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New evidence for associations between vitamin D receptor polymorphism and obesity: case-control and family-based studies.
Journal of Human Genetics ( IF 2.6 ) Pub Date : 2019-12-09 , DOI: 10.1038/s10038-019-0702-5
Songcheng Yu 1 , Xing Li 1 , Fei Yu 1 , Zhenxing Mao 1 , Yan Wang 1 , Yuan Xue 1 , Hualei Sun 1 , Yue Ba 1 , Chongjian Wang 1 , Wenjie Li 1
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Association between vitamin D receptor (VDR) genetic polymorphism and obesity was observed in several case-control studies. This study hypothesized that these associations could be verified in family-based study. We aimed at investigating the associations between VDR SNPs and obesity (BMI ≥ 28 kg/m2) by case-control study with 688 subjects and family-based study with 419 pedigrees. The results of case-control study suggested that rs3847987 (AC vs CC, Adjusted OR: 1.938, 95% CI: 1.359-2.763, P = 0.000405) was associated with obesity. Allele C of rs3847987 was risk factors for obesity (P = 0.006). Furthermore, association of rs3847987 with BMI was verified in family-based study (Z = 2.077, P = 0.037811). In addition, sibling with AC genotype of rs3847987 had significant higher BMI than CC genotype in the same family (P = 0.03). Therefore, it could be concluded that VDR genetic polymorphism (rs3847987) may be associated with obesity.

中文翻译:

维生素 D 受体多态性与肥胖之间关联的新证据:病例对照和基于家庭的研究。

在几项病例对照研究中观察到维生素 D 受体 (VDR) 基因多态性与肥胖之间的关联。本研究假设这些关联可以在基于家庭的研究中得到验证。我们旨在通过 688 名受试者的病例对照研究和 419 名家系的基于家庭的研究来调查 VDR SNP 与肥胖(BMI ≥ 28 kg/m2)之间的关联。病例对照研究的结果表明,rs3847987(AC vs CC,调整后的 OR:1.938,95% CI:1.359-2.763,P = 0.000405)与肥胖相关。rs3847987的等位基因C是肥胖的危险因素(P = 0.006)。此外,在基于家庭的研究中验证了 rs3847987 与 BMI 的关联(Z = 2.077,P = 0.037811)。此外,具有rs3847987基因型AC的兄弟姐妹的BMI显着高于同一家族中的CC基因型(P = 0.03)。所以,
更新日期:2019-12-09
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