Male idiopathic infertility accounts for 15–25% of reproductive failure. One of the factors that has been linked to this condition is oxidative stress (OS), defined as the imbalance between antioxidants and reactive oxygen species. Amongst the different factors that protect the cell against OS, the members of the glutathione S-transferase (GST) superfamily play an important role. Interestingly, reduction or lack of some GSTs has been associated to infertility in men. Therefore, and to clarify the relationship between GSTs and male fertility, the aim of this work is to describe the role that GSTs play in the male reproductive tract and in sperm physiology. To that end, the present review provides a novel perspective on the triple role of GSTs (detoxification, regulation of cell signalling and fertilisation), and reports their localisation in sperm, seminal plasma and the male reproductive tract. Furthermore, we also tackle the existing correlation between some GST classes and male fertility. Due to the considerable impact of GSTs in human pathology and their tight relationship with fertility, future research should address the specific role of these proteins in male fertility, which could result in new approaches for the diagnosis and/or treatment of male infertility.

男性特发性不育症占生殖障碍的 15-25%。与这种情况相关的因素之一是氧化应激（OS），定义为抗氧化剂和活性氧之间的不平衡。在保护细胞免受 OS 侵害的不同因素中，谷胱甘肽 S-转移酶 (GST) 超家族的成员发挥着重要作用。有趣的是，某些商品及服务税的减少或缺乏与男性不育有关。因此，为了阐明 GST 与男性生育力之间的关系，本工作的目的是描述 GST 在男性生殖道和精子生理学中所发挥的作用。为此，本综述对 GST 的三重作用（解毒、细胞信号传导调节和受精）提供了新的视角，并报告了它们在精子、精浆和男性生殖道中的定位。此外，我们还解决了某些商品及服务税类别与男性生育力之间现有的相关性。由于 GST 在人类病理学中具有相当大的影响及其与生育力的密切关系，未来的研究应该解决这些蛋白质在男性生育力中的具体作用，这可能会产生诊断和/或治疗男性不育症的新方法。