Both caloric restriction and obesity affect autoimmune diseases. The activation of brainstem neurons in the ventrolateral medulla (VLM) with fasting suppresses experimental autoimmune diseases. Stimulation of VLM neurons alters T cell traffic by redistributing immune cells to bone marrow and reduces inflammatory cytokine production, thus providing therapy of experimental autoimmunity.

中文翻译：

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饥饿引导对朋友与敌人的免疫力

热量限制和肥胖都会影响自身免疫性疾病。禁食激活腹外侧延髓（VLM）中的脑干神经元可抑制实验性自身免疫性疾病。刺激 VLM 神经元通过将免疫细胞重新分配到骨髓来改变 T 细胞运输，并减少炎症细胞因子的产生，从而提供实验性自身免疫的治疗。