显示样式:     当前期刊: Carbohydrate Polymers    加入关注       排序: 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Comparative Molecular Dynamic Simulation Study on the Use of Chitosan for Temperature Stabilization of Interferon <alpha>II
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-18
    Sajad Moradi, Elnaz Hosseini, Mohadese Abdoli, Solmaz Khani, Mohsen Shahlaei

    Carbohydrate biopolymer of biocompatible biodegradable chitosan, currently become one of the most usable polymer in medical and pharmaceutical sciences. In this regard a large number of protein and peptide drugs are used as therapeutic agents which can be exposed to temperature stresses either in transporting or storage. These stresses can make the protein structure unstable, change the active structure and disrupt its therapeutic function that limits their using as successful drug. In order to overcome these disadvantages associated with protein drugs, different materials such as natural or synthetic polymers are used to make protein loaded biocompatible nano and microspheres. In this research, molecular dynamics simulations were used to study the effects of chitosan with different degree of deacetylation on the stability of Interferon αII structure at high temperature and compare its results with those of commonly used biocompatible synthetic polymers of Poly Ethylene Glycol and Poly Lactic-Co-Glycolic Acid. In these simulations, the conformational changes at high temperatures (343 K) and in the presence and absence of polymers were compared to data related to protein in normal temperature (300 K). In brief, and according to the results, it can be said that low deacetylated chitosan and poly lactic co-glycolic acid are more successful in terms of protein stability at high-temperature. It is also observed that Poly Ethylene Glycol has penetrated into the protein and shows some instability of protein conformation. Eventually, according to the findings of this study, low deacetylated chitosan and Poly Lactic-Co-Glycolic Acid are the preferable copolymers for using in protein delivery systems of this drug.

    更新日期:2018-09-19
  • Effect of Surface Treatment of Cellulose Fiber (CF) on Durability of PLA/CF Bio-composites
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-18
    Hirofumi Kyutoku, Nanaka Maeda, Hiroki Sakamoto, Hiroyuki Nishimura, Kazushi Yamada

    Bio-composites made of polylactic acid (PLA) matrix reinforced with cellulose fibers (CF) were prepared using a twin-screw extruder and injection molding. The CFs were coated with epoxy-based surface treatment agents. Accelerated degradation tests were carried out on these PLA/CF composites at high temperatures (60 °C) or at constant temperature and constant humidity (60 °C/70% RH), and the higher-order structure changes and degradation characteristics of the molded products were evaluated. In the accelerated degradation test at 60 °C, the thermal and mechanical properties of PLA/CF composites showed no degradation, whereas at 60 °C and 70% RH, the melting point decreased ca. 25 °C and the storage modulus with increasing elapsed time decreased more than 50%. However, the thermal and mechanical properties of the PLA/CF composites treated with low-molecular-weight epoxy did not degrade, even at the high humidity of 70% RH. These results strongly suggest that the surface treatment agent not only improves interfacial adhesion between CF and PLA but also plays an important role in inhibiting degradation of the PLA matrix.

    更新日期:2018-09-19
  • One-step fabrication of apatite-chitosan scaffold as a potential injectable construct for bone tissue engineering
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-18
    Kaushar Jahan, Mina Mekhail, Maryam Tabrizian

    Biomineralization of soft scaffolds is a new venture in bone tissue engineering. This work aimed to develop a new injectable and in-situ gelling soft scaffold with chitosan and apatites through a rapid purine-crosslinking reaction. The scaffolds were fabricated by mixing chitosan, adenosine diphosphate and biominerals in an ‘all-in-one-step’ procedure. The gelling of chitosan via the crosslinker occurs in < 4 seconds as measured by impedance spectroscopy. These soft gels could retain up to 4 times their weight in water. Spectroscopy showed the formation of ionic bonds between chitosan and the apatites. Morphological analyses revealed an interconnected, highly porous structure, with pore size ranging from 200 nm-200 μm that was maintained even with the biominerals. Rheology showed a viscoelastic behavior of the solutions and the elastic behavior of the sponges, and therefore their injectability potential. In vitro studies showed good cell adhesion and morphology, as well as potential use for bone tissue engineering applications.

    更新日期:2018-09-18
  • Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-17
    Yuzhi Mu, Yangmu Fu, Jing Li, Xiaoping Yu, Yang Li, Yanan Wang, Xuanjin Wu, Kaichao Zhang, Ming Kong, Chao Feng, Xiguang Chen

    In this study, quercetin-chitosan conjugate (QT-CS) was synthesized for oral delivery of doxorubicin (DOX) to improve its oral bioavailability by increasing its water solubility, opening tight junction and bypassing the P-glycoprotein (P-gp). The prepared QT-CS self-assembled into micelles which could encapsulate DOX with high encapsulation rate, small particle size (136.9 nm) and strong zeta potential ( + 16.2 mV). QT-CS-DOX micelles displayed sustained-release profile in gastrointestinal simulation fluid (pH 1.2/pH 7.4). QT-CS micelles could promote cellular uptake of doxorubicin, which was 2.2 folds higher than that of free doxorubicin. The trans epithelial electrical resistance (TEER) value of Caco-2 monolayer cells was significantly reduced (about 57 %) by drug loaded QT-CS micelles, leading to a high apparent permeability coefficient (Papp) of doxorubicin, which was 10.17 folds higher than that of free doxorubicin. Above results indicate that QT-CS micelles are promising vehicles for the oral delivery of insoluble anticancer drugs.

    更新日期:2018-09-18
  • Surfactant-free emulsion Pickering polymerization stabilized by aldehyde-functionalized cellulose nanocrystals
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-17
    Mariem Errezma, Ayman Ben Mabrouk, Albert Magnin, Alain Dufresne, Sami Boufi

    Aldehyde-functionalized cellulose nanocrystals (CN) with two aldehyde contents were produced by periodate oxidation and gentle sonication. The aldehyde-functionalized CNCs were shown to be an effective stabilizer in the Pickering emulsion polymerization of acrylate monomers using potassium persulfate (KPS)/metabisulfite redox initiation system at 50 °C without any added surfactant. The effect of CNC content on the particle size, zeta-potential, colloidal stability and film properties were discussed. CNCs with the highest aldehyde content impart better colloidal stability to the polymer dispersion and lower particle size. The stabilization process was explained by the reaction of bisulfite with aldehyde groups borne by CNC, forming an adduct that contributes to the initiation of the polymerization and nucleation of polymer particles. This favors the effective attachment of CNCs onto the polymer particle, which is prerequisite for the effective Pickering stabilization process. The optical and mechanical properties of the nanocomposite films obtained by simple casting of the polymer dispersion and water evaporation were also investigated by transmittance and dynamic mechanical analysis (DMA). Better transparency was observed for films prepared in the presence of CNCs with the highest aldehyde content, while a reverse trend was noted for the mechanical properties.

    更新日期:2018-09-18
  • Graphene oxide enhanced Polyacrylamide-Alginate aerogels catalysts
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-17
    Cong Shan, Lianxu Wang, Zhongxu Li, Xin Zhong, Yaheng Hou, Long Zhang, Fengwei Shi
    更新日期:2018-09-18
  • Magnetic quaternary chitosan hybrid nanoparticles for the efficient uptake of diclofenac from water
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-17
    Sofia F. Soares, Tiago Fernandes, Margarida Sacramento, Tito Trindade, Ana L. Daniel-da-Silva

    The occurrence of pharmaceuticals in the environment and the water cycle, even at trace levels, has been a matter of great discussion in the literature in the recent years. Despite the clinical relevance of diclofenac (DCF), several studies indicate that it is one of the most frequently detected anti-inflammatory drugs in surface waters, with potential harmful impact on environment and human health. Herein, novel magnetic hybrid nanosorbents composed of magnetite cores encapsulated within a siliceous network highly enriched in a quaternary chitosan (HTCC) were successfully prepared and tested in magnetically assisted removal of sodium diclofenac from aqueous solutions. The DCF adsorption by the produced core–shell nanoparticles was assessed based on several experimental parameters. It was found that under optimal conditions, the modelling of the equilibrium data was best fit with Langmuir and Toth models where the maximum adsorption capacity of DCF was 240.4 mg/g. These results indicate that these hybrid biosorbents are among the most effective magnetic systems for the removal of this pharmaceutical from water. Through the strategy proposed in this work, novel hybrid magnetic nanoparticles containing a cationic surface charge in a broad pH range, from acidic to neutral pH values, is reported. Therefore, these materials may provide a new way of removing a wider class of other anionic contaminants from water.

    更新日期:2018-09-18
  • Antibacterial Poly (3,4-ethylenedioxythiophene): Poly(styrene-sulfonate)/Agarose Nanocomposite Hydrogels with Thermo-processability and Self-healing
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-17
    Youngsang Ko, Jeonghun Kim, Ho Young Jeong, Goomin Kwon, Dabum Kim, Minhee Ku, Jaemoon Yang, Yusuke Yamauchi, Hae-Yeong Kim, Chanhui Lee, Jungmok You

    Recently, Near-infrared (NIR)-induced photothermal killing of pathogenic bacteria has received considerable attention due to the increase in antibiotic resistant bacteria. In this paper, we report a simple aqueous solution-based strategy to construct an effective photothermal nanocomposite composed of poly(3,4-ethylenedioxythiophene):poly(styrene-sulfonate) (PEDOT:PSS) and agarose with thermo-processability, light triggered self-healing, and excellent antibacterial activity. Our experiments revealed that PEDOT:PSS/agarose was easily coated on both a 2D glass substrate and 3D cotton structure. Additionally, PEDOT:PSS/agarose can be designed into free-standing objects of diverse shape as well as restored through an NIR light-induced self-healing effect after damage. Taking advantage of strong NIR light absorption, PEDOT:PSS/agarose exhibited a sharp temperature increase of 24.5 °C during NIR exposure for 100 sec. More importantly, we demonstrated that the temperature increase on PEDOT:PSS/agarose via photothermal conversion resulted in the rapid and effective killing of nearly 100% of the pathogenic bacteria within 2 min of NIR irradiation.

    更新日期:2018-09-18
  • Fabrication of superhydrophobic caffeic acid/Fe@cotton fabric and its oil-water separation performance
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-17
    Qingqing Zhou, Biaobiao Yan, Tieling Xing, Guoqiang Chen
    更新日期:2018-09-18
  • Porous Chitosan Microspheres as Microcarriers for 3D Cell Culture
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-17
    Lixia Huang, Lin Xiao, Abishek Jung Poudel, Jixiang Li, Ping Zhou, Mario Gauthier, Haiqing Liu, Zhihong Wu, Guang Yang
    更新日期:2018-09-17
  • Green functionalization of cellulose nanocrystals for application in reinforced poly(methyl methacrylate) nanocomposites
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-15
    Wei Wang, Tao Liang, Baikai Zhang, Huiyu Bai, Piming Ma, Weifu Dong

    Cellulose nanocrystals (CNC) were carboxylated through an organic solvent free esterification method using l-malic acid (MA) to improve performance of transparent poly(methyl methacrylate) (PMMA) nanocomposites. A series of CNC carboxylated with a degree-of-substitution (DS) of 0, 0.035, and 0.20 were obtained. The presence of grafted carboxyl groups was characterized by Fourier transform infrared (FT-IR) spectroscopy and 13C NMR analysis, meanwhile effects of content and DS of CNC on the structure, thermal, mechanical, and optical transparency properties of the nanocomposites were assessed. The results indicated that the homogeneous dispersion of CNC and a favorable PMMA-CNC interface were necessary to enhance the properties of nanocomposites. Facilitated through hydrogen bonding interactions, the resulting films demonstrated that a low percentage loading of CNC with high DS worked as effective reinforcing agents, producing stronger and tougher films than neat PMMA films, with an improved thermal stability and retention of good transparency.

    更新日期:2018-09-17
  • Bioperformance of chitosan/fluoride-doped diopside nanocomposite coatings deposited on medical stainless steel
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-14
    S. Karimi, E. Salahinejad, E. Sharifi, A. Nourian, L. Tayebi

    This work focuses on the structure, bioactivity, corrosion, and biocompatibility characteristics of chitosan-matrix composites reinforced with various amounts of fluoride-doped diopside nanoparticles (at 20, 40, 60, and 80 wt%) deposited on stainless steel 316 L. Bioactivity studies reveal that the presence of the nanoparticles in the coatings induces apatite-forming ability to the surfaces. Based on electrochemical impedance spectroscopy and polarization experiments, the in vitro corrosion resistance of the substrate was enhanced by increasing the level of the nanoparticles in the coating. The sample containing 60% of the nanoparticles presented the highest osteoblast-like MG63 cell viability, in comparison to the other prepared and even control samples. Also, the cell attachment on the surfaces was improved with increasing the amount of the nanoparticles in the coatings. It is eventually concluded that the application of chitosan/fluoride-doped diopside nanocomposite coatings improves the bioperformance of metallic implants.

    更新日期:2018-09-15
  • A Recoverable Dendritic Polyamidoamine Immobilized TEMPO for Efficient Catalytic Oxidation of Cellulose
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-13
    Shaojie Liu, Huazhe Liang, Tingting Sun, Desheng Yang, Meng Cao

    Polyamidoamine (PAMAM) dendrimers of G1.0 and 2.0 were synthesized by the repeated Michael addition and ester aminolysis of ethylenediamine and methyl acrylate. Through the reductive amination reaction of primary amines in PAMAM and carbonyl groups in 4-oxo-2,2,6,6-tetramethylpiperidine-1-oxyl (4-oxo-TEMPO), the water-soluble PAMAM immobilized TEMPO (PAMAM-TEMPO) was successfully prepared. The obtained PAMAM-TEMPO was characterized by Fourier transform infrared spectroscopy (FT-IR) and ultraviolet-visible spectrophotometer (UV-Vis). PAMAM-TEMPO was used as catalyst instead of free TEMPO for selective catalytic oxidation of primary hydroxyl groups in cellulose with water as reaction medium. The results showed that the catalytic performance of G1.0 PAMAM-TEMPO with 28.8% TEMPO loading was equivalent to free TEMPO. After salting out the supernatant of oxidation mixture, PAMAM-TEMPO was recovered by extraction with N,N-dimethylformamide and reused for further oxidation cycles. No significant reduction in catalytic performance was found after 4 oxidation cycles. The recovery of PAMAM-TEMPO after each cycle was about 90%. By sonication of oxidized cellulose obtained with G1.0 PAMAM-TEMPO as catalyst, the individualized cellulose nanofibers with approximately 10 nm in diameter were successfully prepared. This is the first report on the use of immobilized TEMPO catalysts comparable to the performance of free TEMPO to oxidize cellulose in water.

    更新日期:2018-09-14
  • Influence of cations on texture, compressive elastic modulus, sol-gel transition and freeze-thaw properties of kappa-carrageenan gel
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-13
    Yanli Wang, Chao Yuan, Bo Cui, Yawei Liu

    The influences of 4 mono- and di-valent cations (K+, Na+, Mg2+ and Ca2+) on the mechanical, sol-gel transition and freeze-thaw properties of κ-carrageenan gel were investigated. Texture profile analysis results demonstrated that the texture behavior of gelatinized κ-carrageenan was obviously influenced by the cation types and concentrations and the influence of K+ was the greatest. The gelling temperature (Tg) of κ-carrageenan gel showed a positive correlation with cation concentrations and the influence of K+ was still the largest. However, the viscosities of κ-carrageenan gels evoked by divalent cations were higher than monovalent cations. Furthermore, cations reduced freeze-thaw stability of κ-carrageenan gels and followed the same influence tendency as viscosities. It was proposed that divalent cations form direct crosslinking between κ-carrageenan helices while monovalent cations only bind single sulphate groups on κ-carrageenan molecules. There were more junction zones in divalent cations invoked gels. Furthermore, K+ and Ca2+ cations showed apparent synergistic effect in the research.

    更新日期:2018-09-14
  • SUPERHYDROPHOBICITY, UV PROTECTION AND OIL/WATER SEPARATION PROPERTIES OF FLY ASH/TRIMETHOXY(OCTADECYL)SILANE COATED COTTON FABRICS
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-12
    Muhammad Zaman Khan, Vijay Baheti, Jiri Militky, Azam Ali, Martina Vikova

    The presented study proposed simple and low-cost approach for improvement in UV protection and superhydrophobic properties of cotton fabrics by coating of mechanically activated fly ash particles. The maximum UV blocking was observed for 3 wt% fly ash, where UV transmittance decreased from 14.19% of untreated fabric to 0.11% of coated fabric. After subsequent treatment of Trimethoxy(octadecyl)silane (OTMS) on fly ash coated fabrics, the water contact angle was increased to 143°, 147° and 153° for fly ash concentration of 1, 2 and 3 wt% respectively. From Cassie-Baxter theories, the unwetted fraction of air pockets were estimated to be 43%, 55% and 67% respectively for 1, 2 and 3 wt% of fly ash particles. Furthermore, the coated fabrics showed great potentials for separation of floating oil layer, underwater oil droplet or oil/water mixture. The separation efficiency of 98%, 96%, 97% and 95% was obtained for selected model oils toluene, n-hexane, chloroform and petro ether, respectively.

    更新日期:2018-09-13
  • MWCNT-coated cellulose nanopapers: Droplet-coating, process factors, and electrical conductivity performance
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-12
    Mahdi Mashkour, Maryam Sharifinia, Hossein Yousefi, Elyas Afra
    更新日期:2018-09-13
  • Facile strategy involving low-temperature chemical cross-linking to enhance the physical and biological properties of hyaluronic acid hydrogel
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-11
    Jaeuk Baek, Yingfang Fan, Seol-Ha Jeong, Ho-Yong Lee, Hyun-Do Jung, Hyoun-Ee Kim, Sukwha Kim, Tae-Sik Jang

    Here, we present a novel strategy to fabricate hyaluronic acid (HA) hydrogels with excellent physical and biological properties. The cross-linking of HA hydrogel by butanediol diglycidyle ether (BDDE) was characterized under different reaction temperatures, and the resulting physical properties (i.e., the storage modulus and swelling ratio) were measured. The ratio between the cross-linking rate (a strengthening effect) and the hydrolysis rate (a weakening effect) was much greater with lower cross-linking temperatures after sufficient cross-linking time, resulting in a noticeably higher storage modulus. As the cross-linking temperature decreased, the formed HA hydrogel structure became denser with smaller pores. Moreover, the introduction of low-temperature HA cross-linking strategy also resulted in an enhanced several important characteristics of HA hydrogels including its enzymatic resistivity and its ability to elicit a cellular response. These results indicate the performance of HA hydrogels can be markedly enhanced without further additives or modifications, which is expected to contribute to the advancement of applications of HA hydrogels in all industrial fields.

    更新日期:2018-09-11
  • Extraction optimization of pectin from cocoa pod husks (Theobroma cacao L.) with ascorbic acid using response surface methodology
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-11
    Florentina Priyangini, Sudhir G. Walde, Chidambaram Ramalingam
    更新日期:2018-09-11
  • 更新日期:2018-09-11
  • Hyaluronic acid-functionalized half-generation of sectorial dendrimers for anticancer drug delivery and enhanced biocompatibility
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-09
    Xiao Du, Shaoping Yin, Yang Wang, Xiaochen Gu, Guangji Wang, Juan Li

    Biocompatible, pH-sensitive and charge-conversion micelles derived from hyaluronic acid (HA), poly(lactide) (PLA) and half-generation of sectorial poly(amidoamine) dendrimers (sPA G4.5) were designed and fabricated to target delivery of docetaxel (DTX) to cancer cells. The novel micelles (HA-PALA-DTX) possessed stability against rat plasma and were capable of reversing surface zeta potential under acidic conditions in the presence of HAase. Moreover, the blank micelles demonstrated satisfactory biocompatibility and viability for biomedical applications. A cellular internalization experiment indicated that HA played an important role in increasing intracellular accumulation of DTX delivered by the micelles. Compared to Taxotere® and PALA-DTX, HA-PALA-DTX showed an enhanced anticancer activity in vivo, with a tumor growth inhibition rate of 72.32 ± 5.22%. Overall, the functionalized micelles could be utilized as an alternative carrier for effective targeted delivery of anticancer agents to improve therapeutic efficacy and minimize adverse effects.

    更新日期:2018-09-10
  • Chemical characteristics, antioxidant capacities and hepatoprotection of polysaccharides from pomegranate peel
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-07
    Xichuan Zhai, Caiping Zhu, Yang Zhang, Jingru Sun, Aamina Alim, Xingbin Yang

    This proposed work aimed to investigate the chemical characteristic, antioxidant capacities and hepatoprotection effect of pomegranate peel polysaccharides (PPP) on CCl4-induced oxidative damage in mice. PPP was identified as the acidic heteropolysaccharides by HPLC methods. In vitro test showed that PPP had excellent reducing power and scavenging effects against free radicals. Administration of PPP (50, 100 and 200 mg/kg·bw) in mice before the injection of CCl4 could observably antagonize the increased serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and hepatic malonaldehyde level in CCl4-induced mice, especially administrated with 200 mg/kg·bw of PPP. Hepatic enzymatic activities of total superoxide dismutase, glutathione peroxidase, catalase and non-enzymatic activity of glutathione were markedly increased at high dosage of PPP, respectively. In addition, histopathological observation of liver further proved these biochemical characteristics. Therefore, it can be concluded that PPP exhibits strong protective effects against CCl4-induced liver injury in mice.

    更新日期:2018-09-09
  • An arabinogalactan-glycoconjugate from Genipa americana leaves present anticoagulant, antiplatelet and antithrombotic effects
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-08
    Juliana C. Madeira, Gabriel V.L. da Silva, José Josenildo Batista, Gilberto Dantas Saraiva, Gustavo R.C. Santos, Ana Maria S. Assreuy, Paulo A.S. Mourão, Maria G. Pereira

    Glycoconjugates extracted from Genipa americana leaves (PE-Ga) were separated into two fractions, denominated as PFI and PFII (total carbohydrate: 23-36%/uronic acid: 9-30%; protein:4-5%; polyphenols:0.776-0.812 mg/g), mainly composed by arabinose, galactose and uronic acid and presenting high (PFI) and low (PFII) molecular weight (based on polyacrylamide electrophoresis gel and gel permeation chromatography). Uronic acid was also detected by FT-IR (wavenumbers: 1410 and 1333 cm-1) and NMR (α-GalpA). Deproteinization of glycoconjugates showed reduced protein and polyphenol levels with loss of its biological effects. PE-Ga and PFII prolonged clotting time-aPTT (3.6 and 1.8x), while PE-Ga and PFI inhibited by 48% (100 µg/µL) the ADP-induced platelet aggregation. In vivo, these glycoconjugates at 1 mg/kg inhibited (37-53%) venous thrombus formation (4.7 ± 0.1 mg) and increased bleeding time (PE-Ga and PFI:3.0x; PFII:1.7x vs. PBS:906 ± 16.7 s). In conclusion, the arabinogalactan-rich glycoconjugate of G. americana leaves, containing uronic acid, present antiplatelet, anticoagulant (intrinsic/common pathway) and antithrombotic effects, with low hemorrhagic risk.

    更新日期:2018-09-09
  • STARCH/GRAPHENE HYDROGELS VIA CLICK CHEMISTRY WITH RELEVANT ELECTRICAL AND ANTIBACTERIAL PROPERTIES
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-06
    Kizkitza González, Clara García-Astrain, Arantzazu Santamaria-Echart, Lorena Ugarte, Luc Avérous, Arantxa Eceiza, Nagore Gabilondo

    Starch-based hydrogels were performed by Diels-Alder cross-linking reactions between furan-modified starch and a water soluble bismaleimide, with improving conducting properties by using graphene layers as active nanofillers. The characterization results demonstrated that the Diels-Alder reaction and the corresponding conditions for the hydrogel formation were appropriate. The effect of increasing the furan/maleimide ratio on the architecture of the hydrogels and on the morphological, rheological and swelling properties was thoroughly evaluated. Effective network structure was obtained by increasing the cross-linker content leading to decreasing pore size and increasing storage modulus value of the final material. It was shown that the swelling behavior of hydrogels was mainly governed by the hydrophilic character of bismaleimide. Graphene nanosheets were added for the synthesis of nanocomposite hydrogel and it was characterized in terms of rheological properties, electrical conductivity and antimicrobial activity. The nanocomposite hydrogel presented enhanced mechanical performance, antimicrobial activity and increased conductivity values, up to a decade, indicating that conductive and active hydrogels could be satisfactory obtained, for a large range of potential applications such as biomed.

    更新日期:2018-09-07
  • 更新日期:2018-09-07
  • The three dimensional cues-integrated-biomaterial potentiates differentiation of human mesenchymal stem cells
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-06
    Min Hee Park, Ramesh Subbiah, Min Jung Kwon, Woo Jun Kim, Sang Heon Kim, Kwideok Park, Kangwon Lee

    Alginate (Alg) hydrogels, the most popular natural biomaterials, mimic extracellular matrix (ECM) microenvironment and offer potential biomedical applications. Despite their excellent properties such as biocompatibility, hydrophilicity and ionic crosslinking, the absence of an intrinsic cell adhesion domain lessens their cell-carrier applications in tissue engineering. Herein, we suggest a three-dimensional (3D) cell culture system by integrating Alg hydrogel and fibroblast-derived matrix (FDM). FDM including cell-adhesion motifs, signaling, and physico-mechanical cues is prepared by the decellularization process by avoiding unfavorable chemical reactions. This cues-integrated-biomaterials (CiB) 3D platform shows increased cell viability, proliferation, chondrogenic and osteogenic differentiation of human bone-marrow-derived mesenchymal stem cells (hMSCs) in situ. The results show that the Alg/FDM hydrogel (CiB) matrix provides an excellent microenvironment for cell adhesion and can control the differentiation of hMSCs into specific lineages. Thus, these results suggest the potential applications of the Alg/FDM hydrogel matrix as a viable 3D culture system for tissue regeneration.

    更新日期:2018-09-07
  • Modification of chitin structure with tailored ionic liquids
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-06
    Małgorzata M. Jaworska, Izabela Stepniak, Maciej Galiński, Dawid Kasprzak, Dorota Biniaś, Andrzej Górak

    Chitin, poly N-acetylglucosamine, has a great potential for use on an industrial scale as an enzyme carrier but it has an unfavorable particle structure that can be modified using ionic liquids (ILs). Several ionic liquids were investigated that have the same substituents on the ring (methyl- and propyl-) but differed in the type of cationic ring (pyrrolidinium, piperidinium, and piperazinium). Organic acid ions (acetic and lactic) were used as counter ions. 1-ethyl-3-methyl-imidazolium acetate and 1-ethyl-3-methyl-imidazolium lactate were used as a reference. The results confirm that the chitin particle structure or size, or both, simultaneously changes if chitin is dissolved in an IL and then precipitated. Organic acid anions and short substituents on the cationic ring of ILs influenced particle modification substantially, whereas the type of ring played a minor role. Additionally, the ionic liquids [MPpyrr][OAc], [MPpip][OAc] and [DMPpz][OAc] could be reused up to at least 4 times without losing their ability to dissolve chitin.

    更新日期:2018-09-07
  • SULFONATED AND SULFATED CHITOSAN DERIVATIVES FOR BIOMEDICAL APPLICATIONS: A REVIEW
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-06
    Syrine Dimassi, Nicolas Tabary, Feng Chai, Nicolas Blanchemain, Bernard Martel

    From 20th century, chitosan, a natural polysaccharide, has received much attention for use in biomedical applications thanks to its remarkable properties, such as biodegradability, biocompatibility, hemostasis and antibacterial activity. Over the last decades, many researchers have attempted to generate new chitosan derivatives-based biomaterials though chemical modifications, especially through sulfonation or sulfation reactions in order to tailor the physicochemical and biochemical properties. Due to the presence of residual amino groups, the generated polyampholytic derivatives are characterized by convenient biological properties, such as antioxidation, antiviral activity, anticoagulation and bone regeneration, expanding their application scope. This paper provides an overview of the strategies used to chemically modify chitosan by introduction of sulfonate groups on chitosan backbone, focusing on various sulfonating or sulfating agents used and substitution regioselectivity, and highlights their applications in biomedical field.

    更新日期:2018-09-07
  • Crosslinking of agar by diisocyanates
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-06
    Amit Kumar Sonker, Mezigebu Belay, Kalpana Rathore, Kousar Jahan, Sankalp Verma, Gurunath Ramanathan, Vivek Verma

    In the present study, crosslinking of agar using diisocyanate (DI) was demonstrated to limit the high water absorption property of agar. In addition, the efficacy of aromatic diisocyanate, DDI (4, 4 diphenyl diisocyanate) and aliphatic diisocyanate, HDI (1, 6 hexamethylene diisocyanate) on crosslinked agar properties was compared. The water uptake was successfully reduced by crosslinking and its minimum values observed for DDI and HDI crosslinked agar was 33.6% and 43.6%, respectively in comparison to agar (206%). The maximum tensile strength was observed for DDI crosslinked agar (45.3 MPa) which was higher than HDI crosslinked agar (30.6 MPa) and agar (31.7 MPa). The aromatic diisocyanates crosslinked agar showed better thermal resistance at higher temperature. It was observed that aromatic diisocyanate crosslinked agar more effectively than the aliphatic diisocyanate due to the higher reactivity. The crosslinked agar samples were hemocompatible and show non-toxic nature for cell proliferation.

    更新日期:2018-09-07
  • 更新日期:2018-09-07
  • Nanocellulose and chitosan based films as low cost, green piezoelectric materials
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-05
    Aleksi Hänninen, Essi Sarlin, Inari Lyyra, Timo Salpavaara, Minna Kellomäki, Sampo Tuukkanen

    Nanocellulose and chitosan have recently started to get attention as environmentally friendly piezoelectric materials for sensor and energy harvesting applications. Conversely, current commercially available flexible piezoelectric films made of for example polyvinylidene difluoride (PVDF) are relatively expensive and made from non-renewable materials. We measured the piezoelectric responses (2-8 pC/N) for solvent casted films based on nanocellulose, microcrystalline chitosan and their blends. In addition, the tensile properties of the piezoelectric films were characterized to find out if chitosan could be used to enhance the flexibility of the brittle nanocellulose films. Based on the results, plain chitosan is an interesting piezoelectric material itself. In addition, blending nanocellulose and chitosan could be a potential method for tailoring the properties of solvent casted low cost, green piezoelectric films.

    更新日期:2018-09-06
  • Fabrication and characterization of Gum arabic-cl-poly(acrylamide) nanohydrogel for effective adsorption of crystal violet dye
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-05
    Gaurav Sharma, Amit Kumar, Mu Naushad, Alberto García-Peñas, Ala'a H. Al-Muhtaseb, Ayman A. Ghfar, Vikrant Sharma, Tansir Ahamad, Florian J. Stadler
    更新日期:2018-09-05
  • Water dynamics in silanized hydroxypropyl methylcellulose based hydrogels designed for tissue engineering
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-05
    N. Buchtová, A. D’Orlando, P. Judeinstein, O. Chauvet, P. Weiss, J. Le Bideau

    Silanized hydroxypropyl methylcellulose based hydrogels were developed for cartilage and intervertebral disc tissue engineering. Herein, study of dynamics of confined water showed two different populations, identified as hydration and bulk-like water. The diffusion coefficient showed that bulk-like water diffuses over distances ~10 µm without being affected by the hydrogel matrix. Addition of silica nanofibers leads to improved mechanical properties and enhanced diffusion coefficient. Good diffusion within hydrogels is essential for the application.

    更新日期:2018-09-05
  • Study of the behavior of biodegradable starch/polyvinyl alcohol/rosin blends
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-05
    D. Domene-López, M.M. Guillén, I. Martin-Gullon, J.C. García-Quesada, M.G. Montalbán

    Biodegradable potato starch/PVA samples containing different concentrations of rosin were prepared by melt-mixing in order to study the enhancement of the properties of native starch films. Glycerol and polyvinyl alcohol (PVA) are commonly used as plasticizers of starch. Their relatively low molecular weight (compared with starch) contributes to a good processability. Rosin is a renewable product whose incorporation in the starch/PVA matrix induces processing aid and reinforcing effects. Its relatively high molecular weight might prevent its migration to the surface of the final product. Water content, solubility in water, mechanical properties, microstructure and dynamic mechanical analysis of the samples were studied. The addition of 8% rosin to starch/PVA blends led to tensile strength values higher than 10 MPa and elongation at break values close to 2000%, values comparable to those offered by conventional polymers used in food packaging, for example LDPE. Furthermore, starch compounds have low cost and high biodegradability.

    更新日期:2018-09-05
  • Chitosan functionalized poly(ε-caprolactone) nanoparticles for amphotericin B delivery
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-05
    Rossana Gabriela Vásquez Marcano, Tania Toyomi Tominaga, Najeh Maissar Khalil, Lígia Santos Pedroso, Rubiana Mara Mainardes

    Amphotericin B (AmB) is a broad-spectrum antifungal drug used in the treatment of fungal invasive infections. However, its clinical use has been limited due to its side effects and toxicity, especially the nephrotoxicity. Furthermore, AmB presents low aqueous solubility, low permeability over the membranes and poor stability in the gastric environment, which makes it unavailable to be administered by the oral route. In this study, chitosan-coated poly (ε-caprolactone) nanoparticles were developed to provide the oral delivery of AmB and reduce its toxicity. Nanoparticles were obtained by nanoprecipitation and parameters as particle size, polydispersity index (PDI), zeta potential, morphology, in vitro AmB release (in physiological pH and simulated gastrointestinal fluids), state of molecular aggregation, cytotoxicity over erythrocytes and Vero cells line and in vitro antifungal activity were fully investigated. Nanoparticles presented mean size of 318 ± 35 nm, PDI of 0.24 ± 0.02, zeta potential of +36.2 ± 1.8 mV due to chitosan-coating, and 69% of AmB encapsulation. The kinetic release profile of AmB from nanoparticles was of second order and diffusion-governed in pH 7.4. The release in the gastrointestinal simulated fluids showed that the chitosan-coated PCL nanoparticles presented good stability during the time evaluated. AmB was released from nanoparticles in a state of low molecular aggregation. Cytotoxicity over erythrocytes and Vero cells line revealed that nanoencapsulation significantly reduced the AmB-related cytotoxicity (p < 0.05) compared to the free drug. In the antifungal activity against Candida parapsilosis strain, the MIC of AmB-loaded nanoparticles was 5-fold higher than free AmB, but the strain was susceptible to nanostructured AmB. Chitosan-functionalized PCL are potential carriers for the oral AmB delivery, reducing its cytotoxicity and maintaining its activity.

    更新日期:2018-09-05
  • Natural Polymer Konjac Glucomannan Mediated Assembly of Graphene Oxide as Versatile Sponges for Water Pollution Control
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-05
    Tao Chen, Peiheng Shi, Jian Zhang, Yi Li, Tao Duan, Lichun Dai, Liang Wang, Xiaofang Yu, Wenkun Zhu

    Three-dimensional network structure of konjac glucomannan/graphene oxide (KGM/GO) sponges was successfully prepared by ice template method. The KGM/GO sponges was rich in functional groups, negatively charged under pH 2 to 10. Batch adsorption experiment was conducted to investigate the adsorption performance of the as-prepared KGM/GO sponges for organic dye (malachite green (MG)) and radionuclide (uranium U(Ⅵ)). The results showed that the maximum adsorption capacities of KGM/GO sponges were 266.97, 189.96 mg/g for U(Ⅵ) and MG, respectively. Moreover, the KGM/GO sponges exhibited an excellent selectivity for capturing U(Ⅵ) in multi-ion system. The adsorption process was fitted better to pseudo-second order model, while adsorption isotherms for these pollutants were well matched up to Langmuir models. In addition, KGM/GO sponges can be easily separated from the aqueous solution and could be effectively reused for 5 times without obvious loss in adsorption performance. The advantages of eco-friendliness, low cost, simple preparation process, controllable shape and size, as well as high adsorption capacities for MG and U(Ⅵ), suggested that KGM/GO sponges promising in water pollution control.

    更新日期:2018-09-05
  • pH-responsive hyaluronate-anchored extracellular vesicles to promote tumor-targeted drug delivery
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-05
    Hyuk Lee, Hongsuk Park, Gwang Jin Noh, Eun Seong Lee

    pH-Responsive drug vehicles targeting the specific extracellular pH of tumors have served as potent tools to overcome the limitation (e.g., low tumor seletivity) in antitumor drug delivery system. Here, we describe the advantage of pH-responsive extracellular vesicles (HDEA@EVs) containing the hyaluronic acid grafted with 3-(diethylamino)propylamine (HDEA) and a model antitumor drug, doxorubicin (DOX). We demonstrated their physicochemical characteristics through in vitro cell endocytosis, in vitro tumor cell toxicity, in vivo biodistribution, and in vivo tumor regression efficacy experiments. Because the HDEA@EVs efficiently responded to extracellular tumor pH (pH 6.5) and actively bound to CD44 receptors on HCT-116 tumor cells, the EVs selectively inhibited CD44+ tumor cell growth in vitro, and CD44+ tumor development in vivo. From these results, we conclude that HDEA@EVs can help in designing effective strategies for pharmacologic intervention in tumor therapy.

    更新日期:2018-09-05
  • Efficient removal of Pb(II), Cr(VI) and organic dyes by polydopamine modified chitosan aerogels
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-05
    Dong-Mei Guo, Qing-Da An, Zuo-Yi Xiao, Shang-Ru Zhai, Dong-Jiang Yang
    更新日期:2018-09-05
  • Cytocompatible - chitosan based multi-network hydrogels with antimicrobial, cell anti-adhesive and mechanical properties
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-04
    Wanjing Zou, Yuxiang Chen, Xingcai Zhang, Jianna Li, Leming Sun, Zifan Gui, Bing Du, Shiguo Chen

    Hydrogel with good mechanical and biological properties has great potential and promise for biomedical applications. Here we fabricated a series of novel cytocompatible chitosan (CS) based double-network (DN) and triple-network (TN) hydrogels by physically-chemically crosslinking methods. Natural polysaccharide CS with abundant resources was chosen as the first network due to its good antimicrobial activity, biocompatibility and easy cross-linking reaction. Zwitterionic sulfopropylbetaine (PDMAPS) was chosen as the second network due its good biocompatibility, antimicrobial and antifouling properties. And nonionic poly(2-hydroxyethyl acrylate) (PHEA) was chosen as the final network due to its good biocompatibility, excellent nonfouling and mechanical properties. Cross-section SEM images showed that both CS/PHEA (DN1, the molar ratio of glutaraldehyde to structural unit of CS is 0.2/3.0) and CS/PDMAPS/PHEA (TN1, the molar ratio of glutaraldehyde to structural unit of CS is 0.2/3.0) hydogels exhibited a smooth and uniformly dispersed porous microstructures with pore size distribution in the range of 20~100 μm. The largest compressive stress and tensile stress of DN1 hydrogels reached 84.7 MPa and 292 kPa, respectively, and largest compressive stress and tensile stress of TN1 hydrogels could reach 81.9 MPa and 384 kPa, respectively. Moreover, the value of failure strain for TN1 gels reached 1020 %. Besides excellent mechanical properties, DN1 and TN1 gels exhibited good antimicrobial, cytocompatible and antifouling properties due to introduction of antimicrobial chitosan, cell anti-adhesive PDMAPS and PHEA. The combination of the excellent mechanical and biological properties of multiple network hydrogels can provide a potential pathway to develop biomedical hydrogels as promising bioapplications in wound dressing and other biomedical applications.

    更新日期:2018-09-04
  • Chitosan as a substrate for simultaneous surface imprinting of salicylic acid and cadmium
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-03
    Deepali Rahangdale, Anupama Kumar

    The present work demonstrates functionalized chitosan as an ecofriendly substitute to the conventional costly substrates and monomers for simultaneous surface imprinting of salicylic acid (SA) and cadmium (Cd). Dual surface imprinted acrylamide functionalized chitosan based polymer (AGDMIP), with higher numbers of imprinted sites for SA and Cd was synthesized using acrylamide grafted chitosan, epichlorohydrin as crosslinker, Cd as template and 4 hydroxy benzoic acid (4HBA) as mimic template (supported by computational modeling). FTIR, SEM, XRD, BET surface area and TEM analysis confirmed successful preparation, mesoporous nature and surface imprinting of AGDMIP. The adsorption data could be fitted into Langmuir isotherm model with the maximum adsorption capacity of 45.77 mg g-1 (SA) and 53.42 mg g-1 (Cd). Temkin and Intraparticle diffusion models confirmed the chemical nature and presence of imprint sites within AGDMIP respectively. AGDMIP could be reused for six cycles and exhibited good removal efficiency in real samples.

    更新日期:2018-09-04
  • Modified cellulose by polyethyleneimine and ethylenediamine with induced Cu(II) and Pb(II) adsorption potentialities
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-03
    Zhujian Huang, Zhiyan Huang, Lijing Feng, Xuewen Luo, Pingxiao Wu, Lihua Cui, Xiaoyun Mao
    更新日期:2018-09-04
  • Ganoderma atrum polysaccharide improves doxorubicin-induced cardiotoxicity in mice by regulation of apoptotic pathway in mitochondria
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-03
    Wen-Juan Li, Xian-Yi Zhang, Rui-Ting Wu, Ye-Hao Song, Ming-Yong Xie

    The present study aimed to determine the cardioprotective effect of Ganoderma atrum polysaccharide (PSG-1) in doxorubicin (DOX)-treated mice and its underlying mechanism. Results indicated that PSG-1 treatment significantly alleviated DOX-induced myocardial damage via attenuating apoptosis and maintaining the structure of myocardial mitochondria. Meanwhile, PSG-1-evoked cardioprotection was associated with an increase of manganese superoxide dismutase activity and decrease of caspases activities. Moreover, administration of PSG-1 suppressed DOX-induced mitochondrial disorders, which was evidenced by reducing reactive oxygen species, elevating mitochondrial membrane potential and inhibiting the opening of mitochondrial permeability transition pore. PSG-1 was also found to reduce the release of cytochrome c from mitochondria to cytoplasm in mice subjected to DOX. Finally, our findings have provided comprehensive evidence for the cardioprotective effects of PSG-1 via reduction of apoptosis mediated by modification of the mitochondrial intrinsic apoptotic pathway, indicating that PSG-1 could be developed as an effective therapeutic strategy to prevent DOX-induced cardiotoxicity in clinical settings.

    更新日期:2018-09-04
  • 更新日期:2018-09-03
  • Heparin as a molecular spacer immobilized on microspheres to improve blood compatibility in hemoperfusion
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-09-01
    Qi Dang, Chun-Gong Li, Xin-Xin Jin, Ya-Jin Zhao, Xiang Wang
    更新日期:2018-09-03
  • 更新日期:2018-09-03
  • 更新日期:2018-09-01
  • In vitro and in vivo evaluation of pirfenidone loaded acrylamide grafted pullulan-poly(vinyl alcohol) interpenetrating polymer networks
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-08-31
    Saundray Raj Soni, Nimmy Kumari, Bibhas K. Bhunia, Biswatrish Sarkar, Biman B. Mandal, Animesh Ghosh

    The aim of present study was to develop controlled release formulation of pirfenidone using acrylamide grafted pullulan. Interpenetrating polymer network (IPN) microspheres were prepared using acrylamide grafted pullulan and PVA utilizing glutaraldehyde assisted water-in-oil emulsion crosslinking method. IPN microspheres were characterized by FTIR, solid state 13C NMR and XRD spectroscopy. In vitro enzymatic degradation study showed 34.30 % degradation after 24 h with degradation rate constant of 0.0088 min-1. In vitro biocompatibility test showed no changes in cellular morphology and cell adherence to microspheres, indicating its biocompatible nature. The release exponent value of all formulations was less than 0.45, indicating the release mechanism to be Fickian diffusion. Finally, in vivo pharmacokinetic study showed longer Tmax (1.16 h) and greater AUC value (31754.83) as compared to Pirfenex® (Tmax = 0.5 h; AUC = 13039.45). The results indicated that the prepared formulation could successfully control the drug release for prolonged time period.

    更新日期:2018-09-01
  • Sulfated O-polysaccharide with anticancer activity from the marine bacterium Poseidonocella sedimentorum KMM 9023T
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-08-31
    Maxim S. Kokoulin, Alexandra S. Kuzmich, Lyudmila A. Romanenko, Ekaterina S. Menchinskaya, Valery V. Mikhailov, Oleg V. Chernikov

    The sulfated polysaccharides are of study interest due to their high structural diversity and broad spectrum of biological activity including antitumor properties. In this paper, we report on the structural analysis of sulfated O-specific polysaccharide (OPS) and in vitro anticancer activity of O-deacylated lipopolysaccharide (DPS) of the marine-derived bacterium Poseidonocella sedimentorum KMM 9023T achieved by a multidisciplinary approach (chemical analysis, NMR, MS, and bioassay). The OPS is shown to include two rare monosaccharide derivatives: 3-deoxy-9-O-methyl-D-glycero-D-galacto-non-2-ulosonic acid (Kdn9Me) and 3-O-acetyl-2-O-sulfate-D-glucuronic acid (D-GlcA2S3Ac). The structure of polysaccharide moiety of a previously unknown carbohydrate-containing biopolymer is established:→4)-α-Kdnp9Me-(2→4)-α-D-GlcpA2S3Ac-(1→.From a biological point of view, we demonstrate that DPS of the P. sedimentorum KMM 9023T has no cytotoxicity and inhibits colony formation of human HT-29, MCF-7 and SK-MEL-5 cells in a dose-dependent manner. The investigated polysaccharide is the second glycan isolated from the bacteria of the genus Poseidonocella: previously we studied the OPS of P. pacifica KMM 9010T (Kokoulin et al., 2017). Both polysaccharides are sulfated and contain rare residues of ulosonic acids. Thus, obtained findings provide a new knowledge about kinds and antitumor properties of sulfated polysaccharides and can be a starting point for further investigations of mechanisms of anticancer action of carbohydrate-containing biopolymers from marine Gram-negative bacteria.

    更新日期:2018-09-01
  • Electroactive polyaniline/silica hybrid gels: controllable sol-gel transition adjusted by chitosan derivatives
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-08-31
    Guan-Hai Wang, Li-Ming Zhang

    In this study, the electroactive hybrid gels with controllable sol-gel process were fabricated based on the water soluble polyaniline complex and water soluble silica precursor. β-cyclodextrin grafted on chitosan (CSCD) acted as a template, a new route for the synthesis of water soluble polyaniline complex (PA@CSCD) was designed by in-situ polymerization. Then, the hybrid silica gels without severe shrinkage were prepared by mixing PA@CSCD complex with water soluble precursor (tetrakis(2-hydroxyethyl)orthosilicates, THEOS). By dynamic rheological measurements, it was found that PA@CSCD complex could trigger and accelerate the sol-gel transition of the silica precursor. The gelation time could be largely shortened with the increase of PA@CSCD complex amount. By SEM observation, the PA@CSCD complex could be well compatible with the silica matrix. Moreover, the hybrid gels showed the good redox electroactivity, which could be successfully applied in a HRP-based biosensor.

    更新日期:2018-09-01
  • Bio-inspired consolidants derived from crystalline nanocellulose for decayed wood
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-08-31
    Roberta Basile, Laura Bergamonti, Federica Fernandez, Claudia Graiff, Azar Haghighi, Clelia Isca, Pier Paolo Lottici, Benedetto Pizzo, Giovanni Predieri

    Novel bio-inspired materials derived from crystalline nanocellulose (CNC) have been tested as wood consolidants. A suspension of CNC, produced by acid hydrolysis of cellulose and used as such or mixed with lignin and/or siloxane derivatives (PDMS), was applied on rotted wood samples of Norway spruce. X-Ray diffraction analysis on CNC powder showed high crystallinity index. Dynamic light scattering (DLS) measurement indicated a nearly uniform particle size distribution with an average hydrodynamic diameter for pure CNC smaller than that in the mixtures. Raman and FTIR spectroscopies suggested interactions between lignin, PDMS and CNC components.The storage modulus of wood samples, measured by Dynamic Mechanical Analysis on the same specimen before and after consolidation, confirmed the efficiency of pure CNC, which displayed a considerable improvement of stiffness. A substantial increase of E’ was observed particularly for most decayed classes. These results suggest a closer interaction between nanocellulose and decayed wood.

    更新日期:2018-09-01
  • Accurate molar masses of cellulose for the determination of degradation rates in complex paper samples
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-08-31
    Anne-Laurence Dupont, Denis Réau, Paul Bégin, Sabrina Paris-Lacombe, Jean Tétreault, Gérard Mortha
    更新日期:2018-09-01
  • Enhanced antibacterial profile of nanoparticle impregnated cellulose foam filter paper for drinking water filtration
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-08-30
    Shikha Jain, Gaurav Bhanjana, Solmaz Heydarifard, Neeraj Dilbaghi, Mousa M. Nazhad, Vanish Kumar, Ki-Hyun Kim, Sandeep Kumar

    Filtration is a promising water treatment method to purify drinking water. To develop highly efficient drinking water filter paper, water-resistant cellulose foam paper with a high wet strength property was fabricated using diverse metal oxide (e.g., copper oxide (CuO), zinc oxide (ZnO), and silver oxide (Ag2O)) nanoparticles. These nanoparticles were synthesized using the hydrothermal reaction method. Their morphological structures were studied using a field emission scanning electron microscope (FESEM). The presence of coated nanoparticles on the cellulose foam filter was verified by energy dispersive X-ray spectroscopy (EDX) methods. The antibacterial performance of different types of modified cellulose foam filters was studied against E. coli, P. aeruginosa, B. subtilis, and B. cereus strains using the zone of inhibition test. The antibacterial profile of the cellulose foam filter impregnated with Ag2O nanoparticles, when tested against different types of bacteria, exhibited higher antibacterial activity than the cellulose foam filter impregnated with ZnO and CuO nanoparticles.

    更新日期:2018-08-31
  • A Holistic Approach to Unravelling Chondroitin Sulfation: Correlations between Surface Charge, Structure and Binding to Growth Factors
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-08-30
    Raúl Benito-Arenas, Ernesto Doncel-Pérez, Mar Fernández-Gutiérrez, Leoncio Garrido, Eduardo García-Junceda, Julia Revuelta, Agatha Bastida, Alfonso Fernández-Mayoralas
    更新日期:2018-08-31
  • Preparation, characterization and in vitro evaluation of melatonin-loaded porous starch for enhanced bioavailability
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-08-30
    Yuanyuan Li, Xiuhua Zhao, Lingling Wang, Yanjie Liu, Weiwei Wu, Chen Zhong, Qian Zhang, Jianhang Yang

    The present work aimed to apply porous starch (PS) as carrier to improve the oral bioavailability of poorly soluble drug melatonin (MLT). The drug loading and encapsulation efficiency of MLT-loaded porous starch (MPS) were optimized. The characteristics of MPS were analyzed using scanning electron microscopy, Brunauer–Emmett–Teller surface area, Fourier–transform infrared spectroscopy, x-ray diffraction, differential scanning calorimetry and thermo gravimetric analysis. Most MLT transformed into their amorphous form in the PS pores. MPS showed higher MLT solubility and cumulative release rate compared with raw MLT in SGF and SIF. MPS exhibited a higher inhibition to DCFH–DA-oxidized peroxyl radicals at a lower EC50 than that of the raw MLT. Furthermore, the plasma concentrations of MLT and MPS reached a Cmax of 134.26 and 291.77 ng/mL at 15 and 20 min, respectively. The AUC0–360min of the formulated MPS-treated group was approximately 2.34-fold higher than that of raw MLT.

    更新日期:2018-08-31
  • 更新日期:2018-08-31
  • 更新日期:2018-08-31
  • Effects of weak-light stress during grain filling on the physicochemical properties of normal maize starch
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-08-29
    Kai Shi, Xiaotian Gu, Weiping Lu, Dalei Lu

    The grain development of normal maize in Southern China is affected by decreases in sunlight intensity over the period of mid-June to mid-July. This study examined the starch structure and function of four normal maize varieties that had been exposed to weak-light stress (50% light deprivation; ambient light conditions served as the control) during grain filling. In all tested varieties, light deprivation decreased the contents of starch and amylose, and increased the size of starch granules and the proportion of long chains in amylopectin. Shading increased the relative crystallinity and ordered-to-amorphous ratio of starch. Shading decreased the gelatinization and retrogradation enthalpies and pasting and gelatinization temperatures of starches but increased retrogradation percentage and pasting viscosities. In conclusion, weak-light stress during grain filling increases starch viscosity and retrogradation tendency and decreases thermal stability by reducing amylose content, increasing the sizes of starch granules and the proportion of long chains in amylopectin, and improving the relative crystallinity.

    更新日期:2018-08-30
  • Periodate oxidation of xylan-based hemicelluloses and its effect on their thermal properties
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-08-29
    Mikaela Börjesson, Anette Larsson, Gunnar Westman, Anna Ström

    Hemicellulose from pulp mill process water and crop residuals from food production often end up in waste streams or burnt for energy contribution. These waste products contain valuable biopolymers but lack many attributes needed for use in applications such as food and medical or consumer products. This study reports on an investigation of the periodate oxidation of hardwood xylan and arabinoxylan (AX) from wheat bran to produce materials with new functionalities. The study explores how to control the oxidation degree and describes structural differences between the two xylan-based polymers. For the xylan samples, the oxidation resulted in a lowering of the glass transition temperature (Tg), indicating a more flexible chain due to ring-opening of the xylan anhydro-sugar units. For the AX samples, the arabinose side-groups were instead oxidized, hindering oxidation on part of the xylose units, which resulted in a crosslinked network with an unchanged Tg but reduced intrinsic viscosity.

    更新日期:2018-08-30
  • 更新日期:2018-08-30
  • Preparation, characterization and functional evaluation of chitosan-based films with zein coatings produced by cold plasma
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-08-29
    Guiyun Chen, Fatma Ali, Shuang Dong, Zhonglin Yin, Shuhong Li, Ye Chen

    Chitosan-based films with zein coatings were prepared in order to modify the drug release properties. The adhesion of zein layers to the films was ensured via a cold plasma treatment. Using ciprofloxacin hydrochloride as model, the effect of cold plasma on the functional properties and structures was evaluated. The results suggest that the encapsulation efficiency, chemical composition and crystal type of ciprofloxacin hydrochloride in chitosan/drug films were not altered by cold plasma treatment, while the wettability and surface free energy displayed a notable increase. After being coated with zein, the chitosan interacted with the zein through hydrogen bonding and electrostatic interactions. The burst release phenomenon of the chitosan/drug films was prevented by the zein coating. Furthermore, the plasma treatment provided the coated film with a slower release rate within 24 h, from 72.8% to 49.3%. The enhanced coating thickness and the more compact interface structure were responsible for this improvement.

    更新日期:2018-08-30
  • A Mussel-inspired Approach towards Heparin-immobilized Cellulose Gel Beads for Selective Removal of Low Density Lipoprotein from Whole Blood
    Carbohydr. Polym. (IF 5.158) Pub Date : 2018-08-29
    Yupei Li, Mei Han, Yilin Wang, Qiang Liu, Weifeng Zhao, Su Baihai, Changsheng Zhao

    In this study, we report a mussel-inspired approach to fabricate heparin-immobilized cellulose (HeTaCe) gel beads with self-anticoagulative and biocompatible properties which can selectively remove low density lipoprotein (LDL) from whole blood directly. First, a phase inversion technique was applied to prepare cellulose gel beads. Then the as-prepared gel beads were dipped into a mixed solution of heparin and tannic acid in phosphate buffered saline (PBS, pH 8.5) to obtain HeTaCe gel beads. Blood compatibility experiments indicated that the HeTaCe gel beads could suppress complement activation as well as contact activation and prolong the clotting times to the upper detect limits (activated partial thromboplastin time >600 s and thrombin time >180 s) of the automated blood coagulation analyzer. An ideal adsorption capacity of LDL in vitro was achieved by the HeTaCe gel beads with an amount of 79.1 mg/g. Besides, dynamic column adsorption test further demonstrated a selective adsorption of LDL without a significant reduction of high density lipoprotein (HDL) in a simulative hemoperfusion system. It is believed that the HeTaCe gel beads will be quite appealing to future clinical practice aiming at lowering LDL and improving the outcomes of patients with high cardiovascular risk.

    更新日期:2018-08-30
Some contents have been Reproduced with permission of the American Chemical Society.
Some contents have been Reproduced by permission of The Royal Society of Chemistry.
化学 • 材料 期刊列表