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Organized assembly of chitosan into mechanically strong bio-composite by introducing a recombinant insect structural protein OfCPH-1 Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-12 Lei Chen, Fei Shao, Kaiwen Chen, Nan Wu, Bingbing Sun, Dan Ge, Guirong Wang, Huanan Wang, Qing Yang
Chitosan, known for its appealing biological properties in packaging and biomedical applications, faces challenges in achieving a well-organized crystalline structure for mechanical excellence under mild conditions. Herein, we propose a facile and mild bioengineering approach to induce organized assembly of amorphous chitosan into mechanically strong bio-composite via incorporating a genetically engineered
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Novel films of pectin extracted from ambarella fruit peel and jackfruit seed slimy sheath: Effect of ionic crosslinking on the properties of pectin film Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-12 Thuy Thi Thanh Nguyen, Hao Tan Ho, Quy Thi Dong Hoang, Quynh Anh Phan Nguyen, Thuan Van Tran
Here, we prepared ionically crosslinked films using pectin extracted from agro-wastes, specifically ambarella peels (AFP) and jackfruit seed slimy sheath (JFS). Physiochemical properties of pectins, including moisture content, molecular weight (Mw), degree of esterification (DE), and galacturonic acid (GA), were analyzed. Optimal extraction was determined, i.e., citric acid concentration 0.3 M, time
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Unraveling interplay between lignocellulosic structures caused by chemical pretreatments in enhancing enzymatic hydrolysis Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-12 Usama Shakeel, Yu Zhang, Evangelos Topakas, Wen Wang, Cuiyi Liang, Wei Qi
To investigate the interplay between substrate structure and enzymatic hydrolysis (EH) efficiency, poplar was pretreated with acidic sodium-chlorite (ASC), 3 % sodium-hydroxide (3-SH), and 3 % sulfuric acid (3-SA), resulting in different glucose yields of 94.10 %, 74.35 %, and 24.51 %, respectively, of pretreated residues. Residues were fractionated into cellulose, lignin and unhydrolyzed residue after
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Influence of carboxymethyl cellulose on the stability, rheology, and curcumin bioaccessibility of high internal phase Pickering emulsions Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-11 Wenjuan Wang, Suping Ji, Qiang Xia
Recently, there has been a focus on using biopolymer-based particles to stabilize high internal phase Pickering emulsions (HIPPEs) due to the notable advances in biocompatibility and biodegradability. In this work, the complex particles of peanut protein isolate and carboxymethyl cellulose (CMC) with various substitution degrees (DS; 0.7 and 0.9) and weight average molecular weights (Mw; 90, 250, and
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An ultrasound-triggered injectable sodium alginate scaffold loaded with electrospun microspheres for on-demand drug delivery to accelerate bone defect regeneration Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-11 Yin Yi, Jinlin Song, Pengfei Zhou, Yu Shu, Panpan Liang, Huimin Liang, Yanling Liu, Xiaoyan Yuan, Xujia Shan, Xiaohong Wu
Biological processes, such as bone defects healing are precisely controlled in both time and space. This spatiotemporal characteristic inspires novel therapeutic strategies. The sustained-release systems including hydrogels are commonly utilized in the treatment of bone defect; however, traditional hydrogels often release drugs at a consistent rate, lacking temporal precision. In this study, a hybrid
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Trends in polysaccharide-based hydrogels and their role in enhancing the bioavailability and bioactivity of phytocompounds Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-11 Claudiu-Augustin Ghiorghita, Ioana-Victoria Platon, Maria Marinela Lazar, Maria Valentina Dinu, Ana Clara Aprotosoaie
Over the years, polysaccharides such as chitosan, alginate, hyaluronic acid, k-carrageenan, xanthan gum, carboxymethyl cellulose, pectin, and starch, alone or in combination with proteins and/or synthetic polymers, have been used to engineer an extensive portfolio of hydrogels with remarkable features. The application of polysaccharide-based hydrogels has the potential to alleviate challenges related
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Biodegradable and flame-retardant cellulose-based wearable triboelectric nanogenerator for mechanical energy harvesting in firefighting clothing Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-11 Zhicai Yu, Zhenyu Zhu, Yingzi Zhang, Xiaoqian Li, Xin Liu, Yi Qin, Zhenrong Zheng, Lianyang Zhang, Hualing He
Integrating flexible triboelectric nanogenerators (TENGs) into firefighting clothing offers exciting opportunities for wearable portable electronics in personal protective technology. However, it is still a grand challenge to produce eco-friendly TENGs from biodegradable and low-cost natural polymers for mechanical-energy harvesting and self-powered sensing. Herein, conductive polypyrrole (PPy) and
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Protein-assisted synthesis of chitosan-coated minicells enhance dendritic cell recruitment for therapeutic immunomodulation within pulmonary tumors Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-08 Jing Feng, Yiting Liu, Xiaoran Zheng, Min Gao, Li Wang, Lígia R. Rodrigues, Yuting Wen, Hangcheng Pan, Gege Li, Longjiang Zhang, Bing Wan, Yunlei Zhang
The efficacy of cancer therapies is significantly compromised by the immunosuppressive tumor milieu. Herein, we introduce a previously unidentified therapeutic strategy that harnesses the synergistic potential of chitosan-coated bacterial vesicles and a targeted chemotherapeutic agent to activate dendritic cells, thereby reshaping the immunosuppressive milieu for enhanced cancer therapy. Our study
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Dynamically bonded cellulose nanocrystal hydrogels: Structure, rheology and fire prevention performance Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-08 Nazlınur Koparipek-Arslan, Elif Kaynak-Uraz, Erkan Senses
Flame retardant composite hydrogels offer many advantages over conventional flame retardants, such as high water-retention capacity, enhanced fire resistance, and mechanical tunability. Herein, we developed flame-retardant dynamic covalent hydrogels using wood-derived cellulose nanocrystals (CNCs) crosslinked with boronate ester bonds, addressing environmental and health issues associated with the
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From sea to sea: Edible, hydrostable, and degradable straws based on seaweed-derived insoluble cellulose fibers and soluble polysaccharides Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-08 Haojie Ni, Huatao Li, Wenna Hou, Jian Chen, Song Miao, Yanbo Wang, Huan Li
The widespread use of disposable plastic straws has caused a long-lasting environmental problem. Potential alternatives for plastic straws are far from satisfactory due to the low utility, poor water stability, and non-ideal natural degradability. In this work, an edible, hydrostable, and degradable straw was developed from the economically significant seaweed. Seaweed-derived insoluble cellulose fibers
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Effect of hemicellulose hydrolysate addition on the dehydration and redispersion characteristic of cellulose nanofibrils Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-08 Jungkyu Kim, Jonghwa Kim, Seungoh Jung, Heecheol Yun, Sungwook Won, In-Gyu Choi, Hyo Won Kwak
Nanocellulose, owing to its environmentally friendly and unique attributes, is gaining traction in various industries. However, commercialization of nanocellulose faces challenges due to structural alterations during drying process, leading to irreversible aggregation. This study, inspired by wood's natural structure, introduces a cellulose nanofibril (CNF) drying system using hemicellulose hydrolysate
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Biomimetic design of micro- and nano-wrinkle wood surface via coating reinforced with hyperbranched polymer grafted cellulose nanofibers for skin-tactile performance Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-08 Ru Liu, Yuhui Sun, Yingchun Sun, Hui Li, Minggui Chen, Ling Long, Jingya Gong, Bin Lv, Yonghao Ni
Inspired from human skin, micro- and nano-wrinkled wood surface with skin-tactile performance was designed and developed using a waterborne UV-curable polyurethane acrylate coating and cellulose nofibers (CNF). To further improve the properties, the CNF was diacetylated to D-CNF and further grafted with a hyperbranched polymer containing rich end amino groups (HB-CNF). The surface structure and chemical
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Processable Pickering emulsion for composite cryogel with cellulose nanofibrils and nanochitin Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-08 Rao Guo, Hao Li, Kunyang Liu, Haotian Xu, Kaiyue Wang, Zhaolin Yang, Yin Zhao, Siqi Huan, Chuanling Si, Chengyu Wang
Cryogels that are constructed with cellulose nanofibrils (CNF) are important as green materials for a wide range of applications. However, their utilization is limited by inherent hydrophilicity and insufficient mechanical properties. Herein, a processable CNF/nanochitin (NCh)-stabilized Pickering emulsion that contains polylactide (PLA) in the oil phase is developed to directly produce ternary composite
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Synthesis of β-cyclodextrin derivatives substituted at larger or smaller rims via amine-catalyzed ring-opening oligomerization of ε-caprolactone Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-07 Diana-Andreea Blaj, Mihaela Balan-Porcarasu, Valeria Harabagiu, Cristian Peptu
The involvement of cyclodextrins in transesterification reactions with active esters has been described to mimic enzyme-catalyzed reactions, making cyclodextrin molecules suitable as enzyme models. Cyclodextrin-catalyzed ring-opening of cyclic esters in bulk reaction conditions was considered to proceed similarly. However, the mechanism of activating cyclic esters through inclusion in the cyclodextrin
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Pre-dry heat treatment alters the structure and ultimate in vitro digestibility of wheat starch-lipids complex in hot-extrusion 3D printing Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-07 Bo Zheng, Zhipeng Qiu, Zipeng Liu, Ling Chen
Herein, we proposed dry heat treatment (DHT) as a pre-treatment method for modifying printed materials, with a particular focus on its application in the control of starch-lipid interactions during hot-extrusion 3D printing (HE-3DP). The results showed that pre-DHT could promote the complexation of wheat starch (WS) and oleic acid (OA)/corn oil (CO) during HE-3DP and thus increase the resistant starch
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Chitin nanofibrils assisted 3D printing all-chitin hydrogels for wound dressing Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-06 Yiran Zheng, Hao Zhang, Zhiwei Wang, Ang Lu, Aixi Yu, Bo Duan
The direct ink writing technique used in 3D printing technology is generally applied to designing biomedical hydrogels. Herein, we proposed a strategy for preparing all-chitin-based inks for wound dressing via direct ink writing technique. The β-chitin nanofibers (MACNF) with a high aspect ratio were applied as a nanofiller to modulate the rheological properties of the alkaline dissolved chitin solution
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Behavior of endo-xylanases on wheat milling products in relation with variable solid loading conditions Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-06 Allah Rakha, Loïc Foucat, Luc Saulnier, Estelle Bonnin
To investigate the incubation conditions encountered by enzymes in cereal-based product transformation processes, this study aims to provide comprehensive information on the effect of low (18 %) to high (72 %) solid loading on the behavior of bacterial and fungal xylanases towards wheat grain fractions, i.e. white flour, ground whole grain and bran. Both enzymes are effective from 30 % water content
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Formation of small-granule starch oleogels based on capillary force: Impact of starch surface lipids on lubrication performance Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-06 Chuanwu Han, Gaoshang Wang, Shouwei Yin, Guangxin Feng, Jinmei Wang, Jian Guo, Xiaoquan Yang
Starch granule oleogels were prepared and their rheological properties were precisely tuned using the capillary bridging phenomenon. The addition of a small amount of water to an oily suspension of starch granules can lead to starch granule bridging and network formation, transitioning it from a fluid-like to a gel-like state. Small-granule starches with high specific surface area and interfacial area
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Structural characterization of a galactoglucomannan with anti-neuroinflammatory activity from Ganoderma lucidum Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-06 Chao Cao, Yuechan Liao, Qian Yu, Dawei Zhang, Jiqi Huang, Yifan Su, Chunyan Yan
According to traditional Chinese medicine theory, () presents certain effects for nourishing nerves and calming the mind. polysaccharides (GLPs) have various biological activities; however, the structural characterization and the structure-activity relationship in anti-neuroinflammation of GLPs needs to be further investigated. In this work, the crude polysaccharide GL70 exhibited a remarkable impact
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Effects of different oil additives on water resistance of corn starch straws Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-06 Jinyu Zhang, Xueting Li, Kun Wang, Yu Zhu, Li Guo, Bo Cui, Lu Lu
To investigate the effect of oil additives on improving the water resistance of corn starch straws, corn oil (CO), soybean oil (SO), rapeseed oil (RO), peanut oil (PO), lard (LD) and coconut oil (CCO) were chosen and compared the structure and properties of starch straws with different oil additives. Corn starch straws (CS), and starch straws supplemented with CO, SO, RO, PO, LD and CCO were prepared
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Advances in porphyrins and chlorins associated with polysaccharides and polysaccharides-based materials for biomedical and pharmaceutical applications Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-06 Rafael F.N. Quadrado, Siara Silvestri, Jaqueline F. de Souza, Bernardo A. Iglesias, André R. Fajardo
Over the last decade, the convergence of advanced materials and innovative applications has fostered notable scientific progress within the biomedical and pharmaceutical fields. Porphyrins and their derivatives, distinguished by an extended conjugated π-electron system, have a relevant role in propelling these advancements, especially in drug delivery systems, photodynamic therapy, wound healing, and
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Role of microfibril angle in molecular deformation of cellulose fibrils in Pinus massoniana compression wood and opposite wood studied by in-situ WAXS Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-06 Fei Guo, Jiahao Wang, Wenxuan Liu, Jie Hu, Ye Chen, Xuexia Zhang, Rilong Yang, Yan Yu
Upon tensile stress, the spiral cellulose fibrils in wood cell walls rotate like springs with decreasing microfibril angle (MFA), and the cellulose molecules elongate in the chain direction. Compression wood with high MFA and opposite wood with low MFA were comparatively studied by tensile tests combined with synchrotron radiation WAXS in the present study. FTIR spectroscopy revealed that compression
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A tough and bioadhesive injectable hydrogel formed with maleimidyl alginate and pristine gelatin Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-05 Yin Chen, Baiqi Chen, Jianpei Dong, Deyu Yang, Hao Tang, Lan Wen, Jianshu Li, Lu Huang, Jianhua Zhou
Injectable hydrogels have wide applications in clinical practice. However, the development of tough and bioadhesive ones based on biopolymers, along with biofriendly and robust crosslinking strategies, still represents a great challenge. Herein, we report an injectable hydrogel composed of maleimidyl alginate and pristine gelatin, for which the precursor solutions could self-crosslink via mild Michael-type
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Conversion of chitosan and biomass fiber into recyclable superhydrophobic aerogel for efficient oil/water separation through a facile and green approach Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-05 Hongli Chen, Yuping Guo, Gang Liu
Developing high performance and recyclable sorbent through a facile, low-cost, and eco-friendly way is quite important for oily wastewater treatment. Among the various fabrication approaches developed so far, the one using biomass waste as starting materials is particularly attractive in view of the cost and environmental benignity. Herein, a magnetic chitosan/typha orientalis fibers aerogel (MCS/TOFs)
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Bio-formulated chitosan nanoparticles enhance disease resistance against rice blast by physiomorphic, transcriptional, and microbiome modulation of rice (Oryza sativa L.) Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-05 Rahila Hafeez, Junning Guo, Temoor Ahmed, Hubiao Jiang, Mubashar Raza, Muhammad Shahid, Ezzeldin Ibrahim, Yanli Wang, Jiaoyu Wang, Chengqi Yan, Qianli An, Jason C. White, Bin Li
Rice blast disease (RBD) caused by , threaten food security by cutting agricultural output. Nano agrochemicals are now perceived as sustainable, cost-effective alternatives to traditional pesticides. This study investigated bioformulation of moringa chitosan nanoparticles (M-CsNPs) and their mechanisms for suppressing RBD while minimizing toxic effects on the microenvironment. M-CsNPs, sized 46 nm
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Sulfated hyaluronic acid/collagen-based biomimetic hybrid nanofiber skin for diabetic wound healing: Development and preliminary evaluation Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-05 Yuanmeng Zhou, Weibin Jia, Jiexue Bi, Meng Liu, Liling Liu, Hang Zhou, Guofeng Gu, Zonggang Chen
Diabetic foot ulcers (DFUs) are one of the most serious and devastating complication of diabetes, manifesting as foot ulcers and impaired wound healing in patients with diabetes mellitus. To solve this problem, sulfated hyaluronic acid (SHA)/collagen-based nanofibrous biomimetic skins was developed and used to promote the diabetic wound healing and skin remodeling. First, SHA was successfully synthetized
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Effects of pectin methyl-esterification on intestinal microbiota and its immunomodulatory properties in naive mice Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-05 Hanna Steigerwald, Frank Blanco-Pérez, Andrea Macías-Camero, Melanie Albrecht, Melanie Huch, Caroline Bender, Stefan Schülke, Judith Keller, Maren Krause, Carol Barbas, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Masako Toda, Domingo Barber, Sabine Kulling, Mirko Bunzel, Stefan Vieths, Alma Villaseñor, Dominic Stoll, Stephan Scheurer
Pectins are dietary fibers that are attributed with several beneficial immunomodulatory effects. Depending on the degree of esterification (DE), pectins can be classified as high methoxyl pectin (HMP) or low methoxyl pectin (LMP).
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Recent updates on guar gum derivatives in colon specific drug delivery Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-05 Sreejan Manna, Sandip Karmakar, Olivia Sen, Puspita Sinha, Subrata Jana, Sougata Jana
Colon specific delivery of therapeutics have gained much attention of pharmaceutical researchers in the recent past. Colonic specific targeting of drugs is used not only for facilitating absorption of protein or peptide drugs, but also localization of therapeutic agents in colon to treat several colonic disorders. Among various biopolymers, guar gum (GG) exhibits pH dependent swelling, which allows
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Isolation, structural, biological activity and application of Gleditsia species seeds galactomannans Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-05 Jiaqi Sang, Gang Zhao, Anastasios Koidis, Xiaoqun Wei, Weijuan Huang, Zonglin Guo, Shaozong Wu, Riming Huang, Hongtao Lei
fruits have been known as a valuable traditional Chinese herb for tens of centuries. Previous studies showed that the galactomannans are considered as one of the major bioactive components in fruits seeds (GSGs). Here, we systematically review the major studies of GSGs in recent years to promote their better understanding. The extraction methods of GSGs mainly include hot water extraction, microwave-assisted
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Recent advances on biomedical applications of gellan gum: A review Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-04 Farnaz Lalebeigi, Amirmohamad Alimohamadi, Shahin Afarin, Hooman Aghamirza Moghim Aliabadi, Mohammad Mahdavi, Fatemeh Farahbakhshpour, Neginsadat Hashemiaval, Kimia Kalantari Khandani, Reza Eivazzadeh-Keihan, Ali Maleki
Gellan gum (GG) has attracted considerable attention as a versatile biopolymer with numerous potential biological applications, especially in the fields of tissue engineering, wound healing, and cargo delivery. Due to its distinctive characteristics like biocompatibility, biodegradability, nontoxicity, and gel-forming ability, GG is well-suited for these applications. This review focuses on recent
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Unraveling the molecular dynamics of sugammadex-rocuronium complexation: A blueprint for cyclodextrin drug design Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-04 Amelia Anderson, Rebeca García-Fandiño, Ángel Piñeiro, Matthew S. O'Connor
Sugammadex, marketed as Bridion™, is an approved cyclodextrin (CD) based drug for the reversal of neuromuscular blockade in adults undergoing surgery. Sugammadex forms an inclusion complex with the neuromuscular blocking agent (NMBA) rocuronium, allowing rapid reversal of muscle paralysis. In silico methods have been developed for studying CD inclusion complexes, aimed at accurately predicting their
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Bioinspired wet adhesive carboxymethyl cellulose-based hydrogel with rapid shape adaptability and antioxidant activity for diabetic wound repair Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-04 Hongxia Xie, Ge Shi, Ruizi Wang, Xueyu Jiang, Qianqian Chen, Aixi Yu, Ang Lu
Currently, adhesive hydrogels have shown promising effect in chronic diabetic wound repair. However, there are issues and challenges in treating diabetic wounds due to inadequate wet adhesion, unable to fill irregular and deep wounds, and oxidative stress. Herein, a mussel-inspired naturally hydrogel dressing with rapid shape adaptability, wet adhesion and antioxidant abilities for irregular, deep
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Strong, highly porous and sustainable nanocellulose foam made using bioderived hyperbranched crosslinker for thermal insulation and sound absorption Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-04 Dinesh, Bijender Kumar, Duc H. Pham, Jaehwan Kim
This paper reports an environment-friendly biobased foam made with cellulose nanofiber (CNF) and a biobased hyperbranched crosslinker, glycerol succinic anhydride (GSA). As a biobased hyperbranched crosslinker, carboxyl-terminated GSA is synthesized through a straightforward esterification process involving glycerol and succinic anhydride. The GSA-crosslinked CNF (GSA/CNF) foam is prepared using a
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In situ fabricated ZnO nanostructures within carboxymethyl cellulose-based ternary hydrogels for wound healing applications Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-04 Ramasubba Reddy Palem, Byoung Ju Kim, Inho Baek, Hyejong Choi, Maduru Suneetha, Ganesh Shimoga, Soo-Hong Lee
Zinc oxide nanostructures (ZnO NS) were fabricated in situ within a ternary hydrogel system composed of carboxymethyl cellulose-agarose-polyvinylpyrrolidone (CAP@ZnO TNCHs) by a one-pot method employing moist-heat solution casting. The percentages of CMC and ZnO NS were varied in the CAP hydrogel films and then they were investigated by different techniques, such as ATR/FTIR, TGA, XRD, XPS, and FE-SEM
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Boron nitride-alginate coordination interactions enabling hydrogels with enhanced mechanical strength and heat resistance Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-03 Wenjing Geng, Yaohui Xu, Chan Guo, Yuchen Liu, Xinxin Ye, Qiuwen Liu, Hui Zhang, Chen Fu, Fengguang Liu, Weiwei Lei, Liang Yuan, Cheng Chen
Developing large-scale hydrogels with high tensile strength and robust mechanical properties is an intricate challenge of great industrial significance. In this study, we demonstrate an efficient method for producing nanocomposite hydrogels with extraordinary mechanical properties. Our approach involves a two-step process: an initial stage of pre-cross-linking boron nitride (BN)-enriched pre-gel sodium
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Assessing high-temperature and pressure extraction of bioactive water-soluble polysaccharides from passion fruit mesocarp Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-02 Lucas de Freitas Pedrosa, Henk Schols, Paul de Vos, João Paulo Fabi
The mesocarp (albedo) of passion fruit is considered a waste product but rich in soluble fibers, especially pectins. Biological activity and health benefits of pectins have recently emerged, especially in colorectal cancer and attenuating inflammation. Pectin conventional extraction often uses mineral acids, which can be hazardous to the environment, and alternatives can be costly. Here, we assessed
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From production to performance: Tailoring moisture and oxygen barrier of cellulose nanomaterials for sustainable applications – A review Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-02 Bruno Las-Casas, Valdeir Arantes
Barrier materials are crucial in preserving product quality, safety and longevity across numerous applications, thereby contributing to sustainability, reducing waste and advancing technology. Among these materials, cellulose nanomaterials (CNs) have emerged as promising alternatives for traditional petroleum-based polymers. However, the wide range of sources and the different methods used to isolate
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Polymeric liposomes targeting dual transporters for highly efficient oral delivery of paclitaxel Carbohydr. Polym. (IF 11.2) Pub Date : 2024-03-01 YaBing Xing, XinJie Lian, YuRu Zhang, YuLu Zhang, XinHong Guo
A novel delivery system comprising -succinic anhydride (N-SAA) and D-fructose -conjugated chitosan (NSCF)-modified polymeric liposomes (NSCF-PLip) were designed to enhance oral delivery of paclitaxel (PTX) by targeting monocarboxylate transporters (MCT) and glucose transporters (GLUT). The synthesized NSCF was characterised by FT-IR and H NMR spectra. The prepared 30.78 % (degree of substitution of
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Impacts of monosaccharide composition on immunomodulation by cello-pentaose, manno-pentaose, and xylo-pentaose: Unraveling the underlying molecular mechanisms Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-29 Bin Bian, Xiaoxue Zhao, Xiaoyang Miao, Chenhuan Lai, Yanan Chen, Mengyi Zhou, Qiang Yong
Different types of functional oligosaccharides exhibit varying degrees of immune-enhancing effects, which might be attributable to differences in their glycosyl structures. The differences in the immunomodulatory action of three functional oligosaccharides with distinct glycosyl compositions: cello-oligosaccharides (COS), manno-oligosaccharides (MOS), and xylo-oligosaccharides (XOS), were investigated
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Structural characterization of a Chlorella heteropolysaccharide by analyzing its depolymerized product and finding an inducer of human dendritic cell maturation Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-29 Qingxia Yuan, Rongyi Liang, Kunling Lv, Xiaohuo Shi, Jing Leng, Yonghong Liu, Jian Xiao, Lifeng Zhang, Longyan Zhao
polysaccharides have been gaining increasing attention because of their high yield from dried powder and their remarkable immunomodulatory activity. In this study, the major polysaccharide fraction, CPP-3a, in , was isolated, and its detailed structure was investigated by analyzing the low-molecular-weight product prepared via free radical depolymerization. The results indicated that CPP-3a with a
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Design strategy for blends of biodegradable polyester and thermoplastic starch based on a molecular dynamics study of the phase-separated interface Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-29 Akihiro Yamaguchi, Satoshi Arai, Noriyoshi Arai
Molecular insight into the phase-separated interface formed when biodegradable polyesters and thermoplastic starch (TPS) are melt-blended is valuable for the design of composites. In this study, eight different interfaces combining four major biodegradable polyesters (PLA, PBS, PHB and PBAT) and two TPSs [unmodified TPS (nTPS) and citrate-modified TPS (cTPS)] were investigated by using molecular dynamics
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Unveiling the inverse antimicrobial impact of a hetero-chitooligosaccharide on Candida tropicalis growth and biofilm formation Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-28 Yangyang Liu, Ruilian Li, Yuchen Zhang, Siming Jiao, Tong Xu, Yuhang Zhou, Yujing Wang, Jinhua Wei, Wei Du, Morihisa Fujita, Yuguang Du, Zhuo A. Wang
Chitosan and chitooligosaccharide (COS) are renowned for their potent antimicrobial prowess, yet the precise antimicrobial efficacy of COS remains elusive due to scant structural information about the utilized saccharides. This study delves into the antimicrobial potential of COS, spotlighting a distinct hetero-chitooligosaccharide dubbed DACOS. In contrast to other COS, DACOS remarkably fosters the
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Structural elucidation and anti-psoriasis activity of a novel polysaccharide from Saussurea Costus Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-28 Xiaobao Gong, Zhipeng Zhang, Xiang Shi, Yurong Zhu, Fawad Ali, Yong Dong, Feng Zhang, Baoshun Zhang
PSCP, a novel water-soluble polysaccharide, was extracted from the root of and subsequently purified using DEAE-52 cellulose and Sephadax G-50 columns. The elucidation of its structure involved various techniques including HPGPC, FT-IR, HPLC-ELSD, GC–MS, NMR, AFM, and SEM. The results show that PSCP was a homogeneous heteropoly saccharide having molecular weight of 4131 Da and mainly composed of 1
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A supramolecular assembly of sulfobutyl ether-β-cyclodextrin and viologen calix[4]resorcinol as the master key to sustainable and eco-friendly catalyst for paraoxon hydrolysis Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-28 Yuliya Razuvaeva, Ruslan Kashapov, Albina Ziganshina, Nadezda Kashapova, Vadim Salnikov, Lucia Zakharova
The search for effective ways of paraoxon (POX) degradation becomes an extremely urgent problem, which can be solved by creating effective bioscavengers in the form of three-dimensional macrocycles. In this work, supramolecular interactions in an aqueous medium were studied between (4-sulfobutyl)-β-cyclodextrin, the hydrophobic cavity of which is capable of binding POX, and viologen calix[4]resorcinol
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Effects of particle properties, intermolecular forces, and molecular structure on the shear-thickening behavior of waxy starch dispersions Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-28 Xinyan Duan, Qiannan Liu, Ruixuan Zhao, Wei Liu, Liang Zhang, Honghai Hu
The shear-thickening phenomenon in waxy starch dispersions has been reported; however, the influence of starch properties on it remains unclear. Herein, the shear-thickening behavior of five waxy starch dispersions at different concentrations is investigated, and two shear-thickening areas are identified for the first time. Waxy potato and cassava starch dispersions present two shear-thickening areas
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Insights into the molecular mechanisms, structure-activity relationships and application prospects of polysaccharides by regulating Nrf2-mediated antioxidant response Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-27 Nuo Chen, Meifen Hu, Tingyue Jiang, Ping Xiao, Jin-ao Duan
The occurrence and development of many diseases are closely related to oxidative stress. In this context, accumulating evidence suggests that Nrf2, as the master switch of cellular antioxidant signaling, plays a central role in controlling the expression of antioxidant genes. The core molecular mechanism of polysaccharides treatment of oxidative stress-induced diseases is to activate Keap1/Nrf2/ARE
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Gluing blood into adhesive gel by oppositely charged polysaccharide dry powder inspired by fibrin fibers coagulation mediator Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-27 Yan Fang, Yukai Lin, Linyu Wang, Qinhui Chen, Yunxiang Weng, Haiqing Liu
Hemostatic powders that adapt to irregularly shaped wounds, allowing for easy application and stable storage, have gained popularity for first-aid hemorrhage control. However, traditional powders often provide weak thrombus support and exhibit limited tissue adhesion, making them susceptible to dislodgment by the bloodstream. Inspired by fibrin fibers coagulation mediator, we have developed a bi-component
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Preparation of an injectable and photocurable carboxymethyl cellulose/hydroxyapatite composite and its application in cranial regeneration Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-27 He Qiu, Jing Wang, Hong Hu, Lu Song, Zhanhong Liu, Yang Xu, Shuo Liu, Xiangdong Zhu, Hang Wang, Chongyun Bao, Hai Lin
Limited bone regeneration, uncontrollable degradation rate, mismatched defect zone and poor operability have plagued the reconstruction of irregular bone defect by tissue-engineered materials. A combination of biomimetic scaffolds with hydroxyapatite has gained great popularity in promoting bone regeneration. Therefore, we designed an injectable, photocurable and curing hydrogel by methacrylic anhydride
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Controllable acetylation of cellulose nanocrystal by uniform design and response surface methodology Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-27 Wenwen Li, Wanqing Li, Zhixin Xiong, Pudun Zhang
Acetylation of Cellulose nanocrystal (CNC) can reduce its surface polarity and therefore extends its application in biomedical and chemical fields. A method combining uniform design (UD) and response surface methodology (RSM) was developed to produce the acetylated CNC with arbitrary degree of substitution (DS) and crystallinity index (CrI). The effects of three factors (i.e., temperature, reaction
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Coordinated optimization of the polymerization and transportation processes to enhance the yield of exopolysaccharide heparosan Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-27 Shan Hu, Siyan Zhou, Yang Wang, Wuxia Chen, Guobin Yin, Jian Chen, Guocheng Du, Zhen Kang
Heparosan as the precursor for heparin biosynthesis has attracted intensive attention while Nissle 1917 (EcN) has been applied as a chassis for heparosan biosynthesis. Here, after uncovering the pivotal role of KfiB in heparosan biosynthesis, we further demonstrate KfiB is involved in facilitating KpsT to translocate the nascent heparosan polysaccharide chain. As a result, an artificial expression
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A rapid interactive chitosan-based medium with antioxidant and pro-vascularization properties for infected burn wound healing Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-27 Zhentao Li, Xianglong Xing, Chaoran Zhao, Qi Wu, Junjie Liu, Xiaozhong Qiu, Leyu Wang
Large-pore hydrogels are better suited to meet the management needs of nutrient transportation and gas exchange between infected burn wounds and normal tissues. However, better construction strategies are required to balance the pore size and mechanical strength of hydrogels to construct a faster substance/gas interaction medium between tissues. Herein, we developed spongy large pore size hydrogel
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Threading the needle: Achieving simplicity and performance in cellulose alkanoate ω-carboxyalkanoates for amorphous solid dispersion Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-27 Stella P. Petrova, Mennatallah A. Mohamed, Huiming Wu, Lynne S. Taylor, Kevin J. Edgar
Most active pharmaceutical ingredients (APIs) suffer from poor water solubility, often keeping them from reaching patients. To overcome the issues of poor drug solubility and subsequent low bioavailability, amorphous solid dispersions (ASDs) have garnered much attention. Cellulose ester derivatives are of interest for ASD applications as they are benign, sustainable-based, and successful in commercial
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Rational synthesis of a heparan sulfate saccharide that promotes the activity of BMP2 Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-25 Karl J. Shaffer, Raymond A.A. Smith, Alison M. Daines, Xiaoman Luo, Xiaohua Lu, Tuan Chun Tan, Bach Q. Le, Ralf Schwörer, Simon F.R. Hinkley, Peter C. Tyler, Victor Nurcombe, Simon M. Cool
Heparan sulfate (HS) is a glycosaminoglycan (GAG) found throughout nature and is involved in a wide range of functions including modulation of cell signalling via sequestration of growth factors. Current consensus is that the specificity of HS motifs for protein binding are individual for each protein. Given the structural complexity of HS the synthesis of libraries of these compounds to probe this
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Enhancing char formation of flame retardant epoxy composites: Onigiri-like ZIF-67 modification with carboxymethyl β-cyclodextrin crosslinking Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-25 Qianlong Li, Zhengde Han, Xiaoning Song, Ye-Tang Pan, Zhishuai Geng, Henri Vahabi, Vera Realinho, Rongjie Yang
To enhance char formation of flame retardant epoxy (EP) composites, carboxymethyl β-cyclodextrin (CM-β-CD) is employed as an etchant for or ZIF-67 derivatives. In the early stage, etching plays a dominant role. The mismatch in size between CM-β-CD opening and ZIF-67 pore leads to the stacking of carboxyl cobalt complexes on the shell. When the reaction time is prolonged, crosslinking occurs between
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Harnessing the potential of de-sulfated heparin for targeted drug delivery: A three-component approach exemplified by conjugation with galactose and paclitaxel Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-25 Jing Yang, Xiongyan Meng, Yong Rao, Xin Wang, Shuai Meng, Changcai Teng, Tiantian Sun, Chengli Zong
Heparin, an anticoagulant with a century-long history of use, has been investigated over the past decade as a potential drug delivery vehicle. Despite its safety and efficacy, its interactions with many proteins through specific sulfate patterns can complicate drug delivery by mediating diverse biological functions. Here, we present the synthesis of a three-component drug delivery system comprising
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Mechanical activation-enhanced metal-organic coordination strategy to fabricate high-performance starch/polyvinyl alcohol films by extrusion blowing Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-24 Hongrui Wu, Wanhe Li, Zirong Liang, Tao Gan, Huayu Hu, Zuqiang Huang, Yuben Qin, Yanjuan Zhang
The production of high-performance starch-based packaging films by extrusion blowing is challenging, ascribed to poor processability of the blend precursors. In this study, a new strategy of mechanical activation (MA)-enhanced metal-organic coordination was proposed to improve the processability of starch (St)/polyvinyl alcohol (PVA) blend precursor, with calcium acetate (CA) as a chelating agent and
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PFAS-free superhydrophobic chitosan coating for fabrics Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-24 Irene Tagliaro, Massimiliano Mariani, Raziyeh Akbari, Marco Contardi, Maria Summa, Francesco Saliu, Roberto Nisticò, Carlo Antonini
In view of health and environmental concerns, together with the upcoming restrictive regulations on - and polyfluoroalkyl substances (PFAS), less impactful materials must be explored for the hydrophobization of surfaces. Polysaccharides, and especially chitosan, are being explored for their desirable properties of film formation and ease of modification. We present a PFAS-free chitosan superhydrophobic
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Application of sodium sulfobutylether-β-cyclodextrin based on encapsulation Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-24 Jiaqi Huang, Xiaofeng Wang, Ting Huang, Yang Yang, Jiasheng Tu, Jian Zou, Huiying Yang, Rui Yang
Sodium Sulfobutylether-β-cyclodextrin (SBE-β-CD) is a derivative of β-cyclodextrin, characterized by its stereo structure, which closely resembles a truncated cone with a hydrophobic internal cavity. The solubility of insoluble substances within the hydrophobic cavity is significantly enhanced, reducing contact between the guest and the environment. Consequently, SBE-β-CD is frequently employed as
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An overview on mushroom polysaccharides: Health-promoting properties, prebiotic and gut microbiota modulation effects and structure-function correlation Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-24 Helena Araújo-Rodrigues, Ana Sofia Sousa, João Bettencourt Relvas, Freni K. Tavaria, Manuela Pintado
Mushroom polysaccharides are recognized as “biological response modifiers”. Besides several bioactivities, a growing interest in their prebiotic potential has been raised due to the gut microbiota modulation potential. This review comprehensively summarizes mushroom polysaccharides' biological properties, structure-function relationship, and underlying mechanisms. It provides a recent overview of the
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Structural elucidation and immunomodulatory activities in vitro of type I and II arabinogalactans from different origins of Astragalus membranaceus Carbohydr. Polym. (IF 11.2) Pub Date : 2024-02-24 Kaiping Wang, Yinxing Zhou, Mengqing Li, Zehong Chen, Zhijing Wu, Wenting Ji, Jinglin Wang, Yu Zhang
polysaccharide (APS) possesses excellent immunomodulatory activity. However, there are several studies on the structural characterization of APS. Here, we aimed to elucidate the repeating units of polysaccharides (APS1, 106.5 kDa; APS2, 114.5 kDa) obtained from different origins and further investigated their immunomodulatory activities. Based on structural analysis, types of the two polysaccharides