This research aimed to produce three chitosan-based biodegradable sponge composites from collagen, gelatin, and sodium alginate and through addition of curcumin to investigate their biological effects on wound healing. To this end, the Chitosan-Collagen-Curcumin (Chs, Col, Cur), Chitosan-Gelatin-Curcumin (Chs, Gel, Cur), and Chitosan-Alginate-Curcumin (Chs, Alg, Cur) sponge composites were prepared and subject to FT-IR, SEM, TGA, water absorption, biodegradability, wound healing and anti-bacterial analyses. Based on the results, the highest and lowest water absorptions were associated with Chitosan-Alginate-Curcumin and Chitosan-Collagen-Curcumin composites, respectively. Moreover, according to the SEM images, the highest porosity and the largest cavity size were associated with the Chitosan-Alginate-Curcumin composite. The biodegradability analysis results revealed that Chitosan-Alginate-Curcumin was completely destroyed in 4 days, while the Chitosan-Collagen-Curcumin composite showed the lowest level of destruction. Moreover, the highest amount of curcumin was released by the Chitosan-Gelatin-Curcumin composite which happened during the first hour. Finally, the highest wound healing effect was achieved within a 10-day period using the Chitosan-Gelatin-Curcumin composite, completely healing the wound on the mouse skin. On the other hand, the lowest effect was associated with the Chitosan-Alginate-Curcumin composite. The antibacterial tests suggested that all composites exhibited anti-bacterial capabilities, the highest level of which was associated with the Chitosan-Gelatin-Curcumin composite. Moreover, based on the histological tests, the fastest tissue repair process with the highest quality was achieved using the Chitosan-Gelatin-Curcumin sponge composite.

这项研究旨在从胶原蛋白，明胶和藻酸钠生产三种基于壳聚糖的可生物降解海绵复合材料，并通过添加姜黄素来研究其对伤口愈合的生物学影响。为此，制备了壳聚糖-胶原-姜黄素（Chs，Col，Cur），壳聚糖-明胶-姜黄素（Chs，Gel，Cur）和壳聚糖-藻酸盐-姜黄素（Chs，Alg，Cur）海绵复合材料并对其进行了研究。 FT-IR，SEM，TGA，吸水率，生物降解性，伤口愈合和抗菌分析​​。根据结果​​，壳聚糖-海藻酸钠-姜黄素和壳聚糖-胶原-姜黄素复合材料分别具有最高和最低的吸水率。此外，根据SEM图像，最高的孔隙率和最大的腔尺寸与壳聚糖-海藻酸盐-姜黄素复合物有关。生物降解性分析结果表明，壳聚糖-海藻酸钠-姜黄素在4天内被完全破坏，而壳聚糖-胶原蛋白-姜黄素复合材料的破坏程度最低。此外，壳聚糖-明胶-姜黄素复合物释放的姜黄素量最高，发生在第一个小时。最终，使用壳聚糖-明胶-姜黄素复合材料在10天的时间内达到了最高的伤口愈合效果，从而完全治愈了小鼠皮肤上的伤口。另一方面，最低的作用与壳聚糖-海藻酸盐-姜黄素复合物有关。抗菌测试表明，所有复合材料均具有抗菌能力，其中最高水平与壳聚糖-明胶-姜黄素复合材料有关。此外，根据组织学检查，