The choice of food is governed largely by the sense of taste. To date, five basic taste modalities have been described; however, there is an increasing agreement on the existence of a 6^th fat taste. The taste modalities might interact with each other and also with other senses. The advancements in cellular and molecular biology have helped the characterization of taste signaling mechanisms, down to the receptor level and beyond. CD36 and GPR120 have been shown to be involved in the detection of fat taste while bitter taste is perceived by a number of receptors that belong to a family of taste-type 2 receptors (T2R or TAS2R). Hence, the most common role is played by TAS2R16 and TAS2R38 in bitter taste perception in humans. Increasing evidences from behavioural studies suggest that fat and bitter taste modalities might interact with each other, and this interaction might be critical in obesity. In the current review, we will discuss the evidence from genetic and behavioural studies and propose the molecular mechanism of a cross-talk between fat and bitter tastes.

食物的选择主要取决于味觉。迄今为止，已经描述了五种基本的口味形式。然而，关于第六^个存在的共识越来越多肥腻的味道。味觉方式可能彼此相互作用，也可能与其他感官相互作用。细胞和分子生物学的进步已有助于表征味觉信号传导机制，直至受体水平甚至更高。已证明CD36和GPR120参与了脂肪味的检测，而属于2型味觉受体家族的许多受体（T2R或TAS2R）则感觉到苦味。因此，TAS2R16和TAS2R38在人类的苦味感知中起着最常见的作用。越来越多的行为研究证据表明，脂肪和苦味形式可能会相互影响，而这种相互作用可能对肥胖至关重要。在目前的评论中，