Food which is consumed by living organisms contains many antioxidants often with different antioxidant abilities. In the case of antioxidants mixture its potential is not always an additive value of antioxidant properties of their individual ingredients. Despite the extensive research there is still no knowledge about the reasons for observing the antioxidant antagonism and synergism in mixtures. The paper is a review which contains the literature information available about the antioxidant activity of binary mixtures. The manuscript presents different examples of natural mixtures with the literature proposed explanation of the observed antioxidant effects. It also describes different factors (i.e.: applied method, mechanisms of radical neutralization, composition of reacting mixture—chemical structures of antioxidants, concentration and molecular ratio, applied solvent, treatment of sample or reaction time) which have influence on the observed antioxidant effects. Additionally, the ways of expressing of the antioxidant effects are presented.

活生物体消耗的食物含有许多抗氧化剂，这些抗氧化剂通常具有不同的抗氧化能力。在抗氧化剂混合物的情况下，其潜力并不总是其各个成分的抗氧化剂性能的累加值。尽管进行了广泛的研究，但尚无关于观察混合物中抗氧化剂拮抗作用和协同作用的原因的知识。本文是一篇综述，其中包含有关二元混合物抗氧化活性的文献资料。该手稿介绍了天然混合物的不同示例，并提出了有关观察到的抗氧化剂作用的文献解释。它还描述了不同的因素（即：应用的方法，自由基中和的机理，反应混合物的组成，抗氧化剂的化学结构，浓度和分子比，所用溶剂，样品处理或反应时间）对观察到的抗氧化作用有影响。此外，提出了抗氧化作用的表达方式。