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Methods for obtaining solid dispersions of drugs and their properties

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Abstract

The possibility of improving the solubility of drugs by obtaining solid dispersions (SDs) with polymers is demonstrated. The solubility of these SDs is dependent both on the nature of drug and polymer and on the conditions of their preparation. IR spectroscopy of the obtained SDs and the analysis of results found in literature indicate that inclusion complexes are formed within them.

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation

    S. S. Khalikov, B. V. Lokshin & M. M. Ilyin Jr.

  2. All-Russian Research Institute of Fundamental and Applied Parasitology of Animals and Plants – Branch of the Federal State Budgetary Scientific Institution “Federal Scientific Center – K. I. Skryabin and Ya. R. Kovalenko All-Russian Scientific Research Institute of Experimental Veterenary Medicine”, Russian Academy of Sciences, 28 ul. B. Cheremushkinskaya, 117218, Moscow, Russian Federation

    A. I. Varlamova, M. B. Musaev & I. A. Arhipov

Authors
  1. S. S. Khalikov
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  2. B. V. Lokshin
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  3. M. M. Ilyin Jr.
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  4. A. I. Varlamova
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  5. M. B. Musaev
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  6. I. A. Arhipov
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Correspondence to S. S. Khalikov.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1924–1932, October, 2019.

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Khalikov, S.S., Lokshin, B.V., Ilyin, M.M. et al. Methods for obtaining solid dispersions of drugs and their properties. Russ Chem Bull 68, 1924–1932 (2019). https://doi.org/10.1007/s11172-019-2648-3

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  • DOI: https://doi.org/10.1007/s11172-019-2648-3

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