Astrocytes have important roles in disease and are difficult to modulate, owing to a paucity of known targets. Clayton et al. develop a screening platform to unbiasedly identify modulators of astrocyte reactivity. They discover that HDAC3 inhibitors regulate astrocyte transitions into their reactive phenotype in vitro and in vivo.

中文翻译：

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反应性星形胶质细胞的沉默

星形胶质细胞在疾病中发挥重要作用，但由于缺乏已知靶点而难以调节。克莱顿等人。开发一个筛选平台来公正地识别星形胶质细胞反应性调节剂。他们发现 HDAC3 抑制剂在体外和体内调节星形胶质细胞向其反应表型的转变。