High-resolution structural studies on G-protein-coupled receptors (GPCRs) have flourished recently, providing long-sought insights into the dynamic process of guanine nucleotide-binding protein (G-protein) activation. In parallel, analogous studies are starting to shed light on how the same G-proteins are activated by non-GPCR proteins. Can we learn about common themes and variations in G-protein activation from them?

中文翻译：

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在G蛋白激活过程中，所有道路都通向罗马吗？

最近，有关G蛋白偶联受体（GPCR）的高分辨率结构研究蓬勃发展，这为鸟嘌呤核苷酸结合蛋白（G蛋白）激活的动态过程提供了长久以来的见识。同时，类似的研究开始阐明非GPCR蛋白质如何激活相同的G蛋白质。我们可以从中了解通用主题和G蛋白激活的变化吗？