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Iron-Catalyzed Oxidative C(sp3)–C(sp3) Radical Coupling Reaction between Thiohydantoins and O-Acetyloximes for the Synthesis of 1,3-Dibenzyl-3,4-dihydropyrrolo[2,3-d]imidazole-2(1H)-thione Derivatives Synlett (IF 2.0) Pub Date : 2024-04-24 Parth P. Patel, Kishor H. Chikhalia
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Introduction of an N-Amino Group onto 4-(Tetrazol-5-yl)-5-nitro-1,2,3-triazole: A Strategy for Enhancing the Density and Performance of Energetic Materials Synlett (IF 2.0) Pub Date : 2024-04-24 Xun Huang, Pinxu Zhao, Haifeng Huang, Jun Yang
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A Facile Procedure for Halodecarboxylation of Hydroxyaromatic Carboxylic Acids Synlett (IF 2.0) Pub Date : 2024-04-23 Zhenbei Zhang, Wenhui Sun, Zhishan Cao, Guisheng Zhang, Olha Bakumenko, Feng Xue
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Triton B Catalyzed Rapid and Mild Synthetic Protocol for both Henry Reaction of Isatin and Michael Reaction of Chalcone with Nitroalkane Synlett (IF 2.0) Pub Date : 2024-04-23 Mrinal Talukdar, Nasreen Islam, Akanksha Mishra, Alpa Y Dave, Eeshwaraiah Begari
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A Personal Account from Inside Keith Fagnou’s Research Laboratory Synlett (IF 2.0) Pub Date : 2024-04-23 Louis-Charles Campeau
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An Improved Iodine-Catalyzed Aromatization Reaction and Its Application in the Synthesis of a Key Intermediate of Cannabidiol Synlett (IF 2.0) Pub Date : 2024-04-22 Safomuddin Abduahadi, Emmanuel Mintah Bonku, Hongjian Qin, Abdullajon Odilov, Fuqiang Zhu, Haji Akber Aisa, Jingshan Shen
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Advances in the Synthesis of Sulfur-Containing Cyclic Architectures via Insertion of SO2 Synlett (IF 2.0) Pub Date : 2024-04-22 Xi Lu, Yuyang Huang, Yuxing Yang, Chao Shu
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Microwave-Assisted Transfer Hydrogenation of Carbonyl and Nitro Compounds Using Bimetallic Ru(II) Cymene Complexes Synlett (IF 2.0) Pub Date : 2024-04-19 Gopal Deshmukh, Ramaswamy Murugavel
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AgSCF3 Radical Addition Based on an Oxidant-Free α,β-Amide (Trifluoromethyl)sulfanylation Reaction Synlett (IF 2.0) Pub Date : 2024-04-18 Zhi-Bo Li, Jin Zhang, Yi-Ran Shi, Hong Li, Min-Ge Yang, Wen-Qing Zhu, Qiang-Wei Fan, Yang Li
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Stereocontrolled Synthesis of a Heptose- and Kdo-Containing Common Inner-Core Trisaccharide of Lipopolysaccharides from Multiple Pathogenic Bacteria Synlett (IF 2.0) Pub Date : 2024-04-18 Jiawei Li, Runing Gao, Tianhui Hao, Tiehai Li
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Copper-Catalyzed [4+1] and [4+2] Reactions through Tandem Remote Propargylation/Cyclization/Isomerization with an Amine or a Hydrazine Synlett (IF 2.0) Pub Date : 2024-04-15 Yu-Ze Sun, Guo-Qiang Lin, Zhi-Tao He
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Synthesis of α-Phenyl β-Enamino γ-Sultims: the New Horizon of the CSIC Reaction Synlett (IF 2.0) Pub Date : 2024-04-15 Yaroslav O. Chuchvera, Valentyna Tararina, Inna Chuchvera, Eugeniy N. Ostapchuk, Maria V. Popova, Svitlana V. Shishkina, Yulian M. Volovenko, Alexey V. Dobrydnev
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Visible-Light-Catalyzed Regioselective Arylcarboxylation of Allenes with CO2 Synlett (IF 2.0) Pub Date : 2024-04-09 Xianming Zhang, Zhenqiang Zhang, Zhuangping Zhan
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Expedient Synthesis of gem-CF2-2H-Thiophenes from Enaminothiones Synlett (IF 2.0) Pub Date : 2024-04-08 Xinyu Zhang, Xuheng Zhang, Rui Fu, Zhengyu Zhang, Yaojia Jiang
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Rapid Cyclic Acetal and Cyclic Ketal Synthesis Assisted by a Rotary Evaporator Synlett (IF 2.0) Pub Date : 2024-04-08 Fuyao Jiang, Yinzhe Chen, Weiding Wang, Qian Zhang
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Towards Catalytic C–H Activation Using Main Group Elements Synlett (IF 2.0) Pub Date : 2024-04-05 Andrew McNally
Catalytic C–H activation reactions are now established as a means to directly transform organic molecules and are commonly associated with metals such as palladium, rhodium, ruthenium and iridium. This Account will describe a short number of reports demonstrating that structures containing main group elements can facilitate C–H activation processes. In particular, boron-based catalysts can promote
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(n+3)-Cyclization for the Formation of Benzo[7]annulene Derivatives via a [1,4]-Hydride Shift: A Novel Cyclization Mode Involving an Internal Redox Reaction Synlett (IF 2.0) Pub Date : 2024-04-04 Jun Nagaki, Tomoko Kawasaki-Takasuka, Keiji Mori
We report a unique synthetic route to benzo[7]annulene derivatives. When benzylidene malonates having a 1-(N,N-dialkylamino)alkyl group at the ortho-position are treated with a stoichiometric amount of M(OTf)3 (M = Sc, Yb, Gd), three transformations ([1,4]-hydride shift/isomerization into an enamine/intramolecular Stork enamine acylation) proceed sequentially to afford various benzo[7]annulene derivatives
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Synthesis of Fused-Ring Pyrrolizine Derivatives via a Copper-Catalyzed Radical Cascade Cyclization Synlett (IF 2.0) Pub Date : 2024-04-03
Herein, an atom-economic method for the synthesis of fused-ring pyrrolizine derivatives by a cycloaddition reaction of easily accessible N-substituted pyrrole-2-carboxaldehydes with N-substituted maleimides in the presence of di-tert-butyl peroxide has been successfully developed. A total of 23 compounds were obtained by using this method, with a maximum yield of 72%, providing a practical and efficient
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Palladium-Catalyzed Asymmetric [3+2] Cycloaddition Reaction of Vinyl Cyclopropane with Electron-Deficient Dienes Synlett (IF 2.0) Pub Date : 2024-04-03 Yun-Fan Li, Cun Yang, Yu-Ting Xi, Qitao Tan, Chang-Hua Ding, Bin Xu
Palladium-catalyzed asymmetric [3+2] cycloaddition reaction of vinyl cyclopropane and electron-deficient dienes was realized. The cycloaddition reaction proceeded regioselectively on the distant C=C double bond of electron-deficient dienes, and was mainly controlled by the steric hindrance of the 5-substituent of electron-deficient dienes. Chiral multi-substituted cyclopentanes bearing three functional
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Stereoselective Synthesis of Unsymmetrical 1,1-Diborylalkenes Synlett (IF 2.0) Pub Date : 2024-04-02
1,1-Diborylalkene, a class of important diboryl species, serves as the synthetic precursor of multisubstituted olefin, which is a prevalent building block in natural products, functional materials, and pharmaceuticals. Current methods mainly afford symmetrical 1,1-diborylalkenes, and late-stage differentiation of the two identical boryl groups is required to achieve selective difunctionalization. In
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Design of Indole-Functionalized Phosphepines towards New Organic Chromophores Synlett (IF 2.0) Pub Date : 2024-04-02
Organic chromophores emerged as diverse functional materials in the areas of organic catalysis, toxic materials sensing, bio-imaging, and organic electronic devices. With rich chemical and electronic structures, main-group elements have been extensively implanted in organic chromophores to fine-tune the chemical/electronic structures and optoelectronic properties. In this Synpact article, we present
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Regiocontrolled Ruthenium-Catalyzed Isomerization of Propargyl Alcohols Synlett (IF 2.0) Pub Date : 2024-04-02 Steffen Skowaisa, Edgar Haak
A diaminocyclopentadienone ruthenium complex allows control of regioselectivity in the ruthenium-catalyzed isomerization of propargyl alcohols through the choice of additive. Thereby, both products of the Meyer–Schuster rearrangement and redox isomerization products are selectively accessible. In the presence of hydroxylamine-O-sulfonic acid, unsaturated nitriles are formed instead. The ruthenium catalyst
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Total Synthesis of Moiramide B Using an Allylic Alkylation Approach Synlett (IF 2.0) Pub Date : 2024-04-02
An allylic side chain is introduced onto a chiral γ-amino-β-ketoamide by a Pd-catalyzed allylic alkylation. Subsequent ozonolysis and oxidation proceed only with Cbz-protected ketoamides. The total synthesis of moiramide B is finalized by peptide coupling.
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Are β-Lactones Involved in Carbon-Based Olefination Reactions? Synlett (IF 2.0) Pub Date : 2024-04-02 Jan Nowak, Michał Tryniszewski, Michał Barbasiewicz
Heteroatom-based olefinating reagents (e.g., organic phosphonates, sulfonates, etc.) are used to transform carbonyl compounds into alkenes, and their mechanism of action involves aldol-type addition, cyclization, and fragmentation of four-membered ring intermediates. We have developed an analogous process using ethyl 1,1,1,3,3,3-hexafluoroisopropyl methylmalonate, which converts electrophilic aryl
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TfOH-Catalyzed Facile Access for One-Pot Synthesis of β-Acylamino Ketones by Avoiding the Usage of Acetyl Chloride Synlett (IF 2.0) Pub Date : 2024-03-28 Sachin D. Kharat, Prasad B. Rupnavar, Keshav S. Pakhare, Ayesha A. Khan, Bapurao D. Rupanawar, Mahadev P. Shinde
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Enantioselective Heterogeneous Heck–Matsuda Reaction with Polymer-Supported PyOx Ligands Synlett (IF 2.0) Pub Date : 2024-03-28 Christian L. Herrera, Rafael L. Oliveira, Rodrigo C. Silva, Carlos R. D. Correia, Julio C. Pastre
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Compatibility Assessment of Unactivated Internal Alkynes in Rhodium-Catalyzed [2+2+2] Cycloadditions Synlett (IF 2.0) Pub Date : 2024-03-28 John M. Halford-McGuff, Aidan P. McKay, Allan J. B. Watson
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Improved Protocols for the Synthesis of Precursors of Thiazol-2-ylidene N-Heterocyclic Carbenes Synlett (IF 2.0) Pub Date : 2024-03-28 Ludivine Delfau, Jacques Pecaut, Eder Tomás-Mendivil, David Martin
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Electrochemical Efficient Synthesis of Two Azo Energetic Compounds Synlett (IF 2.0) Pub Date : 2024-03-27 Jinhao Zhang, Yulan Song, Wenjia Hao, Rufang Peng, Bo Jin
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Synthesis of Three-Dimensional Benzophenone Analogues Based on a [2.2]Paracyclophane Scaffold Synlett (IF 2.0) Pub Date : 2024-03-26 Shiqi Wu, Laurent Micouin, Erica Benedetti
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A Practical Method for the Synthesis of Mesoionic 1,3-Diaryltetrazolium Derivatives Bearing a para-Substituted Phenyl Group at the 1- or 3-Position from Anilines Synlett (IF 2.0) Pub Date : 2024-03-26 Yuta Matsukawa, Tsunehisa Hirashita
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The Difunctionalization of Alkenes Completed by DMTSM and CF3SO2Na without Metal Catalysts Synlett (IF 2.0) Pub Date : 2024-03-22 Siwei Shen, Jinzhao Gao, Xiaofeng Luo, Tianqiang Wang, Peihua Liu, Rulong Yan
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Late-Stage C–H Deuteration of Organic Compounds via Ligand-Enabled Palladium-Catalyzed Hydrogen Isotope Exchange Synlett (IF 2.0) Pub Date : 2024-03-22 Jyotirmoy Dey, Manuel van Gemmeren
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A Simple Tool to Benchmark Reactivity in Asymmetric Catalysis Synlett (IF 2.0) Pub Date : 2024-03-21 Alberto Muñoz, Tomislav Rovis
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Rhodium-Catalyzed Decarbonylative Intramolecular Arylation of 2-(1H-Indole-1-carbonyl)benzoic Acids Synlett (IF 2.0) Pub Date : 2024-03-20 Hirotsugu Suzuki, Yosuke Takemura, Takanori Matsuda
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The Electrochemical trans-Chloroformyloxylation of Unactivated Alkenes Synlett (IF 2.0) Pub Date : 2024-03-20 Jona Queder, Gerhard Hilt
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Advances on the Synthesis of C-Aryl-glycosides Since 2019 Synlett (IF 2.0) Pub Date : 2024-03-20 Jiagen Li, Xuefeng Jiang
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Bioorthogonal Chemistry at Radboud University: Past, Present and Future Synlett (IF 2.0) Pub Date : 2024-03-14 Floris P. J. T. Rutjes, Kimberly M. Bonger, Kevin Neumann
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Nickel-Catalyzed Asymmetric Borylative Coupling of 1,3-Dienes with Aldehydes Synlett (IF 2.0) Pub Date : 2024-03-13
The nickel-catalyzed borylative coupling of aldehydes and 1,3-dienes with diboron reagents offers an efficient method for synthesizing valuable homoallylic alcohols from easily accessible starting materials. However, achieving enantioselectivity in this reaction has been a significant challenge. We discuss our recent report on the first example of a nickel-catalyzed enantioselective borylative coupling
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Photoinduced Direct Carbamoylation of Ethers with Isocyanates towards the Synthesis of α-Amide-Substituted Ether Derivatives Synlett (IF 2.0) Pub Date : 2024-03-11
Photoinduced carbamoylation of ethers using isocyanates as amide sources was accomplished under mild and environmentally friendly reaction conditions. A series of isocyanates were tolerated in this protocol to construct α-amide-substituted ether derivatives with desired yields. The method featured broad substrate scope and good functional group tolerance, which could play an important role in the construction
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Synthesis of Racemosin B and Its Analogues by a Photochemical Cyclization Synlett (IF 2.0) Pub Date : 2024-03-06 Irfan Wazir, Rajagopal Nagarajan
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Catalytic Chain Transfer in Crosslinking Photopolymerizations Synlett (IF 2.0) Pub Date : 2024-03-05
Presented here is a detailed account of the development and implementation of macrocyclic cobaloxime complexes as sulfur-free, catalytic chain transfer agents (CTAs) in crosslinking photopolymerizations. Although much of this review is dedicated to understanding the fundamentals of catalytic chain transfer (CCT) in photopolymerizations, its impact on network topology and resultant mechanical properties
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Validation and Application of an Innovative Protective Group Concept: Enhancing Substrate Reactivity in Glycosylations by Disrupting Intermolecular Interactions Synlett (IF 2.0) Pub Date : 2024-03-05 Kumpei Yano, Takuya Yoshimoto, Masato Tsutsui, Yoshiyuki Manabe, Koichi Fukase
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Trideuteromethylation of Alkyl and Aryl Bromides by Nickel-Catalyzed Electrochemical Reductive Cross-Electrophile Coupling Synlett (IF 2.0) Pub Date : 2024-03-04
A new nickel-catalyzed electrochemical, reductive cross-coupling for the trideuteromethylation of alkyl and aryl bromides is reported in which CD3 arenesulfonate derivatives were used as effective and readily available CD3 sources. The CD3-labeled products were obtained with good yields. It was demonstrated that this methodology is scalable and can be efficiently used for various methylations, including
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Fragments Synthesis of A. baumannii ATCC 17961 O-Antigen Synlett (IF 2.0) Pub Date : 2024-03-04 Xinxin Li, Liangshen Duan, Deyong Liu, Jianying Qi, Liming Wang, Qingju Zhang
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The FeBr3-Catalyzed Transfer Hydrogenation of Styrene Derivatives under Mild Reaction Conditions Synlett (IF 2.0) Pub Date : 2024-03-01
The transfer hydrogenation of alkenes was realized by using a simple transition-metal compound (FeBr3) and 1,4-cyclohexadiene (1,4-CHD) as the hydrogen donor. The conversion of a number of di- and trisubstituted alkenes was investigated, and even a tetrasubstituted alkene was successfully converted. Compared with previously published work with the more expensive InBr3, the reaction times were considerably
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Sulfonium-Based Activity-Based Probes for Lysine-Selective Protein Profiling under Alkaline Conditions Synlett (IF 2.0) Pub Date : 2024-03-01 Changxing Hu, Rui Wang, Yuhao An, Chuan Wan, Feng Yin, Fei Lu, Zigang Li
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Enzymatic Synthesis of Hydroxycinnamic Acid Amides in Water Using the Promiscuous Hydrolase/Acyltransferase PestE from Pyrobaculum calidifontis VA1 Synlett (IF 2.0) Pub Date : 2024-03-01 Benjamin Baumert, Henrik Terholsen, Clemens Cziegler, Isabel Thier, Christoffel P. S. Badenhorst, Karsten Siems, Uwe T. Bornscheuer
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Organic Photoredox Carbonylation of Arenediazonium under Mild Conditions Synlett (IF 2.0) Pub Date : 2024-02-29 Robin Stuhr, Axel Jacobi von Wangelin
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Modification of an N-Methyl Group toward a New Energetic Melt-Castable Material with a Good Energy-Stability Balance Synlett (IF 2.0) Pub Date : 2024-02-28 Fang Chen, Siwei Song, Qinghua Zhang, Yi Wang
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Manganese(I)-Catalyzed C–H Allylation of Tryptophans and Their Oligopeptides On Water Synlett (IF 2.0) Pub Date : 2024-02-27 Julia Struwe, Tsuyoshi Oyama, Fabrice Gallou, Lutz Ackermann
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Brønsted Acid Catalyzed Stereospecific Dearomative Spirocyclization of Benzothiophenyl Analogues of Tertiary cis-β-Benzylstyrenes Synlett (IF 2.0) Pub Date : 2024-02-26 Anargul Tohti, Victoria Lerda, Benjamin J. Stokes
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Facile In Situ Difluoromethylation of Phenols and Thiols Using Ethyl Bromodifluoroacetate and K2CO3 Synlett (IF 2.0) Pub Date : 2024-02-26 Bharat D. Dond, Vijay P. Chavan, Shivaji N. Thore
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Ultrasound-Mediated Green Synthesis of Imidazo[1,2-a]pyridines and Imidazo[2,1-b]thiazoles through C(sp3)–H Functionalization Synlett (IF 2.0) Pub Date : 2024-02-26 Swati Chauhan, Pratibha Verma, Vandana Srivastava
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Current Strategies on the Enantioselective Synthesis of Modified Nucleosides Synlett (IF 2.0) Pub Date : 2024-02-23
The isolation of two carbocyclic nucleosides, viz., neplanocin A and aristeromycin, from natural sources, triggered a revolution in the scientific community, leading to the development of more versatile and therapeutically useful compounds. For this purpose, many new methods for the synthesis of the carbocyclic framework of nucleosides have been developed. These efforts resulted in the successful development
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Synthesis and Antibacterial Studies of Phenethylamine Alkaloid Natural Products Along with Their Analogues: Discolin A, B, E and Bacillimidazole B Synlett (IF 2.0) Pub Date : 2024-02-23 Rashmi Ranjan Khatua, Sarwat Asma Ziya Ahmad, Susmita Das, Roy Anindya, Faiz Ahmed Khan
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Spectroscopic Investigation of the Remote C–H Allylation of Amides via Photoredox and Nickel Dual Catalysis Synlett (IF 2.0) Pub Date : 2024-02-23 Céline Bourgois, Simon De Kreijger, Bin Xu, Uttam K. Tambar, Ludovic Troian-Gautier
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Accessing Reactive Metal Hydrides through Designed Heterometallic Bridges Synlett (IF 2.0) Pub Date : 2024-02-22 Fernando Gonzalez, Edgardo De Leon, Manar M. Shoshani
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An Efficient Access to Heteroaryl/Aryl-Annulated Pyridine Derivatives and a Study of Their Mosquito Larvicidal Activity Against Dengue Vector Synlett (IF 2.0) Pub Date : 2024-02-22 Pamela Pal, Sayanti Show, Sukanya Das, Sayantika Bhakta, Swarupa Mondal, Priya Roy, Tapas Ghosh, Raj K. Nandi