An expedient and easy-to-handle synthetic platform has been established for the constructing of 2H-thiophenes carrying fluorine atoms through [4+1] cyclization of enaminothiones with fluorinated carbene precursors. This simple reaction system is well compatible with a wide range of substrates under completely metal-free conditions. The resulting 2H-thiophenes can undergo further late-stage modifications to yield a wide range of fluorine-substituted heterocycles.

中文翻译：

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由烯胺硫酮便捷合成 gem-CF2-2H-噻吩

通过烯胺硫酮与氟化卡宾前体的[4+1]环化，建立了一个方便且易于操作的合成平台，用于构建带有氟原子的2H-噻吩。这种简单的反应系统在完全无金属的条件下与多种基材具有良好的兼容性。所得的 2 H-噻吩可以进行进一步的后期修饰，以产生各种氟取代的杂环。