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Plasma membrane damage is a new trigger of cellular senescence Trends Cell Biol. (IF 19.0) Pub Date : 2024-03-15 Nadine Martin, Céline Margand, David Bernard
By blocking proliferation and inducing a secretory phenotype, cellular senescence has beneficial and deleterious effects, the latter being linked to aging. . recently reported that plasma membrane (PM) damage (PMD) triggers senescence, suggesting that PMD inducers promote senescence and that the PMD repair machinery can regulate it.
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A20: a jack of all trades Trends Cell Biol. (IF 19.0) Pub Date : 2024-03-09 Pieter Hertens, Geert van Loo
Mutations and polymorphisms in / have been linked to various inflammatory disorders. However, in addition to its well-known role in inflammation, A20 also controls EDAR- and receptor activator of NF-κB (RANK)-induced NF-κB signaling, regulating the development of epidermal skin appendages and bone, respectively. Furthermore, A20 regulates synapse remodeling through a mechanism dependent on NF-κB.
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Tear down this wall: phosphorylation regulates the internal interfaces of postsynaptic condensates Trends Cell Biol. (IF 19.0) Pub Date : 2024-02-29 Gerard Aguilar Pérez, Rohit V. Pappu, Dragomir Milovanovic
Can the fusion/fission of biomolecular condensates be regulated in cells? In a recent study, show that phosphorylation of a key scaffold protein that drives condensates in postsynaptic densities modulates the apparent miscibility of underlying components, thus enabling intracondensate demixing-to-mixing transitions.
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ER: a critical hub for STING signaling regulation Trends Cell Biol. (IF 19.0) Pub Date : 2024-02-28 Yuan Luo, Lei Chang, Yewei Ji, Tingbo Liang
The Stimulator of Interferon Genes (STING) has a crucial role in mediating the immune response against cytosolic double-stranded DNA (dsDNA) and its activation is critically involved in various diseases. STING is synthesized, modified, and resides in the endoplasmic reticulum (ER), and its ER exit is intimately connected with its signaling. The ER, primarily known for its roles in protein folding,
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Epigenetic control of circadian clocks by environmental signals Trends Cell Biol. (IF 19.0) Pub Date : 2024-02-28 Xiao-Lan Liu, Zeyu Duan, Muqun Yu, Xiao Liu
Circadian clocks have evolved to enable organisms to respond to daily environmental changes. Maintaining a robust circadian rhythm under various perturbations and stresses is essential for the fitness of an organism. In the core circadian oscillator conserved in eukaryotes (from fungi to mammals), a negative feedback loop based on both transcription and translation drives circadian rhythms. The expression
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Translation is an emerging constraint on protein homeostasis in ageing Trends Cell Biol. (IF 19.0) Pub Date : 2024-02-28 Jack Llewellyn, Simon J. Hubbard, Joe Swift
Proteins are molecular machines that provide structure and perform vital transport, signalling and enzymatic roles. Proteins expressed by cells require tight regulation of their concentration, folding, localisation, and modifications; however, this state of protein homeostasis is continuously perturbed by tissue-level stresses. While cells in healthy tissues are able to buffer against these perturbations
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Driving factors of neuronal ferroptosis Trends Cell Biol. (IF 19.0) Pub Date : 2024-02-23 Julie Jacquemyn, Isha Ralhan, Maria S. Ioannou
Ferroptosis is an oxidative form of iron-dependent cell death characterized by the accumulation of lipid peroxides on membranes. Iron and lipids containing polyunsaturated fatty acids are essential for this process. Ferroptosis is central to several neurological diseases and underlies the importance of balanced iron and polyunsaturated fatty acid metabolism in the brain, particularly in neurons. Here
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ER remodeling via lipid metabolism Trends Cell Biol. (IF 19.0) Pub Date : 2024-02-23 Wonyul Jang, Volker Haucke
Unlike most other organelles found in multiple copies, the endoplasmic reticulum (ER) is a unique singular organelle within eukaryotic cells. Despite its continuous membrane structure, encompassing more than half of the cellular endomembrane system, the ER is subdivided into specialized sub-compartments, including morphological, membrane contact site (MCS), and organelle biogenesis domains. In this
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Chromosome compartmentalization: causes, changes, consequences, and conundrums Trends Cell Biol. (IF 19.0) Pub Date : 2024-02-22 Heng Li, Christopher Playter, Priyojit Das, Rachel Patton McCord
The spatial segregation of the genome into compartments is a major feature of 3D genome organization. New data on mammalian chromosome organization across different conditions reveal important information about how and why these compartments form and change. A combination of epigenetic state, nuclear body tethering, physical forces, gene expression, and replication timing (RT) can all influence the
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Functional analysis of cell plasticity using single-cell technologies Trends Cell Biol. (IF 19.0) Pub Date : 2024-02-13 Xiao Qin, Christopher J. Tape
Metazoan organisms are heterocellular systems composed of hundreds of different cell types, which arise from an isogenic genome through differentiation. Cellular ‘plasticity’ further enables cells to alter their fate in response to exogenous cues and is involved in a variety of processes, such as wound healing, infection, and cancer. Recent advances in cellular model systems, high-dimensional single-cell
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Regulatory landscape of enhancer-mediated transcriptional activation Trends Cell Biol. (IF 19.0) Pub Date : 2024-02-13 Koji Kawasaki, Takashi Fukaya
Enhancers are noncoding regulatory elements that instruct spatial and temporal specificity of gene transcription in response to a variety of intrinsic and extrinsic signals during development. Although it has long been postulated that enhancers physically interact with target promoters through the formation of stable loops, recent studies have changed this static view: sequence-specific transcription
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Epithelial metabolism as a rheostat for intestinal inflammation and malignancy Trends Cell Biol. (IF 19.0) Pub Date : 2024-02-10 Julian Schwärzler, Lisa Mayr, Felix Grabherr, Herbert Tilg, Timon E. Adolph
The gut epithelium protects the host from a potentially hostile environment while allowing nutrient uptake that is vital for the organism. To maintain this delicate task, the gut epithelium has evolved multilayered cellular functions ranging from mucus production to hormone release and orchestration of mucosal immunity. Here, we review the execution of intestinal epithelial metabolism in health and
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RNA G-quadruplexes and stress: emerging mechanisms and functions Trends Cell Biol. (IF 19.0) Pub Date : 2024-02-09 Prakash Kharel, Pavel Ivanov
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Modulation of extrinsic apoptotic pathway by intracellular glycosylation Trends Cell Biol. (IF 19.0) Pub Date : 2024-02-08 Kamil Seyrek, Nikita V. Ivanisenko, Corinna König, Inna N. Lavrik
The importance of post-translational modifications (PTMs), particularly O-GlcNAcylation, of cytoplasmic proteins in apoptosis has been neglected for quite a while. Modification of cytoplasmic proteins by a single N-acetylglucosamine sugar is a dynamic and reversible PTM exhibiting properties more like phosphorylation than classical O- and N-linked glycosylation. Due to the sparse information existing
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SUMO proteases: from cellular functions to disease Trends Cell Biol. (IF 19.0) Pub Date : 2024-02-06 Laura A. Claessens, Alfred C.O. Vertegaal
Posttranslational modification by small ubiquitin-like modifiers (SUMOs) is critical in regulating diverse cellular processes including gene expression, cell cycle progression, genome integrity, cellular metabolism, and inflammation and immunity. The covalent attachment of SUMOs to target proteins is highly dynamic and reversible through the concerted action of SUMO conjugating and deconjugating enzymes
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Coordinated in confined migration: crosstalk between the nucleus and ion channel-mediated mechanosensation Trends Cell Biol. (IF 19.0) Pub Date : 2024-01-29 Panagiotis Mistriotis, Emily O. Wisniewski, Bishwa R. Si, Petr Kalab, Konstantinos Konstantopoulos
Cell surface and intracellular mechanosensors enable cells to perceive different geometric, topographical, and physical cues. Mechanosensitive ion channels (MICs) localized at the cell surface and on the nuclear envelope (NE) are among the first to sense and transduce these signals. Beyond compartmentalizing the genome of the cell and its transcription, the nucleus also serves as a mechanical gauge
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Advisory Board and Contents Trends Cell Biol. (IF 19.0) Pub Date : 2024-02-01
Abstract not available
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Subscription and Copyright Information Trends Cell Biol. (IF 19.0) Pub Date : 2024-02-01
Abstract not available
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The yin and yang of nuclear envelope breakdown through the activity of phosphatase holoenzyme PP2A-B55SUR-6 Trends Cell Biol. (IF 19.0) Pub Date : 2024-01-31 Joseph S. Glavy
Cell division is a highly regulated and guardedly orchestrated process including nuclear envelope breakdown (NEBD). A recent study from Kapoor, Adhikary, and Kotak identifies the symphonic role of a phosphatase holoenzyme in NEBD.
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Membrane remodeling and trafficking piloted by SARS-CoV-2 Trends Cell Biol. (IF 19.0) Pub Date : 2024-01-22 Maria Concetta Sergio, Simona Ricciardi, Andrea M. Guarino, Laura Giaquinto, Maria Antonietta De Matteis
The molecular mechanisms underlying SARS-CoV-2 host cell invasion and life cycle have been studied extensively in recent years, with a primary focus on viral entry and internalization with the aim of identifying antiviral therapies. By contrast, our understanding of the molecular mechanisms involved in the later steps of the coronavirus life cycle is relatively limited. In this review, we describe
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The uncharted territory of NAD+-capped RNA Trends Cell Biol. (IF 19.0) Pub Date : 2024-01-18 Quan Ma, Jianzhao Liu, Hao Hu, Zisheng Luo
The critical redox cofactor NAD+ was recently reported to serve as an RNA cap in both eukaryotes and prokaryotes. However, its reversible regulation and biological functions remain unclear. Here, we provide insights into its discovery, capping and decapping mechanisms, for further discovery of their potential functional implications.
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Crosstalk between gut microbiota and cellular senescence: a vicious cycle leading to aging gut Trends Cell Biol. (IF 19.0) Pub Date : 2024-01-13 Shimpei Kawamoto, Eiji Hara
Two phenomena, the accumulation of senescent cells and changes in the gut microbiota, are thought to contribute to the decline of biological functions and the development of diseases associated with aging. However, the relationship between these two phenomena and their effects on aging remains to be clarified. Recently, we have reported that gut bacteria induce cellular senescence in ileal germinal
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Advancing cell biology with nanoscale fluorescence imaging: essential practical considerations Trends Cell Biol. (IF 19.0) Pub Date : 2024-01-05 Elisa DʼEste, Gražvydas Lukinavičius, Richard Lincoln, Felipe Opazo, Eugenio F. Fornasiero
Recently, biologists have gained access to several far-field fluorescence nanoscopy (FN) technologies that allow the observation of cellular components with ~20 nm resolution. FN is revolutionizing cell biology by enabling the visualization of previously inaccessible subcellular details. While technological advances in microscopy are critical to the field, optimal sample preparation and labeling are
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Advisory Board and Contents Trends Cell Biol. (IF 19.0) Pub Date : 2024-01-04
Abstract not available
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Subscription and Copyright Information Trends Cell Biol. (IF 19.0) Pub Date : 2024-01-04
Abstract not available
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An ATM D-compartmentalization in DNA damage response Trends Cell Biol. (IF 19.0) Pub Date : 2023-12-29 Anjali Prasad, Arun Kanakkanthara
How chromatin configuration impacts DNA repair is an emerging question. A recent study by shows that ATM orchestrates a new chromatin compartment (D compartment) following DNA double-strand breaks and establishes that this compartment enhances cellular response to such breaks but also introduces a risk to genome integrity.
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Mechanical activation of mitochondria in germ cell differentiation Trends Cell Biol. (IF 19.0) Pub Date : 2023-12-21 Christoph G. Gäbelein, Ruth Lehmann
Mitochondria are activated during stem cell differentiation. Recently, Wang et al. found that mechanical stimulation from tissue surrounding differentiating germ cells in the female fly ovary is necessary to sustain intracellular calcium levels, promoting mitochondrial activity. This suggests a molecular link between cell mechanics and developmental metabolic transitions in eukaryotes.
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Lysosomal microautophagy: an emerging dimension in mammalian autophagy Trends Cell Biol. (IF 19.0) Pub Date : 2023-12-15 Yoshihiko Kuchitsu, Tomohiko Taguchi
Autophagy is a self-catabolic process through which cellular components are delivered to lysosomes for degradation. There are three types of autophagy, i.e., macroautophagy, chaperone-mediated autophagy (CMA), and microautophagy. In macroautophagy, a portion of the cytoplasm is wrapped by the autophagosome, which then fuses with lysosomes and delivers the engulfed cytoplasm for degradation. In CMA
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Mechanism-aware and multimodal AI: beyond model-agnostic interpretation Trends Cell Biol. (IF 19.0) Pub Date : 2023-12-11 Annalisa Occhipinti, Suraj Verma, Le Minh Thao Doan, Claudio Angione
Artificial intelligence (AI) is widely used for exploiting multimodal biomedical data, with increasingly accurate predictions and model-agnostic interpretations, which are however also agnostic to biological mechanisms. Combining metabolic modelling, ‘omics, and imaging data via multimodal AI can generate predictions that can be interpreted mechanistically and transparently, therefore with significantly
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The interplay of the circadian clock and metabolic tumorigenesis Trends Cell Biol. (IF 19.0) Pub Date : 2023-12-06 Zheng Wang, Leina Ma, Ying Meng, Jing Fang, Daqian Xu, Zhimin Lu
The circadian clock and cell metabolism are both dysregulated in cancer cells through intrinsic cell-autonomous mechanisms and external influences from the tumor microenvironment. The intricate interplay between the circadian clock and cancer cell metabolism exerts control over various metabolic processes, including aerobic glycolysis, de novo nucleotide synthesis, glutamine and protein metabolism
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Metabolic immunity against microbes Trends Cell Biol. (IF 19.0) Pub Date : 2023-11-29 Sebastian Kreimendahl, Lena Pernas
Pathogens, including viruses, bacteria, fungi, and parasites, remodel the metabolism of their host to acquire the nutrients they need to proliferate. Thus, host cells are often perceived as mere exploitable nutrient pools during infection. Mounting reports challenge this perception and instead suggest that host cells can actively reprogram their metabolism to the detriment of the microbial invader
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Opportunities and challenges for deep learning in cell dynamics research Trends Cell Biol. (IF 19.0) Pub Date : 2023-11-28 Binghao Chai, Christoforos Efstathiou, Haoran Yue, Viji M. Draviam
The growth of artificial intelligence (AI) has led to an increase in the adoption of computer vision and deep learning (DL) techniques for the evaluation of microscopy images and movies. This adoption has not only addressed hurdles in quantitative analysis of dynamic cell biological processes but has also started to support advances in drug development, precision medicine, and genome–phenome mapping
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Cutting through the stress: RNA decay pathways at the endoplasmic reticulum Trends Cell Biol. (IF 19.0) Pub Date : 2023-11-25 Franziska Ottens, Sotirios Efstathiou, Thorsten Hoppe
The endoplasmic reticulum (ER) is central to the processing of luminal, transmembrane, and secretory proteins, and maintaining a functional ER is essential for organismal physiology and health. Increased protein-folding load on the ER causes ER stress, which activates quality control mechanisms to restore ER function and protein homeostasis. Beyond protein quality control, mRNA decay pathways have
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Emerging roles of nuclear bodies in genome spatial organization Trends Cell Biol. (IF 19.0) Pub Date : 2023-11-21 Lin Shan, Pan Li, Hongtao Yu, Ling-Ling Chen
Nuclear bodies (NBs) are biomolecular condensates that participate in various cellular processes and respond to cellular stimuli in the nucleus. The assembly and function of these protein- and RNA-rich bodies, such as nucleoli, nuclear speckles, and promyelocytic leukemia (PML) NBs, contribute to the spatial organization of the nucleus, regulating chromatin activities locally and globally. Recent technological
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Olfaction: an emerging regulator of longevity and metabolism Trends Cell Biol. (IF 19.0) Pub Date : 2023-11-25 Maximillian A. Thompson, Evandro A. De-Souza
Ageing is a malleable process influenced by the environment. Recent research reveals that neurons interact with peripheral organs to regulate metabolism and longevity by responding to olfactory cues through specific pathways, such as the unfolded protein response (UPR) and microRNAs. Here, we examine the significance of these findings.
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Phenotypic noise and plasticity in cancer evolution Trends Cell Biol. (IF 19.0) Pub Date : 2023-11-15 Frederick J.H. Whiting, Jacob Househam, Ann-Marie Baker, Andrea Sottoriva, Trevor A. Graham
Non-genetic alterations can produce changes in a cell’s phenotype. In cancer, these phenomena can influence a cell’s fitness by conferring access to heritable, beneficial phenotypes. Herein, we argue that current discussions of ‘phenotypic plasticity’ in cancer evolution ignore a salient feature of the original definition: namely, that it occurs in response to an environmental change. We suggest ‘phenotypic
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Cancer takes many paths through G1/S Trends Cell Biol. (IF 19.0) Pub Date : 2023-11-10 Erik S. Knudsen, Agnieszka K. Witkiewicz, Seth M. Rubin
In the commonly accepted paradigm for control of the mammalian cell cycle, sequential cyclin-dependent kinase (CDK) and cyclin activities drive the orderly transition from G1 to S phase. However, recent studies using different technological approaches and examining a broad range of cancer cell types are challenging this established paradigm. An alternative model is evolving in which cell cycles utilize
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Fumarate hydratase as a metabolic regulator of immunity Trends Cell Biol. (IF 19.0) Pub Date : 2023-11-06 Christian G. Peace, Shane M. O’Carroll, Luke A.J. O’Neill
Tricarboxylic acid (TCA) cycle metabolites have been implicated in modulating signalling pathways in immune cells. Notable examples include succinate and itaconate, which have pro- and anti-inflammatory roles, respectively. Recently, fumarate has emerged as having specific roles in macrophage activation, regulating the production of such cytokines as interleukin (IL)-10 and type I interferons (IFNs)
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Advisory Board and Contents Trends Cell Biol. (IF 19.0) Pub Date : 2023-11-09
Abstract not available
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Subscription and Copyright Information Trends Cell Biol. (IF 19.0) Pub Date : 2023-11-09
Abstract not available
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Hard to handle: how lipid saturation affects the nuclear envelope Trends Cell Biol. (IF 19.0) Pub Date : 2023-11-08 Pascal Höhne, Maria Bohnert
The nuclear envelope is a unique subdomain of the endoplasmic reticulum (ER) that encapsulates the genome and mediates communication between the nucleus and the rest of the cell via nuclear pore complexes. A recent study by Romanauska and Köhler shows that balanced lipid unsaturation is critical for nuclear envelope and nuclear pore complex architecture and function.
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Multiplicity of stem cell memories of inflammation and tissue repair in epithelia Trends Cell Biol. (IF 19.0) Pub Date : 2023-11-06 Chiara Levra Levron, Giacomo Donati
Adaptation enables cells to change their behavior in response to transient stimuli. While adaptive programs of immune cells have been widely described, it has recently emerged that epithelial cells also acquire memories in vivo. Here, we discuss and classify the adaptations identified in epithelia and describe the associated long-term consequences.
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Mitochondrial complexome and import network Trends Cell Biol. (IF 19.0) Pub Date : 2023-10-31 Fabian den Brave, Uwe Schulte, Bernd Fakler, Nikolaus Pfanner, Thomas Becker
Mitochondria perform crucial functions in cellular metabolism, protein and lipid biogenesis, quality control, and signaling. The systematic analysis of protein complexes and interaction networks provided exciting insights into the structural and functional organization of mitochondria. Most mitochondrial proteins do not act as independent units, but are interconnected by stable or dynamic protein–protein
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Mitochondrial regulation in stem cells Trends Cell Biol. (IF 19.0) Pub Date : 2023-10-31 Yifei Wang, Marine Barthez, Danica Chen
Stem cells persist throughout the lifespan to repair and regenerate tissues due to their unique ability to self-renew and differentiate. Here we reflect on the recent discoveries in stem cells that highlight a mitochondrial metabolic checkpoint at the restriction point of the stem cell cycle. Mitochondrial activation supports stem cell proliferation and differentiation by providing energy supply and
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Regulation of leukemogenesis via redox metabolism Trends Cell Biol. (IF 19.0) Pub Date : 2023-10-28 Zhuo Zhang, Chiqi Chen, Xie Li, Junke Zheng, Yuzheng Zhao
Redox metabolism plays a central role in the cellular metabolism network, involves catabolic and anabolic reactions of diverse biomass, and determines the redox state of cells. It can be quantitatively and conveniently measured in living cells and organisms with genetically encoded fluorescent sensors, providing novel insights that cannot be readily acquired via conventional metabolic assays. Here
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Astrocyte morphology Trends Cell Biol. (IF 19.0) Pub Date : 2023-10-26 Katherine T. Baldwin, Keith K. Murai, Baljit S. Khakh
Astrocytes are predominant glial cells that tile the central nervous system (CNS). A cardinal feature of astrocytes is their complex and visually enchanting morphology, referred to as bushy, spongy, and star-like. A central precept of this review is that such complex morphological shapes evolved to allow astrocytes to contact and signal with diverse cells at a range of distances in order to sample
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Lysosomal cystine: an unexpected alarm bell for cysteine scarcity Trends Cell Biol. (IF 19.0) Pub Date : 2023-10-23 Fabio Hecht, Isaac S. Harris
Cells respond to amino acid depletion by activating stress responses. A recent study by Swanda et al. reveals that a decrease in lysosomal cystine triggers a novel stress response that transcriptionally activates ATF4 and protects cells from ferroptosis. A synthetic mRNA, CysRx, can prevent ATF4 activation and enhance antitumor effects.
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Advancements in kidney organoids and tubuloids to study (dys)function Trends Cell Biol. (IF 19.0) Pub Date : 2023-10-19 E. Dilmen, I. Orhon, J. Jansen, J.G.J. Hoenderop
The rising prevalence of kidney diseases urges the need for novel therapies. Kidney organoids and tubuloids are advanced in vitro models and have recently been described as promising tools to study kidney (patho)physiology. Recent developments have shown their application in disease modeling, drug screening, and nephrotoxicity. These applications rely on their ability to mimic (dys)function in vitro
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Control of mitochondrial dynamics by a fusogenic lipid Trends Cell Biol. (IF 19.0) Pub Date : 2023-10-17 Zheng Yang, David C. Chan
Mitochondrial fusion enables cooperation between the mitochondrial population and is critical for mitochondrial function. Phosphatidic acid (PA) on the mitochondrial surface has a key role in mitochondrial fusion. A recent study by Su et al. shows that the nucleoside diphosphate (NDP) kinase NME3 recognizes PA and mediates its effects on mitochondrial dynamics.
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Subscription and Copyright Information Trends Cell Biol. (IF 19.0) Pub Date : 2023-10-12
Abstract not available
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Advisory Board and Contents Trends Cell Biol. (IF 19.0) Pub Date : 2023-10-12
Abstract not available
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The cell biology of APOE in the brain Trends Cell Biol. (IF 19.0) Pub Date : 2023-10-05 Ian A. Windham, Sarah Cohen
Apolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic risk factor for Alzheimer’s disease (AD) and a multitude of other neurodegenerative diseases, yet the molecular mechanisms by which APOE4 drives disease are still unclear. A growing collection of studies in iPSC models, knock-in mice, and human postmortem brain tissue have demonstrated that
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Tetraspanins: structure, dynamics, and principles of partner-protein recognition Trends Cell Biol. (IF 19.0) Pub Date : 2023-09-30 Katherine J. Susa, Andrew C. Kruse, Stephen C. Blacklow
Tetraspanins are a large, highly conserved family of four-pass transmembrane (TM) proteins that play critical roles in a variety of essential cellular functions, including cell migration, protein trafficking, maintenance of membrane integrity, and regulation of signal transduction. Tetraspanins carry out these biological functions primarily by interacting with partner proteins. Here, we summarize significant
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The ubiquitous role of ubiquitination in lipid metabolism Trends Cell Biol. (IF 19.0) Pub Date : 2023-09-26 Melanie Loix, Noam Zelcer, Jeroen F.J. Bogie, Jerome J.A. Hendriks
Lipids are essential molecules that play key roles in cell physiology by serving as structural components, for storage of energy, and in signal transduction. Hence, efficient regulation and maintenance of lipid homeostasis are crucial for normal cellular and tissue function. In the past decade, increasing research has shown the importance of ubiquitination in regulating the stability of key players
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The emerging role of receptor tyrosine kinase phase separation in cancer Trends Cell Biol. (IF 19.0) Pub Date : 2023-09-28 Chi-Chuan Lin, Kin Man Suen, Jessica Lidster, John E. Ladbury
Receptor tyrosine kinase (RTK)-mediated signal transduction is fundamental to cell function and drives important cellular outcomes which, when dysregulated, can lead to malignant tumour growth and metastasis. The initiation of signals from plasma membrane-bound RTKs is subjected to multiple regulatory mechanisms that control downstream effector protein recruitment and function. The high propensity
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Regulatory architecture of cell identity genes and housekeeping genes Trends Cell Biol. (IF 19.0) Pub Date : 2023-09-27 Alessandra Dall’Agnese, Richard Young
Gene regulation and chromosome architecture are intimately linked. Genes with prominent roles in cell identity are often regulated by clusters of enhancer elements. By contrast, a recent study shows housekeeping genes are often regulated through clustering of promoters. We discuss here new regulatory insights for these two types of genes.
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Towards solving the mystery of peroxisomal matrix protein import Trends Cell Biol. (IF 19.0) Pub Date : 2023-09-22 Michael L. Skowyra, Peiqiang Feng, Tom A. Rapoport
Peroxisomes are vital metabolic organelles that import their lumenal (matrix) enzymes from the cytosol using mobile receptors. Surprisingly, the receptors can even import folded proteins, but the underlying mechanism has been a mystery. Recent results reveal how import receptors shuttle cargo into peroxisomes. The cargo-bound receptors move from the cytosol across the peroxisomal membrane completely
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Vimentin at the core of wound healing Trends Cell Biol. (IF 19.0) Pub Date : 2023-09-23 Leila S. Coelho-Rato, Sepideh Parvanian, Mayank Kumar Modi, John E. Eriksson
As a member of the large family of intermediate filaments (IFs), vimentin has emerged as a highly dynamic and versatile cytoskeletal protein involved in many key processes of wound healing. It is well established that vimentin is involved in epithelial–mesenchymal transition (EMT) during wound healing and metastasis, during which epithelial cells acquire more dynamic and motile characteristics. Moreover
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Responses of organ precursors to correct and incorrect inductive signals Trends Cell Biol. (IF 19.0) Pub Date : 2023-09-20 Yun Yang, Shuang Li, Lingfei Luo
During embryonic development, the inductive molecules produced by local origins normally arrive at their target tissues in a nondirectional, diffusion manner. The target organ precursor cells must correctly interpret these inductive signals to ensure proper specification/differentiation, which is dependent on two prerequisites: (i) obtaining cell-intrinsic competence; and (ii) receiving correct inductive
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Spermidine – an old molecule with a new age-defying immune function Trends Cell Biol. (IF 19.0) Pub Date : 2023-09-16 Kenji Chamoto, Baihao Zhang, Masaki Tajima, Tasuku Honjo, Sidonia Fagarasan
Polyamines – putrescine, spermidine, and spermine – are widely distributed aliphatic compounds known to regulate important biological processes in prokaryotic and eukaryotic cells. Therefore, spermidine insufficiency is associated with various physio-pathological processes, such as aging and cancers. Recent advances in immuno-metabolism and immunotherapy shed new light on the role of spermidine in