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Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model.
Molecular Psychiatry ( IF 9.6 ) Pub Date : 2019-12-04 , DOI: 10.1038/s41380-019-0615-x
Rebecca B Price 1 , Ronald Duman 2
Affiliation  

Chronic stress and depressive-like behaviors in basic neuroscience research have been associated with impairments of neuroplasticity, such as neuronal atrophy and synaptic loss in the medial prefrontal cortex (mPFC) and hippocampus. The current review presents a novel integrative model of neuroplasticity as a multi-domain neurobiological, cognitive, and psychological construct relevant in depression and other related disorders of negative affect (e.g., anxiety). We delineate a working conceptual model in which synaptic plasticity deficits described in animal models are integrated and conceptually linked with human patient findings from cognitive science and clinical psychology. We review relevant reports including neuroimaging findings (e.g., decreased functional connectivity in prefrontal-limbic circuits), cognitive deficits (e.g., executive function and memory impairments), affective information processing patterns (e.g., rigid, negative biases in attention, memory, interpretations, and self-associations), and patient-reported symptoms (perseverative, inflexible thought patterns; inflexible and maladaptive behaviors). Finally, we incorporate discussion of integrative research methods capable of building additional direct empirical support, including using rapid-acting treatments (e.g., ketamine) as a means to test this integrative model by attempting to simultaneously reverse these deficits across levels of analysis.

中文翻译:

抑郁症的认知和心理机制中的神经可塑性:一种综合模型。

基础神经科学研究中的慢性应激和抑郁样行为与神经可塑性受损有关,例如前额内侧皮层和海马神经元萎缩和突触丧失。当前的审查提出了一种新型的神经可塑性综合模型,作为与抑郁症和其他负面影响(例如焦虑)相关的疾病相关的多领域神经生物学,认知和心理建构。我们描述了一个有效的概念模型,其中动物模型中描述的突触可塑性缺陷被整合并在概念上与来自认知科学和临床心理学的人类患者发现相关联。我们审查了相关报告,包括神经影像学发现(例如,前额-边缘回路的功能连接性降低),认知缺陷(例如,执行功能和记忆障碍),情感信息处理模式(例如,注意力,记忆,解释和自我联想的僵化,消极偏向)以及患者报告的症状(持续,僵化的思维模式;僵化和不良适应行为)。最后,我们纳入了有关能够建立更多直接经验支持的综合研究方法的讨论,包括使用速效疗法(例如氯胺酮)作为尝试通过在分析水平上同时逆转这些不足的方法来测试该综合模型的方法。僵硬和适应不良的行为)。最后,我们纳入了有关能够建立更多直接经验支持的综合研究方法的讨论,包括使用速效疗法(例如氯胺酮)作为尝试通过在分析水平上同时逆转这些不足的方法来测试该综合模型的方法。僵硬和适应不良的行为)。最后,我们纳入了有关能够建立更多直接经验支持的综合研究方法的讨论,包括使用速效疗法(例如氯胺酮)作为尝试通过在分析水平上同时逆转这些不足的方法来测试该综合模型的方法。
更新日期:2019-12-05
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