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Methods for obtaining solid dispersions of drugs and their properties
Russian Chemical Bulletin ( IF 1.7 ) Pub Date : 2019-10-01 , DOI: 10.1007/s11172-019-2648-3
S. S. Khalikov , B. V. Lokshin , M. M. Ilyin , A. I. Varlamova , M. B. Musaev , I. A. Arhipov

The possibility of improving the solubility of drugs by obtaining solid dispersions (SDs) with polymers is demonstrated. The solubility of these SDs is dependent both on the nature of drug and polymer and on the conditions of their preparation. IR spectroscopy of the obtained SDs and the analysis of results found in literature indicate that inclusion complexes are formed within them.

中文翻译:

获得药物固体分散体的方法及其性质

证明了通过使用聚合物获得固体分散体 (SD) 来提高药物溶解度的可能性。这些 SD 的溶解度取决于药物和聚合物的性质及其制备条件。获得的 SDs 的红外光谱和文献中发现的结果分析表明在其中形成了包合物。
更新日期:2019-10-01
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