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Interleukin 1 receptor antagonist as biomarker for disease flares in fibrodysplasia ossificans progressiva Bone (IF 4.1) Pub Date : 2024-04-20 Riccardo Papa, Arinna Bertoni, Caterina Matucci-Cerinic, Enrico Drago, Francesca Liberatore, Anna Corcione, Marco Gattorno
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Secondary hyperparathyroidism: Predictors and relationship with vitamin D status, bone turnover markers and bone mineral density Bone (IF 4.1) Pub Date : 2024-04-18 Donal Fitzpatrick, Eamon Laird, Mary Ward, Leane Hoey, Catherine F. Hughes, J.J. Strain, Conal Cunningham, Martin Healy, Anne M. Molloy, Helene McNulty, Rosaleen Lannon, Kevin McCarroll
Secondary hyperparathyroidism (SHPT) has adverse implications for bone health but is relatively understudied. In this study we examine the prevalence and determinants of SHPT and describe the relationship of SHPT with bone turnover markers and bone mineral density (BMD) in older Irish adults. Eligible participants ( = 4139) were identified from the Trinity-Ulster-Department of Agriculture (TUDA) study
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The 40-min HIIT acutely induced bone formation which was likely through the increases in muscle derived interleukin 6 and adiponectin activation: The 16 weeks of HIIT intervention, longitudinal randomized controlled trial Bone (IF 4.1) Pub Date : 2024-04-16 Siriporn Sasimontonkul, Jintana Sirivarasai
There is some controversy regarding cytokines released from adipocytes, particularly adiponectin, leptin, and IL6 that regulate bone remodeling. In addition, IL6 is released from muscle contraction, which might have a distinct role in bone remodeling. Hence, this study investigated whether muscle contraction during a session of 40 min of high intensity interval training (40-min HIIT) and after 16 weeks
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CT-derived vertebral bone mineral density is a useful biomarker to predict COVID-19 outcome Bone (IF 4.1) Pub Date : 2024-04-08 Shuhei Azekawa, Tomoki Maetani, Shotaro Chubachi, Takanori Asakura, Naoya Tanabe, Yusuke Shiraishi, Ho Namkoong, Hiromu Tanaka, Takashi Shimada, Takahiro Fukushima, Shiro Otake, Kensuke Nakagawara, Mayuko Watase, Hideki Terai, Mamoru Sasaki, Soichiro Ueda, Yukari Kato, Norihiro Harada, Shoji Suzuki, Shuichi Yoshida, Hiroki Tateno, Yoshitake Yamada, Masahiro Jinzaki, Toyohiro Hirai, Yukinori Okada,
The low vertebral bone computed tomography (CT) Hounsfield unit values measured on CT scans reflect low bone mineral density (BMD) and are known as diagnostic indicators for osteoporosis. The potential prognostic significance of low BMD defined by vertebral bone CT values for the coronavirus disease 2019 (COVID-19) remains unclear. This study aimed to assess the impact of BMD on the clinical outcome
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Unveiling the role of hydroxyapatite and hydroxyapatite/silver composite in osteoblast-like cell mineralization: An exploration through their viscoelastic properties Bone (IF 4.1) Pub Date : 2024-04-04 David García-Ortiz, Juan José Martínez-Sanmiguel, Diana G. Zárate Triviño, Cristina Rodríguez-Padilla, Guillermo Salceda-Delgado, Jorge Luis Menchaca, Marco A. Bedolla, Maricela Rodríguez-Nieto
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Canonical pathways for validating steroid-associated osteonecrosis in mice Bone (IF 4.1) Pub Date : 2024-04-04 Lizhen Zheng, Yuanming An, Wenxue Tong, Ziyi Chen, Yaofeng Wang, Haozhi Zhang, Shi’an Zhang, Xin Chen, Weiyang Liu, Xinluan Wang, Jiankun Xu, Ling Qin
The present study aimed to establish and evaluate a preclinical model of steroid-associated osteonecrosis (SAON) in mice. Sixteen 24-week-old male C57BL/6 mice were used to establish SAON by two intraperitoneal injections of lipopolysaccharide (LPS), followed by three subcutaneous injections of methylprednisolone (MPS). Each injection was conducted on working day, with an interval of 24 h. Six cycles
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Risk of fracture among patients with spinal cord injury: A nationwide cohort study in South Korea Bone (IF 4.1) Pub Date : 2024-04-03 Seonghye Kim, Bongseong Kim, Kyung-Do Han, Junhee Park, Jung Eun Yoo, Hea Lim Choi, Won Hyuk Chang, In Young Cho, Dong Wook Shin
Clinical concerns about preventing and managing fractures after spinal cord injury (SCI) have been growing. This study investigates the risk of fractures among SCI patients according to the presence of disability, disease severity, and level of injury. We performed a retrospective cohort study using the Korean National Health Insurance Service (KNHIS 2010–2018) database. We included 5190 SCI patients
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Combining raloxifene and mechanical loading improves bone composition and mechanical properties in a murine model of chronic kidney disease (CKD) Bone (IF 4.1) Pub Date : 2024-04-03 Rachel K. Surowiec, Olivia N. Reul, Nusaiba N. Chowdhury, Ratan K. Rai, Dyann Segvich, Andrew A. Tomaschke, John Damrath, Andrea M. Jacobson, Matthew R. Allen, Joseph M. Wallace
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Effects of dietary iron deficiency or overload on bone: Dietary details matter Bone (IF 4.1) Pub Date : 2024-04-02 Ulrike Baschant, Brie K. Fuqua, Maria Ledesma-Colunga, Christopher D. Vulpe, Stela McLachlan, Lorenz C. Hofbauer, Aldons J. Lusis, Martina Rauner
Bone is susceptible to fluctuations in iron homeostasis, as both iron deficiency and overload are linked to poor bone strength in humans. In mice, however, inconsistent results have been reported, likely due to different diet setups or genetic backgrounds. Here, we assessed the effect of different high and low iron diets on bone in six inbred mouse strains (C57BL/6J, A/J, BALB/cJ, AKR/J, C3H/HeJ, and
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Human nonunion tissues display differential gene expression in comparison to physiological fracture callus Bone (IF 4.1) Pub Date : 2024-04-02 Leonidas Salichos, Rishika Thayavally, Peter Kloen, Michael Hadjiargyrou
The healing of bone fractures can become aberrant and lead to nonunions which in turn have a negative impact on patient health. Understanding why a bone fails to normally heal will enable us to make a positive impact in a patient's life. While we have a wealth of molecular data on rodent models of fracture repair, it is not the same with humans. As such, there is still a lack of information regarding
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Skeletal abnormalities in mice with Dnmt3a missense mutations Bone (IF 4.1) Pub Date : 2024-03-23 Austin Bell-Hensley, Diana C. Beard, Kathryn Feeney, Hongjun Zheng, Yunhao Jiang, Xiyun Zhang, Jin Liu, Harrison Gabel, Audrey McAlinden
Overgrowth and intellectual disability disorders in humans are typified by length/height and/or head circumference ≥ 2 standard deviations above the mean as well as intellectual disability and behavioral comorbidities, including autism and anxiety. Tatton-Brown-Rahman Syndrome is one type of overgrowth and intellectual disability disorder caused by heterozygous missense mutations in the DNA methyltransferase
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Associations of global biomarkers of oxidative stress with osteoporosis, bone microstructure and bone turnover: Evidence from human and animal studies Bone (IF 4.1) Pub Date : 2024-03-22 Xue Shen, Mengmeng Zhang, Hanqing Cai, William D. Leslie, Lisa M. Lix, Depeng Jiang, Lijie Feng, Haitao Cheng, Xianbao Shi, Yuzhong Gao, Shuman Yang
Human evidence on the association between oxidative stress and osteoporosis is inconsistent. Fluorescent Oxidation Products (FlOPs) are global biomarkers of oxidative stress. We examined the associations of FlOPs (excitation/emission wavelengths 320/420 nm for FlOP_320, 360/420 nm for FlOP_360, and 400/475 nm for FlOP_400) with osteoporosis, bone microstructure, and bone turnover markers in humans
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Skeleton-derived extracellular vesicles in bone and whole-body aging: From mechanisms to potential applications Bone (IF 4.1) Pub Date : 2024-03-21 Jiahui Shen, Lingling Hu, Xiaoyuan Huang, Jiajie Mao, Yuzhu Wu, Zhijian Xie, Yanhua Lan
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Elucidating the role of the GC/GR/GLUT1 axis in steroid-induced osteonecrosis of the femoral head: A proteomic approach Bone (IF 4.1) Pub Date : 2024-03-20 Hongbin Luo, Jie Wei, Songye Wu, Qunya Zheng, Xinhua Lin, Peng Chen
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Development and application of hydroxyapatite-based scaffolds for bone tissue regeneration: A systematic literature review Bone (IF 4.1) Pub Date : 2024-03-18 Fendi Fendi, Bualkar Abdullah, Sri Suryani, Andi Nilawati Usman, Dahlang Tahir
Hydroxyapatite [HA, Ca(PO)(OH)], with its robust biocompatibility and bioactivity, has found extensive utility in bone grafting, replacement therapies, and supplemental medical materials. HA is highly regarded for its osteoconductive properties because it boasts hydrophilicity, nontoxicity, non-allergenicity, and non-mutagenicity. Nevertheless, HA's intrinsic mechanical weakness has spurred efforts
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Vascular study of decellularized porcine long bones: Characterization of a tissue engineering model Bone (IF 4.1) Pub Date : 2024-03-15 R. Evrard, J. Manon, C. Rafferty, L. Fieve, O. Cornu, T. Kirchgesner, F.E. Lecouvet, T. Schubert, B. Lengele
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Postmenopausal women with normal BMD who have fractures have deteriorated bone microarchitecture: A prospective analysis from The OFELY study Bone (IF 4.1) Pub Date : 2024-03-15 E. Sornay-Rendu, F. Duboeuf, R.D. Chapurlat
Most postmenopausal women who sustain fragility fracture (Fx) have their areal bone mineral density (BMD) above the osteoporosis threshold. A sizeable proportion of them have normal aBMD. This study aimed to prospectively investigate the association of fragility Fx with bone microarchitecture (MA) assessed by high-resolution peripheral computed tomography (HR-pQCT) in postmenopausal women without low
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Corrigendum to “Machine learning applied to HR-pQCT images improves fracture discrimination provided by DXA and clinical risk factors” [Bone. 2023 Mar:168:116653] Bone (IF 4.1) Pub Date : 2024-03-15 Shengyu Lu, Nicholas R. Fuggle, Leo D. Westbury, Mícheál Ó. Breasail, Gregorio Bevilacqua, Kate A. Ward, Elaine M. Dennison, Sasan Mahmoodi, Mahesan Niranjan, Cyrus Cooper
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Bone health index in the assessment of bone health: The Generation R Study Bone (IF 4.1) Pub Date : 2024-03-07 Vid Prijatelj, Olja Grgic, André G. Uitterlinden, Eppo B. Wolvius, Fernando Rivadeneira, Carolina Medina-Gomez
Bone Health Index (BHI) has been proposed as a useful instrument for assessing bone health in children. However, its relationship with fracture risk remains unknown. We aimed to investigate whether BHI is associated with bone mineral density (BMD) and prevalent fracture odds in children from the Generation R Study. We also implemented genome-wide association study (GWAS) and polygenic score (PGS) approaches
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Influence of zoledronic acid and pamidronate on tooth eruption in children with osteogenesis imperfecta Bone (IF 4.1) Pub Date : 2024-03-06 Natalia Del Rio Cantero, María Rosa Mourelle Martínez, Belén Sagastizabal Cardelús, Joaquín Manuel De Nova García
Osteogenesis imperfecta (OI) is a congenital disease comprising a heterogeneous group of inherited connective tissue disorders. The main treatment in children is bisphosphonate therapy. Previous animal studies have shown that bisphosphonates delay tooth eruption. The aim of this study is to determine whether patients with OI treated with pamidronate and/or zoledronic acid have a delayed eruption age
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Pronounced cortical porosity and sex-specific patterns of increased bone and osteocyte lacunar mineralization characterize the human distal fibula with aging Bone (IF 4.1) Pub Date : 2024-03-06 Robin-Nicolas Hering, Simon von Kroge, Julian Delsmann, Alexander Simon, Benjamin Ondruschka, Klaus Püschel, Felix Nikolai Schmidt, Tim Rolvien
The high occurrence of distal fibula fractures among older women suggests a potential link to impaired bone health. Here we used a multiscale imaging approach to investigate the microarchitecture, mineralization, and biomechanics of the human distal fibula in relation to age and sex. Micro-computed tomography was performed to analyze the local volumetric bone mineral density and various microarchitectural
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Cognitive function and skeletal size and mineral density at age 6–7 years: Findings from the Southampton Women's Survey Bone (IF 4.1) Pub Date : 2024-03-02 Rebecca J. Moon, Stefania D'Angelo, Sarah R. Crozier, Michelle Fernandes, Caroline Fall, Catharine R. Gale, Keith M. Godfrey, Justin H. Davies, Cyrus Cooper, Nicholas C. Harvey
Poor cognitive function and osteoporosis commonly co-exist in later life. In women, this is often attributed to post-menopausal estrogen loss. However, a common early life origin for these conditions and the associations between cognitive function and bone mineral density (BMD) in childhood have not previously been explored. We examined these relationships at age 6–7 years in the Southampton Women's
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PPI use is not associated with bone microarchitecture and strength assessed with HR-pQCT after three-years follow-up in patients visiting the Fracture Liaison Service Bone (IF 4.1) Pub Date : 2024-03-02 M.R. Schene, M.S.A.M. Bevers, W.J.F. van der Vijgh, J.H.M. Driessen, L. Vranken, R.Y. van der Velde, H.C. Willems, C.E. Wyers, J.P. van den Bergh
The use of proton pump inhibitors (PPIs) has been associated with an increased fracture risk in observational studies. However, the reported association between PPI use and bone mineral density (BMD), bone microarchitecture, and bone strength is inconsistent. This study aims to assess the association between PPI use and bone microarchitecture and strength using high-resolution peripheral quantitative
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Unraveling the transcriptome profile of pulsed electromagnetic field stimulation in bone regeneration using a bioreactor-based investigation platform Bone (IF 4.1) Pub Date : 2024-02-28 Farah Daou, Beatrice Masante, Stefano Gabetti, Federico Mochi, Giovanni Putame, Eleonora Zenobi, Elisa Scatena, Federica Dell'Atti, Francesco Favero, Massimiliano Leigheb, Costantino Del Gaudio, Cristina Bignardi, Diana Massai, Andrea Cochis, Lia Rimondini
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Familial cases with adult-onset FGF23-related hypophosphatemic osteomalacia -A PHEX 3’-UTR change as a possible cause- Bone (IF 4.1) Pub Date : 2024-02-25 Shun Sawatsubashi, Yuichi Takashi, Itsuro Endo, Takeshi Kondo, Masahiro Abe, Toshio Matsumoto, Seiji Fukumoto
Excessive actions of FGF23 cause several kinds of hypophosphatemic rickets/osteomalacia. It is possible that there still remain unknown causes or mechanisms for FGF23-related hypophosphatemic diseases. We report two male cousins who had been suffering form FGF23-related hypophosphatemic osteomalacia. Sequencing of exons and exon-intron junctions of known causative genes for FGF23-related hypophosphatemic
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Chondrocyte hypertrophy in the growth plate promotes stress anisotropy affecting long bone development through chondrocyte column formation Bone (IF 4.1) Pub Date : 2024-02-25 Yuka Yokoyama, Yoshitaka Kameo, Junko Sunaga, Koichiro Maki, Taiji Adachi
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DDIT3 deficiency accelerates bone remodeling during bone healing by enhancing osteoblast and osteoclast differentiation through ULK1-mediated autophagy Bone (IF 4.1) Pub Date : 2024-02-24 Meie Jia, Zhipeng Dong, Wei Dong, Beining Yang, Ying He, Yan Wang, Jiawei Wang
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Crosstalk between ALK3(BMPR1A) deficiency and autophagy signaling mitigates pathological bone loss in osteoporosis Bone (IF 4.1) Pub Date : 2024-02-24 Zhixing Niu, Yumeng Zhou, Muchun Liang, Fuqiang Su, Qiang Guo, Junjun Jing, Jing Xie, Demao Zhang, Xiaoheng Liu
Postmenopausal osteoporosis is recognized to be one of the major skeleton diseases strongly associated with impaired bone formation. Previous reports have indicated that the importance of bone morphogenetic protein (BMP) signaling of osteoblast lineage in bone development via classical Smad signaling, however, its critical role in osteoporosis is still not well understood. In the current study, we
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Abaloparatide promotes bone repair of vertebral defects in ovariectomized rats by increasing bone formation Bone (IF 4.1) Pub Date : 2024-02-23 Akito Makino, Tomoka Hasegawa, Tomomaya Yamamoto, Hideko Takagi, Yoshimasa Takahashi, Naohisa Miyakoshi, Norio Amizuka
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Cancer risk in patients treated with denosumab compared with alendronate: A population-based cohort study Bone (IF 4.1) Pub Date : 2024-02-21 Sam Kafai Yahyavi, Rune Holt, Nadia Krarup Knudsen, Christine Hjorth Andreassen, Christoffer Sejling, Alessandra Meddis, Susanne K. Kjaer, Peter Schwarz, Jens-Erik Beck Jensen, Christian Torp-Pedersen, Anders Juul, Christian Selmer, Martin Blomberg Jensen
Antiresorptive treatment is currently used in millions of patients with osteoporosis and cancer worldwide. Early studies of denosumab suggested a small signal in ovarian cancer incidence and emerging data suggest that denosumab stimulates germ cell proliferation in the gonads. This study aims to determine the association between the use of denosumab and the risk of reproductive cancers compared with
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Influence of microarchitecture on stressed volume and mechanical fatigue behaviour of equine subchondral bone Bone (IF 4.1) Pub Date : 2024-02-21 Andrew Koshyk, Andrew J. Pohl, Yuji Takahashi, W. Michael Scott, Holly D. Sparks, W. Brent Edwards
Fractures of the equine metacarpophalangeal (MCP) joint are among the most common and fatal injuries experienced by racehorses. These bone injuries are a direct result of repetitive, high intensity loading of the skeleton during racing and training and there is consensus that they represent a mechanical fatigue phenomenon. Existing work has found the fatigue life of bone to be strongly determined by
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DXA-based statistical models of shape and intensity outperform aBMD hip fracture prediction: A retrospective study Bone (IF 4.1) Pub Date : 2024-02-20 Alessandra Aldieri, Margaret Paggiosi, Richard Eastell, Cristina Bignardi, Alberto L. Audenino, Pinaki Bhattacharya, Mara Terzini
Areal bone mineral density (aBMD) currently represents the clinical gold standard for hip fracture risk assessment. Nevertheless, it is characterised by a limited prediction accuracy, as about half of the people experiencing a fracture are not classified as at being at risk by aBMD. In the context of a progressively ageing population, the identification of accurate predictive tools would be pivotal
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Osteocalcin improves glucose tolerance, insulin sensitivity and secretion in older male mice Bone (IF 4.1) Pub Date : 2024-02-18 Noorulain Paracha, Paul Mastrokostas, Evan Kello, Yosef Gedailovich, Devorah Segall, Alexis Rizzo, Lawrence Mitelberg, Naif Hassan, Terry Lynne Dowd
Osteocalcin deficient mice (OC-/-), on a mixed 129/BL6J background, were reported to show glucose intolerance, insulin insensitivity and reduced insulin secretion at 1-6 mos of age. This is controversial as two studies in OC-/- mice on different backgrounds (C3H/BL6 (5-6 mos.) and C57BL/6N (5 and 9 mos.)) found no effect on glucose metabolism. To determine the role of OC in glucose metabolism we conducted
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TNF-α promotes osteocyte necroptosis by upregulating TLR4 in postmenopausal osteoporosis Bone (IF 4.1) Pub Date : 2024-02-15 Hongwang Cui, Ji Li, Xiangtao Li, Tian Su, Peng Wen, Chuanling Wang, Xiaozhong Deng, Yonghua Fu, Weijie Zhao, Changjia Li, Pengbing Hua, Yongjun Zhu, Wei Wan
Postmenopausal osteoporosis (PMOP) is a common kind of osteoporosis that is associated with excessive osteocyte death and bone loss. Previous studies have shown that TNF-α-induced osteocyte necroptosis might exert a stronger effect on PMOP than apoptosis, and TLR4 can also induce cell necroptosis, as confirmed by recent studies. However, little is known about the relationship between TNF-α-induced
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Successful treatment approaches for tumoral calcinosis in children and young people: A condition of diverse pathogenesis Bone (IF 4.1) Pub Date : 2024-02-15 A. Anilkumar, W. Högler, J. Bursell, R. Nadar, F. Ryan, T. Randell, N.J. Shaw, S. Uday
Ectopic calcification is inappropriate biomineralization of soft tissues occurring due to genetic or acquired causes of hyperphosphataemia and rarely in normophosphataemic individuals. Tumoral Calcinosis (TC) is a rare metabolic bone disorder commonly presenting in childhood and adolescence with periarticular extra-capsular calcinosis. Three subtypes of TC have been recognised: primary hyperphosphataemic
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Abaloparatide is more potent than teriparatide in restoring bone mass and strength in type 1 diabetic male mice Bone (IF 4.1) Pub Date : 2024-02-13 Silvia Marino, Serra Ucer Ozgurel, Kevin McAndrews, Meloney Cregor, Alma Villaseñor, Maricuz Mamani-Huanca, Coral Barbas, Arancha Gortazar, Amy Y. Sato, Teresita Bellido
This study investigated the efficacy of the two FDA-approved bone anabolic ligands of the parathyroid hormone receptor 1 (PTH1R), teriparatide or human parathyroid hormone 1–34 (PTH) and abaloparatide (ABL), to restoring skeletal health using a preclinical murine model of streptozotocin-induced T1-DM. Intermittent daily subcutaneous injections of equal molar doses (12 pmoles/g/day) of PTH (50 ng/g/day)
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Epigenetic regulators controlling osteogenic lineage commitment and bone formation Bone (IF 4.1) Pub Date : 2024-02-09 Parisa Dashti, Eric A. Lewallen, Jonathan A.R. Gordon, Martin A. Montecino, James R. Davie, Gary S. Stein, Johannes P.T.M. van Leeuwen, Bram C.J. van der Eerden, Andre J. van Wijnen
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Human osteoclasts in vitro are dose dependently both inhibited and stimulated by cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) Bone (IF 4.1) Pub Date : 2024-02-09 Simone S.R. Nielsen, Juliana A.Z. Pedersen, Neha Sharma, Pernille K. Wasehuus, Morten S. Hansen, Anaïs M.J. Møller, Xenia G. Borggaard, Alexander Rauch, Morten Frost, Teis E. Sondergaard, Kent Søe
Legalized use of cannabis for medical or recreational use is becoming more and more common. With respect to potential side-effects on bone health only few clinical trials have been conducted – and with opposing results. Therefore, it seems that there is a need for more knowledge on the potential effects of cannabinoids on human bone cells. We studied the effect of cannabidiol (CBD) and Δ9-tetrahydrocannabinol
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Sustained hypophosphatemia after denosumab in a patient on hemodialysis Bone (IF 4.1) Pub Date : 2024-02-08 Ahmed A.S. Almodares, Grahame J. Elder, Bo Abrahamsen
An 81-year-old Caucasian man who had commenced thrice weekly hemodialysis (HD) three months earlier, presented with a hip fracture, two vertebral fractures and a bone mineral density T-score of −3.6. He had received weekly iron sucrose infusions for 6 weeks and alphacalcidol on dialysis days. Although he suffered from coeliac disease and cirrhosis, he was fully ambulatory and well-nourished. He was
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Cutaneous burn injury represents a major risk factor for the development of traumatic ectopic bone formation following blast-related extremity injury Bone (IF 4.1) Pub Date : 2024-02-07 Cassie J. Rowe, Uloma Nwaolu, Daniela Salinas, Jefferson L. Lansford, Conor F. McCarthy, Joseph A. Anderson, Michael S. Valerio, Benjamin K. Potter, Philip J. Spreadborough, Thomas A. Davis
Blast-related traumatic heterotopic ossification (tHO) impacts clinical outcomes in combat-injured patients, leading to delayed wound healing, inflammatory complications, and reduced quality of life. Blast injured patients often have significant burns. This study investigated whether a partial thickness thermal burn injury exacerbates blast-related tHO in a clinically relevant polytrauma animal model
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A pathogenic role for brain-derived neurotrophic factor (BDNF) in fibrous dysplasia of bone Bone (IF 4.1) Pub Date : 2024-02-07 Biagio Palmisano, Giorgia Farinacci, Federica Campolo, Chiara Tavanti, Alessia Stefano, Samantha Donsante, Ernesto Ippolito, Giuseppe Giannicola, Mary Anna Venneri, Alessandro Corsi, Mara Riminucci
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Compromised femoral and lumbovertebral bone in the Dp(16)1Yey Down syndrome mouse model Bone (IF 4.1) Pub Date : 2024-02-07 Joshua Lamantia, Kourtney Sloan, Joseph M. Wallace, Randall J. Roper
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Transitions - Sundeep Khosla, M.D., Editor-In-Chief for Bone, 2013-2023 Bone (IF 4.1) Pub Date : 2024-02-06 Sundeep Khosla
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Complex intrinsic abnormalities in osteoblast lineage cells of X-linked hypophosphatemia: Analysis of human iPS cell models generated by CRISPR/Cas9-mediated gene ablation Bone (IF 4.1) Pub Date : 2024-02-06 Tatsuro Nakanishi, Miwa Yamazaki, Kanako Tachikawa, Ayu Ueta, Masanobu Kawai, Keiichi Ozono, Toshimi Michigami
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Impact of heavy alcohol consumption on cortical bone mechanical properties in male rhesus macaques Bone (IF 4.1) Pub Date : 2024-02-05 Mihee Shin, Do Kyung Kim, Manish Jain, Penny J. Martens, Russell T. Turner, Urszula T. Iwaniec, Jamie J. Kruzic, Bernd Gludovatz
Chronic heavy alcohol consumption may influence the skeleton by suppressing intracortical bone remodeling which may impact the quality of bone and its mechanical properties. However, this aspect has not been thoroughly assessed in either humans or animal models whose cortical bone microstructure resembles the microstructure of human cortical bone. The current study is the first to investigate the effects
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Bone microarchitectural alterations associated with spinal cord injury: Relation to sex hormones, metabolic factors, and loading Bone (IF 4.1) Pub Date : 2024-02-05 Rodrigo J. Valderrábano, Karol Pencina, Yili-Valentine Shang, Evelyn Echevarria, Robert Dixon, Catherine Ghattas, Lauren Wilson, Kieran F. Reid, Thomas Storer, Margaret Garrahan, Trinity Tedtsen, Ross Zafonte, Mary Bouxsein, Shalender Bhasin
People living with spinal cord injury (SCI) are at high risk for bone fractures. Neural, hormonal and metabolic contributors to bone microarchitectural alterations are incompletely understood. To determine the relationship of physical, metabolic and endocrine characteristics with bone microarchitecture, characterized using high-resolution peripheral quantitative computed tomography (HRpQCT) in SCI
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Iguratimod suppresses sclerostin and receptor activator of NF-κB ligand production via the extracellular signal–regulated kinase/early growth response protein 1/tumor necrosis factor alpha pathway in osteocytes and ameliorates disuse osteoporosis in mice Bone (IF 4.1) Pub Date : 2024-02-05 Taihei Miura, Yuki Etani, Takaaki Noguchi, Makoto Hirao, Kenji Takami, Atsushi Goshima, Takuya Kurihara, Yuji Fukuda, Nagahiro Ochiai, Takashi Kanamoto, Ken Nakata, Seiji Okada, Kosuke Ebina
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Tmem119 is involved in bone anabolic effects of PTH through enhanced osteoblastic bone formation in mice Bone (IF 4.1) Pub Date : 2024-02-04 Naoyuki Kawao, Daichi Matsumura, Ayaka Yamada, Katsumi Okumoto, Takashi Ohira, Yuya Mizukami, Daiki Hashimoto, Hiroshi Kaji
The intermittent administration of parathyroid hormone (PTH) exerts potent bone anabolic effects, which increase bone mineral density (BMD) and reduce fracture risk in osteoporotic patients. However, the underlying mechanisms remain unclear. Tmem119 has been proposed as a factor that is closely linked to the osteoblast phenotype, and we previously reported that PTH enhanced the expression of Tmem119
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The role of Map1b in regulating osteoblast polarity, proliferation, differentiation and migration Bone (IF 4.1) Pub Date : 2024-02-03 Li Peng, Demao Zhang, Heng Tu, Dan Wu, Shuaixi Xiang, Wenbin Yang, Yun Zhao, Jing Yang
Osteoblast polarity, proliferation, differentiation, and migration are essential for maintaining normal bone structure and function. While the microtubule-associated protein Map1b has been extensively studied in nerve cells, its role in bone cells is less known. We investigated the functional significance of Map1b in mouse bone marrow stromal cells (ST2) and elucidated its relationship and influence
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S-nitrosoglutathione reductase-dependent p65 denitrosation promotes osteoclastogenesis by facilitating recruitment of p65 to NFATc1 promoter Bone (IF 4.1) Pub Date : 2024-02-02 Shumin Liu, Qian Lu, Min Wang, Huilin Guo, Yiwen Wang, Jingwen Nong, Shuo Wang, Haibin Xia, Ting Xia, Huifang Sun
Osteoclasts, the exclusive bone resorptive cells, are indispensable for bone remodeling. Hence, understanding novel signaling modulators regulating osteoclastogenesis is clinically important. Nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) is a master transcription factor in osteoclastogenesis, and binding of NF-κB p65 subunit to NFATc1 promoter is required for its expression. It is well-established
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Controlled mechanical loading affects the osteocyte transcriptome in porcine trabecular bone in situ Bone (IF 4.1) Pub Date : 2024-02-02 Meghana Machireddy, Alyssa G. Oberman, Lucas DeBiase, Melissa Stephens, Jun Li, Laurie E. Littlepage, Glen L. Niebur
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Accuracy of photon-counting computed tomography for the measurement of bone quality in the knee Bone (IF 4.1) Pub Date : 2024-02-02 Fahimeh Azari, Piyush Uniyal, Jeroen Soete, Walter Coudyzer, Caroline E. Wyers, Jilmen Quintiens, Joop P. van den Bergh, G. Harry van Lenthe
Visualization and quantification of bone microarchitecture in the human knee allows gaining insight into normal bone structure, and into the structural changes occurring in the onset and progression of bone diseases such as osteoporosis and osteoarthritis. However, current imaging modalities have limitations in capturing the intricacies of bone microarchitecture. Photon counting computed tomography
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A comprehensive set of ultrashort echo time magnetic resonance imaging biomarkers to assess cortical bone health: A feasibility study at clinical field strength Bone (IF 4.1) Pub Date : 2024-02-02 Andrea M. Jacobson, Xuandong Zhao, Stefan Sommer, Farhan Sadik, Stuart J. Warden, Christopher Newman, Thomas Siegmund, Matthew R. Allen, Rachel K. Surowiec
Conventional bone imaging methods primarily use X-ray techniques to assess bone mineral density (BMD), focusing exclusively on the mineral phase. This approach lacks information about the organic phase and bone water content, resulting in an incomplete evaluation of bone health. Recent research highlights the potential of ultrashort echo time magnetic resonance imaging (UTE MRI) to measure cortical
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Health-related quality of life and fatigue in adult rare bone disease patients: A cross-sectional study from Austria Bone (IF 4.1) Pub Date : 2024-02-02 Martina Behanova, Amadea Medibach, Judith Haschka, Daniel Kraus, Adalbert Raimann, Gabriel T. Mindler, Jochen Zwerina, Roland Kocijan
To assess physical and mental health domains of health related quality of life (HRQoL) as well as fatigue in rare bone disease (RBD) patients and to compare to patients with osteoporosis (OPO) and healthy controls (CTRL) without known bone diseases and to study associations of Fatique Severity Scale (FSS) with eight domains of HRQoL. Monocentric, cross-sectional study carried out between 2020 and 2022
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Exposure to low humidex increases the risk of hip fracture admissions in a subtropical coastal Chinese city Bone (IF 4.1) Pub Date : 2024-02-01 Yanhu Ji, Zepeng Huang, Zhongjia Yuan, Jianping Xiong, Liping Li
The adverse impacts of meteorological factors on human health have attracted great attention. However, no studies have investigated the nonlinear effects of humidex on hip fractures (HF), particularly in middle-aged and older adults. This study aimed to quantify the impacts of humidex, a comprehensive index of temperature and relative humidity, on HF admissions. Daily HF admissions, meteorological
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Anti-sclerostin antibody therapy prevents post-ischemic osteonecrosis bone collapse via interleukin-6 association Bone (IF 4.1) Pub Date : 2024-02-01 Yuto Ozawa, Yasuhiko Takegami, Yusuke Osawa, Takamune Asamoto, Shinya Tanaka, Shiro Imagama
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Pyridoxine challenge reflects pediatric hypophosphatasia severity and thereby examines tissue-nonspecific alkaline phosphatase's role in vitamin B6 metabolism Bone (IF 4.1) Pub Date : 2024-02-01 Michael P. Whyte, Fan Zhang, Karen E. Mack, Deborah Wenkert, Gary S. Gottesman, Karen L. Ericson, Jeffrey T. Cole, Stephen P. Coburn
Alkaline phosphatase (ALP) is detected in most human tissues. However, ALP activity is routinely assayed using high concentrations of artificial colorimetric substrates in phosphate-free laboratory buffers at lethal pH. Hypophosphatasia (HPP) is the inborn-error-of-metabolism caused by loss-of-function mutation(s) of the gene that encodes the ALP isoenzyme expressed in bone, liver, kidney, and elsewhere
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Association between physical activity, sedentary behavior patterns with bone health among Chinese older women Bone (IF 4.1) Pub Date : 2024-01-23 Xiaoyu Ren, Chuan Hu, Wenbo Wang, Qiang He, Litao Du, Ting Li, Yang Pan, Si Chen, Xianliang Zhang
We examined the association between physical activity (PA) and sedentary behavior (SEB) time with bone health and whether it changes depending on different patterns. Cross-sectional data were derived from the baseline of the Physical Activity and Health in Older Women Study. PA and SEB were measured using Actigraph wGT3X-BT accelerometers. Bone mineral density (BMD) was derived from the SONOST-2000
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Adaptive enhancement of apatite crystal orientation and Young's modulus under elevated load in rat ulnar cortical bone Bone (IF 4.1) Pub Date : 2024-01-23 Jun Wang, Takuya Ishimoto, Tadaaki Matsuzaka, Aira Matsugaki, Ryosuke Ozasa, Takuya Matsumoto, Mikako Hayashi, Hyoung Seop Kim, Takayoshi Nakano
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Is there a role for N1-N2 neutrophil phenotypes in bone regeneration? A systematic review Bone (IF 4.1) Pub Date : 2024-01-20 Fangzhou Lu, Samai M.N.E. Verleg, Rald V.M. Groven, Martijn Poeze, Martijn van Griensven, Taco J. Blokhuis
This review aims to provide an overview of the multiple functions of neutrophils, with the recognition of the inflammatory (N1) and regenerative (N2) phenotypes, in relation to fracture healing. A literature search was performed using the PubMed database. The quality of the articles was evaluated using critical appraisal checklists. Thirty one studies were included in this review. These studies consistently