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Unveiling Pharmacokinetics and Drug Interaction of Linagliptin and Pioglitazone HCl in Rat Plasma Using LC-MS/MS Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-04-29 Heba Aref, Sherin Hammad, Khaled M. Darwish, Mohamed S. Elgawish
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Psoralen and Isopsoralen, Two Estrogen-Like Natural Products from Psoraleae Fructus, Induced Cholestasis via Activation of ERK1/2 Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-04-22 Liang-Min Chen, Si-Tong Qian, Zhuo-Qing Li, Ming-Fang He, Hui-Jun Li
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A Phenanthrenequinone-Based Ratiometric Fluorescent Probe for Rapid Detection of Peroxynitrite with Imaging in Osteoblast Precursor Cells Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-04-24 Anirban Karak, Dipanjan Banik, Rajdeep Ganguly, Shilpita Banerjee, Pintu Ghosh, Anwesha Maiti, Debasish Mandal, Ajit Kumar Mahapatra
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Effects of Chemicals in Reporter Gene Bioassays with Different Metabolic Activities Compared to Baseline Toxicity Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-04-23 Julia Huchthausen, Jenny Braasch, Beate I. Escher, Maria König, Luise Henneberger
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Burn Pit Smoke Condensate-Mediated Toxicity in Human Airway Epithelial Cells Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-04-23 Arunava Ghosh, Alexis Payton, Samuel C. Gallant, Keith L. Rogers, Jr., Teresa Mascenik, Elise Hickman, Charlotte A. Love, Kevin D. Schichlein, Timothy R. Smyth, Yong Ho Kim, Julia E. Rager, M. Ian Gilmour, Scott H. Randell, Ilona Jaspers
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Quantification of Intracellular DNA–Protein Cross-Links with N7-Methyl-2′-Deoxyguanosine and Their Contribution to Cytotoxicity Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-04-23 Tingyu Wen, Shubo Zhao, Julian Stingele, Jean-Luc Ravanat, Marc M. Greenberg
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Acrylamide-Aggravated Liver Injury by Activating Endoplasmic Reticulum Stress in Female Mice with Diabetes Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-04-18 Yuchao Guo, Ting Zhao, Xiongyi Yao, Hongchen Ji, Yingbiao Luo, Emmanuel Sunday Okeke, Guanghua Mao, Weiwei Feng, Yao Chen, Yangyang Ding, Xiangyang Wu, Liuqing Yang
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Phthalate Exposure and Coronary Heart Disease: Possible Implications of Oxidative Stress and Altered miRNA Expression Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-04-18 Asmaa Mohammad Moawad, Sara Awady, Abla Abd El Rahman Ali, Marwa Abdelgwad, Soliman Belal, Sarah Hamed N. Taha, Marwa Issak Mohamed, Fatma Mohamed Hassan
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Binding of Per- and Polyfluoroalkyl Substances to β-Lactoglobulin from Bovine Milk Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-04-16 P. Chi Pham, Mackenzie Taylor, Giang T. H. Nguyen, Jeunesse Beltran, Jack L. Bennett, Junming Ho, William A. Donald
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In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-04-16 Shotaro Uehara, Norie Murayama, Yuichiro Higuchi, Makiko Shimizu, Hiroshi Suemizu, F. Peter Guengerich, Hiroshi Yamazaki
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Cyanide Trapping of Iminium Ion Reactive Metabolites: Implications for Clinical Hepatotoxicity Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-04-15 Xiusheng Miao, Gordon J. Dear, Claire Beaumont, Giovanni Vitulli, Gary Collins, Peter D. Gorycki, Andrew W. Harrell, Melanie Z. Sakatis
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Activity-Based Protein Profiling to Probe Relationships between Cytochrome P450 Enzymes and Early-Age Metabolism of Two Polycyclic Aromatic Hydrocarbons (PAHs): Phenanthrene and Retene Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-04-11 Kari A. Gaither, Whitney L. Garcia, Kimberly J. Tyrrell, Aaron T. Wright, Jordan N. Smith
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Human Keratinocyte Responses to Woodsmoke Chemicals Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-04-10 Noreen Karim, Yatian Yang, Michelle Salemi, Brett S. Phinney, Blythe P. Durbin-Johnson, David M. Rocke, Robert H. Rice
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MetSim: Integrated Programmatic Access and Pathway Management for Xenobiotic Metabolism Simulators Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-04-10 Louis Groff, Antony Williams, Imran Shah, Grace Patlewicz
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Screening for Forensically Relevant Drugs Using Data-Independent High-Resolution Mass Spectrometry Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-04-04 Maia N. Bates, Abby E. Helm, Heather M. Barkholtz
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Treatment of Organophosphorus Poisoning with 6-Alkoxypyridin-3-ol Quinone Methide Precursors: Resurrection of Methylphosphonate-Aged Acetylcholinesterase Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-03-31 William K. Clay, Anne K. Buck, Yiran He, Dalyanne N. Hernández Sánchez, Nathan A. Ward, Jeremy M. Lear, Kenny Q. Nguyen, Benjamin H. Clark, Ryan J. Sapia, Remy F. Lalisse, Aishwarya Sriraman, C. Linn Cadieux, Craig A. McElroy, Christopher S. Callam, Christopher M. Hadad
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Effects of Heavy Metal Co-Exposure on the formation of DNA Adducts from Aristolochic Acid I: Implications for Balkan Endemic Nephropathy Development Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-03-29 Chun-Kit Au, Stefan Nagl, Wan Chan
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A Novel Inhibitor of Poly(ADP-Ribose) Polymerase-1 Inhibits Proliferation of a BRCA-Deficient Breast Cancer Cell Line via the DNA Damage–Activated cGAS–STING Pathway Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-03-27 Yonglong Jin, Lijie Wang, Chengxue Jin, Na Zhang, Shosei Shimizu, Wenjing Xiao, Chuanlong Guo, Xiguang Liu, Hongzong Si
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Application of Covalent Binding Body Burden in the HμREL Human Hepatocyte Coculture Model for Reactivity Risk Assessment of Metabolically Low Turnover Drugs Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-03-26 Jackie Shang, Kevin J. Coe, Heng Keang Lim, Lu Chen, Buddha B. Khatri, Rhys Salter, Kaushik Mitra, Ramaswamy Iyer
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Long-Term Triclocarban Exposure Induced Enterotoxicity by Triggering Intestinal AhR-Mediated Inflammation and Disrupting Microbial Community in Mice Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-03-25 Yuchen Song, Hehua Lei, Zheng Cao, Cui Zhang, Chuan Chen, Mengjing Wu, Huabao Zhang, Ruichen Du, Liu Lijun, Xiaoyu Chen, Limin Zhang
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Deus Ex Machina? The Rise of Artificial Intelligence in Toxicology Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-03-20 Raymond Lui
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Advances in Metabolism and Metabolic Toxicology of Quinoxaline 1,4-Di-N-oxides Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-03-20 Haoxian An, Yonggang Li, Yanshen Li, Shanmin Gong, Ya’ning Zhu, Xinru Li, Shuang Zhou, Yongning Wu
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Deep Learning Models Compared to Experimental Variability for the Prediction of CYP3A4 Time-Dependent Inhibition Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-03-19 Andrin Fluetsch, Markus Trunzer, Grégori Gerebtzoff, Raquel Rodríguez-Pérez
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Multiquery Similarity Searching Models: An Alternative Approach for Predicting Hemolytic Activity from Peptide Sequence Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-03-19 Kevin Castillo-Mendieta, Guillermin Agüero-Chapin, Edgar Marquez, Yunierkis Perez-Castillo, Stephen J. Barigye, Mariela Pérez-Cárdenas, Facundo Peréz-Giménez, Yovani Marrero-Ponce
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Correction to “Screening DNA Damage in the Rat Kidney and Liver by Untargeted DNA Adductomics” Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-03-18 Nagarjunachary Ragi, Scott J. Walmsley, Foster C. Jacobs, Thomas A. Rosenquist, Viktoriya S. Sidorenko, Lihua Yao, Laura A. Maertens, Christopher J. Weight, Silvia Balbo, Peter W. Villalta, Robert J. Turesky
The Figure 4 legend on page 347 of the published Article has a superfluous sentence. The correct Figure 4 legend is: Figure 4. wSIM-City EICs of wide-SIM/MS2 analysis of precursor and aglycone ions of a proposed novel dC-N4-AL-I adduct in kidneys and liver of untreated and rats treated with the 13-carcinogen mixture 24 h following dosing. The precursor ions are shown in black, and the aglycone ions
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Systematic Approaches for the Encoding of Chemical Groups: A Case Study Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-03-18 Panagiotis G. Karamertzanis, Grace Patlewicz, Marta Sannicola, Katie Paul-Friedman, Imran Shah
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Mass Spectrometry-Based Method to Measure Aflatoxin B1 DNA Adducts in Formalin-Fixed Paraffin-Embedded Tissues Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-03-18 Medjda Bellamri, Lihua Yao, Rachana Tomar, Vladimir Vartanian, Carmelo J. Rizzo, Michael P. Stone, John D. Groopman, R. Stephen Lloyd, Robert J. Turesky
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Role of UDP-Glycosyltransferase (ugt) Genes in Detoxification and Glycosylation of 1-Hydroxyphenazine (1-HP) in Caenorhabditis elegans Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-03-15 Muhammad Zaka Asif, Kelsey A. Nocilla, Li Ngo, Man Shah, Yosef Smadi, Zaki Hafeez, Michael Parnes, Allie Manson, John N. Glushka, Franklin E. Leach, III, Arthur S. Edison
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Chemoproteomic Profiling Maps Zinc-Dependent Cysteine Reactivity Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-03-14 Nan Qiu, Dany Pechalrieu, Daniel Abegg, Alexander Adibekian
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A Reversible Mechanochromic AIEgen Based on Triphenylamine for the Selective Detection of Vitamin B2 (Riboflavin) in Aqueous Media and Histotoxicity Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-03-07 Kishor S. Jagadhane, Nagesh B. Birajdar, Govind B. Kolekar, Prashant V. Anbhule
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Lung Gene Expression Suggests Roles for Interferon-Stimulated Genes and Adenosine Deaminase Acting against RNA-1 in Pathologic Responses to Diisocyanate Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-03-04 Adam V. Wisnewski, Jian Liu
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In Vitro, In Vivo, and In Silico Analysis of Pyraclostrobin and Cyprodinil and Their Mixture Reveal New Targets and Signaling Mechanisms Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-02-28 Yeju Kim, Ceyhun Bereketoglu, Onur Sercinoglu, Ajay Pradhan
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Replication Studies of Alkyl Phosphotriester Lesions in Human Cells Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-02-28 Jun Wu, Jiabin Wu, Garrit Clabaugh, Yinsheng Wang
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Unlocking the Power of Transcriptomic Biomarkers in Qualitative and Quantitative Genotoxicity Assessment of Chemicals Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-02-26 Anouck Thienpont, Eunnara Cho, Andrew Williams, Matthew J. Meier, Carole L. Yauk, Vera Rogiers, Tamara Vanhaecke, Birgit Mertens
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5-Chloro-2′-deoxycytidine Induces a Distinctive High-Resolution Mutational Spectrum of Transition Mutations In Vivo Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-02-23 Marisa Chancharoen, Zhiyu Yang, Esha D. Dalvie, Nina Gubina, Mathuros Ruchirawat, Robert G. Croy, Bogdan I. Fedeles, John M. Essigmann
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In Silico Prediction of Chemical Acute Dermal Toxicity Using Explainable Machine Learning Methods Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-02-21 Shang Lou, Zhuohang Yu, Zejun Huang, Haoqiang Wang, Fei Pan, Weihua Li, Guixia Liu, Yun Tang
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Invitation to Apply or Nominate for Membership in the Early Career Board of Chemical Research in Toxicology Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-02-19 Shana Sturla, Jiayin Dai, Annette Kraegeloh, Daniel Normura, Igor Tetko, Yinsheng Wang, Julio Serrano
Chemical Research in Toxicology invites all interested and eligible members of the community to apply or nominate for membership in the Early Career Board. Duties of Board members include guiding the Journal in the development of its diversity plan and expanding its editorial content. We seek Early Career Board members who will be actively engaged in these activities, where the Early Career Board members
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Mechanisms of Nitrosamine Mutagenicity and Their Relationship to Rodent Carcinogenic Potency Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-02-05 David J. Snodin, Alejandra Trejo-Martin, David J. Ponting, Graham F. Smith, Andreas Czich, Kevin Cross, Laura Custer, Joanne Elloway, Nigel Greene, Amit S. Kalgutkar, Susanne A. Stalford, Rachael E. Tennant, Esther Vock, Adam Zalewski, Verena Ziegler, Krista L. Dobo
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Association of Urinary N7-(1-hydroxyl-3-buten-1-yl) Guanine (EB-GII) Adducts and Butadiene-Mercapturic Acids with Lung Cancer Development in Cigarette Smokers Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-02-05 Caitlin C. Jokipii Krueger, Sungshim L. Park, Yesha Patel, Daniel O. Stram, Melinda Aldrich, Qiuyin Cai, Natalia Y. Tretyakova
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Electron-Induced Damage by UV Photolysis of DNA Attached to Gold Nanoparticles Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-02-05 Alaa Huwaidi, Gabriel Robert, Bhavini Kumari, Andrew D. Bass, Pierre Cloutier, Brigitte Guérin, Léon Sanche, J. Richard Wagner
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Introduction to the Special Issue: Mass Spectrometry Advances for Environmental and Human Health Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-02-02 Natalia Tretyakova, Hitesh V. Motwani, Hailin Wang, Jiayin Dai
Published as part of the Chemical Research in Toxicology virtual special issue “Mass Spectrometry Advances for Environmental and Human Health”. This Special Issue of Chemical Research in Toxicology highlights recent advances in mass spectrometry methodologies and their applications for environmental and human health. Mass spectrometry (MS) is an analytical technique that ionizes chemical compounds
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High-Throughput GPCRome Screen of Pollutants Reveals the Activity of Polychlorinated Biphenyls at Melatonin and Sphingosine-1-phosphate Receptors Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-31 Joshua C. Wilkinson, Hans-Joachim Lehmler, David L. Roman
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AttentiveSkin: To Predict Skin Corrosion/Irritation Potentials of Chemicals via Explainable Machine Learning Methods Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-31 Zejun Huang, Shang Lou, Haoqiang Wang, Weihua Li, Guixia Liu, Yun Tang
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CHIR-98014, a GSK 3β Inhibitor, Protects Against Triptolide/Lipopolysaccharide-Induced Hepatotoxicity by Mitochondria-Dependent Apoptosis Inhibition Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-29 Shaoyun Zhou, Ruohan Cheng, Yue Zhang, Yihan Jiang, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu
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(2-Methylbutyryl)shikonin Naturally Occurring Shikonin Derivative Ameliorates the α-MSH-Induced Melanogenesis via ERK1/2 and p38 MAP Kinase-Mediated Down-Regulation of the MITF Transcription Factor Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-25 Aalim Maqsood Bhat, Rashid Haroon, Shahid Naikoo, Raghu Rai Sharma, Sajeeda Archoo, Sheikh A Tasduq
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MlrA, an Essential Enzyme for Microcystins and Nodularin on First Step Biodegradation in Microcystin-Degrading Bacteria Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-22 Tianxiao Liu, Narumi Kurogo, Miwa Kodato, Naoshi Fujimoto, Tomoaki Itayama, Kunihiro Okano, Motoo Utsumi, Zhenya Zhang, Zhongfang Lei, Tian Yuan, Hideaki Maseda, Norio Sugiura, Kazuya Shimizu
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Enhancement of Benzene Emissions in Special Combinations of Electronic Nicotine Delivery System Liquid Mixtures Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-19 Fatima El Hajj Moussa, Nathalie Hayeck, Salwa Hajir, Rachel El Hage, Rola Salman, Nareg Karaoghlanian, Najat Aoun Saliba
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Regulation of BTB (POZ) Structural Domain 6b by MicroRNA-222b in Zebrafish Embryos after Exposure to Di(2-ethylhexyl)phthalate at Low Concentrations Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-18 Ge Huang, Qi Gong, Kai Zhang, Hossam El Din H. Abdelhafez, Junjie Yu, Jiangfeng Guo
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Tobacco-Specific Nitrosamines in Current Commercial Large Cigars, Cigarillos, and Little Cigars Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-18 Jiu Ai, Matthew Hassink, Kenneth M. Taylor, Peter Kuklenyik, Liza Valentín-Blasini, Clifford Watson
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Tissue Organoid Cultures Metabolize Dietary Carcinogens Proficiently and Are Effective Models for DNA Adduct Formation Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-17 Angela L. Caipa Garcia, Jill E. Kucab, Halh Al-Serori, Rebekah S. S. Beck, Madjda Bellamri, Robert J. Turesky, John D. Groopman, Hayley E. Francies, Mathew J. Garnett, Meritxell Huch, Jarno Drost, Matthias Zilbauer, Volker M. Arlt, David H. Phillips
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Interview with Dr. Yinsheng Wang, 2023 Founders Award Winner, American Chemical Society Division of Chemical Toxicology Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-17 Yuxiang Sun
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Mass Spectral Library for DNA Adductomics Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-17 Scott J. Walmsley, Jingshu Guo, Anamary Tarifa, Anthony P. DeCaprio, Marcus S. Cooke, Robert J. Turesky, Peter W. Villalta
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Mass Spectrometry Evidence for Forming Schiff Base 3′-DNA-Histone Cross-Links from Abasic Sites in Vitro and in Human Cells Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-17 Ying Peng, Cameron Bryan, Kun Yang
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Identification, Organic Synthesis, and Sensitive Analysis of a cis-Homosalate-Specific Exposure Biomarker Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-16 Katharina E. Ebert, Vladimir N. Belov, Michael John, Tobias Weiss, Thomas Brüning, Heiko Hayen, Holger M. Koch, Daniel Bury
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Linking Toxicology and Human Health Through the Exposome Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-16 Erik J. Moran
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Spatiotemporal Visualization of Paraquat Distribution, Toxicokinetics, and Its Detoxification in Zebrafish Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-11 Luyuan Qin, Jiadong Huang, Yuanzhou Feng, Baoquan Zhao, Lei Guo, Jianwei Xie
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Synthesis, Detection, and Metabolism of Pyridone Ribosides, Products of NAD Overoxidation Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-10 Faisal Hayat, J. Trey Deason, Ru Liu Bryan, Robert Terkeltaub, Weidan Song, W. Lee Kraus, Janice Pluth, Natalie R. Gassman, Marie E. Migaud
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TISBE: A Public Web Platform for the Consensus-Based Explainable Prediction of Developmental Toxicity Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-10 Fabrizio Mastrolorito, Maria Vittoria Togo, Nicola Gambacorta, Daniela Trisciuzzi, Viviana Giannuzzi, Fedele Bonifazi, Antonella Liantonio, Paola Imbrici, Annamaria De Luca, Cosimo Damiano Altomare, Fulvio Ciriaco, Nicola Amoroso, Orazio Nicolotti
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Novel Processes Associated with the Repair of Interstrand Cross-Links Derived from Abasic Sites in Duplex DNA: Roles for the Base Excision Repair Glycosylase NEIL3 and the SRAP Protein HMCES Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-10 Nathan E. Price, Kent S. Gates
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Screening DNA Damage in the Rat Kidney and Liver by Untargeted DNA Adductomics Chem. Res. Toxicol. (IF 4.1) Pub Date : 2024-01-09 Nagarjunachary Ragi, Scott J. Walmsley, Foster C. Jacobs, Thomas A. Rosenquist, Viktoriya S. Sidorenko, Lihua Yao, Laura A. Maertens, Christopher J. Weight, Silvia Balbo, Peter W. Villalta, Robert J. Turesky