Review
Surface PEGylation of hollow mesoporous silica nanoparticles via aminated intermediate

https://doi.org/10.1016/j.pnsc.2019.10.002Get rights and content
Under a Creative Commons license
open access

Highlights

  • Hollow mesoporous silica nanoparticles (HMSNs) functionalized with poly(ethylene glycol) (PEG) via aminated intermediate.

  • HMSNs still retain their porous nature after PEGylation.

  • Drug loading efficiency of HMSN-mPEG is about 3 times superior to HMSN.

  • HMSN-mPEG has more controlled release without initial burst effect as naked HMSN experienced.

Abstract

A hybrid of organic/inorganic system, hollow mesoporous silica nanoparticles functionalized with poly(ethylene glycol), was synthesized in the presence of coupling agent and aminated ends. Doxorubicin (DOX) was used as a model drug to evaluate the effect of PEGylation on the loading capacity and release pattern of the system. Characterization with transmission electron microscopy (TEM) and scanning electron microscopy (SEM), X-ray diffraction (XRD), nitrogen adsorption-desorption, thermogravimetric analysis (TGA) and Fourier transformed infrared (FTIR) confirmed the PEG conjugation, as well as the amorphous mesoporous nature of the synthesized particles. Due to the capping effect of PEG molecules over the pores in the silica structure, the synthesized system was able to retain higher amount of cargo and establish a controlled manner when releasing.

Keywords

Hollow mesoporous silica nanoparticles
mPEG
PEGylation
Surface modification

Cited by (0)