Abstract A hybrid of organic/inorganic system, hollow mesoporous silica nanoparticles functionalized with poly(ethylene glycol), was synthesized in the presence of coupling agent and aminated ends. Doxorubicin (DOX) was used as a model drug to evaluate the effect of PEGylation on the loading capacity and release pattern of the system. Characterization with transmission electron microscopy (TEM) and scanning electron microscopy (SEM), X-ray diffraction (XRD), nitrogen adsorption-desorption, thermogravimetric analysis (TGA) and Fourier transformed infrared (FTIR) confirmed the PEG conjugation, as well as the amorphous mesoporous nature of the synthesized particles. Due to the capping effect of PEG molecules over the pores in the silica structure, the synthesized system was able to retain higher amount of cargo and establish a controlled manner when releasing.

中文翻译：

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通过胺化中间体对中空介孔二氧化硅纳米粒子进行表面聚乙二醇化

摘要 在偶联剂和胺化末端存在下，合成了有机/无机系统的混合体，即聚乙二醇功能化的中空介孔二氧化硅纳米粒子。多柔比星 (DOX) 用作模型药物以评估聚乙二醇化对系统负载能力和释放模式的影响。透射电子显微镜 (TEM) 和扫描电子显微镜 (SEM)、X 射线衍射 (XRD)、氮吸附-解吸、热重分析 (TGA) 和傅里叶变换红外 (FTIR) 的表征证实了 PEG 共轭，以及合成颗粒的无定形介孔性质。由于 PEG 分子在二氧化硅结构中的孔上的封盖效应，