The Euterpe oleracea Mart. (açaí) seed extract (ASE), rich in polyphenols, has been evidenced as a potential regulator of body mass with antioxidant and anti-inflammatory actions. We aimed to assess the effects of ASE and enalapril (ENA) on the hepatic steatosis and fibrosis and related overexpressed RAS, oxidative stress and inflammation in C57BL/6 mice fed a high-fat diet (HFD). The animals were fed a standard diet (10% fat, Control), 60% fat (HF), HF + ASE (300 mg kg⁻¹ d⁻¹) and HF + ENA (30 mg kg⁻¹ d⁻¹) for 12 weeks. Our results demonstrate that ASE prevented the obesity and related hepatic steatosis and fibrosis in HFD-fed mice. The negative modulation of RAS in hepatic tissue may contribute to these beneficial effects of ASE by favoring the reduction of the oxidative stress and inflammation, highlighting a greater antioxidant activity of ASE compared to ENA.

该尤特普甘蓝沃尔玛。（açaí）种子提取物（ASE）富含多酚，已被证明是具有抗氧化和抗炎作用的潜在体重调节剂。我们旨在评估ASE和依那普利（ENA）对高脂饮食（HFD）喂养的C57BL / 6小鼠肝脂肪变性和纤维化以及相关的过表达RAS，氧化应激和炎症的影响。给动物饲喂标准饮食（10％脂肪，对照），60％脂肪（HF），HF + ASE（300 mg kg ^-1 d ^-1）和HF + ENA（30 mg kg ^-1 d ^-1）），持续12周。我们的研究结果表明，ASE可以预防由HFD喂养的小鼠的肥胖症以及相关的肝脂肪变性和纤维化。肝组织中RAS的负调控可能通过促进氧化应激和炎症的减轻而有助于ASE的这些有益作用，与ENA相比，突出了ASE的更大的抗氧化活性。