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Interview with Dr. Yinsheng Wang, 2023 Founders Award Winner, American Chemical Society Division of Chemical Toxicology
Chemical Research in Toxicology ( IF 4.1 ) Pub Date : 2024-01-17 , DOI: 10.1021/acs.chemrestox.3c00359 Yuxiang Sun 1
Chemical Research in Toxicology ( IF 4.1 ) Pub Date : 2024-01-17 , DOI: 10.1021/acs.chemrestox.3c00359 Yuxiang Sun 1
Affiliation
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This year’s recipient for the Founders Award, sponsored by the ACS Division of Chemical Toxicology, is Dr. Yinsheng Wang, a distinguished Professor of Chemistry at the University of California, Riverside (UCR). He received the award at the 2023 American Chemical Society National Meeting in San Francisco and delivered a captivating talk about the chemistry and biology of nucleic-acid-binding proteins (Figure 1). Figure 1. Yinsheng Wang receiving the Founders Award from Professor Michael P. Stone, Chair of the Division of Chemical Toxicology. Dr. Wang began his journey in science at Shandong University in China, where he received his bachelor’s degree in Chemistry in 1993. After that, he pursued a master’s degree at the Dalian Institute of Chemical Physics in the Chinese Academy of Sciences, in northeastern China. His Ph.D. work took him across the globe to Washington University in St. Louis, Missouri, where he worked under the joint supervision of Professors Michael L. Gross and John-Stephen A. Taylor. There, he began studying DNA damage using mass spectrometry, a topic that he pursues today as a chemistry professor at UCR. When asked about what he learned from his Ph.D. advisors, he said, “I learned the importance of keeping eyes open while conducting research, and being technically fearless. I also learnt a lot about how to be a good scientific writer.” After his time in Missouri, Dr. Wang accepted a faculty position and started his independent career at UCR. His research focuses on understanding the biological consequences of DNA damage, mechanisms of action for environmental toxicants, and, more recently, the functions of RNA modifications in human health and diseases. He identified and characterized new DNA lesions, including bulky lesions induced by reactive oxygen species. His laboratory developed LC–MS/MS in combination with a plasmid-based shuttle vector to assess quantitatively how structurally defined DNA lesions alter the frequency and efficiency of DNA replication and transcription in cells and to measure the types and frequencies of mutations induced by the lesions. He also discovered that N2-(1-carboxyethyl)-2′-deoxyguanosine (N2-CEdG), the major stable DNA adduct derived from methylglyoxal, constitutes a previously unknown endogenous substrate for DinB family polymerases. “We work at the interface of chemistry and biology,” he explained. “We use a combination of advanced chemical tools to address important biological questions, such as how exposure to toxic chemicals alters our DNA and causes disease,” he said. Recently, his laboratory also made an exciting discovery about the contributions of an RNA modification to neurodegenerative diseases arising from microsatellite repeat expansions. In particular, they showed that the adenosine in expanded CAG repeat RNA can be methylated to N1-methyladenosine (m1A), whose frequency increases with repeat length. Importantly, m1A binds directly to TDP-43, which stimulates its truncation, cytoplasmic mislocalization, and formation of gel-like protein aggregates, recapitulating the observations made for TDP-43 protein in neurological diseases. Furthermore, they showed that m1A in CAG repeat RNA contributes to CAG repeat expansion-induced neurodegeneration in Caenorhabditis elegans and Drosophila. “Clarifying this mechanism may ultimately provide a new target for therapies to treat these neurological diseases,” he said. Dr. Wang’s contributions to the scientific community have also been recognized by other awards. In 2012, the ACS Division of Chemical Toxicology and this Journal, Chemical Research in Toxicology, copresented him with the inaugural Young Investigator Award. In the next year, he received the Biemann Medal from the American Society for Mass Spectrometry, which recognizes middle-career scientists who have made substantial contributions to mass spectrometry instrumentation or application. He was also the recipient of the Outstanding Achievements in Mass Spectrometry Award from the Eastern Analytical Symposium in 2018. When asked about the biggest achievement for his successful career, he said “Being able to work with a large number of talented graduate students and postdocs, and observing them to grow professionally and personally are the most rewarding aspect of my academic career.” Outside of science, Dr. Wang enjoys spending his time hiking and traveling. He mentioned that maintaining a work–life balance was challenging: “It’s difficult to achieve career success without family support. When my kids were young, I tried to spend a couple of hours with kids at around dinner time each day and spent 1 weekend day with them. In retrospect, this is an area that I could have done better by spending more time with family.” He said. At the end of the interview, Dr. Wang’s advice to the younger scientists is being passionate about what you do. Congratulations, Dr. Yinsheng Wang on the 2023 TOXI Founders Award! This article has not yet been cited by other publications. Figure 1. Yinsheng Wang receiving the Founders Award from Professor Michael P. Stone, Chair of the Division of Chemical Toxicology.
更新日期：2024-01-17
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