-
A novel prognostic scoring system for AML patients undergoing allogeneic hematopoietic stem cell transplantation with real world validation J. Adv. Res. (IF 11.4) Pub Date : 2024-09-18 Qing Ya Wang, Yi Fan Han, Yu Han Li, Qing Yun Wang, Jin Ye Zhu, Yu Jun Dong, Wei Liu, Na Han, Han Yun Ren, Yuan Li
This study aims to develop a robust predictive model for survival in AML patients undergoing allo-HSCT.
-
Expression reduction and a variant of a P450 gene mediate chlorpyrifos resistance in Tetranychus urticae Koch J. Adv. Res. (IF 11.4) Pub Date : 2024-09-17 Dandan Xu, Haojie Liao, Chao He, Ke Wang, Rui Dong, Youjun Zhang, Zhaojiang Guo, Xin Yang, Wen Xie, Neil Crickmore, Shaoli Wang
Understanding how insects and mites develop resistance to chlorpyrifos is crucial for effective field management. Although extensive research has demonstrated that T. urticae exhibits high resistance to chlorpyrifos, the specific resistance mechanism remains elusive. Investigating this mechanism could provide valuable insights for pest control strategies.
-
20(S)-Ginsenoside Rh2 overcomes gemcitabine resistance in pancreatic cancer by inhibiting LAMC2-Modulated ABC transporters J. Adv. Res. (IF 11.4) Pub Date : 2024-09-11 Yulin Wu, Juan Zhang, Yuanyang Tian, William Chi Shing Cho, Hong-Xi Xu, Zhi-Xiu Lin, Yan-Fang Xian
Gemcitabine (GEM) is the first-line drug for pancreatic ductal adenocarcinoma (PDAC), but drug resistance severely restricts its chemotherapeutic efficacy. Laminin subunit γ2 (LAMC2) plays a crucial role in extracellular matrix formation in the development of GEM-resistance. However, the biological function of LAMC2 in GEM resistance and its molecular mechanisms are still unclear. 20(S)-Ginsenoside
-
Haploinsufficiency of intraflagellar transport protein 172 causes autism-like behavioral phenotypes in mice through BDNF J. Adv. Res. (IF 11.4) Pub Date : 2024-09-10 Nanxi Zheng, Shilin Luo, Xin Zhang, Ling Hu, Muzhi Huang, Mingyu Li, Colin McCaig, Yu-Qiang Ding, Bing Lang
Primary cilia are hair-like solitary organelles growing on most mammalian cells that play fundamental roles in embryonic patterning and organogenesis. Defective cilia often cause a suite of inherited diseases called ciliopathies with multifaceted manifestations. Intraflagellar transport (IFT), a bidirectional protein trafficking along the cilium, actively facilitates the formation and absorption of
-
tsRNA modifications: An emerging layer of biological regulation in disease J. Adv. Res. (IF 11.4) Pub Date : 2024-09-10 Yaomin Liang, Ding Ji, Xiaoling Ying, Renqiang Ma, Weidong Ji
Transfer RNA (tRNA)-derived small RNA (tsRNA) represents an important and increasingly valued type of small non-coding RNA (sncRNA). The investigation of tRNA and tsRNA modification crosswalks has not only provided novel insights into the information and functions of tsRNA, but has also expanded the diversity and complexity of the tsRNA biological regulation network. Comparing with other sncRNAs, tsRNA
-
Rationally designed BCR-ABL kinase inhibitors for improved leukemia treatment via covalent and pro-/dual-drug targeting strategies J. Adv. Res. (IF 11.4) Pub Date : 2024-09-08 Jie Sun, Liang Lou, Chengjun Zhu, Peng Chen, Guanghui Tang, Mingxi Gu, Shu Xia, Xiao Dong, Zhi-Min Zhang, Liqian Gao, Shao Q. Yao, Qicai Xiao
Chronic Myeloid Leukemia (CML) is a blood cancer that remains challenging to cure due to drug resistance and side effects from current BCR-ABL inhibitors. There is an urgent need for novel and more effective BCR-ABL targeting inhibitors and therapeutic strategies to combat this deadly disease. We disclose an “OH-implant” strategy to improve a noncovalent BCR-ABL inhibitor, PPY-A, by adding a hydroxyl
-
Fabrication of nanogels to improve the toxicity and persistence of cycloxaprid against Diaphorina citri, the vector of citrus huanglongbing J. Adv. Res. (IF 11.4) Pub Date : 2024-09-06 Li Cui, Guiyun Deng, Jianghong Wu, Fang Ding, Wenjie Wang, Haiyang Yu, Zhiyong Song, Changhui Rui, Heyou Han, Huizhu Yuan
Diaphorina citri is the most serious pest of citrus worldwide because it is the natural insect vector of huanglongbing. Cycloxaprid (Cyc) was highly toxic to D. citri. However, the poor solubility and stability had limited its development.
-
Metabolic phenotyping combined with transcriptomics metadata fortifies the diagnosis of early-stage Hepatocellular carcinoma J. Adv. Res. (IF 11.4) Pub Date : 2024-09-06 Sun Jo Kim, Cheol Woon Jung, Nguyen Hoang Anh, Young Cheol Yoon, Nguyen Phuoc Long, Soon-Sun Hong, Eun Ju Cho, Sung Won Kwon
The low sensitivity of alpha-fetoprotein (AFP) renders it unsuitable as a stand-alone marker for early hepatocellular carcinoma (eHCC) surveillance. Therefore, additional blood-based biomarkers with enhanced sensitivities are required.
-
Serum taurine affects lung cancer progression by regulating tumor immune escape mediated by the immune microenvironment J. Adv. Res. (IF 11.4) Pub Date : 2024-09-05 Tu-Liang Liang, Hu-Dan Pan, Pei-Yu Yan, Jia-Ning Mi, Xiao-Cui Liu, Wei-Qian Bao, Li-Rong Lian, Cui-Fen Zhang, Ying Chen, Jing-Rong Wang, Ying Xie, Hua Zhou, Xiao-Jun Yao, Pawlec Graham, Elaine Lai-Han Leung, Liang Liu, Run-Ze Li
Taurine is a naturally occurring sulfonic acid involved in various physiological and pathological processes, such as the regulation of calcium signaling, immune function, inflammatory response, and cellular aging. It has the potential to predict tumor malignant transformation and formation. Our previous work discovered the elevated taurine in lung cancer patients. However, the precise impact and mechanism
-
Brain organoid maturation and implantation integration based on electrical signals input J. Adv. Res. (IF 11.4) Pub Date : 2024-09-05 Xiao-Hong Li, Nan Hu, Zhe-Han Chang, Jian-Xin Shi, Xiu Fan, Meng-Meng Chen, Shuang-Qing Bao, Chong Chen, Jia-Chen Zuo, Xiao-Wang Zhang, Jing-Jing Wang, Dong Ming
Brain organoids are believed to be able to regenerate impaired neural circuits and reinstate brain functionality. The neuronal activity of organoids is considered a crucial factor for restoring host function after implantation. However, the optimal stage of brain organoid post-transplantation has not yet been established. External electrical signal plays a crucial role in the physiology and development
-
Chlorophyllase (PsCLH1) and light-harvesting chlorophyll a/b binding protein 1 (PsLhcb1) and PsLhcb5 maintain petal greenness in Paeonia suffruticosa ‘Lv Mu Yin Yu’ J. Adv. Res. (IF 11.4) Pub Date : 2024-09-03 Qing Hao, Tongtong Li, Gaojie Lu, Shuo Wang, Zhen Li, Cancan Gu, Fan Kong, Qingyan Shu, Yang Li
Green flowers are not an adaptive trait in natural plants due to the challenge for pollinators to discriminate from leaves, but they are valuable in horticulture. The molecular mechanisms of green petals remain unclear. Tree peony () is a globally cultivated ornamental plant and considered the ‘King of Flowers’ in China. The . ‘Lv Mu Yin Yu (LMYY)’ cultivar with green petals could be utilized as a
-
GmBSK1-GmGSK1-GmBES1.5 regulatory module controls heat tolerance in soybean J. Adv. Res. (IF 11.4) Pub Date : 2024-09-03 Ze-Hao Hou, Yuan Gao, Jia-Cheng Zheng, Meng-Jie Zhao, Ying Liu, Xiao-Yu Cui, Zhi-Yong Li, Ji-Tong Wei, Tai-Fei Yu, Lei Zheng, Yuan-Chen Jiao, Shu-Hui Yang, Jia-Min Hao, Jun Chen, Yong-Bin Zhou, Ming Chen, Lijuan Qiu, You-Zhi Ma, Zhao-Shi Xu
Heat stress poses a severe threat to the growth and production of soybean ( max). Brassinosteroids (BRs) actively participate in plant responses to abiotic stresses, however, the role of BR signaling pathway genes in response to heat stress in soybean remains poorly understood. In this study, we investigate the regulatory mechanisms of and in response to heat stress and the physiological characteristics
-
A wearable conductive hydrogel with triple network reinforcement inspired by bio-fibrous scaffolds for real-time quantitatively sensing compression force exerted on fruit surface J. Adv. Res. (IF 11.4) Pub Date : 2024-09-03 Zhichao Yang, Ziqiang Qin, Menglu Wu, Haimin Hu, Pengcheng Nie, Yong Wang, Qilei Li, Di Wu, Yong He, Kunsong Chen
Mechanical stresses incurred during post-harvest fruit storage and transportation profoundly impact decay and losses. Currently, the monitoring of mechanical forces is primarily focused on vibrational forces experienced by containers and vehicles and impact forces affecting containers. However, the detection of compressive forces both among interior fruit and between fruit and packaging surfaces remains
-
Dual-species proteomics and targeted intervention of animal-pathogen interactions J. Adv. Res. (IF 11.4) Pub Date : 2024-09-02 Yang Sylvia Liu, Chengqian Zhang, Bee Luan Khoo, Piliang Hao, Song Lin Chua
Host-microbe interactions are important to human health and ecosystems globally, so elucidating the complex host-microbe interactions and associated protein expressions drives the need to develop sensitive and accurate biochemical techniques. Current proteomics techniques reveal information from the point of view of either the host or microbe, but do not provide data on the corresponding partner. Moreover
-
Formononetin derivatives containing benzyl piperidine: A brand new, highly efficient inhibitor targeting Xanthomonas spp J. Adv. Res. (IF 11.4) Pub Date : 2024-09-02 Miaohe Zhang, Shuang Feng, Junrong Song, Xianghui Ruan, Wei Xue
Plant bacterial diseases take an incalculable toll on global food security. The indiscriminate use of chemical synthetic pesticide not only facilitates pathogen resistance of pathogenic bacteria, but also poses a major threat to human health and environmental protection. Therefore, it is of great economic value and scientific significance to develop a new antibacterial drug with environmental friendliness
-
Integrated ultrasensitive metabolomics and single-cell transcriptomics identify crucial regulators of sheep oocyte maturation and early embryo development in vitro J. Adv. Res. (IF 11.4) Pub Date : 2024-09-02 Bo Pan, JianPeng Qin, KunLin Du, LuYao Zhang, GongXue Jia, JiangFeng Ye, QiuXia Liang, QiEn Yang, GuangBin Zhou
Developmental competence of oocytes matured is limited due to a lack of complete understanding of metabolism and metabolic gene expression during oocyte maturation and embryo development. Conventional metabolic analysis requires a large number of samples and is not efficiently applicable in oocytes and early embryos, thereby posing challenges in identifying key metabolites and regulating their culture
-
XYLEM NAC DOMAIN 1 (EjXND1) relieves cold-induced lignification by negatively regulating the EjHB1-EjPRX12 module in loquat fruit J. Adv. Res. (IF 11.4) Pub Date : 2024-09-02 Zihao Liang, Yanna Shi, Yiqing Huang, Jiao Lu, Mengxue Zhang, Xizhi Cao, Ruoqian Hu, Dongdong Li, Wenbo Chen, Changqing Zhu, Di Wu, Kunsong Chen
Lignin is a principal constituent of the secondary cell wall, which plays a role in both plant growth and defensing against stress, such as low temperature and pest infestation. Additionally, it also accumulates in fleshy fruits and negatively affects fruit quality. Red-fleshed loquat is temperature sensitive and exhibits cold-induced lignification. A number of technologies have been developed, for
-
A 3R-MYB transcription factor is involved in Methyl Jasmonate-Induced disease resistance in Agaricus bisporus and has implications for disease resistance in Arabidopsis J. Adv. Res. (IF 11.4) Pub Date : 2024-09-02 Shuai Yuan, Hanyue Jiang, Yating Wang, Lei Zhang, Zixuan Shi, Lu Jiao, Demei Meng
Methyl jasmonate (MeJA) and MYB transcription factors (TFs) play important roles in pathogen resistance in several plants, but MYB TFs in conjunction with MeJA-induced defense against in edible mushrooms remain unknown. To investigate the role of a novel 3R-MYB transcription factor (AbMYB11) in MeJA-induced disease resistance of and in the resistance of transgenic to . Mushrooms were treated with MeJA
-
CDK4/6 inhibitor PD-0332991 suppresses hepatocarcinogenesis by inducing senescence of hepatic tumor-initiating cells J. Adv. Res. (IF 11.4) Pub Date : 2024-08-31 Miaomiao Chen, Wenjian Chen, Shiwen Sun, Yanli Lu, Guoxiu Wu, Hongyu Xu, Huiru Yang, Chong Li, Weizhi He, Mingyang Xu, Xiuhua Li, Dong Jiang, Yongchao Cai, Changcheng Liu, Wencheng Zhang, Zhiying He
Owing to the limited treatment options for hepatocellular carcinoma (HCC), interventions targeting pre-HCC stages have attracted increasing attention. In the pre-HCC stage, hepatic tumor-initiating cells (hTICs) proliferate abnormally and contribute to hepatocarcinogenesis. Numerous studies have investigated targeted senescence induction as an HCC intervention. However, it remains to be clarified whether
-
A new 1,2,3-triazole-indirubin hybrid suppresses tumor growth and pulmonary metastasis by mitigating the HGF/c-MET axis in hepatocellular carcinoma J. Adv. Res. (IF 11.4) Pub Date : 2024-08-30 Shalini V. Gowda, Kim Na Young, Kachigere B. Harsha, Darshini Gowda, Rajaghatta N. Suresh, Amudha Deivasigamani, Mohan Chakrabhavi Dhananjaya, Hui Kam Man, Gautam Sethi, Ahn Kwang Seok, Kanchugarakoppal S. Rangappa
Hepatocellular carcinoma (HCC) is a fatal cancer that is often diagnosed at the advanced stages which limits the available therapeutic options. The interaction of HGF with c-MET (a receptor tyrosine kinase) results in the activation of c-MET which subsequently triggers the PI3K/Akt/mTOR axis. Overexpression of c-MET in HCC tissues has been demonstrated to contribute to tumor progression and metastasis
-
High-resolution 3D spatial distribution of complex microbial colonies revealed by mass spectrometry imaging J. Adv. Res. (IF 11.4) Pub Date : 2024-08-29 Yuting Shen, Yisu Wang, Jianing Wang, Peisi Xie, Chengyi Xie, Yanyan Chen, Niaz Banaei, Kangning Ren, Zongwei Cai
Bacterial living states and the distribution of microbial colony signaling molecules are widely studied using mass spectrometry imaging (MSI). However, current approaches often treat 3D colonies as flat 2D disks, inadvertently omitting valuable details. The challenge of achieving 3D MSI in biofilms persists due to the unique properties of microbial samples. The study aimed to develop a new biofilm
-
Novel long noncoding lncARF mediated hyperhomocysteinemia-induced atherosclerosis via autophagy inhibition in foam cells J. Adv. Res. (IF 11.4) Pub Date : 2024-08-28 Ning Ding, Shengchao Ma, Qingning Chang, Lin Xie, Guizhong Li, Yinju Hao, Jiantuan Xiong, Anning Yang, Xiaoling Yang, Yideng Jiang, Huiping Zhang
Homocysteine (Hcy) is well recognized to be an independent risk factor for atherosclerosis. Long non-coding RNAs (lncRNAs) are emerging regulators of pathophysiological processes including atherosclerosis, while the underlying mechanisms of its involvement in Hcy induced-atherosclerosis remain largely unknown. The primary aim of this study is to assess the role of lncARF (autophagy-related factor induced
-
Simultaneous detection of membrane protein and mRNA at single extracellular vesicle level by droplet microfluidics for cancer diagnosis J. Adv. Res. (IF 11.4) Pub Date : 2024-08-26 Huixian Lin, Bo Li, Jingyun Guo, Xueying Mai, Haiyang Yu, Weilun Pan, Bodeng Wu, Wei Liu, Mingzhen Zhong, Tong Liao, Ye Zhang, Bo Situ, Xiaohui Yan, Yifan Liu, Chunchen Liu, Lei Zheng
Simultaneous detection of proteins and mRNA within a single extracellular vesicle (EV) enables comprehensive analysis of specific EVs subpopulations, significantly advancing cancer diagnostics. However, developing a sensitive and user-friendly approach for simultaneously detecting multidimensional biomarkers in single EV is still challenging. To facilitate the analysis of multidimensional biomarkers
-
New insights into the function and mechanisms of piRNA PMLCPIR in promoting PM2.5-induced lung cancer J. Adv. Res. (IF 11.4) Pub Date : 2024-08-24 Lin Xu, Wanli Ma, Xiaoyu Huo, Jiao Luo, Ruoxi Li, Xiaoxiao Zhu, Xiangbin Kong, Kunming Zhao, Yuan Jin, Meihua Zhang, Xianshu Li, Ling Wang, Wei Han, Dianke Yu
Extensive studies have established the correlation between long-term PM exposure and lung cancer, yet the mechanisms underlying this association remain poorly understood. PIWI-interacting RNAs (piRNAs), a novel category of small non-coding RNAs, serve important roles in various diseases. However, their biological function and mechanism in PM-induced lung cancer have not been thoroughly investigated
-
Nervonic acid triggered ovarian inflammation by inducing mitochondrial oxidative stress to activate NLRP3/ IL-1β pathway J. Adv. Res. (IF 11.4) Pub Date : 2024-08-22 Xiangzhou Zeng, Xinyin Fan, Haitao Yu, Shuang Cai, Liangrui Zhou, Huanwen Wu, Zhiwen Zhang, Shuang Quan, Siyu Li, Xinyu Wang, Bangxin Xue, Lu Liu, Shiyan Qiao, Xiangfang Zeng
Metabolic syndrome is a serious public health concern across the globe. However, the typical metabolites and mechanisms underlying the decreased fertility related to metabolic syndrome is still elusive. The aim of the present study was to explore the typical metabolites and mechanisms underlying the decreased fertility related with metabolic syndrome. Utilizing metabolomics, a comparative analysis
-
Dual nature of type I interferon responses and feedback regulations by SOCS1 dictate malaria mortality J. Adv. Res. (IF 11.4) Pub Date : 2024-08-22 Jiansen Lu, Zhiqiang Hu, Huaji Jiang, Zebin Wen, Hongyu Li, Jian Li, Ke Zeng, Yingchao Xie, Huadan Chen, Xin-zhuan Su, Chunmei Cai, Xiao Yu
Type I interferon (IFN-I, IFN-α/β), precisely controlled by multiple regulators, including suppressor of cytokine signaling 1 (SOCS1), is critical for host defense against pathogens. However, the impact of IFN-α/β on malaria parasite infections, beneficial or detrimental, remains controversial. The contradictory results are suspected to arise from differences in parasite species and host genetic backgrounds
-
An ABC transporter-mediated transport and metabolism of the pesticide bentazone in rice (Oryza sativa L.) J. Adv. Res. (IF 11.4) Pub Date : 2024-08-20 Yuxin Qiao, Yujue Wang, Yucheng Gu, Nan Zhang, Hong Yang, Jintong Liu
Bentazon (BNTZ) is a selective contact herbicide widely used to control field weeds for crop production. Excessive use of BNTZ leads to its accumulation in soils and crops, becoming an environmental contaminant. Therefore, investigation of the mechanisms for BNTZ detoxification and degradation in crops is fundamentally important to reduce crop contamination and ensure food safety. This study aims to
-
Polydopamine-assisted smart bacteria-responsive hydrogel: Switchable antimicrobial and antifouling capabilities for accelerated wound healing J. Adv. Res. (IF 11.4) Pub Date : 2024-08-19 Zheng Fang, Qingyan He, Yanyu Hu, Xu Chen, Fan Li, Xixi Cai
Wound infections and formation of biofilms caused by multidrug-resistant bacteria have constituted a series of wound deteriorated and life-threatening problems. The resisting bacterial adhesion, killing multidrug-resistance bacteria, and releasing dead bacteria is strongly required to supply a gap of existing sterilization strategies. This study aims to present a facile approach to construct a bacteria-responsive
-
Dialog between mantle cell lymphoma cells and lymphoma-associated macrophages underlies ibrutinib resistance J. Adv. Res. (IF 11.4) Pub Date : 2024-08-19 Xiaoqing Sun, Caiqin Wang, Jianghua Cao, Jing Li, Gang Ma, Xianqiu Wu, Peng Sun, Yu Wang, Jiajia Huang, Robert Peter Gale, Zhiming Li
Patients with mantle cell lymphoma (MCL) frequently develop resistance to ibrutinib. Lymphoma-associated macrophages (LAMs) may play a causal role in this resistance but remain underexplored in current literature. To elucidate the role of LAMs in mediating ibrutinib resistance in MCL. We investigated macrophage polarization through multiparameter flow cytometry (MPFC) using antibodies against CD206
-
CRISPR/Cas genome editing in soybean: challenges and new insights to overcome existing bottlenecks J. Adv. Res. (IF 11.4) Pub Date : 2024-08-18 Nayara Sabrina Freitas-Alves, Clidia E. Moreira-Pinto, Fabiano T.P.K. Távora, Bruno Paes-de-Melo, Fabricio B.M. Arraes, Isabela T. Lourenço-Tessutti, Stéfanie M. Moura, Antonio C. Oliveira, Carolina V. Morgante, Yiping Qi, Maria Fatima Grossi-de-Sa
Soybean is a worldwide-cultivated crop due to its applications in the food, feed, and biodiesel industries. Genome editing in soybean began with ZFN and TALEN technologies; however, CRISPR/Cas has emerged and shortly became the preferable approach for soybean genome manipulation since it is more precise, easy to handle, and cost-effective. Recent reports have focused on the conventional Cas9 nuclease
-
Matrix stiffness-dependent PD-L2 deficiency improves SMYD3/xCT-mediated ferroptosis and the efficacy of anti-PD-1 in HCC J. Adv. Res. (IF 11.4) Pub Date : 2024-08-17 Shunxi Wang, Xiaoxue Yuan, Zetao Yang, Xuan Zhang, Zhiling Xu, Li Yang, Xian Yang, Wei Zhou, Wanqian Liu
Heterogeneous tissue stiffening promotes tumor progression and resistance, and predicts a poor clinical outcome in patients with hepatocellular carcinoma (HCC). Ferroptosis, a congenital tumor suppressive mechanism, mediates the anticancer activity of various tumor suppressors, including immune checkpoint inhibitors, and its induction is currently considered a promising treatment strategy. However
-
Oral microbiome, periodontal disease and systemic bone-related diseases in the era of homeostatic medicine J. Adv. Res. (IF 11.4) Pub Date : 2024-08-17 Weiqi Hu, Shuoling Chen, Xianghui Zou, Yan Chen, Jiayu Luo, Peiliang Zhong, Dandan Ma
Homeostasis is a state of self-regulation and dynamic equilibrium, maintaining the good physiological functions of each system in living organisms. In the oral cavity, the interaction between the host and the oral microbiome forms oral microbial homeostasis. Physiological bone remodeling and renewal can occur under the maintenance of oral microbial homeostasis. The imbalance of bone homeostasis is
-
A potential CO2 carrier to improve the utilization of HCO3– by plant-soil ecosystem for carbon sink enhancement J. Adv. Res. (IF 11.4) Pub Date : 2024-08-16 Feihong Liang, Shihui Wei, Long Ji, Shuiping Yan
Improving the rhizospheric HCO utilization of plant-soil ecosystem could increase the carbon sink effect of terrestrial ecosystem. However, to avoid its physiological stress on the crop growth, the dosage of HCO allowed to add into the rhizosphere soil was always low (, <5–20 mol/m). To facilitate the utilization of relatively high concentrations of HCO by plants in the pursuit of achieving terrestrial
-
Gut microbiota-derived indole-3-propionic acid alleviates diabetic kidney disease through its mitochondrial protective effect via reducing ubiquitination mediated-degradation of SIRT1 J. Adv. Res. (IF 11.4) Pub Date : 2024-08-13 Yan Zeng, Man Guo, Qi Wu, Xiaozhen Tan, Chunxia Jiang, Fangyuan Teng, Jiao Chen, Fanjie Zhang, Xiumei Ma, Xinyue Li, Junling Gu, Wei Huang, Chunxiang Zhang, Betty Yuen-Kwan Law, Yang Long, Yong Xu
Gut microbes and their metabolites play crucial roles in the pathogenesis of diabetic kidney disease (DKD). However, which one and how specific gut-derived metabolites affect the progression of DKD remain largely unknown. This study aimed to investigate the potential roles of indole-3-propionic acid (IPA), a microbial metabolite of tryptophan, in DKD. Metagenomic sequencing was performed to analyze
-
Impaired microglial glycolysis promotes inflammatory responses after intracerebral haemorrhage via HK2-dependent mitochondrial dysfunction J. Adv. Res. (IF 11.4) Pub Date : 2024-08-13 Yin Li, Hang Zhou, Xuchao He, Lingji Jin, Yuhan Zhu, Libin Hu, Majing Feng, Jun Zhu, Liang Wang, Yonghe Zheng, Shiwei Li, Zhiyuan Yan, Peili Cen, Junwen Hu, Zihang Chen, Xiaobo Yu, Xiongjie Fu, Chaoran Xu, Shenglong Cao, Yang Cao, Gao Chen, Lin Wang
Intracerebral haemorrhage (ICH) is a devastating disease that leads to severe neurological deficits. Microglia are the first line of defence in the brain and play a crucial role in neurological recovery after ICH, whose activities are primarily driven by glucose metabolism. However, little is known regarding the status of glucose metabolism in microglia and its interactions with inflammatory responses
-
Targeting NGF but not VEGFR1 or BDNF signaling reduces endometriosis-associated pain in mice J. Adv. Res. (IF 11.4) Pub Date : 2024-08-12 Tiago H. Zaninelli, Victor Fattori, Olivia K. Heintz, Kristeena R. Wright, Philip R. Bennallack, Danielle Sim, Hussain Bukhari, Kathryn L. Terry, Allison F. Vitonis, Stacey A. Missmer, Avacir C. Andrello, Raymond M. Anchan, Stephen K. Godin, Dara Bree, Waldiceu A. Verri Jr., Michael S. Rogers
Endometriosis is a chronic inflammatory disease that affects ∼10 % of women. A significant fraction of patients experience limited or no efficacy with current therapies. Tissue adjacent to endometriosis lesions often exhibits increased neurite and vascular density, suggesting that disease pathology involves neurotrophic activity and angiogenesis. We aim to evaluate the potential for key tyrosine-k
-
An essential role of the E3 ubiquitin ligase RNF126 in ensuring meiosis I completion during spermatogenesis J. Adv. Res. (IF 11.4) Pub Date : 2024-08-12 Wenjing Liu, Xiya Sun, Fubing Li, Qiuyun Jiang, Jianting An, Yingying Wu, Jingyi Yang, Meng Qin, Yuxin Zhao, Yongjia Tang, Tingyue Wu, Zhiqiang Yan, Dewei Jiang, Rong Liu, Wenhui Li, Xu Zhi, Ceshi Chen
Homologous recombination repair during meiosis is essential for the exchange of genetic information between sister chromosomes, underpinning spermatogenesis and, consequently, fertility. The disruption of this process can lead to infertility, highlighting the importance of identifying the molecular actors involved. This study aims to elucidate the role of the E3 ubiquitin ligase Rnf126 in spermatogenesis
-
ARTEMIS: An independently validated prognostic prediction model of breast cancer incorporating epigenetic biomarkers with main effects and gene-gene interactions J. Adv. Res. (IF 11.4) Pub Date : 2024-08-11 Maojie Xue, Ziang Xu, Xiang Wang, Jiajin Chen, Xinxin Kong, Shenxuan Zhou, Jiamin Wu, Yuhao Zhang, Yi Li, David C. Christiani, Feng Chen, Yang Zhao, Ruyang Zhang
Breast cancer, a heterogeneous disease, is influenced by multiple genetic and epigenetic factors. The majority of prognostic models for breast cancer focus merely on the main effects of predictors, disregarding the crucial impacts of gene-gene interactions on prognosis. Using DNA methylation data derived from nine independent breast cancer cohorts, we developed n independently validated prognostic
-
Novel furfural-complexed approach to synthesizing carbon-Doped ZnO with breakthrough photocatalytic efficacy J. Adv. Res. (IF 11.4) Pub Date : 2024-08-10 Sajid Ali Ansari, Nazish Parveen, Abdullah Aljaafari, Adil Alshoaibi, Ghayah M. Alsulaim, Mir Waqas Alam, Mohd Zahid Ansari
The efficiency of zinc oxide (ZnO) nanoparticles for environmental decontamination is limited by their reliance on ultraviolet (UV) light and rapid charge carrier recombination. Carbon doping has been proposed to address these challenges by potentially enhancing visible light absorption and charge separation. This study aims to introduce a novel, single-step synthesis method for carbon-doped ZnO (C-Z)
-
IL-28A/IL-10Rβ axis promotes angiogenesis via eNOS/AKT signaling and AP-1/NF-κB/MMP-2 network by regulating HSP70-1 expression J. Adv. Res. (IF 11.4) Pub Date : 2024-08-09 Jun-Hui Song, Byungdoo Hwang, Sung Lyea Park, Hoon Kim, Soontag Jung, Changsun Choi, Hwan Myung Lee, Seok-Joong Yun, Yung Hyun Choi, Eun-Jong Cha, Cam Patterson, Wun-Jae Kim, Sung-Kwon Moon
Angiogenesis plays a significant role in the development of tumor progression and inflammatory diseases. The role of IL-28A in angiogenesis and its precise regulatory mechanisms remain rarely elucidated. We report the novel regulatory role of IL-28A in physiological angiogenesis. The study aimed to elucidate the regulatory mechanisms involved in IL-28A-mediated angiogenesis and identify key genes associated
-
NDRG1 enhances the sensitivity to Cetuximab by promoting Stat1 ubiquitylation in colorectal cancer J. Adv. Res. (IF 11.4) Pub Date : 2024-08-09 Guang Yang, Chengsheng Ding, Xiao Yang, Jiang Jiang, Shiyuan He, Yanfei Shao, Enkui Zhang, Xiaodong Fan, Xueliang Zhou, Ling Huang, Cindy Xinyu Zhang, Jing Sun, Yu Wang, Lu Zang, Minhua Zheng, Junjun Ma
Cetuximab (CTX) is an effective targeted drug for the treatment of metastatic colorectal cancer, but it is effective only in patients with wild-type KRAS genes. Even in this subset of patients, the sensitivity of CTX in patients with right hemi-colon cancer is much lower than that in patients with left hemi-colon cancer. This significantly limits its clinical application. Therefore, further elucidation
-
Extracellular vesicle-derived miR-146a as a novel crosstalk mechanism for high-fat induced atherosclerosis by targeting SMAD4 J. Adv. Res. (IF 11.4) Pub Date : 2024-08-08 Kefeng Zhai, Liangle Deng, Yuxuan Wu, Han Li, Jing Zhou, Ying Shi, Jianhu Jia, Wei Wang, Sihui Nian, Ghulam Jilany Khan, Hesham R. El-Seedi, Hong Duan, Lili Li, Zhaojun Wei
Exosome-miR-146a is significantly increased in patients with Atherosclerosis (AS), but its mechanism and effect on AS have not been fully elucidated. To explore the change rule and mechanism of exosomes release, and the role and molecular mechanism of exosome-miR-146a in AS. We isolated and identified exosomes from THP-1 macrophages after treating them with ox-LDL. Then used co-immunoprecipitation
-
IRnet: Immunotherapy response prediction using pathway knowledge-informed graph neural network J. Adv. Res. (IF 11.4) Pub Date : 2024-08-07 Yuexu Jiang, Manish Sridhar Immadi, Duolin Wang, Shuai Zeng, Yen On Chan, Jing Zhou, Dong Xu, Trupti Joshi
Immune checkpoint inhibitors (ICIs) are potent and precise therapies for various cancer types, significantly improving survival rates in patients who respond positively to them. However, only a minority of patients benefit from ICI treatments. Identifying ICI responders before treatment could greatly conserve medical resources, minimize potential drug side effects, and expedite the search for alternative
-
Design and construction of light-regulated gene transcription and protein translation systems in yeast P. Pastoris J. Adv. Res. (IF 11.4) Pub Date : 2024-08-06 Siyu Zhang, Jiazhen Zhang, Ru Lin, Chaoyu Lu, Bohao Fang, Jiacheng Shi, Tianyi Jiang, Mian Zhou
is a common host for effective biosynthesis of heterologous proteins as well as small molecules. Accurate regulation of gene transcription and protein synthesis is necessary to coordinate synthetic gene circuits and optimize cellular energy distribution. Traditional methanol or other inducible promoters, natural or engineered, have defects in either fermentation safety or expression capacity. The utilization
-
Impacts of parental genomic divergence in non-syntenic regions on cotton heterosis J. Adv. Res. (IF 11.4) Pub Date : 2024-08-06 Chujun Huang, Yu Cheng, Yan Hu, Xuemei Zhang, Jinwen Chen, Ting Zhao, Zhanfeng Si, Yiwen Cao, Yiqian Li, Lei Fang, Xueying Guan, Tianzhen Zhang
Heterosis has revolutionized crop breeding, enhancing global agricultural production. However, the mechanisms underlying heterosis remain obscure. Xiangzamian 2# (XZM2), a super hybrid upland cotton () characterized by high-yield heterosis, has been developed and extensively planted in China. We conducted a systematic analysis of CRI12 and J8891, two parents of XZM2. We aimed to reveal the precise
-
Loss of Nup155 promotes high fructose-driven podocyte senescence by inhibiting INO80 mRNA nuclear export J. Adv. Res. (IF 11.4) Pub Date : 2024-08-05 Li Chen, Tangdi Xu, Zixuan Wang, Chengzhi Wang, Lei Fang, Lingdong Kong
Podocyte senescence causes podocyte loss and glomerulopathy. Excessive fructose intake is a risk factor for podocyte injury. However, whether high fructose promotes podocyte senescence remains unknown. To explore the pathological mechanism by which high fructose drives podocyte senescence and find natural compounds to alleviate podocyte senescence. Podocyte senescence was characterized with senescence-associated
-
ST6GALNAC1-mediated sialylation in uterine endometrial epithelium facilitates the epithelium-embryo attachment J. Adv. Res. (IF 11.4) Pub Date : 2024-08-05 Xinyue Dong, Hao Wang, Jinxuan Cai, Yichun Wang, Dezhi Chai, Zichen Sun, Jie Chen, Mengxia Li, Tianxia Xiao, Chunhua Shan, Jian V. Zhang, Ming Yu
Embryo implantation requires synergistic interaction between the embryo and the receptive endometrium. Glycoproteins and glycan-binding proteins are involved in endometrium-embryo attachment. Sialyl Tn (sTn), a truncated O-glycan, is catalyzed by ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 1 (ST6GALNAC1) and can be detected by specific Sialic-acid-binding immunoglobulin-like lectins (Siglecs)
-
Short-chain fatty acid butyrate against TMAO activating endoplasmic-reticulum stress and PERK/IRE1-axis with reducing atrial arrhythmia J. Adv. Res. (IF 11.4) Pub Date : 2024-08-05 Tzu-Yu Cheng, Ting-Wei Lee, Shao-Jung Li, Ting-I Lee, Yao-Chang Chen, Yu-Hsun Kao, Satoshi Higa, Pao-Huan Chen, Yi-Jen Chen
The accumulation of microbiota-derived trimethylamine N-oxide (TMAO) in the atrium is linked to the development and progression of atrial arrhythmia. Butyrate, a major short-chain fatty acid, plays a crucial role in sustaining intestinal homeostasis and alleviating systemic inflammation, which may reduce atrial arrhythmogenesis. This study explored the roles of butyrate in regulating TMAO-mediated
-
Pharmacological inhibition of Septins with Forchlorfenuron attenuates thrombus formation in experimental thrombotic mice models with modulating multiple signaling pathways in platelets J. Adv. Res. (IF 11.4) Pub Date : 2024-08-05 Zhen Hao, Minghui Yan, Reyisha Tuerhong, Luying Zhang, Zhen Zhang, Habib Alam, Jun Wu, Yuanhua Qin, Feng Zhao, Lei Shi
The Septin family of cytoskeletal proteins is abundant in platelets. When these proteins are functionally blocked using the compound forchlorfenuron (FCF), it hampers the normal activation processes of purified human platelets. To evaluate the effects of FCF on physiological haemostasis and pathological thrombosis in mice and to investigate possible molecular mechanisms. The impact of FCF on haemorrhage
-
Development of modern Chinese medicine guided by molecular compatibility theory J. Adv. Res. (IF 11.4) Pub Date : 2024-08-05 Lifeng Luo, Jieru Zhou, Xiaonan Liu, Yanyu Chen, Xiao Du, Lili Gao, Yunting Sun, Shuling Wang
Traditional Chinese Medicine (TCM) has gained global attention, particularly after Professor Youyou Tu was awarded the Nobel Prize for her discovery of artemisinin as a treatment for malaria. However, the theory behind TCM is often perceived as a “black-box” with complex components and an unclear structure and mechanism of action. This had hindered the development of TCM within the framework of modern
-
DeepB3P: A transformer-based model for identifying blood-brain barrier penetrating peptides with data augmentation using feedback GAN J. Adv. Res. (IF 11.4) Pub Date : 2024-08-05 Qiang Tang, Wei Chen
The blood–brain barrier (BBB) serves as a critical structural barrier and impedes the entry of most neurotherapeutic drugs into the brain. This poses substantial challenges for central nervous system (CNS) drug development, as there is a lack of efficient drug delivery technologies to overcome this obstacle. BBB penetrating peptides (BBBPs) hold promise in overcoming the BBB and facilitating the delivery
-
Insights of immune cell heterogeneity, tumor-initiated subtype transformation, drug resistance, treatment and detecting technologies in glioma microenvironment J. Adv. Res. (IF 11.4) Pub Date : 2024-08-05 Tongzheng Chen, Wenbin Ma, Xin Wang, Qile Ye, Xintong Hou, Yiwei Wang, Chuanlu Jiang, Xiangqi Meng, Ying Sun, Jinquan Cai
With the gradual understanding of glioma development and the immune microenvironment, many immune cells have been discovered. Despite the growing comprehension of immune cell functions and the clinical application of immunotherapy, the precise roles and characteristics of immune cell subtypes, how glioma induces subtype transformation of immune cells and its impact on glioma progression have yet to
-
Deciphering the dynamic expression network of fiber elongation and the functional role of the GhTUB5 gene for fiber length in cotton based on an introgression population of upland cotton J. Adv. Res. (IF 11.4) Pub Date : 2024-08-04 Jianjiang Ma, Liupeng Yang, Yuanyue Dang, Kashif Shahzad, Jikun Song, Bing Jia, Li Wang, Juanjuan Feng, Nuohan Wang, Wenfeng Pei, Man Wu, Xuexian Zhang, Jinfa Zhang, Jianyong Wu, Jiwen Yu
Interspecific introgression between and allows breeding cotton with outstanding fiber length (FL). However, the dynamic gene regulatory network of FL-related genes has not been characterized, and the functional mechanism through which the hub gene mediates fiber elongation has yet to be determined. Coexpression analyses of 277 developing fiber transcriptomes integrated with QTL mapping using 250 introgression
-
GDF11 protects against mitochondrial-dysfunction-dependent NLRP3 inflammasome activation to attenuate osteoarthritis J. Adv. Res. (IF 11.4) Pub Date : 2024-08-03 Pengfei Zhang, Haoxin Zhai, Shuai Zhang, Xiaojie Ma, Ao Gong, Zhaoning Xu, Wei Zhao, Hui Song, Shufeng Li, Tengfei Zheng, Zhendong Ying, Lei Cheng, Yunpeng Zhao, Lei Zhang
Osteoarthritis (OA) is a highly prevalent degenerative disease worldwide, and tumor necrosis factor (TNF-α) is closely associated with its development. Growth differentiation factor 11 (GDF11) has demonstrated anti-injury and anti-aging abilities in certain tissues; however, its regulatory role in OA remains unclear and requires further investigation. To identify whether GDF11 can attenuate osteoarthritis
-
Inhibition of mitophagy via the EIF2S1-ATF4-PRKN pathway contributes to viral encephalitis J. Adv. Res. (IF 11.4) Pub Date : 2024-08-03 Xiaowei Song, Yiliang Wang, Weixiangmin Zou, Zexu Wang, Wenyan Cao, Minting Liang, Feng Li, Qiongzhen Zeng, Zhe Ren, Yifei Wang, Kai Zheng
Mitophagy, a selective form of autophagy responsible for maintaining mitochondrial homeostasis, regulates the antiviral immune response and acts as viral replication platforms to facilitate infection with various viruses. However, its precise role in herpes simplex virus 1 (HSV-1) infection and herpes simplex encephalitis (HSE) remains largely unknown. We aimed to investigate the regulation of mitophagy
-
ADAM8 deficiency in macrophages promotes cardiac repair after myocardial infarction via ANXA2-mTOR-autophagy pathway J. Adv. Res. (IF 11.4) Pub Date : 2024-08-02 Zhenjun Ji, Jiaqi Guo, Rui Zhang, Wenjie Zuo, Yang Xu, Yangyang Qu, Zaixiao Tao, Xinxin Li, Yongjun Li, Yuyu Yao, Genshan Ma
A disintegrin and metalloproteinase 8 (ADAM8), a crucial regulator in macrophages, is closely associated with cardiovascular disease progression. This study aimed to explore how ADAM8 regulates macrophage function to inhibit cardiac repair after myocardial infarction (MI). Macrophage-specific ADAM8 knockout mice (ADAM8, KO) and corresponding control mice (ADAM8, Flox) were established using the CRISPR/Cas9
-
Glutathione hybrid poly (beta-amino ester)-plasmid nanoparticles for enhancing gene delivery and biosafety J. Adv. Res. (IF 11.4) Pub Date : 2024-08-02 Songwei Tan, Caiyan Yuan, Yuhe Zhu, Shuangyan Chang, Qianru Li, Jiahui Ding, Xueqin Gao, Rui Tian, Zhiqiang Han, Zheng Hu
CRISPR/Cas9 gene editing technology has significantly advanced gene therapy, with gene vectors being one of the key factors for its success. Poly (beta-amino ester) (PBAE), a distinguished non-viral cationic gene vector, is known to elevate intracellular reactive oxygen species (ROS) levels, which may cause cytotoxicity and, consequently, impact gene transfection efficacy (T.E.). To develop a simple
-
Ultra-high static magnetic fields altered the embryonic division and development in Caenorhabditis elegans via multipolar spindles J. Adv. Res. (IF 11.4) Pub Date : 2024-07-31 Lei Cheng, Mudi Wang, Baolin Yang, Yang Li, Tong Wang, Chuanying Xi, Yuyan Han, Ze Wang, Yanwen Fang, Min Wei, Hua Du, An Xu
Ultra-high static magnetic fields (SMFs) have unique advantages in improving medical and academic research. However, the research on the early embryo exposure of ultra-high SMFs is minimal, extensive exploration is indispensable in living organisms. The present study was aimed to study the effects of ultra-high SMFs on the early embryonic division and development of (). Early adult parents containing
-
The molecular mechanism of NF-κB dysregulation across different subtypes of renal cell carcinoma J. Adv. Res. (IF 11.4) Pub Date : 2024-07-31 Nour Abu Jayab, Alaa Abed, Iman M. Talaat, Rifat Hamoudi
The nuclear factor kappa B (NF-κB) is a critical pathway that regulates various cellular functions, including immune response, proliferation, growth, and apoptosis. Furthermore, this pathway is tightly regulated to ensure stability in the presence of immunogenic triggers or genotoxic stimuli. The lack of control of the NF-κB pathway can lead to the initiation of different diseases, mainly autoimmune
-
NAT10 promotes osteoclastogenesis in inflammatory bone loss by catalyzing Fos mRNA ac4C modification and upregulating MAPK signaling pathway J. Adv. Res. (IF 11.4) Pub Date : 2024-07-31 Ruhan Yang, Weijun Yu, Lu Lin, Zhurong Cui, Jiaqi Tang, Guanglong Li, Min Jin, Yuting Gu, Eryi Lu
Excessive osteoclastogenesis is a key driver of inflammatory bone loss. Suppressing osteoclastogenesis has always been considered essential for the treatment of inflammatory bone loss. N-acetyltransferase 10 (NAT10) is the sole enzyme responsible for N4-acetylcytidine (ac4C) modification of mRNA, and is involved in cell development. However, its role in osteoclastogenesis and inflammatory bone loss