Nucleophilic aromatic substitution, one of the most common transformation methods for aromatic organic compounds, is often performed under biphasic conditions using a phase-transfer catalyst. Herein, we investigated the synthesis of 4-nitrophenetole from 4-fluoronitrobenzene in a continuous-flow microreactor, which accelerates mass transfer between the two phases. The reaction proceeded smoothly under slug flow conditions and a slight acceleration effect was observed under ambient pressure. By contrast, high temperature and pressure conditions gave the target compound in good yield within a shorter residence time.

Graphical Abstract Please provide caption for graphical abstract.Nucleophilic aromatic Substitution under microflow conditions

中文翻译：

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在微流条件下使用相转移催化剂对对氟硝基苯进行乙氧基化

亲核芳香族取代是芳香族有机化合物最常见的转化方法之一，通常是在双相条件下使用相转移催化剂进行的。在这里，我们研究了在连续流动的微反应器中由4-氟硝基苯合成4-硝基苯乙炔，这加速了两相之间的传质。反应在团状流动条件下顺利进行，并且在环境压力下观察到轻微的加速作用。相反，高温和高压条件在较短的停留时间内以良好的收率得到了目标化合物。

图形摘要请提供图形摘要的标题。微流条件下的亲核芳香族取代