of past events in hippocampal astrocytes regulated by locus coeruleus Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-03 Peter Rupprecht, Sian N. Duss, Denise Becker, Christopher M. Lewis, Johannes Bohacek, Fritjof Helmchen
An essential feature of neurons is their ability to centrally integrate information from their dendrites. The activity of astrocytes, in contrast, has been described as mostly uncoordinated across cellular compartments without clear central integration. Here we report conditional integration of calcium signals in astrocytic distal processes at their soma. In the hippocampus of adult mice of both sexes
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Climbing fibers provide essential instructive signals for associative learning Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-02 N. Tatiana Silva, Jorge Ramírez-Buriticá, Dominique L. Pritchett, Megan R. Carey
Supervised learning depends on instructive signals that shape the output of neural circuits to support learned changes in behavior. Climbing fiber (CF) inputs to the cerebellar cortex represent one of the strongest candidates in the vertebrate brain for conveying neural instructive signals. However, recent studies have shown that Purkinje cell stimulation can also drive cerebellar learning and the
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Pervasive environmental chemicals impair oligodendrocyte development Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-25 Erin F. Cohn, Benjamin L. L. Clayton, Mayur Madhavan, Kristin A. Lee, Sara Yacoub, Yuriy Fedorov, Marissa A. Scavuzzo, Katie Paul Friedman, Timothy J. Shafer, Paul J. Tesar
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Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-27 Renzo Mancuso, Nicola Fattorelli, Anna Martinez-Muriana, Emma Davis, Leen Wolfs, Johanna Van Den Daele, Ivana Geric, Jessie Premereur, Paula Polanco, Baukje Bijnens, Pranav Preman, Lutgarde Serneels, Suresh Poovathingal, Sriram Balusu, Catherine Verfaillie, Mark Fiers, Bart De Strooper
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TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-27 Edward N. Wilson, Congcong Wang, Michelle S. Swarovski, Kristy A. Zera, Hannah E. Ennerfelt, Qian Wang, Aisling Chaney, Esha Gauba, Javier A. Ramos Benitez, Yann Le Guen, Paras S. Minhas, Maharshi Panchal, Yuting J. Tan, Eran Blacher, Chinyere A. Iweka, Haley Cropper, Poorva Jain, Qingkun Liu, Swapnil S. Mehta, Abigail J. Zuckerman, Matthew Xin, Jacob Umans, Jolie Huang, Aarooran S. Durairaj, Geidy
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Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-27 Michael A. Thornton, Gregory L. Futia, Michael E. Stockton, Samuel A. Budoff, Alexandra N. Ramirez, Baris Ozbay, Omer Tzang, Karl Kilborn, Alon Poleg-Polsky, Diego Restrepo, Emily A. Gibson, Ethan G. Hughes
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A precision functional atlas of personalized network topography and probabilities Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-26 Robert J. M. Hermosillo, Lucille A. Moore, Eric Feczko, Óscar Miranda-Domínguez, Adam Pines, Ally Dworetsky, Gregory Conan, Michael A. Mooney, Anita Randolph, Alice Graham, Babatunde Adeyemo, Eric Earl, Anders Perrone, Cristian Morales Carrasco, Johnny Uriarte-Lopez, Kathy Snider, Olivia Doyle, Michaela Cordova, Sanju Koirala, Gracie J. Grimsrud, Nora Byington, Steven M. Nelson, Caterina Gratton, Steven
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Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-25 Dongwon Choi, Eunkyung Park, Joshua Choi, Renhao Lu, Jin Suh Yu, Chiyoon Kim, Luping Zhao, James Yu, Brandon Nakashima, Sunju Lee, Dhruv Singhal, Joshua P. Scallan, Bin Zhou, Chester J. Koh, Esak Lee, Young-Kwon Hong
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Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-25 Elena Dvoretskova, May C. Ho, Volker Kittke, Florian Neuhaus, Ilaria Vitali, Daniel D. Lam, Irene Delgado, Chao Feng, Miguel Torres, Juliane Winkelmann, Christian Mayer
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Recommendations for the responsible use and communication of race and ethnicity in neuroimaging research Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-22 Carlos Cardenas-Iniguez, Marybel Robledo Gonzalez
The growing availability of large-population human biomedical datasets provides researchers with unique opportunities to conduct rigorous and impactful studies on brain and behavioral development, allowing for a more comprehensive understanding of neurodevelopment in diverse populations. However, the patterns observed in these datasets are more likely to be influenced by upstream structural inequities
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A systems identification approach using Bayes factors to deconstruct the brain bases of emotion regulation Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-22 Ke Bo, Thomas E. Kraynak, Mijin Kwon, Michael Sun, Peter J. Gianaros, Tor D. Wager
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Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-21 Marius Marc-Daniel Mader, Alan Napole, Danwei Wu, Micaiah Atkins, Alexa Scavetti, Yohei Shibuya, Aulden Foltz, Oliver Hahn, Yongjin Yoo, Ron Danziger, Christina Tan, Tony Wyss-Coray, Lawrence Steinman, Marius Wernig
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The dynamic state of a prefrontal–hypothalamic–midbrain circuit commands behavioral transitions Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-18 Changwan Chen, Mahsa Altafi, Mihaela-Anca Corbu, Aleksandra Trenk, Hanna van den Munkhof, Kristin Weineck, Franziska Bender, Marta Carus-Cadavieco, Alisa Bakhareva, Tatiana Korotkova, Alexey Ponomarenko
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Co-dependent excitatory and inhibitory plasticity accounts for quick, stable and long-lasting memories in biological networks Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-20 Everton J. Agnes, Tim P. Vogels
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Natural language instructions induce compositional generalization in networks of neurons Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-18 Reidar Riveland, Alexandre Pouget
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Local origin of excitatory–inhibitory tuning equivalence in a cortical network Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-15 Adrian J. Duszkiewicz, Pierre Orhan, Sofia Skromne Carrasco, Eleanor H. Brown, Eliott Owczarek, Gilberto R. Vite, Emma R. Wood, Adrien Peyrache
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Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-11 Chun-Feng Shang, Yu-Fan Wang, Mei-Ting Zhao, Qiu-Xiang Fan, Shan Zhao, Yu Qian, Sheng-Jin Xu, Yu Mu, Jie Hao, Jiu-Lin Du
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In conversation with Igor Adameyko Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-12 Elisa Floriddia
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved, and where it is heading. This month, we are talking to Igor Adameyko (Department Chair at the Center for Brain Research of the Medical University of Vienna, Austria, and a group leader at the Karolinska
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Liprin-α proteins are master regulators of human presynapse assembly Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-12 Berta Marcó de la Cruz, Joaquín Campos, Angela Molinaro, Xingqiao Xie, Gaowei Jin, Zhiyi Wei, Claudio Acuna, Fredrik H. Sterky
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Identification of a cold sensor in peripheral somatosensory neurons Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-11
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The kainate receptor GluK2 mediates cold sensing in mice Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-11 Wei Cai, Wenwen Zhang, Qin Zheng, Chia Chun Hor, Tong Pan, Mahar Fatima, Xinzhong Dong, Bo Duan, X. Z. Shawn Xu
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Learning with baby Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-07 Rebecca Wright
The rate at which young children learn new words astounds care-givers and scientists alike. Most models of early language acquisition have only been tested in laboratory settings using highly controlled stimuli. In a recent publication in Science, Vong et al. decided to take a more naturalistic approach. They collected 61 h of video footage of a toddler wearing a head-mounted camera as they went about
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The eyes have it Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-07 Leonie Welberg
Many social species use eye contact to guide social behaviors. To study how visual cues shape social decision making, Franch et al. wirelessly recorded eye movements and activity in the visual and prefrontal cortices in two pairs of freely moving macaque monkeys. To retrieve food rewards, paired monkeys — who could see each other through a transparent screen — each had to press and hold a button and
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Slowing human neurons Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-07 Shari Wiseman
Human neurodevelopment is slower than that of other mammalian species, and this timescale appears to be intrinsic to human neural cells. However, not much is known about the mechanisms that govern this maturational timing. In a recent paper in Nature, Ciceri et al. developed a human pluripotent stem cell culture protocol that synchronously generates a uniform population of cortical neurons. The authors
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Population coding of strategic variables during foraging in freely moving macaques Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-05 Neda Shahidi, Melissa Franch, Arun Parajuli, Paul Schrater, Anthony Wright, Xaq Pitkow, Valentin Dragoi
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The silence of the reactive astrocytes Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-29 Francesco Limone, Shane Liddelow
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PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-29 Carmelo Milioto, Mireia Carcolé, Ashling Giblin, Rachel Coneys, Olivia Attrebi, Mhoriam Ahmed, Samuel S. Harris, Byung Il Lee, Mengke Yang, Robert A. Ellingford, Raja S. Nirujogi, Daniel Biggs, Sally Salomonsson, Matteo Zanovello, Paula de Oliveira, Eszter Katona, Idoia Glaria, Alla Mikheenko, Bethany Geary, Evan Udine, Deniz Vaizoglu, Sharifah Anoar, Khrisha Jotangiya, Gerard Crowley, Demelza M. Smeeth
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Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-22 Barbara Hollunder, Jill L. Ostrem, Ilkem Aysu Sahin, Nanditha Rajamani, Simón Oxenford, Konstantin Butenko, Clemens Neudorfer, Pablo Reinhardt, Patricia Zvarova, Mircea Polosan, Harith Akram, Matteo Vissani, Chencheng Zhang, Bomin Sun, Pavel Navratil, Martin M. Reich, Jens Volkmann, Fang-Cheng Yeh, Juan Carlos Baldermann, Till A. Dembek, Veerle Visser-Vandewalle, Eduardo Joaquim Lopes Alho, Paulo Roberto
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Dopamine projections to the basolateral amygdala drive the encoding of identity-specific reward memories Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-23 Ana C. Sias, Yousif Jafar, Caitlin M. Goodpaster, Kathia Ramírez-Armenta, Tyler M. Wrenn, Nicholas K. Griffin, Keshav Patel, Alexander C. Lamparelli, Melissa J. Sharpe, Kate M. Wassum
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Mapping the dysfunctome provides an avenue for targeted brain circuit therapy Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-22
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Leaky blood–brain barrier in long-COVID-associated brain fog Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-22
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Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-22 Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O’Keeffe, Lilia Zaporojan, Jeffrey O’Callaghan, Bennett Thomson, Emma Connolly, Ruth Argue, Ignacio Martin-Loeches, Aideen Long, Cliona Ni Cheallaigh, Niall Conlon, Colin P. Doherty, Matthew Campbell
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A phenotypic screening platform for identifying chemical modulators of astrocyte reactivity Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-20 Benjamin L. L. Clayton, James D. Kristell, Kevin C. Allan, Erin F. Cohn, Molly Karl, Andrew D. Jerome, Eric Garrison, Yuka Maeno-Hikichi, Annalise M. Sturno, Alexis Kerr, H. Elizabeth Shick, Jesse A. Sepeda, Eric C. Freundt, Andrew R. Sas, Benjamin M. Segal, Robert H. Miller, Paul J. Tesar
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Ripple-locked coactivity of stimulus-specific neurons and human associative memory Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-16 Lukas Kunz, Bernhard P. Staresina, Peter C. Reinacher, Armin Brandt, Tim A. Guth, Andreas Schulze-Bonhage, Joshua Jacobs
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Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19 Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-16 Josefine Radke, Jenny Meinhardt, Tom Aschman, Robert Lorenz Chua, Vadim Farztdinov, Sören Lukassen, Foo Wei Ten, Ekaterina Friebel, Naveed Ishaque, Jonas Franz, Valerie Helena Huhle, Ronja Mothes, Kristin Peters, Carolina Thomas, Shirin Schneeberger, Elisa Schumann, Leona Kawelke, Julia Jünger, Viktor Horst, Simon Streit, Regina von Manitius, Péter Körtvélyessy, Stefan Vielhaber, Dirk Reinhold, Anja
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Hunger guides immunity to friend versus foe Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-15 Noga Or-Geva, Lawrence Steinman
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Glial lipid droplets resolve ROS during sleep Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-15 Lindsey D. Goodman, Matthew J. Moulton, Hugo J. Bellen
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A neuron–glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-15 Paula R. Haynes, Elana S. Pyfrom, Yongjun Li, Carly Stein, Vishnu Anand Cuddapah, Jack A. Jacobs, Zhifeng Yue, Amita Sehgal
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A unifying theory explains seemingly contradictory biases in perceptual estimation Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-15 Michael Hahn, Xue-Xin Wei
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Anterior cingulate learns reward distribution Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-13 Tao Hong, William R. Stauffer
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In conversation with Nancy Ip Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-13 Shari Wiseman
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved and where it is heading. This month we are talking to Nancy Ip, Morningside Professor of Life Science and president of the Hong Kong University of Science and Technology. We discussed her path from academia
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A molecularly defined amygdala-independent tetra-synaptic forebrain-to-hindbrain pathway for odor-driven innate fear and anxiety Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-12 Hao Wang, Qin Wang, Liuzhe Cui, Xiaoyang Feng, Ping Dong, Liheng Tan, Lin Lin, Hong Lian, Shuxia Cao, Huiqian Huang, Peng Cao, Xiao-Ming Li
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Independent inhibitory control mechanisms for aggressive motivation and action Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-12 Tomohito Minakuchi, Eartha Mae Guthman, Preeta Acharya, Justin Hinson, Weston Fleming, Ilana B. Witten, Stefan N. Oline, Annegret L. Falkner
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Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-12 Jared M. Cregg, Simrandeep K. Sidhu, Roberto Leiras, Ole Kiehn
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Depression genetics goes global Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-07 Shari Wiseman
Substantial challenges for genome-wide association studies (GWAS) of major depression (as well as other psychiatric conditions) include the heterogeneity of the disorder, its degree of polygenicity and the over-representation of European ancestry among study participants. To improve upon previous efforts, a recent paper in Nature Genetics performed a GWAS meta-analysis of data from 21 cohorts that
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Ibogaine therapy in TBI Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-07 Leonie Welberg
Traumatic brain injury (TBI) in military combat veterans is associated not only with cognitive impairments and reduced daily functioning but also with posttraumatic stress disorder (PTSD), depression and anxiety. Because regular treatments for these conditions seem to have limited efficacy, some veterans with TBI have started to explore the psychedelic ibogaine as a potential treatment. A paper published
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Cerebellar organoids get active Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-07 Rebecca Wright
There is a pressing need to develop human cell-based models of the cerebellum, as mouse models lack human-specific features and do not fully recapitulate disease phenotypes. Using a cerebellar induction strategy based on in vivo developmental signaling molecules, Atamian et al. were able to generate 3D human organoids that reflected the major cell-type composition of the developing cerebellum, including
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Local synaptic inhibition mediates cerebellar granule cell pattern separation and enables learned sensorimotor associations Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-06 Elizabeth A. Fleming, Greg D. Field, Michael R. Tadross, Court Hull