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Overcoming China’s animal waste disposal challenge brought by elevated levels of veterinary antimicrobial residues and antimicrobial resistance Environ. Int. (IF 10.3) Pub Date : 2024-09-12 Grace M. Cheng, Hefa Cheng
Direct application of animal waste on farmlands was banned in China recently, rendering organic fertilizer production a sound solution for disposing of animal manures and recycling their materials and nutrients. Due to the overuse of antimicrobials in livestock and poultry farms, manure-based organic fertilizers often contain elevated residues of antimicrobials and abundant antimicrobial resistance
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Short-term effects of wildfire-specific fine particulate matter and its carbonaceous components on perinatal outcomes: A multicentre cohort study in New South Wales, Australia Environ. Int. (IF 10.3) Pub Date : 2024-09-12 Sylvester Dodzi Nyadanu, Damien Foo, Gavin Pereira, Loretta J. Mickley, Xu Feng, Michelle L. Bell
Epidemiological evidence on the association between wildfire-specific fine particulate matter (PM) and its carbonaceous components with perinatal outcomes is limited. A multicentre cohort of 9743 singleton births during the wildfire seasons from 1 September 2009 to 31 December 2015 across six cities in New South Wales, Australia were linked with daily wildfire-specific PM and carbonaceous components
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Effect of per- and polyfluoroalkyl substances on neurodevelopment: Evidence-based risk assessment in the TRAEC strategy context Environ. Int. (IF 10.3) Pub Date : 2024-09-12 Jie Ning, Chaoshun Ding, Haoyi Xu, Zhaofeng Liu, Quanquan Guan, Yankai Xia, Qing Xu
Although emerging evidence on the association between per- and polyfluoroalkyl substances (PFASs) and neurodevelopment have been investigated, there is no consensus on the effect of maternal PFASs on neurodevelopment in offspring. Here, we assessed the risk of maternal PFASs exposure on the neurodevelopment of offspring using a novel Targeted Risk Assessment of Environmental Chemicals (TRAEC) strategy
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Transforming contaminant ligands at water–solid interfaces via trivalent metal coordination Environ. Int. (IF 10.3) Pub Date : 2024-09-11 Qiandi Wang, Qiongying Xu, Wenzong Liu, Meng Jiao, Zhuqi Chen, Aijie Wang
In environmental matrices, the migration and distribution of contaminants at water–solid interfaces play a crucial role in their capture or dissemination. Scientists working in environmental remediation and wastewater treatment are increasingly aware of metal–contaminant coordination; however, interfacial behaviors remain underexplored. Here, we show that trivalent metal ions (e.g. Al and Fe) mediate
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Unraveling the fate of 6PPD-Q in aquatic environment: Insights into formation, dissipation, and transformation under natural conditions Environ. Int. (IF 10.3) Pub Date : 2024-09-11 Xiaopeng Yan, Jin Xiao, Claude Kiki, Yuanyuan Zhang, Habasi Patrick Manzi, Guangpu Zhao, ShengDa Wang, Qian Sun
The widespread occurrence of N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-Q) in aquatic environments and its hazards to aquatic species underscore the necessity of comprehending its environmental fate. Here, we investigated the transformation from 6PPD to 6PPD-Q and the attenuation of 6PPD-Q in surface water under natural conditions. Contrary to prior findings, this work revealed
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A conceptual framework for landscape-based environmental risk assessment (ERA) of pesticides Environ. Int. (IF 10.3) Pub Date : 2024-09-10 Jose V. Tarazona, Mercedes de Alba-Gonzalez, Carole Bedos, Pierre Benoit, Colette Bertrand, Olivier Crouzet, Cécile Dagès, Jean-Lou CM Dorne, Ana Fernandez-Agudo, Andreas Focks, Maria del Carmen Gonzalez-Caballero, Alexandra Kroll, Matthias Liess, Susana Loureiro, Manuel E. Ortiz-Santaliestra, Jes J. Rasmussen, Raphaël Royauté, Maj Rundlöf, Ralf B. Schäfer, Stephen Short, Ayesha Siddique, José Paulo
While pesticide use is subject to strict regulatory oversight worldwide, it remains a main concern for environmental protection, including biodiversity conservation. This is partly due to the current regulatory approach that relies on separate assessments for each single pesticide, crop use, and non-target organism group at local scales. Such assessments tend to overlook the combined effects of overall
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Circ_0025373 inhibits carbon black nanoparticles-induced malignant transformation of human bronchial epithelial cells by affecting DNA damage through binding to MSH2 Environ. Int. (IF 10.3) Pub Date : 2024-09-07 Han Zhang, Wenfeng Lu, Lan Qiu, Saifeng Li, Liqiu Qiu, Mengnan He, Xintong Chen, Jiajing Wang, Jingwen Fang, Chenghui Zhong, Meiqi Lan, Xiaole Xu, Yun Zhou
Carbon black nanoparticles (CBNPs) have been demonstrated to induce DNA damage in epithelial cells. However, the potential of the damage to initiate carcinogenesis and the underlying mechanism remain poorly understood. Therefore, we constructed an model of malignant transformation of human bronchial epithelial cells (16HBE-T) by treating 40 μg/mL CBNPs for 120 passages. We observed tumor-like transformation
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Epigenetic alterations in bioaccumulators of cadmium: Lessons from mammalian kidneys and plants Environ. Int. (IF 10.3) Pub Date : 2024-09-07 Stephanie Frings, Romy Schmidt-Schippers, Wing-Kee Lee
Faced with unpredictable changes in global weather patterns, release and redistribution of metals through land erosion and water movements add to the increasing use of metals in industrial activities causing high levels of environmental pollution and concern to the health of all living organisms. Cadmium is released into the environment by smelting and mining, entering the food chain via contaminated
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Impacts of different vehicle emissions on ozone levels in Beijing: Insights into source contributions and formation processes Environ. Int. (IF 10.3) Pub Date : 2024-09-07 Jingyuan Cao, Jun Liu, Ying Cheng, Siqi Ai, Fangzhou Li, Tao Xue, Qiang Zhang, Tong Zhu
Beijing, with the highest number of motor vehicles in China, significantly contributes to O pollution through substantial NO and VOC emissions in the on-road transportation sector. Understanding the unique impact of emissions from different vehicle types on O levels is crucial for developing targeted strategies for O pollution. This study applied the Community Multiscale Air Quality Modeling System
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Combining Google traffic map with deep learning model to predict street-level traffic-related air pollutants in a complex urban environment Environ. Int. (IF 10.3) Pub Date : 2024-09-06 Peng Wei, Song Hao, Yuan Shi, Abhishek Anand, Ya Wang, Mengyuan Chu, Zhi Ning
Traffic-related air pollution (TRAP) is a major contributor to urban pollution and varies sharply at the street level, posing a challenge for air quality modeling. Traditional land use regression models combined with data from fixed monitoring stations may be unable to predict and characterize fine-scale TRAP, especially in complex urban environments influenced by various features. This study aims
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Effect of anaerobic digestion on pathogens and antimicrobial resistance in the sewage sludge Environ. Int. (IF 10.3) Pub Date : 2024-09-05 Elena Franchitti, Matilde Pedullà, Anne Mette Madsen, Deborah Traversi
Antimicrobial resistance (AMR) is recognized as a global threat. AMR bacteria accumulate in sewage sludge however, knowledge on the persistence of human pathogens and AMR in the sludge line of the wastewater treatment is limited. Sludge can be used, with or without additional treatment, as fertilizer in agricultural fields. The aim of this study is to obtain knowledge about presence of human pathogens
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Long-term contributions of VOC sources and their link to ozone pollution in Bronx, New York City Environ. Int. (IF 10.3) Pub Date : 2024-09-03 Lucille Borlaza-Lacoste, Md. Aynul Bari, Cheng-Hsuan Lu, Philip K. Hopke
Changes in energy and environmental policies along with changes in the energy markets of New York State over the past two decades, have spurred interest in evaluating their impacts on emissions from various energy generation sectors. This study focused on quantifying these effects on VOC (volatile organic compounds) emissions and their subsequent impacts on air quality within the New York City (NYC)
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Exposure levels and maternal transfer of emerging organophosphate flame retardants (OPFRs) in pregnant women: Comparison with traditional OPFRs Environ. Int. (IF 10.3) Pub Date : 2024-09-02 Linwan Li, Fumei Gao, Chong Huang, Jianying Hu
Prenatal exposure to organophosphorus flame retardants (OPFRs) has been linked with adverse effects on reproductive health, and new OPFRs are continually emerging. In this study, emerging OPFRs, such as bis(2-ethylhexyl) phenyl phosphate (BEHPP), triamyl phosphate (TAP), tris(4--butylphenyl) phosphate (T4tBPPP), oxydi-2,1-ethanediyl phosphoric acid tetrakis(2 chloro-1-methylethyl) ester (RDT905), cresyl
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Knowledge-based machine learning for predicting and understanding the androgen receptor (AR)-mediated reproductive toxicity in zebrafish Environ. Int. (IF 10.3) Pub Date : 2024-09-02 Lei Xin, Sisi Liu, Wenjun Shi, Guang-Guo Ying, Xinyue Hui, Chang-Er Chen
Traditional methods for identifying endocrine-disrupting chemicals (EDCs) that activate androgen receptors (AR) are costly, time-consuming, and low-throughput. This study developed a knowledge-based deep neural network model (AR-DNN) to predict AR-mediated adverse outcomes on female zebrafish fertility. This model started with chemical fingerprints as the input layer and was implemented through a five-layer
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A harmonized occupational biomonitoring approach Environ. Int. (IF 10.3) Pub Date : 2024-08-31 Nancy B. Hopf, Christophe Rousselle, Devika Poddalgoda, Farida Lamkarkach, Jos Bessems, Kaspar Schmid, Kate Jones, Koki Takaki, Ludwine Casteleyn, Maryam Zare Jeddi, Michael Bader, Michael Koller, Patience Browne, Rex FitzGerald, Susana Viegas, Thomas Göen, Tiina Santonen, Virpi Väänänen, Radu - Corneliu Duca, Robert Pasanen-Kase
Biomonitoring has been widely used in assessing exposures in both occupational and public health complementing chemical risk assessments because it measures the concentrations of chemical substances in human body fluids (e.g., urine and blood). Biomonitoring considers all routes and sources of exposure. An occupational biomonitoring guidance document has been elaborated () within the OECD framework
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The effect of exposure to radiofrequency fields on cancer risk in the general and working population: A systematic review of human observational studies – Part I: Most researched outcomes Environ. Int. (IF 10.3) Pub Date : 2024-08-30 Ken Karipidis, Dan Baaken, Tom Loney, Maria Blettner, Chris Brzozek, Mark Elwood, Clement Narh, Nicola Orsini, Martin Röösli, Marilia Silva Paulo, Susanna Lagorio
The objective of this review was to assess the quality and strength of the evidence provided by human observational studies for a causal association between exposure to radiofrequency electromagnetic fields (RF-EMF) and risk of the most investigated neoplastic diseases. : We included cohort and case-control studies of neoplasia risks in relation to three types of exposure to RF-EMF: near-field, head-localized
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A randomized controlled trial of a housing intervention to reduce endocrine disrupting chemical exposures in children Environ. Int. (IF 10.3) Pub Date : 2024-08-30 Alan J. Fossa, Katherine E. Manz, George D. Papandonatos, Aimin Chen, Mark J. La Guardia, Bruce P. Lanphear, Robert C.Hale, Alexandra Pagano, Kurt D. Pennell, Kimberly Yolton, Joseph M. Braun
Few studies have considered household interventions for reducing endocrine disrupting chemical (EDC) exposures. We conducted a secondary analysis of a randomized controlled trial, originally designed to reduce lead exposure, to evaluate if the intervention lowered EDC exposures in young children. Study participants were children from the Cincinnati, Ohio area (n = 250, HOME Study). Prenatally, families
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Identifying groups at-risk to extreme heat: Intersections of age, race/ethnicity, and socioeconomic status Environ. Int. (IF 10.3) Pub Date : 2024-08-30 Austin Clark, Sara Grineski, David S. Curtis, Ethan Siu Leung Cheung
Anthropogenic climate change has resulted in a significant rise in extreme heat events, exerting considerable but unequal impacts on morbidity and mortality. Numerous studies have identified inequities in heat exposure across different groups, but social identities have often been viewed in isolation from each other. Children (5 and under) and older adults (65 and older) also face elevated risks of
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Integrated multi-omics approaches reveal the neurotoxicity of triclocarban in mouse brain Environ. Int. (IF 10.3) Pub Date : 2024-08-30 Qian Song, Chengchen Hu, Xueying Zhang, Pengweilin Ji, Yansong Li, Hanyong Peng, Yuxin Zheng, Hongna Zhang
Triclocarban (TCC) is an antimicrobial ingredient that commonly incorporated in many household and personal care products, raising public concerns about its potential health risks. Previous research has showed that TCC could cross the blood–brain barrier, but to date our understanding of its potential neurotoxicity at human-relevant concentrations remains lacking. In this study, we observed anxiety-like
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Recent advances in environmental antibiotic resistance genes detection and research focus: From genes to ecosystems Environ. Int. (IF 10.3) Pub Date : 2024-08-29 Bowei Ouyang, Cong Yang, Ziyue Lv, Baowei Chen, Lei Tong, Jianbo Shi
Antibiotic resistance genes (ARGs) persistence and potential harm have become more widely recognized in the environment due to its fast-paced research. However, the bibliometric review on the detection, research hotspot, and development trend of environmental ARGs has not been widely conducted. It is essential to provide a comprehensive overview of the last 30 years of research on environmental ARGs
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Response to letter from Bevington M., Electrosensitivity UK Environ. Int. (IF 10.3) Pub Date : 2024-08-29 Xavier Bosch-Capblanch, Ekpereonne Esu, Chioma Moses Oringanje, Stefan Dongus, Hamed Jalilian, John Eyers, Christian Auer, Martin Meremikwu, Martin Röösli
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Thirdhand smoke exposure promotes gastric tumor development in mouse and human Environ. Int. (IF 10.3) Pub Date : 2024-08-26 Chengfei Jiang, Lingyan Chen, Chunping Ye, Suzaynn F. Schick, Peyton Jacob III, Yingjia Zhuang, Jamie L. Inman, Changbin Chen, Lara A. Gundel, Hang Chang, Antoine M. Snijders, Xiaoping Zou, Jian-Hua Mao, Bo Hang, Pin Wang
The pollution of indoor environments and the consequent health risks associated with thirdhand smoke (THS) are increasingly recognized in recent years. However, the carcinogenic potential of THS and its underlying mechanisms have yet to be thoroughly explored. In this study, we examined the effects of short-term THS exposure on the development of gastric cancer (GC) and . In a mouse model of spontaneous
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Neighbourhood environments and cognitive health in the longitudinal Personality and Total Health (PATH) through life study: A 12-year follow-up of older Australians Environ. Int. (IF 10.3) Pub Date : 2024-08-25 Ester Cerin, Maria V. Soloveva, Miguel A. Molina, Ralf-Dieter Schroers, Luke D. Knibbs, Muhammad Akram, Yu-Tzu Wu, Suzanne Mavoa, Matthew Prina, Perminder S. Sachdev, Vibeke Sorensen Catts, Bin Jalaludin, Govinda Poudel, Mark Symmons, Anthony Barnett, Md Hamidul Huque, Yvonne Leung, Nicolas Cherbuin, Kaarin J. Anstey
Urban neighbourhood environments may impact older adults’ cognitive health. However, longitudinal studies examining key environmental correlates of cognitive health are lacking. We estimated cross-sectional and longitudinal associations of neighbourhood built and natural environments and ambient air pollution with multiple cognitive health outcomes in Australian urban dwellers aged 60+ years. The study
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Pesticide residues and polyphenols in urine – A combined LC-HRMS screening to reveal intake patterns Environ. Int. (IF 10.3) Pub Date : 2024-08-25 Carolin Huber, Werner Brack, Stefan Röder, Martin von Bergen, Ulrike Rolle-Kampczyk, Ana Claudia Zenclussen, Martin Krauss, Gunda Herberth
Human exposure to pesticides in the general population occurs mainly through food consumption. However, specific dietary habits or food products that contribute to pesticide exposure are often unknown. In this study, we propose a combined screening for polyphenols and pesticide residues by liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) to assess the diet and the associated
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Carcinogenic industrial air pollution and postmenopausal breast cancer risk in the National Institutes of Health AARP Diet and Health Study Environ. Int. (IF 10.3) Pub Date : 2024-08-24 Jessica M. Madrigal, Caroline N. Pruitt, Jared A. Fisher, Linda M. Liao, Barry I. Graubard, Gretchen L. Gierach, Debra T. Silverman, Mary H. Ward, Rena R. Jones
Chemicals emitted from industrial facilities include known or suspected mammary carcinogens and endocrine disruptors, but epidemiologic studies are limited. We evaluated associations between air emissions of multiple carcinogenic chemicals and postmenopausal breast cancer risk in a large prospective U.S. cohort. We used the U.S. Environmental Protection Agency’s Toxics Release Inventory to estimate
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Mapping air quality trends across 336 cities in India: Insights from three decades of monitoring (1987–2019) Environ. Int. (IF 10.3) Pub Date : 2024-08-24 Garima Sharma, Medhavi Gupta, Prashant Gargava, Sri Harsha Kota
Over a span of 34 years (1987–2019), an in-depth analysis of PM, SO, and NO trends across India was conducted using data from the National Ambient Air Quality Monitoring Programme’s manual monitoring stations in 336 cities. The study encompassed six geographical regions over three time blocks, revealing a correlation between the expansion of monitoring networks and the nation’s economic growth. Regions
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An innovative mixture sampling strategy with uniform design: Application to global sensitivity analysis of mixture toxicity Environ. Int. (IF 10.3) Pub Date : 2024-08-24 Ting-Ting Ding, Ze-Jun Wang, Meng-Ting Tao, Zhong-Wei Gu, Ru-Jun Chen, Ya-Qian Xu, Shu-Shen Liu
Global sensitivity analysis combined with quantitative high-throughput screening (GSA-qHTS) uses random starting points of the trajectories in mixture design, which may lead to potential contingency and a lack of representativeness. Moreover, a scenario in which all factor levels were at stimulatory effects was not considered, thereby hindering a comprehensive understanding of GSA-qHTS. Accordingly
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Pathogen shape: Implication on pathogenicity via respiratory deposition Environ. Int. (IF 10.3) Pub Date : 2024-08-23 Lipeng Lv, Yahong Chen, Bin Zhao
The shape of environmental aerosols contributes to the discrepancy in their dynamic behavior compared to spherical particles, which have received inadequate consideration. We reported deposition patterns of aerosols and aerosol-transmissible pathogens in real human respiratory systems, taking into account their actual shape, using a validated computational-based model. We found that the shape of the
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The trends of non-accidental mortality burden attributed to compound hot-dry events in China and its provinces in a global warming world Environ. Int. (IF 10.3) Pub Date : 2024-08-23 Guanhao He, Yi Lin, Jianxiong Hu, Yang Chen, Yanfang Guo, Min Yu, Fangfang Zeng, Hailai Duan, Ruilin Meng, Chunliang Zhou, Yize Xiao, Biao Huang, Weiwei Gong, Jiangmei Liu, Tao Liu, Maigeng Zhou, Wenjun Ma
Global warming has provoked more co-occurrence of hot extreme and dry extreme, namely compound hot-dry events (CHDEs). However, their health impacts have seldom been investigated. This study aimed to characterize CHDEs and assess its mortality burden in China from 1990 to 2100. CHDEs were defined as a day when daily maximum temperature > its 90th percentile and Standardized Precipitation Index < its
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Chemical and non-chemical stressors in a postpartum cohort through wristband and self report data: Links between increased chemical burden, economic, and racial stress Environ. Int. (IF 10.3) Pub Date : 2024-08-23 Elise Hickman, Jenna Frey, Amanda Wylie, Hadley J. Hartwell, Nicholas J. Herkert, Sarah J. Short, W. Roger Mills-Koonce, Rebecca C. Fry, Heather M. Stapleton, Cathi Propper, Julia E. Rager
Multiple external stressors are known to have adverse impacts on health and development. Certain groups are more vulnerable and/or more likely to be exposed toenvironmental, psychological, and social stressors simultaneously. Yet, few studies have examined combined exposure to environmental toxicants and psychosocial stress. Here, we integrated environmental chemical exposure data collected using silicone
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BaP/BPDE suppresses homologous recombination repair in human trophoblast cells to induce miscarriage: The roles of lnc-HZ08 Environ. Int. (IF 10.3) Pub Date : 2024-08-23 Weina Chen, Chenglong Ma, Manli Wang, Xinying Huang, Xueyu Chen, Zhongyan Xu, Wenxin Huang, Rong Wang, Zhaodian Zheng, Jing Fang, Yanqiu Shen, Depeng Zhao, Huidong Zhang
Benzo(a)pyrene (BaP) or benzo (a) pyrene 7,8-dihydrodiol-9,10-epoxide (BPDE) exposure causes trophoblast cell dysfunctions and induces miscarriage, which is generally epigenetically regulated. Homologous recombination (HR) repair of DNA double strand break (DSB) plays a crucial role in maintenance of genetic stability and cell normal functions. However, whether BaP/BPDE might suppress HR repair in
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Transfer of antibiotic resistance genes from soil to rice in paddy field Environ. Int. (IF 10.3) Pub Date : 2024-08-22 Min Xu, Fang Wang, Robert D. Stedtfeld, Yuhao Fu, Leilei Xiang, Hongjie Sheng, Zhongpei Li, Syed A. Hashsham, Xin Jiang, James M. Tiedje
The global spread and distribution of antibiotic resistance genes (ARGs) has received much attention whereas knowledge about the transmission of ARGs from one matrix to another is still insufficient. In this study, the paddy fields fertilized with chemical fertilizer, swine compost, and no fertilizer were investigated to assess the transfer of ARGs from soil to rice. Soil and plant samples were collected
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Impact of enniatins and beauvericin on lipid metabolism: Insights from a 3D HepaRG spheroid model Environ. Int. (IF 10.3) Pub Date : 2024-08-22 Qiao Wang, Yan Li, Peihao Hu, Yutao Zhang, Yan Liu, Qing Yang, Lin Xu, Zhiyong Gong, Jiangke Yang, Wen Sun, Xin Liu, Yongning Wu
Emerging mycotoxins enniatins (ENNs) and beauvericin (BEA) pose potential health risks to humans through dietary exposure. However, research into their mechanisms of toxicity is limited, with a lack of comprehensive toxicological data. This study investigates from a hepatic lipid metabolism perspective, establishing a more precise and reliable 3D HepaRG hepatocyte spheroid model as an alternative for
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The fate of antibiotics and antibiotic resistance genes in Large-Scale chicken farm Environments: Preliminary view of the performance of National veterinary Antimicrobial use reduction Action in Guangdong, China Environ. Int. (IF 10.3) Pub Date : 2024-08-21 Yu Pan, Jiaxiong Zeng, Lingxuan Zhang, Jianxin Hu, Haihong Hao, Zhenling Zeng, Yafei Li
In 2018, China implemented the Veterinary Antimicrobial Use Reduction Action to curb the rapid development of antibiotic resistance (AR). However, the AR-related pollutions in animal farms after the reduction policy has been poorly investigated. Here, we performed a comprehensive investigation combining UPLC-MS/MS, metagenomic, and bacterial genomic analyses in eight representative large-scale chicken
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Micro-interfacial behavior of antibiotic-resistant bacteria and antibiotic resistance genes in the soil environment: A review Environ. Int. (IF 10.3) Pub Date : 2024-08-21 Jibao Deng, Wenkang Zhang, Lingyu Zhang, Chao Qin, Hefei Wang, Wanting Ling
Overutilization and misuse of antibiotics in recent decades markedly intensified the rapid proliferation and diffusion of antibiotic resistance genes (ARGs) within the environment, thereby elevating ARGs to the status of a global public health crisis. Recognizing that soil acts as a critical reservoir for ARGs, environmental researchers have made great progress in exploring the sources, distribution
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Effects of seasonal management programs on PM2.5 in Seoul and Beijing using DN-PMF: Collaborative efforts from the Korea-China joint research Environ. Int. (IF 10.3) Pub Date : 2024-08-20 Ilhan Ryoo, Lihong Ren, Gang Li, Tao Zhou, Manhua Wang, Xiaoyang Yang, Taeyeon Kim, Yeonseung Cheong, Songkang Kim, Hyeogki Chae, Kyungmi Lee, Kwon-ho Jeon, Philip K. Hopke, Seung-Muk Yi, Jieun Park
South Korea and China have implemented increasingly stringent mitigation measures to reduce the health risks from PM exposure, jointly conducting a ground-based air quality observation study in Northeast Asia. Dispersion normalized positive matrix factorization (DN-PMF) was used to identify PM sources in Seoul and Beijing and assess the effectiveness of the seasonal management programs (SMPs) through
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Intergenerational metabolism-disrupting effects of maternal exposure to plasticizer acetyl tributyl citrate (ATBC) Environ. Int. (IF 10.3) Pub Date : 2024-08-20 Danyang Zhang, Weigao Zhang, Hu Liu, Shuxian Huang, Wangchao Huang, Yunfeng Zhu, Xuening Ma, Yugui Xia, Jianfa Zhang, Wei Lu, Da Shao, Dan Weng
Environmental chemicals and pollutants are increasingly recognized for their potential transgenerational effects. Acetyl tributyl citrate (ATBC), a widely used plasticizer substituting di-(2-ethylhexyl) phthalate (DEHP), was identified as an inducer of lipogenesis in male mice by our previous research. This study aimed to investigate the impact of ATBC exposure on the metabolic homeostasis of female
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Simultaneous biomass concentration and subsequent quantitation of multiple infectious disease agents and antimicrobial resistance genes from community wastewater Environ. Int. (IF 10.3) Pub Date : 2024-08-20 Anniina Sarekoski, Anssi Lipponen, Anna-Maria Hokajärvi, Kati Räisänen, Ananda Tiwari, Dafni Paspaliari, Kirsi-Maarit Lehto, Sami Oikarinen, Annamari Heikinheimo, Tarja Pitkänen, the WastPan Study Group
Wastewater-based surveillance (WBS) of infectious disease agents is increasingly seen as a reliable source of population health data. To date, wastewater-based surveillance efforts have largely focused on individual pathogens. However, given that wastewater contains a broad range of pathogens circulating in the population, a more comprehensive approach could enhance its usability. We focused on the
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Chronic maternal exposure to low-dose PM2.5 impacts cognitive outcomes in a sex-dependent manner Environ. Int. (IF 10.3) Pub Date : 2024-08-20 Brian G Oliver, Xiaomin Huang, Rochelle Yarak, Xu Bai, Qi Wang, Razia Zakarya, Karosham D. Reddy, Chantal Donovan, Richard Y. Kim, James Morkaya, Baoming Wang, Yik Lung Chan, Sonia Saad, Alen Faiz, David van Reyk, Alexei Verkhratsky, Chenju Yi, Hui Chen
There is no safe level of air pollution for human health. Traffic-related particulate matter (PM) is a major toxin, mechanisms of action of which are not fully understood. BALB/c dams were exposed to an Australian level of traffic PM (5 µg/mouse/day, intranasal, 6 weeks before mating, during gestation and lactation). Male offspring had reduced memory in adulthood, whereas memory was normal in female
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Air pollution, traffic noise, mental health, and cognitive development: A multi-exposure longitudinal study of London adolescents in the SCAMP cohort Environ. Int. (IF 10.3) Pub Date : 2024-08-18 Rhiannon Thompson, Gregor Stewart, Tuan Vu, Calvin Jephcote, Shanon Lim, Benjamin Barratt, Rachel B. Smith, Yasmin Bou Karim, Aamirah Mussa, Ian Mudway, Helen L. Fisher, Iroise Dumontheil, Michael S.C. Thomas, John Gulliver, Sean Beevers, Frank J. Kelly, Mireille B. Toledano
There is increasing evidence that air pollution and noise may have detrimental psychological impacts, but there are few studies evaluating adolescents, ground-level ozone exposure, multi-exposure models, or metrics beyond outdoor residential exposure. This study aimed to address these gaps. Annual air pollution and traffic noise exposure at home and school were modelled for adolescents in the Greater
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A novel molecular pathway of lipid accumulation in human hepatocytes caused by PFOA and PFOS Environ. Int. (IF 10.3) Pub Date : 2024-08-18 Xiao Gou, Mingming Tian, Lu Yan, Pu Xia, Huimin Ji, Haoyue Tan, Wei Shi, Hongxia Yu, Xiaowei Zhang
Exposed to ubiquitously perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) has been associated with non-alcoholic fatty liver disease (NAFLD), yet the underlying molecular mechanism remains elusive. The extrapolation of empirical studies correlating per- and polyfluoroalkyl substance (PFAS) exposure with NAFLD occurrence to real-life exposure was hindered by the limited availability
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Understanding the molecular pathway of triclosan-induced ADHD-like behaviour: Involvement of the hnRNPA1-PKM2-STAT3 feedback loop Environ. Int. (IF 10.3) Pub Date : 2024-08-17 Chang Shu, He Cui, Yuxuan Peng, Ziyun Wei, Xiao Ni, Linlin Zheng, Jianing Shang, Fu Liu, Jieyu Liu
Triclosan (TCS) is an environmental pollutant. In recent years, there has been increasing level of concern regarding the potential toxicity of TCS in animals and humans, especially its effects on the nervous system. However, whether TCS induces ADHD-like behaviour and the mechanism by which it affects neural function are unclear. The impact of 60 days of continuous exposure to TCS on the behaviour
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Migration and accumulation of microplastics in soil-plant systems mediated by symbiotic microorganisms and their ecological effects Environ. Int. (IF 10.3) Pub Date : 2024-08-17 Xinru Li, Feng Shi, Min Zhou, Fengchang Wu, Hailei Su, Xuesong Liu, Yuan Wei, Fanfan Wang
The coexistence of microorganisms in complex soil environments greatly affects the environmental behavior and ecological effects of microplastics (MPs). However, relevant studies are sparse, and internal mechanisms remain unclear. Herein, arbuscular mycorrhizal fungi (AMF), a common symbiotic microorganism in the soil–plant system, was proved to significantly affect MPs absorption and migration with
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Soil keystone viruses are regulators of ecosystem multifunctionality Environ. Int. (IF 10.3) Pub Date : 2024-08-17 Pu Jia, Jie-Liang Liang, Jing-li Lu, Sheng-ji Zhong, Tian Xiong, Shi-wei Feng, Yutao Wang, Zhuo-hui Wu, Xin-zhu Yi, Shao-ming Gao, Jin Zheng, Ping Wen, Fenglin Li, Yanying Li, Bin Liao, Wen-sheng Shu, Jin-tian Li
Ecosystem multifunctionality reflects the capacity of ecosystems to simultaneously maintain multiple functions which are essential bases for human sustainable development. Whereas viruses are a major component of the soil microbiome that drive ecosystem functions across biomes, the relationships between soil viral diversity and ecosystem multifunctionality remain under-studied. To address this critical
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Environmental risks in swine biogas slurry-irrigated soils: A comprehensive analysis of antibiotic residues, resistome, and bacterial pathogens Environ. Int. (IF 10.3) Pub Date : 2024-08-16 Jie-Yi Zeng, Miaoling Meng, Lin Qi, Yaying Li, Huaiying Yao
Simple anaerobic digestion is insufficient to completely remove residual parent antibiotics and antibiotic resistance genes (ARGs) from animal manure. ARG prevalence in swine biogas slurry-irrigated soils threatens human health. However, comprehensive analysis of antibiotic residues, high-resolution resistance gene profiles, and pathogenic microbiomes in biogas slurry-irrigated soils is very limited
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Aged fragmented-polypropylene microplastics induced ageing statues-dependent bioenergetic imbalance and reductive stress: In vivo and liver organoids-based in vitro study Environ. Int. (IF 10.3) Pub Date : 2024-08-15 Wei Cheng, Hange Chen, Yue Zhou, Yifei You, Dong Lei, Yan Li, Yan Feng, Yan Wang
Ageing is a nature process of microplastics that occurrs daily, and human beings are inevitably exposed to aged microplastics. However, a systematic understanding of ageing status and its toxic effect is currently still lacking. In this study, plastic cup lids-originated polypropylene (PP) microplastics were UV-photoaged until the carbonyl index (CI), a canonical indicator for plastic ageing, achieved
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Extreme temperatures, PM2.5 and trajectories of impaired thyroid hormone sensitivity: A longitudinal study of patients with schizophrenia Environ. Int. (IF 10.3) Pub Date : 2024-08-15 Jintao Liu, Rong Song, Rubing Pan, Weizhuo Yi, Xiaoyu Jin, Jian Song, Jian Cheng, Xulai Zhang, Hong Su
The climate change scenario has witnessed an increase in extreme temperature events (ETEs), including heat waves and cold spells, and a heightened occurrence of compounding with fine particulate matter (PM). However, the impact of this phenomenon on the sensitivity to thyroid hormones (THs) in humans is unclear, especially in a group as specific as schizophrenia. A longitudinal study was constructed
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Reduced ovarian cholesterol and steroid biosynthesis along with increased inflammation are associated with high DEHP metabolite levels in human ovarian follicular fluids Environ. Int. (IF 10.3) Pub Date : 2024-08-15 Inge Varik, Runyu Zou, Andrea Bellavia, Kristine Rosenberg, Ylva Sjunnesson, Ida Hallberg, Jan Holte, Virissa Lenters, Majorie Van Duursen, Mikael Pedersen, Terje Svingen, Roel Vermeulen, Andres Salumets, Pauliina Damdimopoulou, Agne Velthut-Meikas
The plasticizer di(2-ethylhexyl) phthalate (DEHP) is known to have endocrine-disrupting properties mediated by its many metabolites that form upon exposure in biological systems. In a previous study, we reported an inverse association between DEHP metabolites in the human ovarian follicular fluid (FF) and the responsiveness of the follicles to controlled ovarian stimulation during fertilization (IVF)
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Cadmium exposure induces multigenerational inheritance of germ cell apoptosis and fertility suppression in Caenorhabditis elegans Environ. Int. (IF 10.3) Pub Date : 2024-08-14 Xiaobing Huang, Qunshan Ye, Wenyu Dai, Jingming Zheng, Yimin Li, Cheng Wang, Zhenhuan Luo, Jing Yang, Wenyan Zhuo, Qin-Li Wan
Cadmium is a significant environmental pollutant that poses a substantial health hazard to humans due to its propensity to accumulate in the body and resist excretion. We have a comprehensive understanding of the damage caused by Cd exposure and the mechanisms of tolerance, however, the intricate mechanisms underlying multigenerational effects resulting from Cd exposure remain poorly understood. In
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Long-term changes of methane emissions from rice cultivation during 2000 – 2060 in China: Trends, driving factors, predictions and policy implications Environ. Int. (IF 10.3) Pub Date : 2024-08-14 Nanchi Shen, Jiani Tan, Wenjin Wang, Wenbo Xue, Yangjun Wang, Ling Huang, Gang Yan, Yu Song, Li Li
Regional budget assessments of methane (CH) are critical for future climate and environmental management. CH emissions from rice cultivation (CH) constitute one of the most significant sources. However, previous studies mainly focus on historical emission estimates and lack consideration of future changes in CH under climate change or anthropogenic policy intervention, which hampers our understanding
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The effect of endocrine-disrupting chemicals in follicular fluid: The insights from oocyte to fertilization Environ. Int. (IF 10.3) Pub Date : 2024-08-14 Jiehao Li, Lixin Zhou, Songyi Huang, Tiantian Duan, Jinying Xie, Xiaojie Li, Langjing Deng, Chenyan Zeng, Fengrui Jing, Sui Zhu, Chaoqun Liu, Yajie Gong, Yaqing Shu, Xiaoting Shen, Pan Yang
Endocrine-disrupting chemicals (EDCs) exhibited the detriment in female reproductive health. Our objective was to investigate the individual and mixture effects of EDCs present in follicular fluid, the environment in which oocytes grow and develop, on early reproductive outcomes. We recruited 188 women seeking reproduction examination from the Study of Exposure and Reproductive Health (SEARCH) cohort
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An epigenome-wide study of selenium status and DNA methylation in the Strong Heart Study Environ. Int. (IF 10.3) Pub Date : 2024-08-14 Wil Lieberman-Cribbin, Arce Domingo-Relloso, Ronald A. Glabonjat, Kathrin Schilling, Shelley A. Cole, Marcia O’Leary, Lyle G. Best, Ying Zhang, Amanda M. Fretts, Jason G. Umans, Walter Goessler, Ana Navas-Acien, Maria Tellez-Plaza, Allison Kupsco
Selenium (Se) is an essential nutrient linked to adverse health endpoints at low and high levels. The mechanisms behind these relationships remain unclear and there is a need to further understand the epigenetic impacts of Se and their relationship to disease. We investigated the association between urinary Se levels and DNA methylation (DNAm) in the Strong Heart Study (SHS), a prospective study of
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Land use conversion to uplands significantly increased the risk of antibiotic resistance genes in estuary area Environ. Int. (IF 10.3) Pub Date : 2024-08-14 Jupei Shen, Danting Yu, Zikai Liu, Hongjie Di, Ji-Zheng He
Land use conversion in estuary wetlands may affect the transmission of antibiotic resistance genes (ARGs), while the risk rank of the ARGs and the change of clinically relevant ARGs under various land-use types are not well understood. This study used metagenomics to reveal the diversity and abundance of ARGs across five distinct land uses: reed wetland, tidal flat, grassland, agricultural land and
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Do greenspaces really reduce heat health impacts? Evidence for different vegetation types and distance-based greenspace exposure Environ. Int. (IF 10.3) Pub Date : 2024-08-13 Jinglu Song, Antonio Gasparrini, Di Wei, Yi Lu, Kejia Hu, Thomas B. Fischer, Mark Nieuwenhuijsen
While vegetation type, population density and proximity to greenspaces have been linked to human health, what type and location of greenspace matter most have remained unclear. In this context, there are question marks over investment-style metrics. This paper aims at establishing what vegetation type may matter most in modifying heat-mortality associations, and what the optimal buffer distances of
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Estimation of couple fecundity in the general population and the association with monthly time-varying ambient particulate matter exposure in low- and middle-income countries: A population-based multi-center epidemiological study Environ. Int. (IF 10.3) Pub Date : 2024-08-13 Huailin Wang, Zhenghong Zhu, Tarik Benmarhnia, Xin Chen, Bin Jalaludin, Maimaitiminjiang Wulayin, Cunrui Huang, Tuantuan Zhang, Lianlian Xu, Qiong Wang
Declining total fertility rates have been observed in low- and middle-income countries (LMICs). However, it remains unclear if this trend is related to a reduction in fecundity of general population. Research evidence on contributing factors to fecundity reduction is also limited. We aimed to first estimate couple fecundity in LMICs and then investigate its association with ambient particulate matter
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Heterogeneity effects of bisphenol A and its substitute, fluorene-9-bisphenol, on intestinal homeostasis Environ. Int. (IF 10.3) Pub Date : 2024-08-13 Junxuan Peng, Shengda Cao, Zhen Hu, Jiayi Zhu, Yi Zhu, Xiaole Sheng, Zuchao Cai, Rongpan Bai, Xushen Xiong, Jinghao Sheng
Bisphenol A (BPA) and its substitute fluorene-9-bisphenol (BHPF) are used in consumer products; however, their toxic effects on intestinal epithelium remain largely unknown. In this study, we combined intestinal organoids and single-cell RNA sequencing to investigate the impact of BPA and BHPF exposure on intestinal cell composition, differentiation, and function. Both compounds inhibited the growth
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Unveiling the health impacts of air pollution transport in China Environ. Int. (IF 10.3) Pub Date : 2024-08-13 Dian Ding, Yueqi Jiang, Shuxiao Wang, Jia Xing, Zhaoxin Dong, Jiming Hao, Pauli Paasonen
The transport of atmospheric pollutants plays a pivotal role in regional air pollution, highlighting critical concerns over the unequal health outcomes that arise from such transport. While previous researches predominantly focused on key areas in the battle against air pollution, the intensification of control measures necessitates a national perspective to comprehend the health impacts due to pollution
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Metagenomic insights into ecological risk of antibiotic resistome and mobilome in riverine plastisphere under impact of urbanization Environ. Int. (IF 10.3) Pub Date : 2024-08-11 Weifu Yan, Rui Bai, Qinghua Zhang, Yuhao Jiang, Geng Chen, Yanru Zhang, Yicheng Wu, Xuetao Guo, Yong Xiao, Feng Zhao
Microplastics (MPs) are of increasing concern due to their role as reservoirs for antibiotic resistance genes (ARGs) and pathogens. To date, few studies have explored the influence of anthropogenic activities on ARGs and mobile genetic elements (MGEs) within various riverine MPs, in comparison to their natural counterparts. Here an incubation was conducted along heavily anthropogenically-impacted Houxi
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Failure of the three-way catalyst (TWC) introduces “super emitters” Environ. Int. (IF 10.3) Pub Date : 2024-08-10 Xinping Yang, Miao Tian, Yunjing Wang, Kai Song, Kai Li, Jiaju Liu, Yi Wen, Junfang Wang, Hang Yin, Yan Ding
Vehicle exhaust is one of the major organic sources in urban areas. Old taxis equipped with failed three-way catalysts (TWCs) have been regarded as “super emitters”. Compressed natural gas (CNG) is a regular substitution fuel for gasoline in taxis. The relative effect of fuel substitution and TWC failure has not been thoroughly investigated. In this work, vehicle exhausts from gasoline and CNG taxis
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Role of primary drivers leading to emission reduction of major air pollutants and CO2 from global power plants Environ. Int. (IF 10.3) Pub Date : 2024-08-10 Haoran Xu, Wenxiao Zhang, Yu’ang Ren, Yuanzheng Zhang, Jin Li, Shuxiu Zheng, Rong Dai, Jianying Hu, Hefa Cheng, Guofeng Shen, Huizhong Shen, Jianmin Ma, Shu Tao
Electricity production is a significant source of air pollution. Various factors, including electricity demand, generation efficiency, energy mix, and end-of-pipe control measures, are responsible for the emission changes during electricity generation. Although electricity production more than doubled from 1990 to 2017, air pollutant emissions showed a moderate increase or decrease, which was attributed