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Treg cell-based therapies: challenges and perspectives.
Nature Reviews Immunology ( IF 67.7 ) Pub Date : 2019-12-06 , DOI: 10.1038/s41577-019-0232-6
Caroline Raffin 1 , Linda T Vo 1 , Jeffrey A Bluestone 1
Affiliation  

Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In this Review, we discuss the biology of Treg cells and describe new efforts in Treg cell engineering to enhance specificity, stability, functional activity and delivery. Finally, we envision that the success of Treg cell therapy in autoimmunity and transplantation will encourage the clinical use of adoptive Treg cell therapy for non-immune diseases, such as neurological disorders and tissue repair.

中文翻译:


基于 Treg 细胞的疗法:挑战和前景。



使用调节性 T (Treg) 细胞的细胞疗法目前正在进行治疗自身免疫性疾病、移植排斥和移植物抗宿主病的临床试验。在这篇综述中,我们讨论了 Treg 细胞的生物学,并描述了 Treg 细胞工程在增强特异性、稳定性、功能活性和递送方面的新努力。最后,我们预计Treg细胞疗法在自身免疫和移植方面的成功将鼓励过继性Treg细胞疗法在临床上用于治疗非免疫性疾病,例如神经系统疾病和组织修复。
更新日期:2019-12-06
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