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Effectiveness of Cognitive Stimulation Therapy (CST) for mild to moderate dementia: A systematic literature review and meta-analysis of randomised control trials using the original CST protocol Ageing Res. Rev. (IF 13.1) Pub Date : 2024-04-16 Roopal Desai, Wing Gi Leung, Caroline Fearn, Amber John, Joshua Stott, Aimee Spector
We aimed to conduct a systematic literature review and meta-analysis to evaluate the efficacy of the original 14 session Cognitive Stimulation Therapy (CST) protocol in improving cognitive function and related outcomes in people with mild to moderate dementia. Four databases were searched, up to May 2023, for randomized controlled trials of CST using the original protocol. Pre- and post-test means
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The significance of precisely regulating heme oxygenase-1 expression: Another avenue for treating age-related ocular disease? Ageing Res. Rev. (IF 13.1) Pub Date : 2024-04-12 Dong Wei, Chengkang Qu, Na Zhao, Siyu Li, Ning Pu, Zongming Song, Ye Tao
Aging entails the deterioration of the body's organs, including overall damages at both the genetic and cellular levels. The prevalence of age-related ocular disease such as macular degeneration, dry eye diseases, glaucoma and cataracts is increasing as the world's population ages, imposing a considerable economic burden on individuals and society. The development of age-related ocular disease is predominantly
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Treating Alzheimer’s disease using nanoparticle-mediated drug delivery strategies/systems Ageing Res. Rev. (IF 13.1) Pub Date : 2024-04-12 Aryan Kia Roghani, Ricardo Isaiah Garcia, Ali Roghani, Aananya Reddy, Sachi Khemka, Ruhananhad P. Reddy, Vasanthkumar Pattoor, Michael Jacob, P. Hemachandra Reddy, Ujala Sehar
The administration of promising medications for the treatment of neurodegenerative disorders (NDDs), such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS) is significantly hampered by the blood-brain barrier (BBB). Nanotechnology has recently come to light as a viable strategy for overcoming this obstacle and improving drug delivery
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Innovative approaches to Alzheimer's therapy: Harnessing the power of heterocycles, oxidative stress management, and nanomaterial drug delivery system Ageing Res. Rev. (IF 13.1) Pub Date : 2024-04-10 Mohammad Umar, Yasir Rehman, Subiya Ambreen, Sayed Md Mumtaz, Mohd Shaququzzaman, Mohammad Mumtaz Alam, Ruhi Ali
Alzheimer's disease (AD) presents a complex pathology involving amyloidogenic proteolysis, neuroinflammation, mitochondrial dysfunction, and cholinergic deficits. Oxidative stress exacerbates AD progression through pathways like macromolecular peroxidation, mitochondrial dysfunction, and metal ion redox potential alteration linked to amyloid-beta (Aβ). Despite limited approved medications, heterocyclic
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The neuroprotective effects of ferulic acid in toxin-induced models of Parkinson's disease: A review Ageing Res. Rev. (IF 13.1) Pub Date : 2024-04-09 Samira Hassani, Abolghasem Esmaeili
Parkinson's disease is predominantly caused by dopaminergic neuron loss in the substantia nigra pars compacta and the accumulation of alpha-synuclein protein. Though the general consensus is that several factors, such as aging, environmental factors, mitochondrial dysfunction, accumulations of neurotoxic alpha-synuclein, malfunctions of the lysosomal and proteasomal protein degradation systems, oxidative
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NETosis in tumour microenvironment of liver: From primary to metastatic hepatic carcinoma Ageing Res. Rev. (IF 13.1) Pub Date : 2024-04-09 Yi Yang, Siyue Yu, Chao Lv, Yu Tian
Hepatocellular carcinoma is a common and highly lethal tumour. The tumour microenvironment (TME) plays an important role in the progression and metastasis of hepatocellular carcinoma (HCC). A cell death mechanism, termed NETosis, has been found to play an important role in the TME of HCC. This review article focuses on the role of NETosis in the TME of HCC, a novel form of cell death in which neutrophils
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Effects of home-based and telerehabilitation exercise on mental and physical health, and disease cost in people with Alzheimer’s disease: A meta-analysis Ageing Res. Rev. (IF 13.1) Pub Date : 2024-04-09 Auwal Abdullahi, Thomson W.L. Wong, Shamay S.M. Ng
Alzheimer’s disease (AD) is a very disabling long-term disease that requires continuous regular care. A cost-effective and sustainable means of such care may be physical activity or exercise delivered at home or through telerehabilitation. The aim of this study is to determine the effects of home-based or telerehabilitation exercise in people with AD. : PubMED, Embase, Web of Science (WoS), PEDro,
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Tissue fibroblasts are versatile immune regulators: An evaluation of their impact on the aging process Ageing Res. Rev. (IF 13.1) Pub Date : 2024-04-07 Antero Salminen, Kai Kaarniranta, Anu Kauppinen
Fibroblasts are abundant stromal cells which not only control the integrity of extracellular matrix (ECM) but also act as immune regulators. It is known that the structural cells within tissues can establish an organ-specific immunity expressing many immune-related genes and closely interact with immune cells. In fact, fibroblasts can modify their immune properties to display both pro-inflammatory
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A systematic review of lifespan studies in rodents using stem cell transplantations Ageing Res. Rev. (IF 13.1) Pub Date : 2024-04-06 Oliver G. Frost, Pranav Ramkilawan, Abdelhadi Rebbaa, Alexandra Stolzing
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Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases Ageing Res. Rev. (IF 13.1) Pub Date : 2024-04-05 Qing Zeng, Yongzhen Gong, Neng Zhu, Yaning Shi, Chanjuan Zhang, Li Qin
Cellular senescence is a kind of cellular state triggered by endogenous or exogenous stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence-associated secretory phenotype (SASP). Once senescent cells accumulate in tissues, they may eventually accelerate the progression of age-related diseases, such as atherosclerosis, osteoarthritis, chronic lung diseases, cancers
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The impact of maternal age on aneuploidy in oocytes: Reproductive consequences, molecular mechanisms, and future directions Ageing Res. Rev. (IF 13.1) Pub Date : 2024-04-04 Weiwei Huang, Xinyuan Li, Hongbo Yang, Hefeng Huang
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Potential convergence of olfactory dysfunction in Parkinson’s disease and COVID-19: The role of neuroinflammation Ageing Res. Rev. (IF 13.1) Pub Date : 2024-04-04 Hui Li, Junliang Qian, Youcui Wang, Juan Wang, Xiaoqing Mi, Le Qu, Ning Song, Junxia Xie
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder that affects 7–10 million individuals worldwide. A common early symptom of PD is olfactory dysfunction (OD), and more than 90% of PD patients suffer from OD. Recent studies have highlighted a high incidence of OD in patients with SARS-CoV-2 infection. This review investigates the potential convergence of OD in PD and COVID-19, particularly
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A critical appraisal of blood-based biomarkers for Alzheimer’s disease Ageing Res. Rev. (IF 13.1) Pub Date : 2024-04-04 Simone Lista, Mark Mapstone, Filippo Caraci, Enzo Emanuele, Susana López-Ortiz, Juan Martín-Hernández, Viviana Triaca, Camillo Imbimbo, Audrey Gabelle, Michelle M. Mielke, Robert Nisticò, Alejandro Santos-Lozano, Bruno P. Imbimbo
Biomarkers that predict the clinical onset of Alzheimer’s disease (AD) enable the identification of individuals in the early, preclinical stages of the disease. Detecting AD at this point may allow for more effective therapeutic interventions and optimized enrollment for clinical trials of novel drugs. The current biological diagnosis of AD is based on the AT(N) classification system with the measurement
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Types of memory, dementia, Alzheimer’s disease, and their various pathological cascades as targets for potential pharmacological drugs Ageing Res. Rev. (IF 13.1) Pub Date : 2024-04-04 Ansab Akhtar, Siddharth Singh, Ravinder Kaushik, Rajendra Awasthi, Tapan Behl
Alzheimer's disease (AD) is the most common type of dementia accounting for 90% of cases; however, frontotemporal dementia, vascular dementia, etc. prevails only in a minority of populations. The term dementia is defined as loss of memory which further takes several other categories of memories like working memory, spatial memory, fear memory, and long-term, and short-term memory into consideration
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The role of quality of life data as an endpoint for collecting real-world evidence within geroscience clinical trials Ageing Res. Rev. (IF 13.1) Pub Date : 2024-04-03 Girish Harinath, Sajad Zalzala, Andy Nyquist, Maartje Wouters, Anar Isman, Mauricio Moel, Eric Verdin, Matt Kaeberlein, Brian Kennedy, Evelyne Bischof
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Advances on Senescence-associated secretory phenotype regulated by circular RNAs in tumors Ageing Res. Rev. (IF 13.1) Pub Date : 2024-04-02 Yue Qiu, Shiqi Zhang, Changfeng Man, Dandan Gong, Ying Xu, Yu Fan, Xiaoyan Wang, Wenbo Zhang
The components that comprise the senescence-associated secretory phenotype (SASP) include growth factors, proteases, chemokines, cytokines, and bioactive lipids. It drives secondary aging and disrupts tissue homeostasis, ultimately leading to tissue repair and regeneration loss. It has a two-way regulatory effect on tumor cells, resisting cancer occurrence and promoting its progression. A category
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CCR5 and inflammatory storm Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-30 Yuting Lin, Shasha Liu, Yang Sun, Chen Chen, Songwei Yang, Gang Pei, Meiyu Lin, Jingbo Yu, Xuan Liu, Huiqin Wang, Junpeng Long, Qian Yan, Jinping Liang, Jiao Yao, Fan Yi, Lei Meng, Yong Tan, Naihong Chen, Yantao Yang, Qidi Ai
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Physical activity, sedentary behaviour, and cognitive function among older adults: A bibliometric analysis from 2004 to 2024 Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-28 Zhen Yang, Pauline Hotterbeex, Pieter-Jan Marent, Ester Cerin, Martine Thomis, Jannique van Uffelen
Because of population ageing, there will be a vast increase in the prevalence of cognitive decline and dementia. Physical activity and sedentary behaviour have been identified as modifiable lifestyle behaviours associated with these cognitive conditions. Therefore, the aim of this bibliometric analysis is to reveal the knowledge structure of the field of physical activity, sedentary behaviour, and
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Parkinson’s disease diagnosis using deep learning: A bibliometric analysis and literature review Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-28 Rabab Ali Abumalloh, Mehrbakhsh Nilashi, Sarminah Samad, Hossein Ahmadi, Abdullah Alghamdi, Mesfer Alrizq, Sultan Alyami
Parkinson’s Disease (PD) is a progressive neurodegenerative illness triggered by decreased dopamine secretion. Deep Learning (DL) has gained substantial attention in PD diagnosis research, with an increase in the number of published papers in this discipline. PD detection using DL has presented more promising outcomes as compared with common machine learning approaches. This article aims to conduct
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Exploring role of natural compounds in molecular alterations associated with brain ageing: A perspective towards nutrition for ageing brain Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-27 Nazia Siddiqui, Alok Sharma, Anuradha Kesharwani, Anurag, Vipan Kumar Parihar
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Ubiquitin E3 ligases assisted technologies in protein degradation: Sharing pathways in neurodegenerative disorders and cancer Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-21 Aastha Kaushik, Somya Parashar, Rashmi K. Ambasta, Pravir Kumar
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Optical coherence tomography as a potential surrogate marker of dopaminergic modulation across the life span Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-20 Julia Elmers, Lorenza S. Colzato, Focke Ziemssen, Tjalf Ziemssen, Christian Beste
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Alzheimer’s drugs, APPlication for Down syndrome? Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-19 Deborah K. Sokol, Debomoy K. Lahiri
Accumulation of the amyloid β (Aβ) peptide, derived from Aβ precursor protein (APP), is a trait of Down syndrome (DS), as is early development of dementia that resembles Alzheimer's disease (AD). Treatments for this AD in DS simply do not. New drug therapies for AD, e.g., Lecanemab, are monoclonal antibodies designed to clear amyloid plaques composed of Aβ. The increasingly real ability to target and
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Vascular dementia: From pathobiology to emerging perspectives Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-19 Amy Elizabeth Morgan, Mark Tomás Mc Auley
Vascular dementia (VaD) is the second most common type of dementia. VaD is synonymous with ageing, and its symptoms place a significant burden on the health and wellbeing of older people. Despite the identification of a substantial number of risk factors for VaD, the pathological mechanisms underpinning this disease remain to be fully elucidated. Consequently, a biogerontological imperative exists
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Worldwide cohort studies to support healthy ageing research: data availabilities and gaps Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-17 Saman Khalatbari-Soltani, Yafei Si, Marielle Dominguez, Tabitha Scott, Fiona M. Blyth
Population ageing is a transforming demographic force. To support evidence-based efforts for promoting healthy ageing, a summary of data availabilities and gaps to study ageing is needed. Through a multifaceted search strategy, we identified relevant cohort studies worldwide to studying ageing and provided a summary of available pertinent measurements. Following the World Health Organization's definition
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Intermittent fasting and longevity: From animal models to implication for humans Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-17 Olha Strilbytska, Svitlana Klishch, Kenneth B. Storey, Alexander Koliada, Oleh Lushchak
In recent years, intermittent fasting (IF) and its numerous modifications have been increasingly suggested as a promising therapy for age-related problems and a non-pharmacological strategy to extend lifespan. Despite the great variability in feeding schedules that we describe in the current work, underlying physiological processes are the same and include a periodic switch from glucose metabolism
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Amyloid-induced neurodegeneration: A comprehensive review through aggregomics perception of proteins in health and pathology Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-16 Sania Bashir, Ayesha Aiman, Mohammad Shahid, Anis Ahmad Chaudhary, Neha Sami, Seemi Farhat Basir, Imtaiyaz Hassan, Asimul Islam Professor
Amyloidosis of protein caused by fibrillation and aggregation are some of the most exciting new edges not only in protein sciences but also in molecular medicines. The present review discusses recent advancements in the field of neurodegenerative diseases and therapeutic applications with ongoing clinical trials, featuring new areas of protein misfolding resulting in aggregation. The endogenous accretion
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Sonic hedgehog signalling pathway contributes in age-related disorders and Alzheimer's disease Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-16 Arun Parashar, Dhruv jha, Vineet Mehta, Bonney Chauhan, Pappu Ghosh, Prashanta Kumar Deb, Mohit Jaiswal, Santosh Kumar Prajapati
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Senolytic therapeutics: An emerging treatment modality for osteoarthritis Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-15 Md. Meraj Ansari, Mrinmoy Ghosh, Dong-Sun Lee, Young-Ok Son
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Improving geriatric outcomes through nutritional and immunonutritional strategies: Focus on surgical setting by a comprehensive evidence review Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-15 Virginia Boccardi, Luigi Marano
The aging population worldwide has led to an increased request for surgical interventions in older, geriatric, and frail patients. However, all the physiological changes related to aging are associated with many challenges in the perioperative period, strongly impacting surgical outcomes. Nutritional status plays a pivotal role in determining the resilience of older adults to surgical stress and their
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Understanding the intricacies of cellular senescence in atherosclerosis: Mechanisms and therapeutic implications Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-14 Ilyas Ali, Hongliang Zhang, Syed Aqib Ali Zaidi, Guangqian Zhou
Cardiovascular disease is currently the largest cause of mortality and disability globally, surpassing communicable diseases, and atherosclerosis is the main contributor to this epidemic. Aging is intimately linked to atherosclerosis development and progression, however, the mechanism of aging in atherosclerosis is not well known. To emphasize the significant research on the involvement of senescent
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Unveiling the interplay of AMPK/SIRT1/PGC-1α axis in brain health: Promising targets against aging and NDDs Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-14 Pratik Shankar Rakshe, Bhaskar Jyoti Dutta, Shivani Chib, Niyogita Maurya, Sanjiv Singh
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Somatostatin and the pathophysiology of Alzheimer’s disease Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-13 Victor N. Almeida
Among the central features of Alzheimer’s disease (AD) progression are altered levels of the neuropeptide somatostatin (SST), and the colocalisation of SST-positive interneurons (SST-INs) with amyloid-β plaques, leading to cell death. In this theoretical review, I propose a molecular model for the pathogenesis of AD based on SST-IN hypofunction and hyperactivity. Namely, hypofunctional and hyperactive
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Somatic mutations in human ageing: New insights from DNA sequencing and inherited mutations Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-13 Kasit Chatsirisupachai, João Pedro de Magalhães
The accumulation of somatic mutations is a driver of cancer and has long been associated with ageing. Due to limitations in quantifying mutation burden with age in non-cancerous tissues, the impact of somatic mutations in other ageing phenotypes is unclear. Recent advances in DNA sequencing technologies have allowed the large-scale quantification of somatic mutations in ageing tissues. These studies
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The underlying roles and neurobiological mechanisms of music-based intervention in Alzheimer's disease: A comprehensive review Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-12 Liyang Sun, Qin Wang, Jing Ai
Non-pharmacological therapy has gained popularity in the intervention of Alzheimer's disease (AD) due to its apparent therapeutic effectiveness and the limitation of biological drug. A wealth of research indicates that music interventions can enhance cognition, mood and behavior in individuals with AD. Nonetheless, the underlying mechanisms behind these improvements have yet to be fully and systematically
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The efficacy of dyadic interventions for community-dwelling people with dementia and their caregivers: A systematic review and meta-analysis Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-12 Sanne C.E. Balvert, Giovanna C. Del Sordo, Maarten V. Milders
Most people with dementia live at home and depend on informal caregivers for care. Both caregivers and persons with dementia can experience negative psychological and behavioural effects as the disease progresses. Non-pharmacological interventions can alleviate these effects and dyadic interventions, involving both caregiver and person with dementia, may be particularly effective. In this systematic
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Agmatine as a novel intervention for Alzheimer's disease: Pathological insights and cognitive benefits Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-11 Raj A. Katariya, Shivkumar S. Sammeta, Mayur B. Kale, Nandkishor R. Kotagale, Milind J. Umekar, Brijesh G. Taksande
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Restoration of epigenetic impairment in the skeletal muscle and chronic inflammation resolution as a therapeutic approach in sarcopenia Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-09 Gregory Livshits, Alexander Kalinkovich
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Estimated prevalence of frailty and prefrailty in patients undergoing coronary artery or valvular surgeries/procedures: A systematic review and proportional meta-analysis Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-09 Cathy W.Y. Wong, Polly W.C. Li, Doris S.F. Yu, Benjamin M.H. Ho, Bernice Shinyi Chan
The aging population has led to an increasing number of older patients undergoing cardiac surgeries/procedures. Frailty and prefrailty have emerged as important prognostic indicators among these patients. This proportional meta-analysis estimated the prevalence of frailty and prefrailty among patients undergoing cardiac surgery. We searched seven electronic databases for observational studies that
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Aging phenotype in AD brain organoids: Track to success and challenges Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-07 Muhammad Kamal Hossain, Hyung-Ryong Kim, Han Jung Chae
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Organ-specific biological clocks: Ageotyping for personalized anti-aging medicine Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-04 Francesco Prattichizzo, Chiara Frigé, Valeria Pellegrini, Lucia Scisciola, Aurelia Santoro, Daniela Monti, Maria Rita Rippo, Mikhail Ivanchenko, Fabiola Olivieri, Claudio Franceschi
Aging is a complex multidimensional, progressive remodeling process affecting multiple organ systems. While many studies have focused on studying aging across multiple organs, assessment of the contribution of individual organs to overall aging processes is a cutting-edge issue. An organ’s biological age might influence the aging of other organs, revealing a multiorgan aging network. Recent data demonstrated
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Effects of clitorienolactones from Clitoria ternatea root on calcium channel mediating hippocampal long-term potentiation in rats induced chronic cerebral hypoperfusion Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-03 Mohamad Anuar Ahad, Nelson Jeng-Yeou Chear, Muhammad Hazim Abdullah, Tan Ai Fein Ching-Ga, Ping Liao, Shunhui Wei, Vikneswaran Murugaiyah, Zurina Hassan
Chronic cerebral hypoperfusion (CCH) is a common mechanism of acute brain injury due to impairment of blood flow to the brain. Moreover, a prolonged lack of oxygen supply may result in cerebral infarction or global ischemia, which subsequently causes long-term memory impairment. Research on using root extract for treating long-term memory has been studied extensively. However, the bioactive compound
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Circulating biomarkers of inflammaging and Alzheimer’s disease to track age-related trajectories of dementia: Can we develop a clinically relevant composite combination? Ageing Res. Rev. (IF 13.1) Pub Date : 2024-03-02 Angela Marie Abbatecola, Angelica Giuliani, Leonardo Biscetti, Lucia Scisciola, Petronilla Battista, Michelangela Barbieri, Jacopo Sabbatinelli, Fabiola Olivieri
Alzheimer's disease (AD) is a rapidly growing global concern due to a consistent rise of the prevalence of dementia which is mainly caused by the aging population worldwide. An early diagnosis of AD remains important as interventions are plausibly more effective when started at the earliest stages. Recent developments in clinical research have focused on the use of blood-based biomarkers for improve
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Associations of environmental factors with neurodegeneration: An exposome-wide Mendelian randomization investigation Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-29 Dun Li, Lihui Zhou, Zhi Cao, Jida Wang, Hongxi Yang, Mingqian Lyu, Yuan Zhang, Rongrong Yang, Ju Wang, Yuhong Bian, Weili Xu, Yaogang Wang
Neurodegenerative diseases (NDDs) remain a global health challenge. Previous studies have reported potential links between environmental factors and NDDs, however, findings remain controversial across studies and elusive to be interpreted as evidence of robust causal associations. In this study, we comprehensively explored the causal associations of the common environmental factors with major NDDs
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Involvement of regulated cell deaths in aging and age-related pathologies Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-28 Laura Della Torre, Antonio Beato, Vincenza Capone, Daniela Carannante, Giulia Verrilli, Gregorio Favale, Nunzio Del Gaudio, Wouter Leonard Megchelenbrink, Rosaria Benedetti, Lucia Altucci, Vincenzo Carafa
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Mechanisms of pain in aging and age-related conditions: Focus on caregivers Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-27 Peyton Presto, Ujala Sehar, Jonathan Kopel, P. Hemachandra Reddy
Pain is a complex, subjective experience that can significantly impact quality of life, particularly in aging individuals, by adversely affecting physical and emotional well-being. Whereas acute pain usually serves a protective function, chronic pain is a persistent pathological condition that contributes to functional deficits, cognitive decline, and emotional disturbances in the elderly. Despite
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Blood-based biomarkers of cerebral small vessel disease Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-27 Liu-Yun Wu, Yuek Ling Chai, Irwin K. Cheah, Rachel S.L. Chia, Saima Hilal, Thiruma V. Arumugam, Christopher P. Chen, Mitchell K.P. Lai
Age-associated cerebral small vessel disease (CSVD) represents a clinically heterogenous condition, arising from diverse microvascular mechanisms. These lead to chronic cerebrovascular dysfunction and carry a substantial risk of subsequent stroke and vascular cognitive impairment in aging populations. Owing to advances in neuroimaging, visualization of cerebral vasculature abnormities and detection
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Hepatopancreatic metabolic disorders and their implications in the development of Alzheimer's disease and vascular dementia Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-26 Francisco I. Pinheiro, Irami Araújo-Filho, Amália C.M. do Rego, Eduardo P. de Azevedo, Ricardo N. Cobucci, Fausto P. Guzen
Dementia has been faced with significant public health challenges and economic burdens that urges the need to develop safe and effective interventions. In recent years, an increasing number of studies have focused on the relationship between dementia and liver and pancreatic metabolic disorders that result in diseases such as diabetes, obesity, hypertension and dyslipidemia. Previous reports have shown
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The effect of ferroptosis-related mitochondrial dysfunction in the development of temporal lobe epilepsy Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-24 Yang Su, Ningrui Cao, Dingkun Zhang, Minjin Wang
Temporal lobe epilepsy (TLE) is the most common form of epileptic syndrome. It has been established that due to its complex pathogenesis, a considerable proportion of TLE patients often progress to drug-resistant epilepsy. Ferroptosis has emerged as an important neuronal death mechanism in TLE, which is primarily influenced by lipid accumulation and oxidative stress. In previous studies of ferroptosis
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Understanding age-related pathologic changes in TDP-43 functions and the consequence on RNA splicing and signalling in health and disease Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-23 Flora Cheng, Tyler Chapman, Selina Zhang, Marco Morsch, Roger Chung, Albert Lee, Stephanie L. Rayner
TAR DNA binding protein-43 (TDP-43) is a key component in RNA splicing which plays a crucial role in the aging process In neurodegenerative diseases such as amyotrophic lateral sclerosis, frontotemporal dementia and limbic-predominant age-related TDP-43 encephalopathy, TDP-43 can be mutated, mislocalised out of the nucleus of neurons and glial cells and form cytoplasmic inclusions. These TDP-43 alterations
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Multiomics insights into the female reproductive aging Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-23 Simin Wei, Weicheng Tang, Dan Chen, Jiaqiang Xiong, Liru Xue, Yun Dai, Yican Guo, Chuqing Wu, Jun Dai, Meng Wu, Shixuan Wang
The human female reproductive lifespan significantly diminishes with age, leading to decreased fertility, reduced fertility quality and endocrine function disorders. While many aspects of aging in general have been extensively documented, the precise mechanisms governing programmed aging in the female reproductive system remain elusive. Recent advancements in omics technologies and computational capabilities
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A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-22 Xinyue Tang, Zixuan Guo, Guanmao Chen, Shilin Sun, Shu Xiao, Pan Chen, Guixian Tang, Li Huang, Ying Wang
Numerous neuroimaging studies have reported that Alzheimer's disease (AD) spectrum have been linked to alterations in intrinsic functional activity and cortical thickness (CT) of some brain areas. However, the findings have been inconsistent and the correlation with the transcriptional profile and neurotransmitter systems remain largely unknown. We conducted a meta-analysis to identify multimodal differences
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The measurement properties and feasibility of FRAIL scale in older adults: A systematic review and meta-analysis Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-21 Yu Xuan NG, Ling Jie CHENG, Yu Yi QUEK, Ruby YU, Xi Vivien WU
Frailty is a prevalent condition amongst older adults, significantly affecting their quality of life. The FRAIL tool has been purposefully designed for clinical application by assisting healthcare professionals in identifying and managing frailty-related issues in older adults, making it a preferred choice for assessing frailty across diverse older populations. This review aimed to synthesize the measurement
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Role of succinylation modification in central nervous system diseases Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-21 Chao Wang, Weigang Cui, Bing Yu, Han Zhou, Zhenwen Cui, Pin Guo, Tao Yu, Yugong Feng
Diseases of the central nervous system (CNS), including stroke, brain tumors, and neurodegenerative diseases, have a serious impact on human health worldwide, especially in elderly patients. The brain, which is one of the body's most metabolically dynamic organs, lacks fuel stores and therefore requires a continuous supply of energy substrates. Metabolic abnormalities are closely associated with the
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Vitamin D and ischemic stroke - Association, mechanisms, and therapeutics Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-21 Pan Cui, Haiman Hou, Bo Song, Zongping Xia, Yuming Xu
Confronting the rising tide of ischemic stroke and its associated mortality and morbidity with ageing, prevention and acute management of ischemic stroke is of paramount importance. Mounting observational studies have established a non-linear association of vitamin D status with cardiovascular diseases, including ischemic stroke. Paradoxically, current clinical trials fail to demonstrate the cardiovascular
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Macrophage membrane-camouflaged biomimetic nanovesicles for targeted treatment of arthritis Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-21 Xin Huang, Weiyue Zhang
Arthritis has become the most common joint disease globally. Current attention has shifted towards preventing the disease and exploring pharmaceutical and surgical treatments for early-stage arthritis. M2 macrophages are known for their anti-inflammatory properties and their ability to support cartilage repair, offering relief from arthritis. Whereas, it remains a great challenge to promote the beneficial
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Therapeutic effect of dietary ingredients on cellular senescence in animals and humans: A systematic review Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-19 Lihuan Guan, Anna Eisenmenger, Karen C. Crasta, Elena Sandalova, Andrea B. Maier
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Social determinants of intrinsic capacity: A systematic review of observational studies Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-19 Zi-Ting Huang, Eric T.C. Lai, Yan Luo, Jean Woo
The World Health Organization defined healthy ageing as the maintenance of functional ability with ageing. Intrinsic capacity is a measurement of healthy ageing, and can be shaped by social determinants. However, an overall understanding of how multiple social determinants contribute to intrinsic capacity remains unclear. We aim to summarize observational studies investigating the relationships between
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Efficacy of deprescribing on health outcomes: An umbrella review of systematic reviews with meta-analysis of randomized controlled trials Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-16 Nicola Veronese, Umberto Gallo, Virginia Boccardi, Jacopo Demurtas, Alberto Michielon, Xhoajda Taci, Giulia Zanchetta, Sophia Elizabeth Campbell Davis, Marco Chiumente, Francesca Venturini, Alberto Pilotto
Deprescribing is an important intervention across different settings in medicine, but the literature supporting such a practice is still conflicting. Therefore, we aimed to capture the breadth of outcomes reported and assess the strength of evidence of the use of deprescribing for health outcomes. Umbrella review of systematic reviews of the use of deprescribing searching in Medline, Scopus, and Web
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The role and mechanism of RNA-binding proteins in bone metabolism and osteoporosis Ageing Res. Rev. (IF 13.1) Pub Date : 2024-02-16 Jiaqiang Wu, Liyan Niu, Kangping Yang, Jingdong Xu, Deju Zhang, Jitao Ling, Panpan Xia, Yuting Wu, Xiao Liu, Jianping Liu, Jing Zhang, Peng Yu
Osteoporosis is a prevalent chronic metabolic bone disease that poses a significant risk of fractures or mortality in elderly individuals. Its pathophysiological basis is often attributed to postmenopausal estrogen deficiency and natural aging, making the progression of primary osteoporosis among elderly people, especially older women, seemingly inevitable. The treatment and prevention of osteoporosis