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The myriad ways to engineer cells Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-04-23
The widening range of strategies to alter the phenotypes and functions of mammalian cells is a boon for their biomedical applications.
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Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-04-19 DaeYong Lee, Kristin Huntoon, Yifan Wang, Minjeong Kang, Yifei Lu, Seong Dong Jeong, Todd M. Link, Thomas D. Gallup, Yaqing Qie, Xuefeng Li, Shiyan Dong, Benjamin R. Schrank, Adam J. Grippin, Abin Antony, JongHoon Ha, Mengyu Chang, Yi An, Liang Wang, Dadi Jiang, Jing Li, Albert C. Koong, John A. Tainer, Wen Jiang, Betty Y. S. Kim
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Histopathological biomarkers for predicting the tumour accumulation of nanomedicines Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-04-08 Jan-Niklas May, Jennifer I. Moss, Florian Mueller, Susanne K. Golombek, Ilaria Biancacci, Larissa Rizzo, Asmaa Said Elshafei, Felix Gremse, Robert Pola, Michal Pechar, Tomáš Etrych, Svea Becker, Christian Trautwein, Roman D. Bülow, Peter Boor, Ruth Knuechel, Saskia von Stillfried, Gert Storm, Sanyogitta Puri, Simon T. Barry, Volkmar Schulz, Fabian Kiessling, Marianne B. Ashford, Twan Lammers
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A serine-conjugated butyrate prodrug with high oral bioavailability suppresses autoimmune arthritis and neuroinflammation in mice Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-04-01 Shijie Cao, Erica Budina, Michal M. Raczy, Ani Solanki, Mindy Nguyen, Taryn N. Beckman, Joseph W. Reda, Kevin Hultgren, Phillip S. Ang, Anna J. Slezak, Lauren A. Hesser, Aaron T. Alpar, Kirsten C. Refvik, Lucas S. Shores, Ishita Pillai, Rachel P. Wallace, Arjun Dhar, Elyse A. Watkins, Jeffrey A. Hubbell
Butyrate—a metabolite produced by commensal bacteria—has been extensively studied for its immunomodulatory effects on immune cells, including regulatory T cells, macrophages and dendritic cells. However, the development of butyrate as a drug has been hindered by butyrate’s poor oral bioavailability, owing to its rapid metabolism in the gut, its low potency (hence, necessitating high dosing), and its
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Mesenchymal stromal cells with chimaeric antigen receptors for enhanced immunosuppression Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-04-01 Olivia Sirpilla, R. Leo Sakemura, Mehrdad Hefazi, Truc N. Huynh, Ismail Can, James H. Girsch, Erin E. Tapper, Michelle J. Cox, Kendall J. Schick, Claudia Manriquez-Roman, Kun Yun, Carli M. Stewart, Ekene J. Ogbodo, Brooke L. Kimball, Long K. Mai, Omar L. Gutierrez-Ruiz, Makena L. Rodriguez, Martina Gluscevic, Daniel P. Larson, Alex M. Abel, Wesley A. Wierson, Gloria Olivier, Elizabeth L. Siegler, Saad
Allogeneic mesenchymal stromal cells (MSCs) are a safe treatment option for many disorders of the immune system. However, clinical trials using MSCs have shown inconsistent therapeutic efficacy, mostly owing to MSCs providing insufficient immunosuppression in target tissues. Here we show that antigen-specific immunosuppression can be enhanced by genetically modifying MSCs with chimaeric antigen receptors
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Targeting the PIEZO1 pathway boosts T cell antitumour cytotoxicity Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-27
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Mineralized bacteria as an immunotherapy agent against various cancer types Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-27
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Oncolytic mineralized bacteria as potent locally administered immunotherapeutics Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-21 Chenya Wang, Liping Zhong, Jiachen Xu, Qi Zhuang, Fei Gong, Xiaojing Chen, Huiquan Tao, Cong Hu, Fuquan Huang, Nailin Yang, Junyan Li, Qi Zhao, Xinjun Sun, Yu Huo, Qian Chen, Yongxiang Zhao, Rui Peng, Zhuang Liu
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PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-21 Ruiyang Pang, Weihao Sun, Yingyun Yang, Dahan Wen, Feng Lin, Dingding Wang, Kailong Li, Ning Zhang, Junbo Liang, Chunyang Xiong, Yuying Liu
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Generation of synthetic whole-slide image tiles of tumours from RNA-sequencing data via cascaded diffusion models Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-21 Francisco Carrillo-Perez, Marija Pizurica, Yuanning Zheng, Tarak Nath Nandi, Ravi Madduri, Jeanne Shen, Olivier Gevaert
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Affinity maturation of CRISPR-engineered B cell receptors in vivo Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-20
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Techniques for supercharging academic writing with generative AI Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-18 Zhicheng Lin
Generalist large language models can elevate the quality and efficiency of academic writing.
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Towards on-skin analysis of sweat for managing disorders of substance abuse Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-18 Noe Brasier, Juliane R. Sempionatto, Steven Bourke, George Havenith, Dietmar Schaffarczyk, Jörg Goldhahn, Christian Lüscher, Wei Gao
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Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-18 Surabhi R. Madhvapathy, Matthew I. Bury, Larry W. Wang, Joanna L. Ciatti, Raudel Avila, Yonggang Huang, Arun K. Sharma, John A. Rogers
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Bacteria-mediated resistance of neutrophil extracellular traps to enzymatic degradation drives the formation of dental calculi Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-15 Mei-chen Wan, Kai Jiao, Yi-na Zhu, Qian-qian Wan, Yi-peng Zhang, Long-zhang Niu, Chen Lei, Jing-han Song, Wei-cheng Lu, Hua-jie Liu, Zhao-yang Ren, Franklin Tay, Li-na Niu
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In vivo affinity maturation of mouse B cells reprogrammed to express human antibodies Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-14 Yiming Yin, Yan Guo, Yuxuan Jiang, Brian Quinlan, Haiyong Peng, Gogce Crynen, Wenhui He, Lizhou Zhang, Tianling Ou, Charles C. Bailey, Michael Farzan
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Severely polarized extracellular acidity around tumour cells Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-04 Qiang Feng, Zachary Bennett, Anthony Grichuk, Raymundo Pantoja, Tongyi Huang, Brandon Faubert, Gang Huang, Mingyi Chen, Ralph J. DeBerardinis, Baran D. Sumer, Jinming Gao
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Neutrophils bearing adhesive polymer micropatches as a drug-free cancer immunotherapy Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-02-29 Ninad Kumbhojkar, Supriya Prakash, Tatsuya Fukuta, Kwasi Adu-Berchie, Neha Kapate, Rocky An, Solomina Darko, Vineeth Chandran Suja, Kyung Soo Park, Alexander P. Gottlieb, Michael Griffith Bibbey, Malini Mukherji, Lily Li-Wen Wang, David J. Mooney, Samir Mitragotri
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Screening oral drugs for their interactions with the intestinal transportome via porcine tissue explants and machine learning Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-02-20 Yunhua Shi, Daniel Reker, James D. Byrne, Ameya R. Kirtane, Kaitlyn Hess, Zhuyi Wang, Natsuda Navamajiti, Cameron C. Young, Zachary Fralish, Zilu Zhang, Aaron Lopes, Vance Soares, Jacob Wainer, Thomas von Erlach, Lei Miao, Robert Langer, Giovanni Traverso
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How to appeal well Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-02-21
Appealing against an editor’s negative decision is likely to be more fruitful when considering the basis of the editorial assessment and offering ways forward.
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Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-02-20 Ningqiang Gong, Xuexiang Han, Lulu Xue, Margaret M. Billingsley, Xisha Huang, Rakan El-Mayta, Jingya Qin, Neil C. Sheppard, Carl H. June, Michael J. Mitchell
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Extracellular vesicles incorporating retrovirus-like capsids for the enhanced packaging and systemic delivery of mRNA into neurons Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-02-19 Wenchao Gu, Sijin Luozhong, Simian Cai, Ketaki Londhe, Nadine Elkasri, Robert Hawkins, Zhefan Yuan, Kai Su-Greene, Yujie Yin, Margaret Cruz, Yu-Wei Chang, Patrick McMullen, Chunyan Wu, Changwoo Seo, Akash Guru, Wenting Gao, Tara Sarmiento, Chris Schaffer, Nozomi Nishimura, Richard Cerione, Qiuming Yu, Melissa Warden, Robert Langer, Shaoyi Jiang
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Hail the AI journal editor Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-01-22
A handy go-between may soon assist authors and editors.
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Screening for drivers of SARS-CoV-2 uptake Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-29 Alexis Autour, Christoph A. Merten
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Auditing the inference processes of medical-image classifiers by leveraging generative AI and the expertise of physicians Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-28 Alex J. DeGrave, Zhuo Ran Cai, Joseph D. Janizek, Roxana Daneshjou, Su-In Lee
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Fast capturing of deep blood flow Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-27 Rongkang Gao, Zhiqiang Xu, Chengbo Liu
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Designing stable humanized antibodies Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-27 Alissa M. Hummer, Charlotte M. Deane
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Deep screening of antibody–antigen affinities Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-27 Timothy A. Whitehead
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Towards in vitro models for reducing or replacing the use of animals in drug testing Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-27 David M. Stresser, Anna K. Kopec, Philip Hewitt, Rhiannon N. Hardwick, Terry R. Van Vleet, Prathap Kumar S. Mahalingaiah, Denice O’Connell, Gary J. Jenkins, Rhiannon David, Jessica Graham, Donna Lee, Jason Ekert, Aaron Fullerton, Remi Villenave, Piyush Bajaj, James R. Gosset, Sherry L. Ralston, Manti Guha, Alejandro Amador-Arjona, Kainat Khan, Saket Agarwal, Catrin Hasselgren, Xiaoting Wang, Khary
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Subcutaneous pancreatic islet transplantation without immunosuppression Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-25
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Probing when dCas9 tolerates DNA mismatches Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-22 Weihua Guan
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Assessing the toxicity of bispecific antibodies Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-22 Marta Buzzetti, Marco Gerlinger
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Engineering cell-derived extracellular vesicles for gene therapy Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-22
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A needle that softens on intravenous insertion Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-21 Eoin D. O’Cearbhaill
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Mutation corrections in spinal muscular atrophy Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-21 Andrew Portell, Prashant Mali
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Multimodal evidence suggests the linearity of brain dynamics at the macroscale Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-21
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Multipass high-dimensional flow cytometry Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-20 Enrico Lugli, Mario Roederer, Rosa Sottile
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Explaining counterfactual images Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-20 Oran Lang, Ilana Traynis, Yun Liu
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Analysis of off-tumour toxicities of T-cell-engaging bispecific antibodies via donor-matched intestinal organoids and tumouroids Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-19 Marius F. Harter, Timothy Recaldin, Regine Gerard, Blandine Avignon, Yannik Bollen, Cinzia Esposito, Karolina Guja-Jarosz, Kristina Kromer, Adrian Filip, Julien Aubert, Anneliese Schneider, Marina Bacac, Michael Bscheider, Nadine Stokar-Regenscheit, Salvatore Piscuoglio, Joep Beumer, Nikolche Gjorevski
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DNA-based computation for multiple biomarkers Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-14 Lu Yu, Hao Yan
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Restoration of sensory feedback from the foot and reduction of phantom limb pain via closed-loop spinal cord stimulation Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-14 Ameya C. Nanivadekar, Rohit Bose, Bailey A. Petersen, Elizaveta V. Okorokova, Devapratim Sarma, Tyler J. Madonna, Beatrice Barra, Juhi Farooqui, Ashley N. Dalrymple, Isaiah Levy, Eric R. Helm, Vincent J. Miele, Michael L. Boninger, Marco Capogrosso, Sliman J. Bensmaia, Douglas J. Weber, Lee E. Fisher
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Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-13 Beau R. Webber, Matthew J. Johnson, Joseph G. Skeate, Nicholas J. Slipek, Walker S. Lahr, Anthony P. DeFeo, Lauren J. Mills, Xiaohong Qiu, Blaine Rathmann, Miechaleen D. Diers, Bryce Wick, Tom Henley, Modassir Choudhry, Timothy K. Starr, R. Scott McIvor, Branden S. Moriarity
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A neural network that enables flexible nonlinear inference from neural population activity Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-12
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Dynamical flexible inference of nonlinear latent factors and structures in neural population activity Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-11 Hamidreza Abbaspourazad, Eray Erturk, Bijan Pesaran, Maryam M. Shanechi
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Blood–wall fluttering instability as a physiomarker of the progression of thoracic aortic aneurysms Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-11 Tom Y. Zhao, Ethan M. I. Johnson, Guy Elisha, Sourav Halder, Ben C. Smith, Bradley D. Allen, Michael Markl, Neelesh A. Patankar
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Screening for lipid nanoparticles that modulate the immune activity of helper T cells towards enhanced antitumour activity Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-11 Yining Zhu, Jingyao Ma, Ruochen Shen, Jinghan Lin, Shuyi Li, Xiaoya Lu, Jessica L. Stelzel, Jiayuan Kong, Leonardo Cheng, Ivan Vuong, Zhi-Cheng Yao, Christine Wei, Nicole M. Korinetz, Wu Han Toh, Joseph Choy, Rebekah A. Reynolds, Melanie J. Shears, Won June Cho, Natalie K. Livingston, Gregory P. Howard, Yizong Hu, Stephany Y. Tzeng, Donald J. Zack, Jordan J. Green, Lei Zheng, Joshua C. Doloff, Jonathan
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Macroscopic resting-state brain dynamics are best described by linear models Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-11 Erfan Nozari, Maxwell A. Bertolero, Jennifer Stiso, Lorenzo Caciagli, Eli J. Cornblath, Xiaosong He, Arun S. Mahadevan, George J. Pappas, Dani S. Bassett
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Generation of antigen-specific mature T cells from RAG1−/−RAG2−/−B2M−/− stem cells by engineering their microenvironment Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-07 Patrick C Chang, Xuegang Yuan, Alexandre Zampieri, Chloe Towns, Sang Pil Yoo, Claire Engstrom, Steven Tsai, Christopher R. Robles, Yuhua Zhu, Shawn Lopez, Amelie Montel-Hagen, Christopher S. Seet, Gay M. Crooks
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Optogenetic control of β cell function Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-06 Maria Jimenez-Gonzalez, Sarah Stanley
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Multifocal fluorescence video-rate imaging of centimetre-wide arbitrarily shaped brain surfaces at micrometric resolution Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-06 Hao Xie, Xiaofei Han, Guihua Xiao, Hanyun Xu, Yuanlong Zhang, Guoxun Zhang, Qingwei Li, Jing He, Dan Zhu, Xinguang Yu, Qionghai Dai
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Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-06 Christiano R. R. Alves, Leillani L. Ha, Rebecca Yaworski, Emma R. Sutton, Cicera R. Lazzarotto, Kathleen A. Christie, Aoife Reilly, Ariane Beauvais, Roman M. Doll, Demitri de la Cruz, Casey A. Maguire, Kathryn J. Swoboda, Shengdar Q. Tsai, Rashmi Kothary, Benjamin P. Kleinstiver
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Week-long norm glycaemia in diabetic mice and minipigs via a subcutaneous dose of a glucose-responsive insulin complex Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-06 Juan Zhang, Xiangqian Wei, Wei Liu, Yanfang Wang, Anna R. Kahkoska, Xianchi Zhou, Huimin Zheng, Wentao Zhang, Tao Sheng, Yang Zhang, Yun Liu, Kangfan Ji, Yichen Xu, Peng Zhang, Jianchang Xu, John. B. Buse, Jinqiang Wang, Zhen Gu
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Inflammation-induced subcutaneous neovascularization for the long-term survival of encapsulated islets without immunosuppression Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-05 Long-Hai Wang, Braulio A. Marfil-Garza, Alexander U. Ernst, Rena L. Pawlick, Andrew R. Pepper, Kento Okada, Boris Epel, Navin Viswakarma, Mrignayani Kotecha, James Arthur Flanders, Ashim K. Datta, Hong-Jie Gao, Ye-Zi You, Minglin Ma, A. M. James Shapiro
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An injectable subcutaneous colon-specific immune niche for the treatment of ulcerative colitis Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-04 Kin Man Au, Justin E. Wilson, Jenny P.-Y. Ting, Andrew Z. Wang
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Dermal features derived from optoacoustic tomograms via machine learning correlate microangiopathy phenotypes with diabetes stage Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-12-04 Angelos Karlas, Nikoletta Katsouli, Nikolina-Alexia Fasoula, Michail Bariotakis, Nikolaos-Kosmas Chlis, Murad Omar, Hailong He, Dimitrios Iakovakis, Christoph Schäffer, Michael Kallmayer, Martin Füchtenbusch, Annette Ziegler, Hans-Henning Eckstein, Leontios Hadjileontiadis, Vasilis Ntziachristos
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Ultrafast longitudinal imaging of haemodynamics via single-shot volumetric photoacoustic tomography with a single-element detector Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-11-30 Yide Zhang, Peng Hu, Lei Li, Rui Cao, Anjul Khadria, Konstantin Maslov, Xin Tong, Yushun Zeng, Laiming Jiang, Qifa Zhou, Lihong V. Wang
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High-dimensional multi-pass flow cytometry via spectrally encoded cellular barcoding Nat. Biomed. Eng. (IF 28.1) Pub Date : 2023-11-30 Sheldon J. J. Kwok, Sarah Forward, Marissa D. Fahlberg, Emane Rose Assita, Sean Cosgriff, Seung Hyung Lee, Geoffrey R. Abbott, Han Zhu, Nicolas H. Minasian, A. Sean Vote, Nicola Martino, Seok-Hyun Yun