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Reach-to-Grasp and tactile discrimination task: A new task for the study of sensory-motor learning Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-20 Yudai Yoshinaga, Nobuya Sato
Although active touch in rodents arises from the forepaws as well as whiskers, most research on active touch only focuses on whiskers. This results in a paucity of tasks designed to assess the process of active touch with a forepaw. We develop a new experimental task, the Reach-to-Grasp and Tactile Discrimination task (RGTD task), to examine active touch with a forepaw in rodents, particularly changes
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Sustained insulin treatment restoring metabolic status, body weight, and cognition in an anorexia nervosa-like animal model in mice Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-19 Yosefa Avraham, Tovi Shapira-Furman, Ravi Saklani, Bob Van Heukelom, Moshe Carmel, Lia Vorobiev, Leah Lipsker, Donna R. Zwas, Elliot M. Berry, Abraham J. Domb
Anorexia Nervosa (AN) is a psycho-socio-biological disease characterized by severe weight loss as result of dieting and hyperactivity. Effective treatments are scarce, despite its significant prevalence and mortality. AN patients show lower basal insulin levels and increased metabolic clearance, leading to weight loss, cognitive deficits, and hormonal imbalances. Low-dose polymer insulin could potentially
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Perturbations in risk/reward decision making and frontal cortical catecholamine regulation induced by mild traumatic brain injury Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-16 Christopher P. Knapp, Eleni Papadopoulos, Jessica A. Loweth, Ramesh Raghupathi, Stan B. Floresco, Barry D. Waterhouse, Rachel L. Navarra
Mild traumatic brain injury (mTBI) disrupts cognitive processes that influence risk taking behavior. Little is known regarding the effects of repetitive mild injury (rmTBI) or whether these outcomes are sex specific. Risk/reward decision making is mediated by the prefrontal cortex (PFC), which is densely innervated by catecholaminergic fibers. Aberrant PFC catecholamine activity has been documented
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Increased sensitivity in detection of deficits following two commonly used animal models of stroke Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-16 Kimberly Prescott, Taitum O. Cothren, John T. Holsten, Christopher J. Evonko, Elan C. Doyle, Faith E. Bullock, Paul T. Marron, Julia G. Staton, Laura S. Hatvany, Justin W. Flack, Stacie L. Beuschel, David A. MacQueen, Todd C. Peterson
Stroke is a leading cause of death and disability in the United States. Most strokes are ischemic, resulting in both cognitive and motor impairments. Animal models of ischemic stroke such as the distal middle cerebral artery occlusion (dMCAO) and photothrombotic stroke (PTS) procedures have become invaluable tools, with their own advantages and disadvantages. The dMCAO model is clinically relevant
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Alterations in the brain serotonin system and serotonin-regulated behavior during aging in zebrafish males and females Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-16 Valentina S. Evsiukova, Ivan E. Sorokin, Peter A. Kulikov, Alexander V. Kulikov
The brain serotonin (5-HT) system performs a neurotrophic function and supports the plasticity of the nervous system, while its age-related changes can increase the risk of senile neurodegeneration. Zebrafish brain is highly resistant to damage and neurodegeneration due to its high regeneration potential and it is a promising model object in searching for molecular factors preventing age-related neurodegeneration
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EEG complexity in emotion conflict task in individuals with psychiatric disorders Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-15 Chao Gu, Tina Chou, Alik S. Widge, Darin D. Dougherty
Analyzing EEG complexity may help to elucidate complex brain dynamics in individuals with psychiatric disorders and provide insight into neural connectivity and its relationship with deficits such as emotion-related impulsivity. EEG complexity was calculated through multiscale entropy and compared between a heterogeneous psychiatric patient group and a healthy control group during the emotion conflict
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Serotonin transporter knockdown relieves depression-like behavior and ethanol-induced CPP in mice after chronic social defeat stress Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-13 Amine Bahi
Patients with stress-triggered major depression disorders (MDD) can often seek comfort or temporary relief through alcohol consumption, as they may turn to it as a means of self-medication or coping with overwhelming emotions. The use of alcohol as a coping mechanism for stressful events can escalate, fostering a cycle where the temporary relief it provides from depression can deepen into alcohol dependence
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Effort-cost decision-making associated with negative symptoms in schizophrenia and bipolar disorder Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-10 Serhan Isıklı, Aslıhan Bilge Bektaş, Şule Tamer, Murat Atabay, Bilgesu Deniz Arkalı, Başak Bağcı, Adem Bayrakcı, Miriam Sebold, Nabi Zorlu
Motivational deficits and reduced goal-directed behavior for external rewards have long been considered an important features of negative symptoms in patients with schizophrenia (SCZ). Negative symptoms have also a high prevalence in bipolar disorder (BP). We used a transdiagnostic approach in order to examine association between negative symptoms and effort allocation for monetary rewards. 41 patients
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A TNF-α inhibitor abolishes sepsis-induced cognitive impairment in mice by modulating acetylcholine and nitric oxide homeostasis, BDNF release, and neuroinflammation Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-09 Mehmet Öz, Hüseyin Erdal
Neurodegenerative disorders have a pathophysiology that heavily involves neuroinflammation. In this study, we used lipopolysaccharide (LPS) to create a model of cognitive impairment by inducing systemic and neuroinflammation in experimental animals. LPS was injected intraperitoneally at a dose of 0.5 mg/kg during the last seven days of the study. Adalimumab (ADA), a TNF-α inhibitor, was injected at
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Structural characteristics of amygdala subregions in type 2 diabetes mellitus Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-09 Wenbin Qiu, Xiaomei Yue, Haoming Huang, Limin Ge, Weiye Lu, Zidong Cao, Yawen Rao, Xin Tan, Yan Wang, Jinjian Wu, Yuna Chen, Shijun Qiu, Gang Li
Type 2 diabetes mellitus (T2DM) patients often suffer from depressive symptoms, which seriously affect cooperation in treatment and nursing. The amygdala plays a significant role in depression. This study aims to explore the microstructural alterations of the amygdala in T2DM and to investigate the relationship between the alterations and depressive symptoms. Fifty T2DM and 50 healthy controls were
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Biomarker triterpenoids of Centella asiatica as potential antidepressant agents: Combining in vivo and in silico studies Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-08 Zaynab Mando, Huda Mando, Adlin Afzan, Khozirah Shaari, Zurina Hassan, Mohamad Nurul Azmi Mohamad Taib, Fauziahanim Zakaria
Although there are various treatments available for depression, some patients may experience resistance to treatment or encounter adverse effects. () is an ancient medicinal herb used in Ayurvedic medicine for its rejuvenating, neuroprotective and psychoactive properties. This study aims to explore the antidepressant-like effects of the major constituents found in , i.e., asiatic acid, asiaticoside
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Task-general or specific: The alertness modulates post-error adjustment Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-04 Na Hu, Quanshan Long, Lijun Wang, Xueping Hu, Xiaoxi Wang, Ruimin Ma, Yuqing Bai, Chen Qian, Antao Chen
Previous studies have shown that alertness is closely related to executive control function, but its impact on components of post-error adjustment is unknown. This study applied the Attentional Networks Test and the Four-choice Flanker task with three response stimulus intervals (RSIs) to explore the correlation between alertness and post-error adjustment. The linear mixed-effects model of alertness
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Creatine supplementation research fails to support the theoretical basis for an effect on cognition: Evidence from a systematic review Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-04 Terry McMorris, Beverley J. Hale, Beatrice S. Pine, Thomas B. Williams
Creatine supplementation has been put forward as a possible aid to cognition, particularly for vegans, vegetarians, the elderly, sleep deprived and hypoxic individuals. However, previous narrative reviews have only provided limited support for these claims. This is despite the fact that research has shown that creatine supplementation can induce increased brain concentrations of creatine, albeit to
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Berberine and hesperidin prevent the memory consolidation impairment induced by pentylenetetrazole in zebrafish Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-04 Kanandra Taisa Bertoncello, Gabriel Rodrigues, Carla Denise Bonan
This study verified the effects of the natural compounds berberine and hesperidin on seizure development and cognitive impairment triggered by pentylenetetrazole (PTZ) in zebrafish. Adult animals were submitted to a training session in the inhibitory avoidance test and, after 10 minutes, they received an intraperitoneal injection of 25, 50, or 100 mg/kg berberine or 100 or 200 mg/kg hesperidin. After
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Neural substrates of the interaction between effort-expenditure reward decision-making and outcome anticipation Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-04 Ling-ling Wang, Jiao Wang, Bing-hui Liu, Donghao Tuo, Simon S.Y. Lui, Wei-qing Wan, Jia Huang, Raymond C.K. Chan
Reward anticipation is important for future decision-making, possibly due to re-evaluation of prior decisions. However, the exact relationship between reward anticipation and prior effort-expenditure decision-making, and its neural substrates are unknown. Thirty-three healthy participants underwent fMRI scanning while performing the Effort-based Pleasure Experience Task (E-pet). Participants were required
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The role of the cholinergic system in the memory-protecting effects of metformin in a model of scopolamine-induced memory impairment in aged rats Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-04 Elif Aksoz, Busra Aslan Akyol, Oguzhan Korkut
As the elderly population grows, the prevalence of dementia is also rapidly increasing worldwide. Metformin, an antidiabetic drug, has been shown to have ameliorative effects on impaired cognitive functions in experimental models. However, studies have generally used young animals. Additionally, although it has a major role in Alzheimer's disease (AD) and memory, literature information about the effects
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Neurophysiological analysis of disadvantageous social inequity: Exploring emotional behavior changes and c-Fos expression in a male rat model Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-03 Yujeong Jeong, Jihyun Noh
Humans and other animals exhibit aversive behavioral and emotional responses to unequal reward distributions compared with their conspecifics. Despite the significance of this phenomenon, experimental animal models designed to investigate social inequity aversion and delve into the underlying neurophysiological mechanisms are limited. In this study, we developed a rat model to determine the effects
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Vulnerable at rest? A resting-state EEG study and psychosocial factors of young adult offspring of alcohol-dependent parents Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-03 Milagros Rubio, Ana Sion, Isabel Domínguez Centeno, Daniel Maldonado Sánchez, Gabriel Rubio, Maartje Luijten, Rosa Jurado Barba
Offspring of parents with alcohol use disorder (AUD) are more susceptible to developing AUD, with an estimated heritability of around 50%. Vulnerability to AUD in first-degree relatives is influenced by biological factors, such as spontaneous brain activity, and high-risk psychosocial characteristics. However, existing resting-state EEG studies in AUD offspring have shown inconsistent findings regarding
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Characterisation of behaviours relevant to apathy syndrome in the aged male rat Behav. Brain Res. (IF 2.7) Pub Date : 2024-04-01 Megan G. Jackson, Stafford L. Lightman, Emma S.J. Robinson
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Reducing younger and older adults’ spatial disorientation during indoor-outdoor transitions: Effects of route alignment and visual access on wayfinding Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-29 Yanling Zuo, Jia Zhou
Getting lost could lead to frustration, anxiety, and even fatal accidents. Previous research primarily focused on disorientation in indoor or outdoor environments separately. The indoor-outdoor transition received little attention, yet it is in this complex transition that individuals often lose their way. Therefore, the effects of indoor-outdoor route alignment, visual access, and age on wayfinding
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Neonatal nociceptive stimulation results in pain sensitization, reduction of hippocampal 5-HT1A receptor, and p-CREB expression in adult female rats Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-28 Jackeline Malheiros, Cristiane Amaral, Luiz Severino da Silva, Ruth Guinsburg, Luciene Covolan
Painful invasive procedures are often performed on newborns admitted to intensive care units (ICU). The acute and long-term effects caused by these stimuli can be investigated in animal models, such as newborn rats. Previous studies have shown that animals subjected to nociceptive stimuli in the neonatal period show sex-specific behavioral changes such as signs of anxiety or depression. Under the same
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Tenuifolin improves learning and memory by regulating long-term potentiation and dendritic structure of hippocampal CA1 area in healthy female mice but not male mice Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-28 Heng Kong, Yuan-Yuan Han, Gai-Ling Yang, Kang Li, Lu Yu, Xun-Kai Xie, Guang-Yuan Xia, Peng-Ju Wei, Wan-Rong Zhang, Chu-Hua Li
is an ancient traditional Chinese medicine. Its main component, tenuifolin (TEN), has been proven to improve cognitive impairment caused by neurodegenerative diseases and ovariectomy. However, there was hardly any pharmacological research about TEN and its potential gender differences. Considering the reduction of TEN on learning and memory dysfunction in ovariectomized animals, therefore, we focused
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GPS tracking technology and re-visiting the relationship between the avian visual Wulst and homing pigeon navigation Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-28 Sara Cioccarelli, Dimitri Giunchi, Enrica Pollonara, Giovanni Casini, Verner P. Bingman, Anna Gagliardo
Within their familiar areas homing pigeons rely on familiar visual landscape features and landmarks for homing. However, the neural basis of visual landmark-based navigation has been so far investigated mainly in relation to the role of the hippocampal formation. The avian visual Wulst is the telencephalic projection field of the thalamofugal pathway that has been suggested to be involved in processing
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The hippocampal salt-inducible kinase 2-CREB-regulated transcription co-activator 1 system mediates the antidepressant actions of paroxetine in mice Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-27 Xiang-Ming Cai, Xiao-Yu Sun, Rui Li, Pei-Juan Wang, Jian-Cheng Qiu, Yu-Xin Ge, Lei Yang
The hippocampal salt-inducible kinase 2 (SIK2)-CREB-regulated transcription co-activator 1 (CRTC1) system has been demonstrated to participate in not only the pathogenesis of depression but also the antidepressant mechanisms of several antidepressant medications including fluoxetine, paroxetine, and mirtazapine. Like fluoxetine, paroxetine is also a widely used selective serotonin (5-HT) reuptake inhibitor
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The protective role of sesame oil against Parkinson's-like disease induced by manganese in rats Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-26 Wedad S. Sarawi, Hala A. Attia, Hatun A. Alomar, Rawan Alhaidar, Esraa Rihan, Nora Aldurgham, Rehab A. Ali
Chronic exposure to manganese (Mn) results in motor dysfunction, biochemical and pathological alterations in the brain. Oxidative stress, inflammation, and dysfunction of dopaminergic and GABAergic systems stimulate activating transcription factor-6 (ATF-6) and protein kinase RNA-like ER kinase (PERK) leading to apoptosis. This study aimed to investigate the protective effect of sesame oil (SO) against
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Age-related changes in species-typical behaviours in the 5xFAD mouse model of Alzheimer’s disease from 4 to 16 months of age Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-24 Timothy P. O’Leary, Richard E. Brown
Alzheimer’s disease (AD) patients show age-related decreases in the ability to perform activities of daily living and the decline in these activities is related to the severity of neurobiological deterioration underlying the disease. The 5xFAD mouse model of AD shows age-related impairments in sensory- motor and cognitive function, but little is known about changes in species-typical behaviours that
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Histamine and receptors in neuroinflammation: Their roles on neurodegenerative diseases Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-23 Zhenyu Zhou, Qi An, Wanying Zhang, Yixin Li, Qihang Zhang, Haijing Yan
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Socially-mediated activation in the snake social-decision-making network Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-22 Morgan Skinner, Dania Daanish, Chelsey C. Damphousse, Randolph W. Krohmer, Paul E. Mallet, Bruce E. McKay, Noam Miller
Brain areas important for social perception, social reward, and social behavior – collectively referred to as the social-decision-making network (SDN) – appear to be highly conserved across taxa. These brain areas facilitate a variety of social behaviors such as conspecific approach/avoidance, aggression, mating, parental care, and recognition. Although the SDN has been investigated across taxa, little
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Gastrodin ameliorates depressive-like behaviors via modulating gut microbiota in CUMS-induced mice Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-21 Yanan Zhao, Shaokun Qin, Zixian Yang, Ye Lu, Zongmin Ma, Xin Ping, Guoqiang Sun, Lin Pei
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β-asarone inhibits autophagy by activating the PI3K/Akt/mTOR pathway in a rat model of depression in Parkinson’s disease Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-20 Zhifang Wang, Ping-e Huang, Nanbu Wang, Qinxin Zhang, Jian Kang, Yongqi Fang, Baile Ning, Ling Li
It is unclear whether β-asarone has a good antidepressant effect and what is the main mechanism in Depression in Parkinson’s disease (DPD) model rats. In this study, DPD model rats were screened from 6-OHDA induced rats by sucrose preference test (SPT) and forced swimming test (FST). DPD model rats were divided into eight groups: model group, pramipexole group, β-asarone low-dose group (β-asarone 7
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Memory loss induced by lisdexamfetamine in the rat: A behavioral, electrophysiological, and histopathological Study Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-16 Seyedeh Naghmeh Nourirad, Amir-Hossein Bayat, Mojtaba Sani, Amirreza Beirami, Maral Hasanzadeh, Susan Roustaee, Mobina Fathi, Kimia Vakili, Siavash Parvardeh, Gholam Hossein Meftahi, Nahid Sarahian, Fariba Khodagholi, Abbas Aliaghaei, Hojjat-Allah Abbaszadeh, Meysam Hassani Moghaddam
Lisdexamfetamine (LDX) is one of the drugs commonly used to treat attention deficit hyperactivity disorder (ADHD). However, its neurological side effects, particularly on cognition, are not fully understood. The present study focused on memory in rats treated with four weeks of LDX injection. We compared LDX-treated rats with control ones, using several methods to evaluate the behavioral responses
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Assessment of rTMS treatment effects for methamphetamine use disorder based on EEG microstates Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-16 Yongcong Li, Banghua Yang, Jun Ma, Shouwei Gao, Hui Zeng, Wen Wang
Microstates have been proposed as topographical maps representing large-scale resting-state networks and have recently been suggested as markers for methamphetamine use disorder (MUD). However, it is unknown whether and how they change after repetitive transcranial magnetic stimulation (rTMS) intervention. This study included a comprehensive subject population to investigate the effect of rTMS on MUD
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Cuscuta chinensis Lam. Flavonoids (CCLF) alleviate the symptoms of sepsis-associated encephalopathy via PI3K/Nrf2 pathway Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-16 Qi Boxiang, Sheng Liping, Qian Tong
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MKP1 may be involved in the occurrence of depression by regulating hippocampal autophagy in rats Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-16 Laipeng Feng, Huiying Wang, Chen Chen, Jiacheng Fu, Liqin Zhao, Xia Zhao, Mengjun Geng, Mengdi Ren, Lidan Tong, Yan Li, Jingyang Gu, Changhong Wang
Mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP1) is upregulated in the hippocampus of patients with depression, while pharmacological inhibition of hippocampal MKP1 can mitigate depression-like behaviors in rodents. In addition, MAPK signaling regulates autophagy, and antidepressants were recently shown to target autophagic signaling pathways. We speculated that MKP1 contributes to depression
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Insular and prelimbic cortices control behavioral accuracy and precision in a temporal decision-making task in rats Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-15 Estela B. Nepomoceno, Samanta Rodrigues, Katia S. de Melo, Tatiana L. Ferreira, David Freestone, Marcelo S. Caetano
The anterior insular cortex (AIC) comprises a region of sensory integration. It appears to detect salient events in order to guide goal-directed behavior, code tracking errors, and estimate the passage of time. Temporal processing in the AIC may be instantiated by the integration of representations of interoception. Projections between the AIC and the medial prefrontal cortex (mPFC) - found both in
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CK2 negatively regulates the extinction of remote fear memory Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-15 Jie Yang, Lin Lin, Guang-Jing Zou, Lai-Fa Wang, Fang Li, Chang-Qi Li, Yan-Hui Cui, Fu-Lian Huang
Cognitive behavioral therapy, rooted in exposure therapy, is currently the primary approach employed in the treatment of anxiety-related conditions, including post-traumatic stress disorder (PTSD). In laboratory settings, fear extinction in animals is a commonly employed technique to investigate exposure therapy; however, the precise mechanisms underlying fear extinction remain elusive. Casein kinase
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The role of lateral hypothalamic nucleus in mediating locomotive behaviors in pigeons (Columba livia) Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-13 Xinmao Tian, Zishi Wang, Yuhua Shi, Chongchong Jia, Xiujuan Li, Mengke Li, Haowei Liu, Zhenlong Wang
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Prefrontal activity during IOWA Gambling Task in young adult women Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-13 Ferran Balada, Anton Aluja, Oscar García, Neus Aymamí, Luis F. García
This study aims to investigate the relationships between personality traits of impulsivity, using the UPPS-P Impulsive Behaviour Scales shortened version, and prefrontal cortex (PFC) activity during the IOWA Gambling Task (IGT) in young adult women. The study included a sample of 83 young, healthy females (19.8 ± 1.4 years), who voluntarily took part in the study. Repeated measures analysis during
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Neuroprotective effects of platinum nanoparticle-based microreactors in bicuculline-induced seizures Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-12 Roberto N. Oliveira, Patrícia S. Carvalhinho-Lopes, Carolina P.F. Carvalho, Rafael Y.S. Hirata, Sandra H. Vaz, Ana Maria Sebastião, Adam Armada-Moreira, Bárbara A. Rosário, Jéssica A. Lemes, Beatriz Soares-Silva, José S. de Andrade, José Ronaldo Santos, Alessandra M. Ribeiro, Milena B. Viana
Epilepsy designates a group of chronic brain disorders, characterized by the recurrence of hypersynchronous, repetitive activity, of neuronal clusters. Epileptic seizures are the hallmark of epilepsy. The primary goal of epilepsy treatment is to eliminate seizures with minimal side effects. Nevertheless, approximately 30% of patients do not respond to the available drugs. An imbalance between excitatory/inhibitory
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Chronic MK-801 administration provokes persistent deficits in social memory in the prairie vole (Microtus ochrogaster): A potential animal model for social deficits of schizophrenia Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-12 Enrique Basurto, Oscar González-Flores, Kurt Hoffman
The prairie vole () is a rodent species that has been used extensively to study biological aspects of human social bonding. Nevertheless, this species has not been studied in the context of modeling social deficits characteristic of schizophrenia. Building on studies in rodents that show that sub-chronic administration of an NMDA receptor antagonist induces persistent behavioral and neurological characteristics
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One-trial odour recognition learning and its underlying brain areas in the zebrafish Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-11 Tyrone Lucon-Xiccato, Gaia De Russi, Elena Frigato, Marco Dadda, Cristiano Bertolucci
Distinguishing familiar from novel stimuli is critical in many animals’ activities, and procedures based on this ability are among the most exploited in translational research in rodents. However, recognition learning and the underlying brain substrates remain unclear outside a few mammalian species. Here, we investigated one-trial recognition learning for olfactory stimuli in a teleost fish using
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Neural correlates of inhibitory control in the context of infant cry and paternal postpartum mental health Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-08 Yael Waizman, Ellen Herschel, Sofia I. Cárdenas, Anthony G. Vaccaro, Elizabeth C. Aviv, Pia E. Sellery, Diane Goldenberg, Jonas Kaplan, Darby E. Saxbe
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The cerebellum and its connections to other brain structures involved in motor and non-motor functions: A comprehensive review Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-06 José Mário Prati, André Pontes-Silva, Anna Carolyna Lepesteur Gianlorenço
The cerebellum has a large network of neurons that communicate with several brain structures and participate in different functions. Recent studies have demonstrated that the cerebellum is not only associated with motor functions but also participates in several non-motor functions. It is suggested that the cerebellum can modulate behavior through many connections with different nervous system structures
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Effects of sensory afferent input on motor cortex excitability of agonist and antagonist muscles Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-06 Kenichi Sugawara, Yuma Takenaka, Tomotaka Suzuki
In this study, we aimed to analyze control mechanisms of short-latency afferent inhibition (SAI) during motor output exertion from an agonist or antagonist muscle. The motor task involved index finger abduction (agonist) and adduction (antagonist). In Experiment 1, motor-evoked potentials (MEPs) were recorded from the first dorsal interosseous (FDI) muscle with and without SAI at three output force
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Transcriptomic analysis to identify genes associated with hypothalamus vulnerability in aging mice with cognitive decline Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-05 Xiaofeng Tian, Zhixing Zhao, Jing Zhao, Dongmei Su, Bin He, Cuige Shi, Ying Shi
The normal aging process is accompanied by cognitive decline, and previous studies have indicated the crucial role of the hypothalamus in regulating both aging and cognition. However, the precise molecular mechanism underlying this relationship remains unclear. Therefore, this present study aimed to identify potential predictors of cognitive decline associated with aging specifically within the hypothalamus
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Acrobatic training prevents motor deficits and neuronal loss in male and female rats following chronic cerebral hypoperfusion Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-05 Ana Paula Rodrigues Martini, Eduarda Hoeper, Débora Piassarollo Dos Santos, Tatiana Norman, Adriana Souza dos Santos, Lenir Orlandi Pereira, Carlos Alexandre Netto
Chronic cerebral hypoperfusion in vascular dementia leads to memory and motor deficits; Physical exercise improves these aspects and promotes neuroprotection. Sexual dimorphism may significantly influence both ischemic and exercise outcomes. The aim of this study was to investigate the effects of 2VO (Two-Vessel occlusion) and the acrobatic training on motor function, functional performance, and tissue
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WITHDRAWN: Pro-inflammatory markers are related to cortical network connectivity in women exposed to interpersonal trauma with PTSD Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-04 Marissa A. Yetter, Taryn R. Fitzgerald, Carissa L. Philippi, Steven E. Bruce
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Quercetin attenuates brain apoptosis in mice with chronic unpredictable mild stress-induced depression Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-02 Chenjie Ge, Shiliang Wang, Xuqi Wu, Lilei Lei
Depression is a common psychiatric disorder with limited effective treatments. Research suggests that depression involves apoptosis mechanisms. Quercetin (QUE) has been reported to have anti-apoptotic activities. In this study, we aimed to investigate the effects and mechanisms of QUE in chronic unpredictable mild stress (CUMS)-induced depression. After establishing mouse models of CUMS-induced depression
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Beauty is in the nose of the beholder: Fragrance modulates attractiveness, confidence and femininity ratings and neural responses to faces of self and others Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-02 Jennifer Davies-Owen, Hannah Roberts, Margaret Scott, Anna Thomas, Soumitra Sen, Simone Sethna, Carl Roberts, Timo Giesbrecht, Nicholas Fallon
Previous research investigated cross-modal influence of olfactory stimuli on perception and evaluation of faces. However, little is known about the neural dynamics underpinning this multisensory perception, and no research examined perception for images of oneself, and others, in presence of fragrances. This study investigated the neural mechanisms of olfactory-visual processing using electroencephalography
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Effects of chronic unpredictable mild stress on gut microbiota and fecal amino acid and short-chain fatty acid pathways in mice Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-02 Mengjing Chen, Lingfeng Wang, Yeliang Lou, Zhen Huang
Depression is a serious disease that has a significant impact on social functioning. However, the exact causes of depression are still not fully understood. Therefore, it is necessary to explore new pathways leading to depression. In this study, we used 16 S rDNA to examine changes in gut microbiota and predict related pathways in depression-like mice. Additionally, we employed liquid chromatography-mass
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Father’s Absence in the Mongolian gerbil (Meriones unguiculatus) is associated with alterations in paternal behavior, T, cort, presence of ERα, and AR in mPOA/ BNST Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-01 Brenda García-Saucedo, Luis Romero-Morales, Carmen Álvarez-Rodríguez, René Cárdenas-Vázquez, María Rosa Ávila-Costa, Juana Luis
Testosterone (T), estrogen receptor alpha (ERα), and androgen receptor (AR) play a significant role in the regulation of paternal behavior. We determined the effects of deprivation of paternal care on alterations in paternal behavior, T concentrations in plasma, and the presence of ERα and AR in the medial preoptic area (mPOA), bed nucleus of the stria terminalis (BNST), medial amygdala (MeA), and
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Electrophysiological indexes of ingroup bias in a group Stroop task: Evidence from an event-related potential study Behav. Brain Res. (IF 2.7) Pub Date : 2024-03-01 Jiashan Sima, Huanke Ma, Fan Liu, Chenjun Lou, Feng Zou, Yufeng Wang, Yanyan Luo, Meng Zhang, Xin Wu
Although cognitive system assigns higher attentional resources to ingroup information than outgroup information, but it is unclear whether the ingroup bias can be measured by the processes that are related to allocation of attentional resources to ingroup information. Thus, a group Stroop task was developed to study the issues combining with event-related potential (ERP) technique in this study. Specifically
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Synergistic effects of citicoline and silymarin nanomicelles in restraint stress-exposed mice Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-29 Elham Shayan, Fatemeh Maheri, Fatemeh Aflaki, Seyyedeh-Elaheh Mousavi, Mohammad-Reza Zarrindast, Nahid Fakhraei, Seyyed-Mahdi Rezayat Sorkhabadi, Seyed-Mohammad-Masoud Shushtarian
This study evaluated the effects of citicoline and silymarin nanomicelles (SMnm) in repeated restraint stress (RRS). Mice were exposed to RRS for four consecutive days, 2 hrs. daily. On day 5 of the study, SMnm (25 and 50 mg/kg, i.p.) and citicoline (25 and 75 mg/kg), and a combination of them (25 mg/kg, i.p.) were initiated. On day 18, anxiety-like behavior, behavioral despair, and exploratory behavior
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Genetic causal association between varicella-zoster virus infection and psychiatric disorders: A 2-sample Mendelian randomization study Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-29 Bo Yan, Pan Liao, Conglin Wang, Zhaoli Han, Fangyuan Cheng, Ping Lei
Psychiatric disorders, such as schizophrenia (SCZ), major depressive (MDD), and bipolar disorder (BD) have a profound impact on millions of individuals worldwide. The critical step toward developing effective preventive and treatment strategies lies in comprehending the causal mechanisms behind these diseases and identifying modifiable risk factors associated with them. In this study, we conducted
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Neural correlates of the addictions neuroclinical assessment (ANA) incentive salience factor among individuals with alcohol use disorder Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-29 Steven J. Nieto, Erica N. Grodin, Lara A. Ray
The Addictions Neuroclinical Assessment (ANA) is a recently-developed framework offering a more holistic understanding of three neurofunctional and behavioral domains that reflect the neurobiological dysfunction seen in alcohol use disorder (AUD). While the ANA domains have been well-validated across independent laboratories, there is a critical need to identify neural markers that subserve the proposed
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Exposure to the psychedelic substance 25 H-NBOMe disrupts maternal care in lactating rats and subsequently impairs the social play behavior of the offspring Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-27 Lidia M. Melo, Wellington A. de Barros, Ângelo de Fátima, Fabiana C.Vilela Giusti, Alexandre Giusti-Paiva
Given the critical role of maternal care in the neurodevelopment of offspring, this study aimed to investigate the effects of the psychedelic substance 25 H-NBOMe on maternal behavior in lactating rats and its subsequent impact on the social and neurodevelopmental behavior of the offspring. We administered two different dosages of 25 H-NBOMe (0.3 mg/kg and 1.0 mg/kg; i,p,) to lactating rats and observed
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Genetic variation in endocannabinoid signaling: Anxiety, depression, and threat- and reward-related brain functioning during the transition into adolescence Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-27 Shreya Desai, Clara G. Zundel, Julia M. Evanski, Leah C. Gowatch, Amanpreet Bhogal, Samantha Ely, Carmen Carpenter, MacKenna Shampine, Emilie O’Mara, Christine A. Rabinak, Hilary A. Marusak
The endocannabinoid system modulates neural activity throughout the lifespan. In adults, neuroimaging studies link a common genetic variant in fatty acid amide hydrolase ()—an enzyme that regulates endocannabinoid signaling—to reduced risk of anxiety and depression, and altered threat- and reward-related neural activity. However, limited research has investigated these associations during the transition
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The 5-HT2A, 5-HT5A, and 5-HT6 serotonergic receptors in the medial prefrontal cortex behave differently in extinction learning: Does social support play a role? Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-24 Clarissa Penha Farias, Ana Karla Oliveira Leite, Bianca Estefani Schmidt, Jociane de Carvalho Myskiw, Angela T.S. Wyse
Studies on the social modulation of fear have revealed that in social species, individuals in a distressed state show better recovery from aversive experiences when accompanied - referred to as social buffering. However, the underlying mechanisms remain unknown, hindering the understanding of such an approach. Our previous data showed that the presence of a conspecific during the extinction task inhibited
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Exploring transgenerational inheritance in epigenotypes of DAT heterozygous rats: Circadian anomalies and attentional vulnerability Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-24 Concetto Puzzo, Fabiana Festucci, Giuseppe Curcio, Antonella Gigantesco, Walter Adriani
Dopamine (DA) is mainly involved in locomotor activity, reward processes and maternal behaviors. Rats with KO gene for dopamine transporter (DAT), coding for a truncated DAT protein, are in hyperdopaminergic conditions and thus develop stereotyped behaviors and hyperactivity. Our aim was to test the prior transgenerational modulation of wild and truncated alleles as expressed in heterozygous DAT rats:
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Age dependent path integration deficit in 5xFAD mice Behav. Brain Res. (IF 2.7) Pub Date : 2024-02-24 Kendall D. Mar, Chanbee So, Yixin Hou, Jun Chul Kim
Alzheimer's disease (AD) is a severe neurodegenerative disorder and the most common form of dementia in elderly individuals, characterized by memory deficits, cognitive decline, and neuropathology. The identification of preclinical markers for AD remains elusive. We employed an ultrasound-evoked spatial memory assay to investigate path integration (PI) in wild type C57BL/6 J and 5xFAD mice. We observed