In this paper we studied the efficiency of magnesium oxide (MgO) nanoparticles with an average size of 27 nm synthesized by a simple soft chemical method, in killing both Gram negative and Gram positive pathogenic bacteria. The antibacterial activity was determined by a minimum inhibitory concentration technique, agar cup method and live count technique. These nanoparticles show the maximum antibacterial activity towards Bacillus sp. in comparison with Escherichia coli. Transmission electron microscopy analyses of the treated-bacterial strains showed a morphological deformation with increased cell wall disruption. From the analysis of the antibacterial activity of MgO nanoparticles it is revealed that 6μgml-1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$6\,\upmu \hbox {g ml}^{-1}$$\end{document} of dose is sufficient for killing Bacillus sp. whereas it is 7.5μgml-1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$7.5\,\upmu \hbox {g ml}^{-1}$$\end{document} for E. coli. These doses may be used in medical application. MgO nanoparticles could be used as antibacterial agents after completion of successful in vivo trials.

中文翻译：

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氧化镁纳米粒子抗菌性能的合成与评价

在本文中，我们研究了通过简单的软化学方法合成的平均尺寸为 27 nm 的氧化镁 (MgO) 纳米粒子在杀死革兰氏阴性和革兰氏阳性病原菌方面的效率。抗菌活性通过最小抑菌浓度技术、琼脂杯法和活细胞计数技术测定。这些纳米颗粒对芽孢杆菌表现出最大的抗菌活性。与大肠杆菌相比。对处理过的细菌菌株的透射电子显微镜分析显示，随着细胞壁破坏的增加，形态变形。从氧化镁纳米粒子的抗菌活性分析可知，6μgml-1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$6\,\upmu \hbox {g ml}^{-1}$$\end{document} of剂量足以杀死芽孢杆菌。而它是 7.5μgml-1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$7.5\,\upmu \hbox {g ml}^{-1}$$\end{document} 用于大肠杆菌。这些剂量可用于医疗应用。