New evidence for associations between vitamin D receptor polymorphism and obesity: case-control and family-based studies.,Journal of Human Genetics

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New evidence for associations between vitamin D receptor polymorphism and obesity: case-control and family-based studies.
Journal of Human Genetics ( IF 2.6 ) Pub Date : 2019-12-09 , DOI: 10.1038/s10038-019-0702-5
Songcheng Yu ₁ , Xing Li ₁ , Fei Yu ₁ , Zhenxing Mao ₁ , Yan Wang ₁ , Yuan Xue ₁ , Hualei Sun ₁ , Yue Ba ₁ , Chongjian Wang ₁ , Wenjie Li ₁

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Association between vitamin D receptor (VDR) genetic polymorphism and obesity was observed in several case-control studies. This study hypothesized that these associations could be verified in family-based study. We aimed at investigating the associations between VDR SNPs and obesity (BMI ≥ 28 kg/m2) by case-control study with 688 subjects and family-based study with 419 pedigrees. The results of case-control study suggested that rs3847987 (AC vs CC, Adjusted OR: 1.938, 95% CI: 1.359-2.763, P = 0.000405) was associated with obesity. Allele C of rs3847987 was risk factors for obesity (P = 0.006). Furthermore, association of rs3847987 with BMI was verified in family-based study (Z = 2.077, P = 0.037811). In addition, sibling with AC genotype of rs3847987 had significant higher BMI than CC genotype in the same family (P = 0.03). Therefore, it could be concluded that VDR genetic polymorphism (rs3847987) may be associated with obesity.

中文翻译：

维生素 D 受体多态性与肥胖之间关联的新证据：病例对照和基于家庭的研究。

在几项病例对照研究中观察到维生素 D 受体 (VDR) 基因多态性与肥胖之间的关联。本研究假设这些关联可以在基于家庭的研究中得到验证。我们旨在通过 688 名受试者的病例对照研究和 419 名家系的基于家庭的研究来调查 VDR SNP 与肥胖（BMI ≥ 28 kg/m2）之间的关联。病例对照研究的结果表明，rs3847987（AC vs CC，调整后的 OR：1.938，95% CI：1.359-2.763，P = 0.000405）与肥胖相关。rs3847987的等位基因C是肥胖的危险因素（P = 0.006）。此外，在基于家庭的研究中验证了 rs3847987 与 BMI 的关联（Z = 2.077，P = 0.037811）。此外，具有rs3847987基因型AC的兄弟姐妹的BMI显着高于同一家族中的CC基因型（P = 0.03）。所以，

更新日期：2019-12-09

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