当前位置: X-MOL 学术Eur. J. Nucl. Med. Mol. Imaging › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Preservation of brain metabolism in recently diagnosed Parkinson's impulse control disorders.
European Journal of Nuclear Medicine and Molecular Imaging ( IF 8.6 ) Pub Date : 2020-01-02 , DOI: 10.1007/s00259-019-04664-2
Juan Marín-Lahoz 1, 2, 3, 4 , Frederic Sampedro 1, 2, 4 , Andrea Horta-Barba 1, 2, 4 , Saül Martínez-Horta 1, 2, 4 , Ignacio Aracil-Bolaños 1, 2, 4 , Valle Camacho 5 , Helena Bejr-Kasem 1, 2, 3, 4, 5, 6 , Berta Pascual-Sedano 1, 2, 4, 6 , Jesús Pérez-Pérez 1, 2, 4 , Alexandre Gironell 1, 2, 4 , Javier Pagonabarraga 1, 2, 3, 4 , Ignasi Carrió 3, 5 , Jaime Kulisevsky 1, 2, 3, 4
Affiliation  

BACKGROUND Impulse control disorders (ICD) are a common and disrupting complication of Parkinson's disease (PD) treatment. Although their relationship with dopaminergic activity is well studied, their brain metabolic correlates are mostly unknown. METHODS In this work we studied brain metabolism using brain 18F-FDG-PET. We performed a case-control study nested within a cohort of PD patients free of ICD at baseline to compare ICD patients right after ICD diagnosis and prior to any treatment modification with matched ICD-free patients. We also compared both PD groups with healthy controls. RESULTS When compared with ICD-free PD patients, PD patients with recently diagnosed ICD showed higher glucose metabolism in widespread areas comprising prefrontal cortices, both amygdalae and default mode network hubs (p < 0.05, corrected). When compared to healthy controls, they did not show hypermetabolism, and the only hypometabolic region was the right caudate. In turn, ICD-free patients showed diffuse hypometabolism when compared to healthy controls. CONCLUSION Our results suggest brain metabolism is more preserved in PD patients with ICD than patients without ICD. This metabolic preservation could be related to ICD development.

中文翻译:

在最近诊断出的帕金森氏症冲动控制障碍中保存脑代谢。

背景技术冲动控制障碍(ICD)是帕金森氏病(PD)治疗的常见且破坏性并发症。尽管它们与多巴胺能活动的关系已得到很好的研究,但它们与大脑代谢的相关性大多未知。方法在这项工作中,我们研究了使用脑18F-FDG-PET的脑代谢。我们进行了一项病例对照研究,该研究嵌套在基线无ICD的PD患者队列中,以比较ICD诊断后和与无ICD匹配患者进行任何治疗修改之前的ICD患者。我们还将两个PD组与健康对照组进行了比较。结果与无ICD的PD患者相比,最近诊断为ICD的PD患者在包括前额叶皮层,杏仁核和默认模式网络中心在内的广泛区域显示较高的葡萄糖代谢(校正后的p <0.05)。与健康对照相比,它们没有显示出新陈代谢,唯一的代谢不足区域是右尾状核。反过来,与健康对照组相比,无ICD的患者则表现为弥漫性低代谢。结论我们的结果表明,患有ICD的PD患者比没有ICD的PD患者的大脑代谢更多。这种代谢保存可能与ICD的发展有关。
更新日期:2020-01-02
down
wechat
bug