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Preparation of Chitosan, Sodium Alginate, Gelatin and Collagen Biodegradable Sponge Composites and their Application in Wound Healing and Curcumin Delivery
Journal of Polymers and the Environment ( IF 4.7 ) Pub Date : 2019-09-20 , DOI: 10.1007/s10924-019-01559-z
Negar Naghshineh , Kambiz Tahvildari , Maryam Nozari

This research aimed to produce three chitosan-based biodegradable sponge composites from collagen, gelatin, and sodium alginate and through addition of curcumin to investigate their biological effects on wound healing. To this end, the Chitosan-Collagen-Curcumin (Chs, Col, Cur), Chitosan-Gelatin-Curcumin (Chs, Gel, Cur), and Chitosan-Alginate-Curcumin (Chs, Alg, Cur) sponge composites were prepared and subject to FT-IR, SEM, TGA, water absorption, biodegradability, wound healing and anti-bacterial analyses. Based on the results, the highest and lowest water absorptions were associated with Chitosan-Alginate-Curcumin and Chitosan-Collagen-Curcumin composites, respectively. Moreover, according to the SEM images, the highest porosity and the largest cavity size were associated with the Chitosan-Alginate-Curcumin composite. The biodegradability analysis results revealed that Chitosan-Alginate-Curcumin was completely destroyed in 4 days, while the Chitosan-Collagen-Curcumin composite showed the lowest level of destruction. Moreover, the highest amount of curcumin was released by the Chitosan-Gelatin-Curcumin composite which happened during the first hour. Finally, the highest wound healing effect was achieved within a 10-day period using the Chitosan-Gelatin-Curcumin composite, completely healing the wound on the mouse skin. On the other hand, the lowest effect was associated with the Chitosan-Alginate-Curcumin composite. The antibacterial tests suggested that all composites exhibited anti-bacterial capabilities, the highest level of which was associated with the Chitosan-Gelatin-Curcumin composite. Moreover, based on the histological tests, the fastest tissue repair process with the highest quality was achieved using the Chitosan-Gelatin-Curcumin sponge composite.



中文翻译:

壳聚糖,海藻酸钠,明胶和胶原蛋白可降解海绵复合材料的制备及其在伤口愈合和姜黄素递送中的应用

这项研究旨在从胶原蛋白,明胶和藻酸钠生产三种基于壳聚糖的可生物降解海绵复合材料,并通过添加姜黄素来研究其对伤口愈合的生物学影响。为此,制备了壳聚糖-胶原-姜黄素(Chs,Col,Cur),壳聚糖-明胶-姜黄素(Chs,Gel,Cur)和壳聚糖-藻酸盐-姜黄素(Chs,Alg,Cur)海绵复合材料并对其进行了研究。 FT-IR,SEM,TGA,吸水率,生物降解性,伤口愈合和抗菌分析​​。根据结果​​,壳聚糖-海藻酸钠-姜黄素和壳聚糖-胶原-姜黄素复合材料分别具有最高和最低的吸水率。此外,根据SEM图像,最高的孔隙率和最大的腔尺寸与壳聚糖-海藻酸盐-姜黄素复合物有关。生物降解性分析结果表明,壳聚糖-海藻酸钠-姜黄素在4天内被完全破坏,而壳聚糖-胶原蛋白-姜黄素复合材料的破坏程度最低。此外,壳聚糖-明胶-姜黄素复合物释放的姜黄素量最高,发生在第一个小时。最终,使用壳聚糖-明胶-姜黄素复合材料在10天的时间内达到了最高的伤口愈合效果,从而完全治愈了小鼠皮肤上的伤口。另一方面,最低的作用与壳聚糖-海藻酸盐-姜黄素复合物有关。抗菌测试表明,所有复合材料均具有抗菌能力,其中最高水平与壳聚糖-明胶-姜黄素复合材料有关。此外,根据组织学检查,

更新日期:2019-09-20
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