OBJECTIVES To measure the testicular volume and testicular fat deposition of middle-aged overweight men and to assess the utility of testicular fat deposition and testicular volume in determining and monitoring testicular infertility. MATERIALS AND METHODS Pelvic MRI with thin slice T2WI, T1WI and mDIXON Quant was performed on 30 middle-aged overweight patients in the treatment group and 30 middle-aged overweight men in the control group. Testicular volume and testicular fat deposition were measured separately based on thin slice T2WI and the fat fraction (FF) map of mDIXON Quant, and the testicular fat deposition observed with T1WI was used as a reference for qualitative diagnosis. Testicular volume and testicular fat deposition in middle-aged overweight individuals were compared using a t test with Bonferroni correction and receiver operating characteristic (ROC) curve. RESULTS The testicular volumes (10.6-17.9 cm3) of individuals in the treatment group were smaller than those (12.6-19.0 cm3) of individuals in the control group (p < 0.05), and the average FF value (2.2-4.6%) of the testes in the treatment group was higher than that (1.5-3.1%) in the control group (p < 0.05). The ROC analysis showed that the area under the curve (AUC) of testicular fat deposition (0.899) was higher than that of testicular volume (0.777), and biopsy and sperm count were used as references to diagnose infertility. The diagnostic sensitivity (90.00%) of testicular fat deposition of the mDIXON Quant sequence was higher than that (50.00%) of the T1W sequence (p < 0.05). Testicular fat deposition was decreased after 6 months of active treatment with exercise weight loss and drug treatment, and no significant change in testicular volume was observed 6 months later. CONCLUSION The findings suggest that the proton density fat fraction (mDIXON Quant sequence in this study) approach is a novel tool for the quantitative and objective evaluation of testicular fat deposition. Testicular fat deposition measurement is more specific than testicular volume measurement in the diagnosis of male infertility, and the mDIXON Quant is more sensitive than T1WI in the diagnosis of testicular fat deposition. Furthermore, our findings may facilitate a more accurate diagnosis and monitoring of testicular infertility, therapeutic effect, and prognosis by measuring testicular fat deposition.

中文翻译：

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量化睾丸脂肪沉积在中年超重男性不育的评估中。

目的测量中年超重男性的睾丸体积和睾丸脂肪沉积，并评估睾丸脂肪沉积和睾丸体积在确定和监测睾丸不育症中的作用。材料与方法对治疗组的30名中年超重患者和对照组的30名中年超重男性进行了薄层T2WI，T1WI和mDIXON Quant骨盆MRI检查。根据薄片T2WI和mDIXON Quant的脂肪分数（FF）图分别测量睾丸体积和睾丸脂肪沉积，并用T1WI观察到的睾丸脂肪沉积作为定性诊断的参考。使用Bonferroni校正和受试者工作特征（ROC）曲线对中年超重个体的睾丸体积和睾丸脂肪沉积进行了比较。结果治疗组个体的睾丸体积（10.6-17.9 cm3）小于对照组（12.6-19.0 cm3）（p <0.05），平均FF值（2.2-4.6％）治疗组的睾丸高于对照组（1.5-3.1％）（p <0.05）。ROC分析显示，睾丸脂肪沉积的曲线下面积（AUC）（0.899）高于睾丸体积（0.777），并且活检和精子计数可作为诊断不育的参考。mDIXON Quant序列的睾丸脂肪沉积的诊断敏感性（90.00％）高于（50。T1W序列的00％（p <0.05）。经过运动减肥和药物治疗的积极治疗6个月后，睾丸脂肪沉积减少，并且在6个月后未观察到睾丸体积的显着变化。结论结论表明，质子密度脂肪分数（本研究中的mDIXON Quant序列）方法是用于定量和客观评估睾丸脂肪沉积的新型工具。在男性不育的诊断中，睾丸脂肪沉积的测量比睾丸体积测量更具体，而在睾丸脂肪沉积的诊断中，mDIXON Quant比T1WI更敏感。此外，我们的发现可能有助于通过测量睾丸脂肪沉积来更准确地诊断和监测睾丸不育症，治疗效果和预后。