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Continuous germinal center invasion contributes to the diversity of the immune response Cell (IF 64.5) Pub Date : 2024-04-23 Thomas Hägglöf, Melissa Cipolla, Maximilian Loewe, Spencer T. Chen, Ervin E. Kara, Luka Mesin, Harald Hartweger, Mohamed A. ElTanbouly, Alice Cho, Anna Gazumyan, Victor Ramos, Leonidas Stamatatos, Thiago Y. Oliveira, Michel C. Nussenzweig, Charlotte Viant
No Abstract
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From periphery to center stage: 50 years of advancements in innate immunity Cell (IF 64.5) Pub Date : 2024-04-25 Susan Carpenter, Luke A.J. O’Neill
Over the past 50 years in the field of immunology, something of a Copernican revolution has happened. For a long time, immunologists were mainly concerned with what is termed adaptive immunity, which involves the exquisitely specific activities of lymphocytes. But the other arm of immunity, so-called “innate immunity,” had been neglected. To celebrate Cell’s 50th anniversary, we have put together a
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Principles and therapeutic applications of adaptive immunity Cell (IF 64.5) Pub Date : 2024-04-25 Hongbo Chi, Marion Pepper, Paul G. Thomas
Adaptive immunity provides protection against infectious and malignant diseases. These effects are mediated by lymphocytes that sense and respond with targeted precision to perturbations induced by pathogens and tissue damage. Here, we review key principles underlying adaptive immunity orchestrated by distinct T cell and B cell populations and their extensions to disease therapies. We discuss the intracellular
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Exploring new perspectives in immunology Cell (IF 64.5) Pub Date : 2024-04-25 Ruslan Medzhitov, Akiko Iwasaki
Several conceptual pillars form the foundation of modern immunology, including the clonal selection theory, antigen receptor diversity, immune memory, and innate control of adaptive immunity. However, some immunological phenomena cannot be explained by the current framework. Thus, we still do not know how to design vaccines that would provide long-lasting protective immunity against certain pathogens
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The plant immune system: From discovery to deployment Cell (IF 64.5) Pub Date : 2024-04-25 Jonathan D.G. Jones, Brian J. Staskawicz, Jeffery L. Dangl
Plant diseases cause famines, drive human migration, and present challenges to agricultural sustainability as pathogen ranges shift under climate change. Plant breeders discovered Mendelian genetic loci conferring disease resistance to specific pathogen isolates over 100 years ago. Subsequent breeding for disease resistance underpins modern agriculture and, along with the emergence and focus on model
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Many paths lead to immunology Cell (IF 64.5) Pub Date : 2024-04-25 Ana J. García-Sáez, Ana I. Domingos, J. Silvio Gutkind, Seema Mattoo, Peng Du
While some people pore over the textbook and train through the classics of the field, many scientists come to immunology when they discover it intersecting with their “first love” interests. Five of these “accidental immunologists” tell us how they found their way to a fascination with the immune system.
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A glycolytic metabolite that drives BRCA2 haploinsufficiency Cell (IF 64.5) Pub Date : 2024-04-25 Peng Jiang
Many types of tumor cells alter metabolic pathways to meet their energy and biosynthetic demands for proliferation or stress adaptation. In this issue of Cell, Kong et al. find that the glycolytic metabolite methylglyoxal causes cancer-associated mutant single-base substitution features by inducing BRCA2 proteolysis, leading to functional haploinsufficiency of BRCA2.
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Mapping the pancancer metastasis tumor microbiome Cell (IF 64.5) Pub Date : 2024-04-25 Chi Chun Wong, Jun Yu
The landscape of the intratumoral microbiome in tumor metastases is largely unchartered. In this issue of Cell, Voest et al. profiled the tumor metastasis-associated microbiome in a pancancer cohort of 4,160 biopsies from 26 cancer types. This dataset offers a useful resource for understanding the role of the microbiome in metastatic cancers.
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Generation of rat forebrain tissues in mice Cell (IF 64.5) Pub Date : 2024-04-25 Jia Huang, Bingbing He, Xiali Yang, Xin Long, Yinghui Wei, Leijie Li, Min Tang, Yanxia Gao, Yuan Fang, Wenqin Ying, Zikang Wang, Chao Li, Yingsi Zhou, Shuaishuai Li, Linyu Shi, Seungwon Choi, Haibo Zhou, Fan Guo, Hui Yang, Jun Wu
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Functional sensory circuits built from neurons of two species Cell (IF 64.5) Pub Date : 2024-04-25 Benjamin T. Throesch, Muhammad Khadeesh bin Imtiaz, Rodrigo Muñoz-Castañeda, Masahiro Sakurai, Andrea L. Hartzell, Kiely N. James, Alberto R. Rodriguez, Greg Martin, Giordano Lippi, Sergey Kupriyanov, Zhuhao Wu, Pavel Osten, Juan Carlos Izpisua Belmonte, Jun Wu, Kristin K. Baldwin
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Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB Cell (IF 64.5) Pub Date : 2024-04-25 Benjamin L. Lampson, Ana S. Ramίrez, Marta Baro, Lixia He, Mudra Hegde, Vidyasagar Koduri, Jamie L. Pfaff, Ruth E. Hanna, Julia Kowal, Nitin H. Shirole, Yanfeng He, John G. Doench, Joseph N. Contessa, Kaspar P. Locher, William G. Kaelin
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Synthetic protein circuits for programmable control of mammalian cell death Cell (IF 64.5) Pub Date : 2024-04-23 Shiyu Xia, Andrew C. Lu, Victoria Tobin, Kaiwen Luo, Lukas Moeller, D. Judy Shon, Rongrong Du, James M. Linton, Margaret Sui, Felix Horns, Michael B. Elowitz
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IGSF8 is an innate immune checkpoint and cancer immunotherapy target Cell (IF 64.5) Pub Date : 2024-04-23 Yulong Li, Xiangyang Wu, Caibin Sheng, Hailing Liu, Huizhu Liu, Yixuan Tang, Chao Liu, Qingyang Ding, Bin Xie, Xi Xiao, Rongbin Zheng, Quan Yu, Zengdan Guo, Jian Ma, Jin Wang, Jinghong Gao, Mei Tian, Wei Wang, Jia Zhou, Li Jiang, Tengfei Xiao
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3D reconstruction of a gastrulating human embryo Cell (IF 64.5) Pub Date : 2024-04-23 Zhenyu Xiao, Lina Cui, Yang Yuan, Nannan He, Xinwei Xie, Sirui Lin, Xiaolong Yang, Xin Zhang, Peifu Shi, Zhifeng Wei, Yang Li, Hongmei Wang, Xiaoyan Wang, Yulei Wei, Jingtao Guo, Leqian Yu
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Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program Cell (IF 64.5) Pub Date : 2024-04-23 Longfei Gao, Heather Lee, Joshua H. Goodman, Lei Ding
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DrugMap: A quantitative pan-cancer analysis of cysteine ligandability Cell (IF 64.5) Pub Date : 2024-04-22 Mariko Takahashi, Harrison B. Chong, Siwen Zhang, Tzu-Yi Yang, Matthew J. Lazarov, Stefan Harry, Michelle Maynard, Brendan Hilbert, Ryan D. White, Heather E. Murrey, Chih-Chiang Tsou, Kira Vordermark, Jonathan Assaad, Magdy Gohar, Benedikt R. Dürr, Marianne Richter, Himani Patel, Gregory Kryukov, Natasja Brooijmans, Aliyu Sidi Omar Alghali, Liron Bar-Peled
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Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway Cell (IF 64.5) Pub Date : 2024-04-22 Qixing Nie, Xi Luo, Kai Wang, Yong Ding, Shumi Jia, Qixiang Zhao, Meng Li, Jinxin Zhang, Yingying Zhuo, Jun Lin, Chenghao Guo, Zhiwei Zhang, Huiying Liu, Guangyi Zeng, Jie You, Lulu Sun, Hua Lu, Ming Ma, Yanxing Jia, Ming-Hua Zheng, Changtao Jiang
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Integrative spatial analysis reveals a multi-layered organization of glioblastoma Cell (IF 64.5) Pub Date : 2024-04-22 Alissa C. Greenwald, Noam Galili Darnell, Rouven Hoefflin, Dor Simkin, Christopher W. Mount, L. Nicolas Gonzalez Castro, Yotam Harnik, Sydney Dumont, Dana Hirsch, Masashi Nomura, Tom Talpir, Merav Kedmi, Inna Goliand, Gioele Medici, Julie Laffy, Baoguo Li, Vamsi Mangena, Hadas Keren-Shaul, Michael Weller, Yoseph Addadi, Marian C. Neidert, Mario L. Suvà, Itay Tirosh
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Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses Cell (IF 64.5) Pub Date : 2024-04-22 Jordan A. Hartmann, Marcella R. Cardoso, Maria Cecilia Ramiro Talarico, Devin J. Kenney, Madison R. Leone, Dagny C. Reese, Jacquelyn Turcinovic, Aoife K. O’Connell, Hans P. Gertje, Caitlin Marino, Pedro E. Ojeda, Erich V. De Paula, Fernanda A. Orsi, Licio Augusto Velloso, Thomas R. Cafiero, John H. Connor, Alexander Ploss, Angelique Hoelzemer, Mary Carrington, Amy K. Barczak, Wilfredo F. Garcia-Beltran
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Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis Cell (IF 64.5) Pub Date : 2024-04-22 Zhi Zong, Feng Xie, Shuai Wang, Xiaojin Wu, Zhenyu Zhang, Bing Yang, Fangfang Zhou
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BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis Cell (IF 64.5) Pub Date : 2024-04-22 Anthony R.P. Verkerke, Dandan Wang, Naofumi Yoshida, Zachary H. Taxin, Xu Shi, Shuning Zheng, Yuka Li, Christopher Auger, Satoshi Oikawa, Jin-Seon Yook, Melia Granath-Panelo, Wentao He, Guo-Fang Zhang, Mami Matsushita, Masayuki Saito, Robert E. Gerszten, Evanna L. Mills, Alexander S. Banks, Yasushi Ishihama, Phillip J. White, Shingo Kajimura
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Dual-role transcription factors stabilize intermediate expression levels Cell (IF 64.5) Pub Date : 2024-04-16 Jinnan He, Xiangru Huo, Gaofeng Pei, Zeran Jia, Yiming Yan, Jiawei Yu, Haozhi Qu, Yunxin Xie, Junsong Yuan, Yuan Zheng, Yanyan Hu, Minglei Shi, Kaiqiang You, Tingting Li, Tianhua Ma, Michael Q. Zhang, Sheng Ding, Pilong Li, Yinqing Li
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Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties Cell (IF 64.5) Pub Date : 2024-04-15 Gabriela Prus, Shankha Satpathy, Brian T. Weinert, Takeo Narita, Chunaram Choudhary
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Creating connections when we talk about science Cell (IF 64.5) Pub Date : 2024-04-15
For Cell’s 50th anniversary Focus on Immunology, scientific editor Cheri Sirois asked science communicator Liz Neeley, founding partner of Liminal and cofounder of Solving for Science, to discuss strategies for tackling technical complexity and for engaging effectively with broad audiences. A lightly edited transcript of their conversation is shared here.
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Direct observation of a condensate effect on super-enhancer controlled gene bursting Cell (IF 64.5) Pub Date : 2024-04-12 Manyu Du, Simon Hendrik Stitzinger, Jan-Hendrik Spille, Won-Ki Cho, Choongman Lee, Mohammed Hijaz, Andrea Quintana, Ibrahim I. Cissé
Abstract not available
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RNA genome packaging and capsid assembly of bluetongue virus visualized in host cells Cell (IF 64.5) Pub Date : 2024-04-12 Xian Xia, Po-Yu Sung, Michael W. Martynowycz, Tamir Gonen, Polly Roy, Z. Hong Zhou
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ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion Cell (IF 64.5) Pub Date : 2024-04-12 Shouyan Deng, Yibo Zhang, Huanbin Wang, Wenhua Liang, Lu Xie, Ning Li, Yuan Fang, Yiting Wang, Jiayang Liu, Hao Chi, Yufan Sun, Rui Ye, Lishen Shan, Jiawei Shi, Zan Shen, Yonggang Wang, Shuhang Wang, Jean-Philippe Brosseau, Feng Wang, Grace Liu, Jie Xu
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NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks Cell (IF 64.5) Pub Date : 2024-04-12 Liron David, Jazlyn P. Borges, L. Robert Hollingsworth, Allen Volchuk, Isabelle Jansen, Evelyn Garlick, Benjamin E. Steinberg, Hao Wu
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Ending “domestic helicopter research” Cell (IF 64.5) Pub Date : 2024-04-11 W. Marcus Lambert, Marlene Camacho-Rivera, Carla Boutin-Foster, Moro Salifu, Wayne J. Riley
“Helicopter research” refers to a practice where researchers from wealthier countries conduct studies in lower-income countries with little involvement of local researchers or community members. This practice also occurs domestically. In this Commentary, we outline strategies to curb domestic helicopter research and to foster equity-centered collaborations.
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Problem choice and decision trees in science and engineering Cell (IF 64.5) Pub Date : 2024-04-11 Michael A. Fischbach
Scientists and engineers often spend days choosing a problem and years solving it. This imbalance limits impact. Here, we offer a framework for problem choice: prompts for ideation, guidelines for evaluating impact and likelihood of success, the importance of fixing one parameter at a time, and opportunities afforded by failure.
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Self-amplifying RNA COVID-19 vaccine Cell (IF 64.5) Pub Date : 2024-04-11 Christopher J. Wayne, Anna K. Blakney
In November 2023, Japan’s Ministry of Health, Labour and Welfare granted regulatory approval of ARCT-154, a self-amplifying RNA COVID-19 vaccine developed by Arcturus Therapeutics. Clinical trials showed comparable safety and efficacy using a lower dose compared to the mRNA vaccine BNT162b2. To view this Bench-to-Bedside, open or download the PDF.
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Elliott Dan Kieff, MD, PhD (1943–2024) Cell (IF 64.5) Pub Date : 2024-04-11 Nancy Raab-Traub, Benjamin E. Gewurz
Abstract not available
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Chromatin context-dependent regulation and epigenetic manipulation of prime editing Cell (IF 64.5) Pub Date : 2024-04-11 Xiaoyi Li, Wei Chen, Beth K. Martin, Diego Calderon, Choli Lee, Junhong Choi, Florence M. Chardon, Troy A. McDiarmid, Riza M. Daza, Haedong Kim, Jean-Benoît Lalanne, Jenny F. Nathans, David S. Lee, Jay Shendure
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A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2 Cell (IF 64.5) Pub Date : 2024-04-11 Li Ren Kong, Komal Gupta, Andy Jialun Wu, David Perera, Roland Ivanyi-Nagy, Syed Moiz Ahmed, Tuan Zea Tan, Shawn Lu-Wen Tan, Alessandra Fuddin, Elayanambi Sundaramoorthy, Grace Shiqing Goh, Regina Tong Xin Wong, Ana S.H. Costa, Callum Oddy, Hannan Wong, C. Pawan K. Patro, Yun Suen Kho, Xiao Zi Huang, Joan Choo, Mona Shehata, Ashok R. Venkitaraman
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Time-series reconstruction of the molecular architecture of human centriole assembly Cell (IF 64.5) Pub Date : 2024-04-10 Marine H. Laporte, Davide Gambarotto, Éloïse Bertiaux, Lorène Bournonville, Vincent Louvel, José M. Nunes, Susanne Borgers, Virginie Hamel, Paul Guichard
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A pan-cancer analysis of the microbiome in metastatic cancer Cell (IF 64.5) Pub Date : 2024-04-09 Thomas W. Battaglia, Iris L. Mimpen, Joleen J.H. Traets, Arne van Hoeck, Laurien J. Zeverijn, Birgit S. Geurts, Gijs F. de Wit, Michaël Noë, Ingrid Hofland, Joris L. Vos, Sten Cornelissen, Maartje Alkemade, Annegien Broeks, Charlotte L. Zuur, Edwin Cuppen, Lodewyk Wessels, Joris van de Haar, Emile Voest
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A genome-wide spectrum of tandem repeat expansions in 338,963 humans Cell (IF 64.5) Pub Date : 2024-04-05 Ya Cui, Wenbin Ye, Jason Sheng Li, Jingyi Jessica Li, Eric Vilain, Tamer Sallam, Wei Li
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Human iPSC 4R tauopathy model uncovers modifiers of tau propagation Cell (IF 64.5) Pub Date : 2024-04-05 Celeste Parra Bravo, Alice Maria Giani, Jesus Madero Perez, Zeping Zhao, Yuansong Wan, Avi J. Samelson, Man Ying Wong, Alessandro Evangelisti, Ethan Cordes, Li Fan, Pearly Ye, Daphne Zhu, Tatyana Pozner, Maria Mercedes, Tark Patel, Allan Yarahmady, Gillian K. Carling, Fredrik H. Sterky, Virginia M.Y. Lee, Edward B. Lee, Li Gan
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Tracing the origin of alveolar stem cells in lung repair and regeneration Cell (IF 64.5) Pub Date : 2024-04-04 Kuo Liu, Xinfeng Meng, Zixin Liu, Muxue Tang, Zan Lv, Xiuzhen Huang, Hengwei Jin, Ximeng Han, Xiuxiu Liu, Wenjuan Pu, Huan Zhu, Bin Zhou
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Infant microbes and metabolites point to childhood neurodevelopmental disorders Cell (IF 64.5) Pub Date : 2024-04-03 Angelica P. Ahrens, Tuulia Hyötyläinen, Joseph R. Petrone, Kajsa Igelström, Christian D. George, Timothy J. Garrett, Matej Orešič, Eric W. Triplett, Johnny Ludvigsson
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Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria Cell (IF 64.5) Pub Date : 2024-04-02 Chenhao Li, Martin Stražar, Ahmed M.T. Mohamed, Julian A. Pacheco, Rebecca L. Walker, Tina Lebar, Shijie Zhao, Julia Lockart, Andrea Dame, Kumar Thurimella, Sarah Jeanfavre, Eric M. Brown, Qi Yan Ang, Brittany Berdy, Dallis Sergio, Rachele Invernizzi, Antonio Tinoco, Gleb Pishchany, Ramachandran S. Vasan, Emily Balskus, Ramnik J. Xavier
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Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling Cell (IF 64.5) Pub Date : 2024-04-02 Paolo Cadinu, Kisha N. Sivanathan, Aditya Misra, Rosalind J. Xu, Davide Mangani, Evan Yang, Joseph M. Rone, Katherine Tooley, Yoon-Chul Kye, Lloyd Bod, Ludwig Geistlinger, Tyrone Lee, Randall T. Mertens, Noriaki Ono, Gang Wang, Liliana Sanmarco, Francisco J. Quintana, Ana C. Anderson, Vijay K. Kuchroo, Jeffrey R. Moffitt, Roni Nowarski
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Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells Cell (IF 64.5) Pub Date : 2024-04-01 Tianyu Cao, Wenyao Zhang, Qi Wang, Chen Wang, Wanqi Ma, Cangang Zhang, Minghui Ge, Miaomiao Tian, Jia Yu, Anjun Jiao, Liang Wang, Manjiao Liu, Pei Wang, Zhiyu Guo, Yun Zhou, Shuyi Chen, Wen Yin, Jing Yi, Hao Guo, Hua Han, Xiaodi Zhao
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Barcoding of episodic memories in the hippocampus of a food-caching bird Cell (IF 64.5) Pub Date : 2024-03-29 Selmaan N. Chettih, Emily L. Mackevicius, Stephanie Hale, Dmitriy Aronov
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The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity Cell (IF 64.5) Pub Date : 2024-03-29 Vidhya Krishnamoorthy, Martina Foglizzo, Robert L. Dilley, Angela Wu, Arindam Datta, Parul Dutta, Lisa J. Campbell, Oksana Degtjarik, Laura J. Musgrove, Antonio N. Calabrese, Elton Zeqiraj, Roger A. Greenberg
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Embracing cancer complexity: Hallmarks of systemic disease Cell (IF 64.5) Pub Date : 2024-03-28 Charles Swanton, Elsa Bernard, Chris Abbosh, Fabrice André, Johan Auwerx, Allan Balmain, Dafna Bar-Sagi, René Bernards, Susan Bullman, James DeGregori, Catherine Elliott, Ayelet Erez, Gerard Evan, Mark A. Febbraio, Andrés Hidalgo, Mariam Jamal-Hanjani, Johanna A. Joyce, Matthew Kaiser, Katja Lamia, Jason W. Locasale, Sherene Loi, Ilaria Malanchi, Miriam Merad, Kathryn Musgrave, Ketan J. Patel, Sergio
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Mastigoneme structure reveals insights into the O-linked glycosylation code of native hydroxyproline-rich helices Cell (IF 64.5) Pub Date : 2024-03-28 Jin Dai, Meisheng Ma, Qingwei Niu, Robyn J. Eisert, Xiangli Wang, Poulomi Das, Karl F. Lechtreck, Susan K. Dutcher, Rui Zhang, Alan Brown
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Challenges and opportunities in oncology drug development and clinical research in China Cell (IF 64.5) Pub Date : 2024-03-28 Feng Wang, Dan-Yun Ruan, Rui-Hua Xu
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Unraveling cellular complexity with transient adapters in highly multiplexed super-resolution imaging Cell (IF 64.5) Pub Date : 2024-03-28 Florian Schueder, Felix Rivera-Molina, Maohan Su, Zach Marin, Phylicia Kidd, James E. Rothman, Derek Toomre, Joerg Bewersdorf
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Structure-guided discovery of protein and glycan components in native mastigonemes Cell (IF 64.5) Pub Date : 2024-03-28 Junhao Huang, Hui Tao, Jikun Chen, Yang Shen, Jianlin Lei, Junmin Pan, Chuangye Yan, Nieng Yan
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Spatial proteomics in neurons at single-protein resolution Cell (IF 64.5) Pub Date : 2024-03-28 Eduard M. Unterauer, Sayedali Shetab Boushehri, Kristina Jevdokimenko, Luciano A. Masullo, Mahipal Ganji, Shama Sograte-Idrissi, Rafal Kowalewski, Sebastian Strauss, Susanne C.M. Reinhardt, Ana Perovic, Carsten Marr, Felipe Opazo, Eugenio F. Fornasiero, Ralf Jungmann
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Only the beginning: 50 years of progress toward curing childhood cancer Cell (IF 64.5) Pub Date : 2024-03-28 Lia Gore, Maureen M. O’Brien
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Cancer biomarkers: Emerging trends and clinical implications for personalized treatment Cell (IF 64.5) Pub Date : 2024-03-28 Antonio Passaro, Maise Al Bakir, Emily G. Hamilton, Maximilian Diehn, Fabrice André, Sinchita Roy-Chowdhuri, Giannis Mountzios, Ignacio I. Wistuba, Charles Swanton, Solange Peters
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It took a long, long time: Ras and the race to cure cancer Cell (IF 64.5) Pub Date : 2024-03-28 Robert A. Weinberg
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Flexible scaffold-based cheminformatics approach for polypharmacological drug design Cell (IF 64.5) Pub Date : 2024-03-28 Zhangcheng Chen, Jing Yu, Huan Wang, Peiyu Xu, Luyu Fan, Fengxiu Sun, Sijie Huang, Pei Zhang, He Huang, Shuo Gu, Bowen Zhang, Yue Zhou, Xiaobo Wan, Gang Pei, H. Eric Xu, Jianjun Cheng, Sheng Wang
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Generating and using real-world data: A worthwhile uphill battle Cell (IF 64.5) Pub Date : 2024-03-28 K. Verkerk, E.E. Voest
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Short-distance vesicle transport via phase separation Cell (IF 64.5) Pub Date : 2024-03-28 Hua Qiu, Xiandeng Wu, Xiaoli Ma, Shulin Li, Qixu Cai, Marcelo Ganzella, Liang Ge, Hong Zhang, Mingjie Zhang