Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

New evidence for associations between vitamin D receptor polymorphism and obesity: case-control and family-based studies

Journal of Human Genetics volume 65, pages 281–285 (2020)Cite this article

Subjects

Abstract

Association between vitamin D receptor (VDR) genetic polymorphism and obesity was observed in several case-control studies. This study hypothesized that these associations could be verified in family-based study. We aimed at investigating the associations between VDR SNPs and obesity (BMI ≥ 28 kg/m2) by case-control study with 688 subjects and family-based study with 419 pedigrees. The results of case-control study suggested that rs3847987 (AC vs CC, Adjusted OR: 1.938, 95% CI: 1.359–2.763, P = 0.000405) was associated with obesity. Allele C of rs3847987 was risk factors for obesity (P = 0.006). Furthermore, association of rs3847987 with BMI was verified in family-based study (Z = 2.077, P = 0.037811). In addition, sibling with AC genotype of rs3847987 had significant higher BMI than CC genotype in the same family (P = 0.03). Therefore, it could be concluded that VDR genetic polymorphism (rs3847987) may be associated with obesity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1

Similar content being viewed by others

References

  1. Flegal KM, Kruszon-Moran D, Carroll MD, Fryar CD, Ogden CL. Trends in obesity among adults in the United States, 2005 to 2014. J Am Med Assoc. 2016;315:2284–91.

    Article  CAS  Google Scholar 

  2. Pereira-Santos M, Costa PRF, Assis AMO, Santos CAST, Santos DB. Obesity and vitamin D deficiency: a systematic review and meta-analysis. Obes Rev. 2015;16:341–9.

    Article  CAS  Google Scholar 

  3. Martini LA, Wood RJ. Vitamin D status and the metabolic syndrome. Nutr Rev. 2006;64:479–86.

    Article  Google Scholar 

  4. Al-Daghri NM, Guerini FR, Al-Attas OS, Alokail MS, Alkharfy KM, Draz HM, et al. Vitamin D receptor gene polymorphisms are associated with obesity and inflammosome activity. PloS One. 2014;9:e102141. https://doi.org/10.1371/journal.pone.0102141.

    Article  CAS  Google Scholar 

  5. Fan HR, Lin LQ, Ma H, Li Y, Sun CH. Association between vitamin D receptor gene polymorphism (TaqI) and obesity in Chinese population. J Genet. 2015;94:473–8.

    Article  Google Scholar 

  6. Song JW, Chung KC. Observational studies: cohort and case-control studies. Plast Reconstr Surg. 2010;126:2234–42.

    Article  CAS  Google Scholar 

  7. Sedgwick P. Case-control studies: advantages and disadvantages. Br Med J. 2013;348:f7707. https://doi.org/10.1136/bmj.f7707.

    Article  Google Scholar 

  8. Evangelou E, Trikalinos TA, Salanti G, Ioannidis JPA. Family-based versus unrelated case-control designs for genetic associations. Plos Genet. 2006;2:1147–55.

    Article  CAS  Google Scholar 

  9. Zhou BF. Effect of body mass index on all-cause mortality and incidence of cardiovascular diseases-report for meta-analysis of prospective studies open optimal cut-off points of body mass index in Chinese adults. Biomed Environ Sci. 2002;15:245–52.

    PubMed  Google Scholar 

  10. Liu X, Mao Z, Li Y, Wu W, Zhang X, Huo W, et al. The Henan Rural Cohort: a prospective study of chronic non-communicable diseases. Int J Epidemiol. 2019;26:dyz039 https://doi.org/10.1093/ije/dyz039

    Article  Google Scholar 

  11. Serrano D, Gnagnarella P, Raimondi S, Gandini S. Meta-analysis on vitamin D receptor and cancer risk: focus on the role of TaqI, ApaI, and Cdx2 polymorphisms. Eur J Cancer Prev. 2016;25:85–96.

    Article  CAS  Google Scholar 

  12. dos Reis GVOP, Gontijo NA, Rodrigues KF, Alves MT, Ferreira CN, Gomes KB. Vitamin D receptor polymorphisms and the polycystic ovary syndrome: a systematic review. J Obstet Gynaecol Res. 2017;43:436–46.

    Article  CAS  Google Scholar 

  13. Koletsi D, Pandis N. Conditional logistic regression. Am J Orthod Dentofac. 2017;151:1191–2.

    Article  Google Scholar 

  14. Horvath S, Xu X, Laird NM. The family based association test method: strategies for studying general genotype-phenotype associations (Reprinted from European Journal of Human Genetics, Vol 9 pgs 301–306, 2001). Eur J Hum Genet. 2017;25:S59–S62.

    Article  CAS  Google Scholar 

  15. Yang M, Liu R, Li X, Liao J, Pu Y, Pan E, et al. Epigenetic repression of miR-218 promotes esophageal carcinogenesis by targeting ROBO1. Int J Mol Sci 2015;16:27781–95.

    Article  CAS  Google Scholar 

  16. You J, Zhang Y, Li Y, Fang N, Liu B, Zu L, et al. MiR-449a suppresses cell invasion by inhibiting MAP2K1 in non-small cell lung cancer. Am J Cancer Res. 2015;5:2730–44.

    PubMed  PubMed Central  CAS  Google Scholar 

  17. Budhathoki S, Yamaji T, Iwasaki M, Sawada N, Shimazu T, Sasazuki S, et al. Vitamin D receptor gene polymorphism and the risk of colorectal cancer: a nested case-control study. PloS One 2016;11:e0164648.

    Article  CAS  Google Scholar 

  18. Ramos-Lopez E, Jansen T, Ivaskevicius V, Kahles H, Klepzig C, Oldenburg J., et al. Protection from type 1 diabetes by vitamin D receptor haplotypes. In: Immunol diabetes IV: progress in our understanding. Ann. N.Y. Acad. Sci. 2006;1079:327–34.

    Article  CAS  Google Scholar 

  19. Mutt SJ, Hypponen E, Saarnio J, Jarvelin MR, Herzig KH. Vitamin D and adipose tissue-more than storage. Front Physiol. 2014;5:228.

    Article  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 81703270, 81573151, 81573243) and the National Key Research and Development Program “Precision Medicine Initiative” of China (No. 2016YFC0900803).

Author information

Authors and Affiliations

  1. College of Public Health, Zhengzhou University, 450001, Zhengzhou, China

    Songcheng Yu, Xing Li, Fei Yu, Zhenxing Mao, Yan Wang, Yuan Xue, Hualei Sun, Yue Ba, Chongjian Wang & Wenjie Li

Authors
  1. Songcheng Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xing Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fei Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zhenxing Mao
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yan Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yuan Xue
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hualei Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yue Ba
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Chongjian Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Wenjie Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Wenjie Li.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This study complied with the Declaration of Helsinki. The protocol was reviewed and approved by the Life Science Ethics Review Committee of Zhengzhou University. All the subjects signed an informed consent when they took part in this study.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yu, S., Li, X., Yu, F. et al. New evidence for associations between vitamin D receptor polymorphism and obesity: case-control and family-based studies. J Hum Genet 65, 281–285 (2020). https://doi.org/10.1038/s10038-019-0702-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s10038-019-0702-5

Search

Advanced search

Quick links