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  • Detection, identification and determination of resveratrol in wine. Problems and challenges
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-03-17
    Magdalena Fabjanowicz, Justyna Płotka-Wysyłka, Jacek Namieśnik

    Resveratrol is a compound synthesized by plants in response to unfavorable conditions of growth like mechanical injury, siege of bacteria or fungi and UV exposure. It is concentrated mostly in grapes skin and further more in the products made from grapes especially red wines. Each wine is characterized by different amount of given stilbene since its occurrence is affected by many factors like: types of grapes, environment (climate, soil, region) and winemaking technologies. Due to its health beneficial effects, people are very interested in resveratrol and its activity to deal with some diseases.. Therefore, its determination and quantification is of high importance. However, the complexity of wine matrix makes its analysis very challenging. The study provides data of the resveratrol occurrence in different types of fruits and wines, regarding region they come from and comparison of analytical techniques and challenges taking into account their process and green assessment.

  • Multi-channel capillaries and photonic crystal fibres for separation sciences
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-03-16
    Sinéad Currivan, Nirved Upadhyay, Brett Paull

    Capillaries of many dimensions are fabricated and modified, for use across a wide range of applications within analytical science. This extends from sample preparation and sample extraction, to separation sciences, and detection sciences. Photonic crystal fibres, emerged in the 1990’s, and were specifically designed for optical applications, predominantly as waveguides. Since then, a range of modifications have been reported, with the fibres applied to a wide variety of analytical applications, in liquid and gas phase analyses or detection. This review aims to provide an overview of photonic crystal fibres and related multi-channel capillaries, the chemical modifications that have been carried out, and the subsequent applications of the developed materials towards analytical separations, including sample preparation.

  • 20th anniversary of axial capacitively coupled contactless conductivity detection in capillary electrophoresis
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-03-15
    Pavel Kubáň, Peter C. Hauser

    Capacitively coupled contactless conductivity detection in its axial electrode arrangement was introduced to capillary electrophoresis 20 years ago. The method has since seen a strong development and has been accepted as a useful tool for the detection of inorganic as well as organic ions not only in electrophoresis but also in other analytical techniques. On this anniversary an overview of the developments is given. It can serve as an introduction for readers not familiar with the field, but it may also fill out details for readers already acquainted with contactless conductivity detection. Historical and fundamental aspects are covered as well as technical developments. Its uses in the different modes of capillary electrophoresis are discussed as are applications outside electrophoresis.

  • Review of Optical Sensors for Pesticides
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-03-15
    Xu Yan, Hongxia Li, Xingguang Su

    Sensors for pesticides with high sensitivity have been urgently required to control food safety, protect ecosystem and prevent disease. In this review, we provide an overview of recent advances and new trends in optical sensors for the detection of pesticide based on fluorescence, colorimetric and surface enhanced Raman scattering, surface plasmon resonance and chemiluminescent strategies. These methods will be classified by the types of recognition elements, including enzyme, antibody, molecularly-imprinted polymers, aptamer and host-guest reaction. This review explores the basic features of established strategies through assessment of their performance. In addition, we provide brief summary of the entire review, the drawbacks of present sensor and future prospects, as well as the ongoing efforts to pesticide optical sensors.

  • Recent developments in quantitative SERS moving towards absolute quantification
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-03-15
    Royston Goodacre, Duncan Graham, Karen Faulds

    Surface enhanced Raman scattering (SERS) generates molecularly specific fingerprints of analytes and when the experimental conditions are carefully controlled this is highly quantitative. This review critiques the development of quantitative SERS from simple univariate assessment of single vibrational modes to multivariate analysis of the whole spectrum for improved quantification. SERS has also been developed for direct multiplex detection and quantification of multiple analytes and this is also discussed, as is the need for LC-SERS for analyte separation should multivariate chemometric approaches fail to effect quantification. Finally, to effect absolute quantification with SERS, the concepts of isotopologues is introduced along with the standard addition method (SAM) and suitable examples that have been developed and exploited these techniques are presented. We believe that SERS will be routinely used for quantitative analysis and it is only a matter of time before this technique translates from the laboratory to the clinical environment.

  • Advances in Structure-Switching Aptasensing Towards Real Time Detection of Cytokines
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-03-10
    Chaomin Cao, Fuyuan Zhang, Ewa M. Goldys, Guozhen Liu

    Structure-switching aptamer-based biosensors (aptasensors) provide a promising strategy for real-time or near real-time monitoring of analytes in vivo, owing to their reversibility, the versatility of methods available to engineer the aptamer switches, and the ability to tune their dynamic range. Monitoring cell-to-cell communication through cytokine secretions has enormous value in biology and medicine. However, cytokine detection is challenging due to the extremely dynamic, transient cytokine secretion process, and typically low abundances in physiological conditions. Here, we summarise recent advances in structure-switching signaling aptamer-based biosensing with specific focus on cytokine sensing. This Review begins with the survey of cytokine-specific aptamers followed by the designs of elegant sensing platforms based on structure-switching aptamers with different signal readouts such as optic, electrochemistry, and other types. We describe the strategies of signal amplification in aptasensors, and highlight future perspectives of aptasensors for real-time or near real-time detection of cytokines.

  • Novel colloidal molybdenum hydrogen bronze (MHB) for instant detection and neutralization of hazardous peroxides
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-03-09
    Sherif Elbasuney

    Ultrasensitive and low-cost detection means for immediate recognition of peroxide explosive compounds such as triacetone triperoxide (TATP) and hexamethylene triperoxide diamine (HMTD) have attracted tremendous attention due to their great significance in home land security. Metal hydrogen bronzes are promising materials for instant detection and neutralization of hazardous peroxides. This study reports on the sustainable fabrication of colloidal molybdenum oxide MoO3 nanorods. Nanoscopic colloidal molybdenum hydrogen bronze (MHB) were evolved from synthesized MoO3 via acidic hydrothermal treatment. Colloidal MHB particles with dark blue colour demonstrated complete change in surface properties from hydrophilic to hydrophobic; they demonstrated effective phase transfer from aqueous phase to organic phase. This novel reducing agent did not only offer neutralization of hazardous peroxides but also demonstrated an instant detection of such compounds with colour disappearance. Furthermore, MHB can act as a desensitizer for different hazardous materials by shuttling reactive hydrogen ions rendering them into non-explosive compounds.

  • A State-of-art review on the agility of quantitative proteomics in tuberculosis research
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-03-09
    Manikandan Muthu, Anbarasu Deenadayalan, D. Ramachandran, Diby Paul, Judy Gopal, Sechul Chun
  • Organic fluorescent thermometers: Highlights from 2013 to 2017
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-03-08
    Tianyi Qin, Bin Liu, Kangning Zhu, Zijie Luo, Yingying Huang, Chengjun Pan, Lei Wang
  • Screening and risk management solutions for steroidal estrogens in surface and wastewater
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-03-08
    Robert Kase, Barbora Javurkova, Eszter Simon, Kees Swart, Sebastian Buchinger, Sarah Könemann, Beate I. Escher, Mario Carere, Valeria Dulio, Selim Ait-Aissa, Henner Hollert, Sara Valsecchi, Stefano Polesello, Peter Behnisch, Carolina di Paolo, Daniel Olbrich, Eliska Sychrova, Michael Gundlach, Rita Schlichting, Lomig Leborgne, Manfred Clara, Christoph Scheffknecht, Yves Marneffe, Carole Chalon, Petr Tusil, Premysl Soldan, Brigitte von Danwitz, Julia Schwaiger, Antonio Moran Palao, Francesca Bersani, Olivier Perceval, Cornelia Kienle, Etienne Vermeirssen, Klara Hilscherova, Georg Reifferscheid, Inge Werner

    BackgroundThe European Commission Implementing Decision EU 2015/495 included three steroidal estrogens, namely 17α-ethinyl estradiol, 17β-estradiol, and estrone, in the so-called “watch list” of the EU Water Framework Directive (WFD). The monitoring of these compounds is difficult because the detection limits of the majority of the available analytical methods cannot achieve the very low target concentrations required to meet proposed environmental quality criteria. In 2014, a combined Science-Policy Interface/Chemical Monitoring of Emerging Pollutants project was launched to meet this monitoring challenge. The project involved 24 research organizations and environmental agencies from 12 different countries.MethodsSixteen surface water (SW) and 17 wastewater (WW) samples were collected across Europe and analysed using five in vitro effect-based and three chemical analytical methods. A general description of the project and data evaluation is provided by Könemann and colleagues in the companion publication 2018. In our study, we compared bioanalytical and chemical analytical results with regard to their application for aquatic status assessment. Therefore we considered the potential to predict population-relevant risks for aquatic organisms and the specificity and sensitivity of the various methods used in both approaches. Finally we tested and discussed the applicability and relevance of previously suggested effect-based trigger values (EBT).Resultsand discussion: Results of the risk assessment based on chemical analytical data correlated highly with estrogenic activities (expressed as 17β-estradiol equivalents (EEQ) determined using effect-based methods), demonstrating the ability of the bioassays to predict mixture risk caused by steroidal estrogens. For about 15 % of SW and 40 % of WW samples detection limits of chemical-analytical methods were too high to allow a status assessment, while detection limits of all effect-based methods were below proposed EBT. This demonstrates that effect-based methods are suitable for status assessment of surface waters. The in vitro effect-based methods were quite specific for steroidal estrogens and highly sensitive, meaning they have a low probability to detect false positive or negative results. After testing of three alternative EBT proposals, we concluded to use preliminary 400 pg/L EEQ as screening EBT corresponding to the AA-EQS of E2. Further test specific refinements in the application of this value are not excluded.ConclusionsWe conclude that water quality assessment can progress from a purely analytical approach to effect-based monitoring, from single substance to known and unknown mixture assessment and from in vitro screening to population-relevant risk assessment. Despite a few limitations, effect-based in vitro methods are recommendable for monitoring steroidal estrogens under the WFD because they, a) are able to sensitively quantify the activity of steroidal estrogens in all surface and wastewater samples, b) are able to detect the combined effect of estrogen mixtures including unknown chemicals with estrogen receptor activating properties, c) allow an ecotoxicological status assessment using EBT to calculate risk quotients. This approach is similar to the risk ratio used in regulatory environmental risk assessments, but allows for an integrated mixture assessment.OutlookThe results of this study support the introduction of a holistic approach for the regulation of chemicals in the aquatic environment under the EU WFD, as proposed recently by EU Water Directors. An ecotoxicological status assessment for one of the most relevant modes of action of endocrine disruption will allow authorities responsible for water quality assessment to focus available monitoring resources and to improve the ecological status of EU waterbodies.

  • Review: Metal-organic framework based crystalline sponge method for structure analysis
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-03-06
    Qiuzheng Du, Jun Peng, Pu Wu, Hua He

    Crystalline sponge method represents a rather new trend in structural analysis. This method is to use networked porous metal complexes as “crystalline sponges”, which does not require the crystallization of the sample. It has large and regular cavities which can absorb the target molecules like sponges and arrange them in an orderly manner, so that their structures can be determined with X-ray diffraction. In this review, we focus on recent trends in crystalline sponge method. Following an introduction in the field, a first main section covers the birth of crystalline sponge method and the improvement of crystal synthesis method. The further section covers structural confirmation, including the guest molecular structure determination and host-guest interactions. The next main section covers the expansion of crystalline sponge method, such as the applications in synthesis, other crystalline sponge and visual observation. The final section covers the limitations and prospects of the crystalline sponge method.

  • Effect-based and chemical analytical methods to monitor estrogens under the European Water Framework Directive
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-03-01
    Sarah Könemann, Robert Kase, Eszter Simon, Kees Swart, Sebastian Buchinger, Michael Schlüsener, Henner Hollert, Beate I. Escher, Inge Werner, Selim Aït-Aïssa, Etienne Vermeirssen, Valeria Dulio, Sara Valsecchi, Stefano Polesello, Peter Behnisch, Barbora Javurkova, Olivier Perceval, Carolina Di Paolo, Daniel Olbrich, Eliska Sychrova, Rita Schlichting, Lomig Leborgne, Manfred Clara, Christoph Scheffknecht, Yves Marneffe, Carole Chalon, Petr Tušil, Přemysl Soldàn, Brigitte von Danwitz, Julia Schwaiger, Maria Isabel San Martín Becares, Francesca Bersani, Klara Hilscherová, Georg Reifferscheid, Thomas Ternes, Mario Carere

    The European Decision EU 2015/495 included three steroidal estrogens, estrone, 17β-estradiol and 17α-ethinyl estradiol, in the “watch-list” of the Water Framework Directive (WFD). As consequence, these substances have to be chemically monitored at the level of their environmental quality standards, which can be challenging. This project aimed to identify reliable effect-based methods (EBMs) for screening of endocrine disrupting compounds, to harmonise monitoring and data interpretation methods, and to contribute to the current WFD review process. Water and wastewater samples were collected across Europe and analysed using chemical analyses and EBMs. The results showed that 17β-estradiol equivalents were comparable among methods, while results can vary between methods based on the relative potencies for individual substances. Further, derived 17β-estradiol equivalents were highly correlated with LC-MS/MS analyses. This study shows that the inclusion of effect-based screening methods into monitoring programmes for estrogens in surface waterbodies would be a valuable complement to chemical analysis.

  • Latest instrumental developments and bioanalytical applications in tip-enhanced Raman spectroscopy
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-02-28
    Robert Meyer, Xiaobin Yao, Volker Deckert

    This review intends to provide an overview about the state-of-the art and the latest instrumental developments of tip-enhanced Raman spectroscopy (TERS), particularly addressing selected applications for biological samples. Additionally, a practical guideline of “How to conduct a TERS experiment?” is presented, in order to understand, motivate and practice TERS experiments. Consequently, this review aims to set a basis for further instrumental developments, especially addressing TERS in liquid for prospective applications towards a larger variety of samples.

  • Graphene-Based Optical Nanosensors for Detection of Heavy Metal Ions
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-02-27
    Li Zhang, Dong Peng, Ru-Ping Liang, Jian-Ding Qiu

    Heavy metal ion pollution has threatened the environmental and human safety. Therefore, there is a remarkable demand to detect heavy metal ions in a fast, sensitive and selective way. Although conventional sensors have been designed and widely applied in heavy metal ion determination, they present many limitations and challenges. Graphene-based nanotechnology overcomes these challenges and endows the sensing platform better performance. In this overview, studies concerning graphene-based optical nanosensors for heavy metal ion detection have been summarized, paying special attention to sensors based on graphene, graphene oxide, and graphene quantum dots. In addition, prospects and developing trends of nanosensors for heavy metal ion analysis are also proposed.

  • Nanosized hydrophobic gels: Advanced supramolecules for use in electrochemical bio- and immunosensing
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-02-27
    Mohammad Hasanzadeh, Nasrin Shadjou, Miguel de la Guardia

    Nanosized hydrogels have emerging as versatile supramolecules materials with application in various electrochemical biosensing devices. This review reports a systematic study of the usefulness of nano-sized hydrogels in the different steps of the process of development of electrochemical biosensing systems. The advantages offered by nano-sized hydrogels in detection of analytes are illustrated with representative recent examples that highlight the scientific interest in widening the use of hydrogel nanoparticles in electrochemical biosensing methods. In this review, different types of hydrogel nanoparticles-based electrochemical biosensors, such as enzyme, protein, and nucleic acids are reviewed in terms of their sensing performance and potential of future development. Various aspects of nano-sized hydrogels, from the point of view of electrochemical biosensor design, were considered hoping that this review will excite researchers into exploiting the exceptional properties of nano-sized hydrogels in electrochemical biosensor development. Finally, some future applications of electrochemical biosensors based on nano-sized hydrogels were discussed.

  • Recent progress in application of nanomaterial-enabled biosensors for ochratoxin A detection
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-02-24
    Chengmei Jiang, Lingyi Lan, Yao Yao, Fengnian Zhao, Jianfeng Ping

    Ochratoxins are the major components of mycotoxin that exist extensively in plant origin food. In the ochratoxins group, ochratoxin A (OTA) as the most toxic compound, which possesses a high chemical and thermal stability in foodstuff and would do harm to human beings. Hence, it is imperative to develop a simple, rapid, sensitive, robust, and accurate way to determinate OTA. Nanomaterial-based biosensors seem to be ideal analysis tools for identifying OTA on account of their tremendous merits, such as high sensitivity, excellent selectivity, simplicity of operation, and rapidity. This review focuses on the application and development of nanomaterial-enabled biosensors in OTA detection in the past years (2007-2018). Three dominant signal transduction mechanisms, i.e. optical, electrochemical, and piezoelectric, are discussed in details. Moreover, the major challenges and perspectives for future developments of OTA biosensors are also contained to provide an overview for the forthcoming research orientation.

  • Multidetector systems in gas chromatography
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-02-24
    Łukasz Dąbrowski

    Multidetector systems have been widely used in GC for many years. Even though the mass spectrometer is still the most popular GC detector in the case of complex samples, a multidetector system can provide all the information needed for the confirmation purposes. This review describes various GC setups for multidetector analysis, and modern systems available on the market. An overview of the application of multidetector systems with various detectors in GC is also enclosed. The most popular system involves parallel detectors and a post-injector or post-column effluent splitter. For routine analysis, metal based splitters are available on the market with dedicated software. More economical devices are also available for the testing purposes or short term experiments. Nevertheless, in both cases, manual operator setup of the system remains necessary.

  • Bioapplications of Acoustic Crystals, A Review
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-02-24
    Munawar Hussain, Frank Rupp, Hans P. Wendel, Frank K. Gehring

    The acoustic crystal innovation is picking up fame as an emerging equipment for ''Point of Care'' (POC) applications in biological part of clinics, while the unprecedented capability of the technology is not perceived yet. The acoustic equipment are the attractive due to their detecting properties of ultra-sensitivity and selectivity, reproducibility and repeatability, precision and constancy. The first part of the review article highlights the ''clinical overlapped biological areas'' especially focusing on proteins and cells, macro-molecules and supra-molecules, drugs and chiral sensing, bio-markers and immuno-sensors, and ''acoustic bio-electronics'' including an overview of the worldwide crystal market. The technology status has been featured by utilizing the approach of ''reviewing the reviews'' for providing an overview of the ''world of the acoustic bio-applications''. The second principle part of the article solidly concentrates the acoustic investigations on haemostasis via reviewing the key literature from 2010 to January 2018.

  • Analytical methodologies for arsenic speciation in macroalgae: a critical review
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-02-22
    Vanessa A.T. Reis, Armando C. Duarte
  • Designing spectroelectrochemical cells: A review
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-02-16
    L. León, J.D. Mozo

    A review on the recent state of spectroelectrochemical techniques is presented. Starting with a discussion of the advantages of the application of spectroelectrochemical techniques instead of an ex-situ combination of spectroscopic and electrochemical methods, the main part of this review is focused on two topics: practical considerations for obtaining the optimal conditions for spectroelectrochemical measurements according to the spectroscopic or electrochemical technique selected, and considerations for the optimal design and construction of spectroelectrochemical cells with examples. The final outlook is intended to the use of spectroelectrochemical detectors in flow injection analysis (FIA) experiments. More than 300 references are collected covering the main contributions on this subject.

  • Recent advances in biological sample preparation methods coupled with chromatography, spectrometry and electrochemistry analysis techniques
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-02-16
    Zongliang Niu, Weiwei Zhang, Chunwei Yu, Jun Zhang, Yingying Wen

    Biological samples are complex and often contain many proteins, lipids and other contaminants, which affect the separation and ionization properties of the analytes. Moreover, the concentration of the analytes is very low in comparison with that of the interfering substances. Therefore, the development of biological sample preparation methods has become more and more challenging. The objective of this review is to provide a broad overview of the main biological samples (urine, blood, plasma, serum, hair, human breast milk, saliva, sweat and skin surface lipids, fecal and tissue), recent advances and applications of various sample preparation methods prior to chromatography, spectrometry and electrochemistry analysis over the past five years. Novel and modern approaches in biological sample preparation are especially emphasized. Finally, challenges and future perspectives to improve development of sample preparation methods are described.

  • New synthetic opioids in biological and non-biological matrices: A review of current analytical methods
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-01-31
    Emilia Marchei, Roberta Pacifici, Giulio Mannocchi, Enrico Marinelli, Francesco Paolo Busardò, Simona Pichini

    Abuse of new synthetic opioids is a worldwide rising issue posing a serious threat to the health of consumers. Unlike commonly abused drugs, which can be identified through routine drug testing, these new psychoactive substances may escape immunological screening tests and appropriate confirmation methods have not yet been developed and validated. Gas chromatography combined with mass spectrometry (GC–MS) and more frequently liquid chromatography tandem mass spectrometry (LC–MS/MS) as well as ultra high-liquid chromatography tandem mass spectrometry (UHPLC–MS/MS) are the methods required to attack this analytical problem. The technologies are sufficiently sensitive and specific to be used with antemortem and postmortem specimens and also to disclose drug metabolism for substances used in very low doses, resulting in minute concentrations in biological matrices. An updated review and current trends concerning analytical methods for the determination of illicit fentanyl analogues and other new synthetic opioids at risk of abuse is reported here for both ante- and postmortem biological matrices and non-biological specimens.

  • Micronutrient status assessment in humans: Current methods of analysis and future trends
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-02-09
    Ulrich Höller, Stephan JL. Bakker, Andre Düsterloh, Balz Frei, Josef Köhrle, Tobias Konz, Georg Lietz, Adrian McCann, Alexander J. Michels, Anne M. Molloy, Hitoshi Murakami, Dietrich Rein, Wim HM. Saris, Karlheinz Schmidt, Kazutaka Shimbo, Soeren Schumacher, Cees Vermeer, Jim Kaput, Peter Weber, Manfred Eggersdorfer, Serge Rezzi

    Micronutrients are essential to health at every life stage and their deficiencies are associated with increased incidence of various pathophysiological states and poor quality of life. Efficient methods are therefore needed to monitor micronutrient status of individuals and to improve evidenced-based recommendations for populations. This review (i) reports current approaches to assess the vitamin and mineral status in humans, (ii) summarizes current analytical advantages and shortcomings and (iii) provides practical information for both nutrition research and nutritional status diagnostics. Future analytical perspectives are discussed in relation to micronutrient profiling, analytical sensitivity, and miniaturized technologies.

  • Application of molecularly imprinted polymers in an analytical chiral separation and analysis
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-02-06
    Małgorzata Rutkowska, Justyna Płotka-Wasylka, Calum Morrison, Piotr Paweł Wieczorek, Jacek Namieśnik, Mariusz Marć

    Over the last two decades the process of development and application of a new types of molecular imprinted polymer (MIP) sorbents in the field of analytical chemistry have been widely described in the literature. One of the new trends in analytical chemistry practice is the use of new types of MIP sorbents as specific sorption materials constituting the stationary phase in advanced separation techniques. The following review paper contains comprehensive information about the application of a specific and well defined MIP sorbents (with the data base in the paper about the reagents used in MIP preparation process) as stationary phases in separation techniques including high performance liquid chromatography and capillary electrochromatography. Coverage includes newly created types of stationary phases (MIP sorbents) used for chiral recognition, with the focus on applications in enantioselective separation.

  • Advances in laser concepts for multiplex, coherent Raman scattering micro-spectroscopy and imaging
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-02-05
    Thomas Gottschall, Tobias Meyer, Michael Schmitt, Jürgen Popp, Jens Limpert, Andreas Tünnermann

    In this contribution, we want to review recent advances and innovations in laser sources and detection concepts for coherent Raman scattering microscopy with special emphasis on hyperspectral and multiplex imaging methods for biomedical applications. Groundbreaking advances have been made to increase the chemical sensitivity while maintaining video-rate imaging speeds. Excitation and detection schemes have been further improved to enhance the image contrast as well as to increase the spectral coverage and speed of multi-spectral data acquisition along with the ongoing quest to develop both compact and robust but also powerful and rapidly tunable laser sources suitable for integration into biomedical equipment.

  • Recent advances in graphene-based magnetic composites for magnetic solid-phase extraction
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-02-03
    Na Li, Hai-Long Jiang, Xiao-Li Wang, Xia Wang, Gui-Ju Xu, Bei-Bei Zhang, Li-Juan Wang, Ru-Song Zhao, Jin-Ming Lin

    In recent years, graphene-based magnetic composites have attracted tremendous research interest owing to its exceptional properties, such as huge surface area, large delocalized π-electron system, strong magnetic responsiveness, and excellent mechanical/thermal stability. These promising properties together with the ease of processibility and functionalization render graphene-based magnetic composites to be ideal adsorbents in magnetic solid-phase extraction. In this review, we outline the state of the art on the preparation approaches for different graphene-based magnetic composites and its application as adsorbents in preconcentrating organic compounds, biological macromolecules, and metal ions. In addition, future research directions of this type of magnetic materials are identified as well.

  • MoS2 Nanostructures for Electrochemical Sensing of Multidisciplinary Targets: A Review
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-02-02
    Ankita Sinha, Dhanjai, Bing Tan, Yujin Huang, Huimin Zhao, Xueming Dang, Jiping Chen, Rajeev Jain
  • Advances in sample preparation strategies for MS-based qualitative and quantitative N-glycomics
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-11-22
    Ying Zhang, Ye Peng, Lijun Yang, Haojie Lu

    N-glycosylation, as the most prevalent post-translational modification of proteins, plays an important part in many life processes. Characterization of N-glycome has been widely applied in the fields like biomarker mining and biopharmaceutical evaluation. However, the inherent low abundance of N-glycans hampers identification, structural elucidation and quantitation of the N-glycome using mass spectrometry (MS). Recently, a series of pre-treatment approaches, including N-glycan release, separation, enrichment and derivatization, are developed to achieve highly sensitive and accurate analysis of N-glycome. Herein, we summarize and highlight recent sample preparation strategies for MS-based identification and quantitation of N-glycome. We hope that this review serves as both an overview of the field and a guide to help scientists employing these powerful approaches in their research.

  • The survey of analytical methods for sample preparation and analysis of fragrances in cosmetics and personal care products
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-02-01
    Ghazaleh Abedi, Zahra Talebpour, Faezeh Jamechenarboo

    Fragrances most widely utilize in cosmetics and personal care products. These are known as allergens and emerging organic contaminants that induce the adverse effects on human health. In addition, dealers are tempted to adulterate the products by adding lower cost materials. It is therefore essential to detect fragrances in raw materials, cosmetics, and personal care products. The aim of this review is a survey of the main sample preparation and analysis methods proposed in previously published works dealing with the detection of fragrances in cosmetics and personal care products. Different sample preparation methods were utilized according to the matrix complexity e.g. dilution for the simple matrix, and headspace, direct, and tandem methods for the complex matrix. Also, different methods have been used for the analysis of fragrances in cosmetics and personal care products, investigated in four parts: chromatography, spectroscopy, mass spectrometry and electronic nose methods.

  • Developments and Interlaboratory Study of the Analysis of Short-Chain Chlorinated Paraffins
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-02-01
    L.M. van Mourik, I. van der Veen, S. Crum, J. de Boer

    To survey the conformity and quality of the results between laboratories for short-chain chlorinated paraffins (SCCPs) determination, we reviewed current and novel analytical methods and organized four worldwide laboratory exercises between 2011 and 2017. Participants were requested to analyse test solutions and extracts of various matrices with their method of choice. Thirty-three laboratories participated (9-22 per round), of which 55-81% were able to submit data. Large differences in results between laboratories were found (CVs 23-137%) but results improved over time, while the levels in the test materials decreased. In the last round acceptable CV values (<25%) were obtained for the test solution. In the last round, results obtained by the GC-ECNI-LRMS technique varied most, which is disconcerting as this technique is most commonly applied. We strongly suggest to continue monitoring comparability of laboratories to assess consensus in SCCP analysis, with a focus on quantification procedures applied.

  • Multisyringe flow injection analysis in spectroanalytical techniques – A review
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-11-07
    Victor Cerdà, Laura Ferrer, Lindomar A. Portugal, Cheilane T. de Souza, Sergio L.C. Ferreira
  • Recombinase polymerase amplification: Basics, applications and recent advances
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-10-26
    Ivan Magriñá Lobato, Ciara K. O'Sullivan

    Recombinase polymerase amplification (RPA) is a highly sensitive and selective isothermal amplification technique, operating at 37–42°C, with minimal sample preparation and capable of amplifying as low as 1–10 DNA target copies in less than 20 min. It has been used to amplify diverse targets, including RNA, miRNA, ssDNA and dsDNA from a wide variety of organisms and samples. An ever increasing number of publications detailing the use of RPA are appearing and amplification has been carried out in solution phase, solid phase as well as in a bridge amplification format. Furthermore, RPA has been successfully integrated with different detection strategies, from end-point lateral flow strips to real-time fluorescent detection amongst others. This review focuses on the different methodologies and advances related to RPA technology, as well as highlighting some of the advantages and drawbacks of the technique.

  • Overview of the techniques used for the study of non-terrestrial bodies: Proposition of novel non-destructive methodology
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-10-31
    J. Aramendia, L. Gomez-Nubla, K. Castro, S. Fdez-Ortiz de Vallejuelo, G. Arana, M. Maguregui, V.G. Baonza, J. Medina, F. Rull, J.M. Madariaga

    Meteorites and impact glasses have been largely analysed using different techniques, but most studies have been focused on their geological–mineralogical characterization and isotopic ratios, mainly of a destructive nature. However, much more information can be gained by applying novel non-destructive analytical procedures and techniques that have been scarcely used to analyse these materials. This overview presents some new methodologies to study these materials and compares these new approaches with the commonly used ones. Techniques such as X-Ray Fluorescence (XRF) and Laser Induced Breakdown Spectroscopy (LIBS), for elemental characterization, the hyphenated Raman spectroscopy-SEM/EDS and the combination of them, allow extracting simultaneous information from elemental, molecular and structural data of the studied sample; furthermore, the spectroscopic image capabilities of such techniques allow a better understanding of the mineralogical distribution.

  • Recent trends in the development of complementary metal oxide semiconductor image sensors to detect foodborne bacterial pathogens
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-11-02
    Buddolla Viswanath, Yuzon Ma Kristine, Sanghyo Kim

    Among the foodborne microorganisms, bacteria are the leading reason for serious outbreaks and lead to spread the diseases irrespective of the region. Therefore, immediate detection has become an important issue to stop the spread of the bacterial pathogens before it leads to serious outbreaks. In recent years, rapid advances in complementary metal oxide semiconductor (CMOS) technology gained importance as a dominant technology for fabricating microdevices to use in biomedical research and diagnosis. This technology is consistent, manufacturable, requires low power, low cost, and, perhaps most importantly, scalable. In this feature article, we discuss the recent progresses of CMOS image sensors in the detection foodborne bacterial pathogens. In addition, this article presents and discusses trends in designing of CMOS sensors along with the challenges and future prospective of these sensors to detect foodborne bacterial pathogens. In conclusion, these methods of pathogen detection would offer a great commercial advantage than other methods.

  • Brazilian requirements for stability indicating methods
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-11-01
    Ana Cerúlia Moraes do Carmo, Raphael Sanches Pereira, Tais Gratieri

    Stability studies guarantees that quality attributes will be maintained during a period under the influence of a variety of environmental factors, consequently maintaining drug product efficacy and safety. In this context, stability indicating analytical methods (SIAM) appears as a regulatory requirement to detect common observed impurities and those likely to appear during product shelf-life due to degradation. U.S. Food and Drug Administration (U.S. FDA), The International Council on Harmonization of Technical Requirements for Medicinal Products for Human Use (ICH), World Health Organization (WHO), European Medicine Agency (EMA) have been discussing SIAM concepts and applications, as well as other scientific organisms. Brazilian Health Regulatory Agency (Anvisa) approached SIAM concept through regulations and guidelines in 2015. Hereupon this note intends to expose Brazilian requirements for drug products registration related to SIAM by establishing a comparison to international scenario.

  • Computational modeling of molecularly imprinted polymers as a green approach to the development of novel analytical sorbents
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-11-03
    Mariusz Marć, Teobald Kupka, Piotr Paweł Wieczorek, Jacek Namieśnik

    The development of novel molecularly imprinted polymers (MIP) sorbents for specific chemical compounds require a lot of tedious and time-consuming laboratory work. Significant quantities of solvents and reagents are consumed in the course of the verification of appropriate configurations of polymerization reagents. Implementation of molecular modeling in the MIP sorbent development process appears to provide a solution to this problem. Appropriate simulations and computations facilitate the determination of the nature of interaction between the reagents and thus the selection of the best configuration of chemicals for the preparation of the sorbent. The article presents literature information on major computer software used for molecular modeling, its application in the development of MIP sorbents, as well as the advantages resulting from the implementation of computer-assisted techniques. The appropriate choice of polymerization reagents and conditions allows for a significant reduction of the adverse environmental impact of the entire laboratory process.

  • Quantification techniques for important environmental contaminants in milk and dairy products
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-11-08
    Nadeem Raza, Ki-Hyun Kim

    The growing demands of milk and milk products necessitated the use of various kinds of chemicals including antibiotics, urea, and hormones. Although they are essential in the bulk production of milk, they can pose serious health issues not only to animals but also to consumers. To identify and quantify various contaminants (e.g., antibiotics, pesticides, and polycyclic aromatic hydrocarbons) in milk and its related products, it is desirable to establish reliable means for instrumental detection. This review was organized to summarize the analytical techniques currently available for the identification and quantification of contaminants in milk and dairy products. To this end, this review emphasizes the compositional diversity of various contaminants in milk and its products. This study thus aims to provide valuable insights into the essential protocols for the quantification of dairy-related contaminants while helping make the fast and firm decisions needed for the legislation, regulations, and health care.

  • Nanostructured (Bio)sensors for smart agriculture
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-11-10
    Amina Antonacci, Fabiana Arduini, Danila Moscone, Giuseppe Palleschi, Viviana Scognamiglio

    Intense farming represents one of the main sources causing detriments to vital resources as lands and water, due to unsustainable agricultural practices and the resulting environmental pollution. Furthermore, the increasing world population and the impact of climate change contribute to worsen these constraints. To these regards, several attempts have been completed to provide pioneering technologies for facing against these challenges, including nanostructured (bio)sensors. Indeed, nanotechnology-based (bio)sensors, thanks to the exploitation of fascinating properties of functional materials at the nanoscale, can support farmers in delivering fast, accurate, cost-effective, and in field analyses of i) soil humidity, ii) water and soil nutrients/pesticides, and iii) plant pathogens. Herein, we report a glance of the nano nanostructured (bio)sensors developed to support smart agriculture, reporting representative examples form the literature of the last 10 years.

  • Magnetic solids in electrochemical analysis
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-11-05
    Jiri Kudr, Borivoj Klejdus, Vojtech Adam, Ondrej Zitka

    Magnetic solids possess several attractive properties for electrochemists as they simplify the creation of nanotechnology-based complex structures directly on electrodes or for electrode modification. In addition, affinity-based immobilization of targets on magnetic solids enables their actuation via the magnetism phenomenon and provides easy washing steps, thereby minimizing the sample matrix effect and reducing the analysis time. Furthermore, magnetic materials increase the specific surface area of electrodes; thus, various sensing platforms benefit from the enlargement of the recognition layer and enhanced target binding efficiency. Here, advances in electrochemical analysis exploiting catalytic and electrocatalytic properties of magnetic particles and molecularly imprinted polymers are discussed. In addition, nucleic acids, proteins and cell biosensors that utilize magnetic materials are reviewed here.

  • Dendrimers based sorbents: Promising materials for analytical extractions
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-11-10
    Muhammad Sajid

    Dendrimers are macromolecules with highly repetitive branched structures resembling with a tree. Their size, shape, inner core and outer functionalities can be tailored and modified per required molecular design, which encourages their use as a selective extracting phase in analytical extractions. Their multifunctional architecture can provide high selectivity as well as enrichment factors. To date, these materials have been widely used in biomedical applications such as drug delivery, gene and cancer therapy, and tissue engineering. Recently, an emerging trend has been seen for using dendrimers based sorbents in analytical extractions such as solid phase extraction, solid phase microextraction, capillary microextraction, dispersive micro solid phase extraction, and stir-bar sorptive extraction. This review intends to provide a brief overview of this trend to analytical community.

  • Literature update of analytical methods for biogenic amines determination in food and beverages
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-11-10
    Myrsini Papageorgiou, Dimitra Lambropoulou, Calum Morrison, Ewa Kłodzińska, Jacek Namieśnik, Justyna Płotka-Wasylka
  • New perspectives in the non-invasive, in situ identification of painting materials: The advanced MWIR hyperspectral imaging
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-11-11
    Alessia Daveri, Simone Paziani, Mathiew Marmion, Harri Harju, Andreas Vidman, Michela Azzarelli, Manuela Vagnini
  • The application of graphene-based materials as chromatographic stationary phases
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-11-15
    Xiaojing Liang, Xiudan Hou, James H.M. Chan, Yong Guo, Emily F. Hilder

    There is tremendous interest in graphene since its discovery. In the past few years, graphene-based materials attracted much attention in analytical chemistry due to their large surface area, π-electron-rich structure and good thermal and chemical stability. In this article, an overview of the most significant results so far achieved in the application of graphene-based materials: graphene, graphene oxide and graphene quantum dot as chromatographic stationary phases is presented. In particular, we focus on the separation performance in capillary gas chromatography, in high performance liquid chromatography and capillary electrochromatography. Different synthesis strategies (physical coating, chemical bonding and some other preparation techniques) in preparing graphene-based stationary phases and the relationship with chromatographic behaviour is also considered. Finally, we discuss possible challenges and future perspectives in this rapidly developing field.

  • Recent developments in analytical quantitation approaches for parabens in human-associated samples
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-11-14
    Nadeem Raza, Ki-Hyun Kim, Muhammad Abdullah, Waseem Raza, Richard J.C. Brown

    Parabens are an important class of antimicrobial compounds used as preservatives. Although they are considered to be safe when used within specified concentration limits, concerns about their potential toxicity have been raised due to their presence in cancerous breast tissues and their association with estrogenic activity, various kinds of allergies, and the malfunctioning of reproductive organs. The small quantities of parabens in human samples and complex nature of biological matrices make it difficult to determine free and/or conjugated forms of parabens and their metabolites. Consequently, it is desirable to develop sophisticated approaches for their sample pretreatments and subsequent determination. This review presents recent developments in the extraction, pre-concentration, and instrumental detection methods needed for the accurate quantification of parabens in human samples. This review is thus expected to help readers assess the potential impacts of parabens on human health through proper description of their exposure routes to human.

  • Voltammetric sensing of biomolecules at carbon based electrode interfaces: A review
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-11-17
    Dhanjai, Ankita Sinha, Xianbo Lu, Lingxia Wu, Dongqin Tan, Yun Li, Jiping Chen, Rajeev Jain
  • Portable and smart devices for monitoring heavy metal ions integrated with nanomaterials
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-11-22
    Yawen Li, Yuzhi Chen, Hao Yu, Limei Tian, Zhuo Wang

    With increasing concerns of ecological environment, safe drinkable water and healthy food, the detection for heavy metal ions (HMIs) becomes an attractive research field. On the basis of optical, electrical and other signals from nanomaterials, many interesting methods and portable devices for detection of HMIs are growing flourishingly. In this review, we focus on the portable and smart devices integrated with nanomaterials for monitoring HMIs. The interesting design of the miniaturization, portability, and commercialization of HMIs detection devices are summarized and introduced comprehensively.

  • Recent trends in rapid detection of influenza infections by bio and nanobiosensor
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-11-23
    Soodabeh Hassanpour, Behzad Baradaran, Maryam Hejazi, Mohammad Hasanzadeh, Ahad Mokhtarzadeh, Miguel de la Guardia

    A literature update has been made about the progress and improvements in the use of biosensors for sensitive, rapid and specific detection of influenza virus. Background information about influenza virus and its structure together with a general discussion about the characteristics and significant aspects of different types of biosensors were used as a frame to put inside the main recent developments on the use of nanobiosensors for the detection of influenza virus. Working criteria of biosensors and their applications in different species of influenza virus diagnosis have been the primary concern of this review, which critically discusses the main advantages and limitations of studies in this field during the last two decades and their applications.

  • Recent advances and applications of polydopamine-derived adsorbents for sample pretreatment
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-08-11
    Dandan Che, Jie Cheng, Zhongyin Ji, Shijuan Zhang, Guoliang Li, Zhiwei Sun, Jinmao You

    Sample pretreatment is a critical and essential step in almost all analytical procedures, especially for the analysis of biological and environmental samples with complex matrices. Dopamine molecules can easily self-polymerize under weak alkaline conditions, leading to a facile deposition of polydopamine (PDA) coatings on various surfaces. Since 2011, PDA chemistry has undergone significant expansion in its applications and is becoming one of the most attractive areas within the materials field. Here, recent advancements in the use of PDA-derived adsorbents for sample pretreatment were reviewed, with especial focus on surface modification strategies, extraction modes, and application fields. In addition, prospects of PDA-derived adsorbents for sample pretreatment are also proposed.

  • “Green” nature of the process of derivatization in analytical sample preparation
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-01-31
    Muhammad Sajid, Justyna Płotka-Wasylka

    Nowadays, Green Analytical Chemistry idea is of high importance what impact on the rapid growth in the sample preparation area with special emphasis on sample preparation simplification, miniaturization and automation. Because the derivatization process is often an essential element of the analytical procedure, it should be important to focus on this issue and conduct a series of experiments in order to develop the most favourable conditions. Application of microextraction techniques coupled with the derivatization perfectly meets the specified requirements. Other approaches to perform derivatization process in “green” way include application of eco-friendly solvents/reagents, enhanced parameters such as microwaves or ultrasound and application of in-port, on-column/in-capillary derivatization modes. This review describes factors that allow making derivatization process more green, different modes and ways of derivatization procedures involving less toxic, hazardous reagents/solvents and more efficient forms of energy. Moreover, microextraction techniques that are often coupled to derivatization are described with examples.

  • Nanomaterial-based optical chemical sensors for the detection of heavy metals in water: Recent advances and challenges
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-01-12
    Nisar Ullah, Muhammad Mansha, Ibrahim Khan, Ahsanulhaq Qurashi
  • Ionic liquids in capillary electrophoresis for enantioseparation
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-01-08
    Qi Zhang

    Ionic liquids (ILs) have received considerable attention in the separation science community due to their unique physical and chemical properties. Several excellent review articles on the application of ILs in analytical chemistry have been published. Rather than provide another comprehensive overview, this review focuses on the development and state-of-the-art of ILs in capillary electrophoresis (CE) for enantioseparation. The contents are divided into six sections according to the application modes of ILs, including achiral ILs modified conventional chiral separation system, chiral ILs synergistic separation system, chiral ILs ligand-exchange CE (LE-CE) system, ILs in micellar electrokinetic chromatography (MEKC), the development of novel ILs chiral selectors, and some other applications. The critical research questions and solutions of each application modes are systematically summarized. Existing problems and future prospects are also discussed.

  • Noble metal nanostructures in optical biosensors: basics, and their introduction to anti-doping detection
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-01-05
    Hedieh Malekzad, Parham Sahandi Zangabad, Hadi Mohammadi, Mohsen Sadroddini, Zahra Jafari, Niloofar Mahlooji, Somaye Abbaspour, Somaye Gholami, Mana Ghanbarpoor, Rahim Pashazadeh, Ali Beyzavi, Mahdi Karimi, Michael. R. Hamblin

    Nanotechnology has illustrated significant potentials in biomolecular-sensing applications; particularly its introduction to anti-doping detection is of great importance. Illicit recreational drugs, substances that can be potentially abused, and drugs with dosage limitations according to the prohibited lists announced by the World Antidoping Agency (WADA) are becoming of increasing interest to forensic chemists. In this review, the theoretical principles of optical biosensors based on noble metal nanoparticles, and the transduction mechanism of commonly-applied plasmonic biosensors are covered. We review different classes of recently-developed plasmonic biosensors for analytic determination and quantification of illicit drugs in anti-doping applications. The important classes of illicit drugs include anabolic steroids, opioids, stimulants, and peptide hormones. The main emphasis is on the advantages that noble metal nanoparticles bring to optical biosensors for signal enhancement and the development of highly sensitive (label-free) biosensors. In the near future, such optical biosensors may be an invaluable substitute for conventional anti-doping detection methods such as chromatography-based approaches, and may even be commercialized for routine anti-doping tests.

  • A Critical Analysis of Extraction Techniques Used for Botanicals: Trends, Priorities, Industrial Uses and Optimization Strategies
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-01-04
    Tarun Belwal, Shahira M. Ezzat, Luca Rastrelli, Indra D. Bhatt, Maria Daglia, Alessandra Baldi, Hari Prasad Devkota, Ilkay Erdogan Orhan, Jayanta Kumar Patra, Gitishree Das, C. Anandharamakrishnan, Lourdes Gomez-Gomez, Seyed Fazel Nabavi, Seyed Mohammad Nabavi, Atanas G. Atanasov

    Plant extracts have been long used by the traditional healers for providing health benefits and are nowadays suitable ingredient for the production of formulated health products and nutraceuticals. Traditional methods of extraction such as maceration, percolation, digestion, and preparation of decoctions and infusions are now been replaced by advanced extraction methods for increased extraction efficiency and selectivity of bioactive compounds to meet up the increasing market demand. Advanced techniques use different ways for extraction such as microwaves, ultrasound waves, supercritical fluids, enzymes, pressurized liquids, electric field, etc. These innovative extraction techniques, afford final extracts selectively rich in compounds of interest without formation of artifacts, and are often simple, fast, environmentally friendly and fully automated compared to existing extraction method. The present review is focused on the recent trends on the extraction of different bioactive chemical constituents depending on the nature of sample matrices and their chemical classes including anthocyanins, flavonoids, polyphenols, alkaloids, oils, etc.. In addition, we review the strategies for designing extraction, selection of most suitable extraction methods, and trends of extraction methods for botanicals. Recent progress on the research based on these advanced methods of extractions and their industrial importance are also discussed in detail.

  • Mass spectrometry for glycan biomarker discovery
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-01-03
    O. Aizpurua-Olaizola, J. Sastre Toraño, J.M. Falcon-Perez, C. Williams, N. Reichardt, G.-J. Boons

    The association between aberrant glycosylation of proteins and many cancers, and autoimmune and inflammatory diseases has been known for many years. Altered glycosylation can occur at the onset and during disease progression and identifying these changes at an early stage may greatly increase survival and improve quality of life. However, the identification of these biomarkers has not been easy, mainly due to the structural diversity and numerous possible glycan isomers. Fortunately, glycomics is becoming more feasible due to major improvements in mass spectrometry and separation science. The present review discusses recent methods for mass-spectrometry (MS) based glycomics for the identification of glycan biomarkers. Recent MS techniques with and without coupling to liquid chromatography, capillary electrophoresis or ion mobility spectrometry are described, and the most recent glycan biomarker studies are presented and future prospects discussed.

  • Recent development of optical methods in rapid and non-destructive detection of aflatoxin and fungal contamination in agricultural products
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-01-03
    Feifei Tao, Haibo Yao, Zuzana Hruska, Wes Burger, Kanniah Rajasekaran, Deepak Bhatnagar

    The demand for developing rapid and non-destructive techniques that is suitable to real-time and on-line detection of aflatoxin and fungal contamination has received significant attentions. Measurement techniques based on fluorescence spectroscopy (FS), near-infrared spectroscopy (NIRS) and hyperspectral imaging (HSI) have provided interesting and promising results for detecting aflatoxin and/or fungal contamination in a variety of foods. As such, the main goal of this article is to give an overview of the current research progress of FS, NIRS and HSI techniques in rapid detection of aflatoxin and fungal contamination in different varieties of agricultural products. These techniques are described in terms of their working principles, features and application advantages in detecting aflatoxins and fungal contamination. The research advances of each technique applied in different agricultural products are reviewed and the results obtained from different studies are compared and discussed. Perspectives on their future trends and challenges are also addressed.

  • Recent advances on nanomaterial based electrochemical and optical aptasesnors for detection of cancer biomarkers
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-01-03
    Reza Eivazzadeh-Keihan, Paria Pashazadeh-Panahi, Behzad Baradaran, Ali Maleki, Maryam Hejazi, Ahad Mokhtarzadeh, Miguel de la Guardia

    Cancer is a real menace to all societies globally since it is the leading cause of premature mortality in men and women. The incidence of malignancies is enhancing as a result of plenty factors. Physically and economically concerns that occur in cancers patients cannot be neglected. However, current diagnostic methods and cure duration do not fulfill patients requirements. Therefore, it is essential to detect and diagnose cancer biomarkers as soon as possible and overcome the current burdens. Novel aptasensors is emerging as one of the most promising strategies for early recognition of cancer. Aptamers an artificial DNA or RNA sequences, possess plenty of merits such as easy production, modification of their structure, lower immunogenicity, and high affinity to target that pave the way for early detection of cancer biomarkers. This review attempts to list novel and advanced investigation progress of aptamers in biosensor platforms for diagnosing of malignancies.

  • Analysis of pesticide residues in olive oil and other vegetable oils
    Trends Anal. Chem. (IF 8.442) Pub Date : 2018-01-02
    E. Hakme, A. Lozano, C. Ferrer, F.J. Díaz-Galiano, A.R. Fernández-Alba

    Pesticide residue analysis in olive oil presents difficulties due to the high amount of co-eluted compounds resulting in high matrix effect. Different extraction/clean-up methods including gel permeation chromatography, liquid/liquid extraction, solid-phase extraction and other extraction methods are applied to overcome these difficulties. Recent approaches such as the addition of the freezing-out step and the application of Enhanced Matrix Removal-Lipid sorbent (EMR-Lipid) are reported. Gas chromatography and liquid chromatography coupled to mass spectrometry are considered the gold standard technologies covering a wide scope of pesticides. This review recapitulates the methods most widely used for the determination of pesticide residues in vegetable oils. As a continuation of previous reviews, the work conducted is an update review of methods from 2006 in this field, evaluating their strengths and limitations. Main analytical parameters of the different extraction procedures and detection methods are discussed in terms of recoveries, robustness, limit of quantification, and matrix effect.

  • Trends in Developments of Certified Reference Materials for Chemical Analysis - Focus on food, water, soil, and sediment matrices
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-12-30
    I.R.B. Olivares, G.B. Souza, A.R.A. Nogueira, G.T.K. Toledo, D.C. Marcki

    The growing demand for traceable and reliable results in analytical chemistry can be illustrated with the growth in ISO/IEC 17025 accreditation. Among different technical requirements in this quality system, the use of CRMs is highlighted because of its applications in many operations, such as method validation, proficiency tests, estimation of the uncertainties and quality control. Over the past several years, there has been an increased need to use different types of CRMs in chemical analysis, new CRM publications about its developments and certification. This paper proposes to show a detailed review considering the development of certified reference materials (CRM) for chemical analysis, focusing on food, water, soil and sediment matrices. An evaluation of the trends and best-applied practices in its development in the last 2 years was performed, to guide new developments for this material that is increasingly necessary to laboratories.

  • Critical assessment of hexavalent chromium species from different solid environmental, industrial and food matrices
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-12-29
    F. Séby, V. Vacchina

    The accurate determination of Cr(VI), the most hazardous form of chromium, is an analytical challenge because of its facility to be reduced during all steps of the analytical procedure. This review presents a synthesis of the available studies for the analysis of Cr species in different solid samples (soils/wastes, working atmosphere, industrial and food samples). A particular attention has been paid on Cr(III) and Cr(VI) interconversions that can occur during extraction and efforts made to avoid these reactions. Although the use of NaOH/Na2CO3 solutions with heating at 90-95°C is the more widespread procedure, species transformation can still occur and several studies suggest that speciated isotope dilution (SID) could be a suitable tool for correction of these interconversions.

  • Key challenges and prospects for optical standoff trace detection of explosives
    Trends Anal. Chem. (IF 8.442) Pub Date : 2017-12-29
    Patrick Wen, Mitesh Amin, William D. Herzog, Roderick R. Kunz

    Sophisticated improvised explosive devices (IEDs) challenge the capabilities of current sensors, particularly in areas away from static checkpoints. This security gap could be filled by standoff chemical sensors that detect IEDs based on external trace explosive residues. Unfortunately, previous efforts have not led to widely deployed capabilities. Crucially, the physical morphology of trace explosive residues and chemical “clutter” present unique challenges to the operational performance of standoff sensors. In this review, an overview of standoff trace explosive detection systems is provided in the context of these unique challenges. Tradespace analysis is performed for two popular standoff detection methods: longwave infrared hyperspectral imaging and deep-UV Raman spectroscopy. The tradespace analysis method described in this review incorporates realistic trace explosive residues and background clutter into the technology development process. The review predicts system performance and areas where additional research is needed for these two technologies to optimize performance.

Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
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